• Clinical and Experimental Pediatrics
• /
• 제48권9호
• /
• pp.935-938
• /
• 2005

목 적 : 소아 비만은 동맥 경화에 따른 성인 심혈관 질환의 독립적인 위험인자이다. 저자들은 비만 소아들을 대상으로, 동맥경화증의 조기 병변인 경동맥 내막중막 두께가 정상아들에 비해 증가되어 있는지를 확인해 보고자 본 연구를 시행하였다. 방 법 : 총 32명을 대상으로 하였는데, 체질량지수가 연령, 성별 표준치의 85 백분위수 이상인 21명의 비만아/과체중아들을 비만군으로 하였고, 85 백분위수 미만이었던 11명을 정상 대조군으로 하였다. 모든 대상 소아들에서 만성 질환력과 약물 투여력이 없었다. 연령, 성별, 신장, 체중, 수축기/이완기 혈압 등이 조사되었고, 초음파를 통해 경동맥 내막중막 두께가 측정되었다. 19명의 비만아군 환아들에서 혈청 포도당, 간 transaminase 수치, 콜레스테롤 수치 등이 검사되었다. 결 과 : 비만아군의 경동맥 내막중막 두께가 대조군에 비해 증가되어 보였으나 유의한 차이를 보이지는 않았다(0.42 vs. 0.40, P=0.0592). 단순선형회귀분석 결과 체질량지수를 포함하여 경동맥 내막중막 두께의 변화를 통계적으로 의미있게 설명해 주는 변수는 없었으나, 체질량지수가 유의성에 근접하였다(P=0.0585). 결 론 : 소아들을 대상으로 경동맥 내막중막 두께 측정이 연구된 것은 저자들이 조사한 바로는 국내에서 본 연구가 시초의 것으로 생각된다. 통계적 유의성에 근접하였으나 조사 대상수의 부족으로 비만아에서 경동맥 내막중막 두께의 상승이나 체질량지수와의 의미있는 연관성을 증명해 내지는 못하였다. 향후 보다 많은 비만 소아들을 포함한 연구가 후속되어야 할 것으로 판단된다.

• 재활치료과학
• /
• 제10권2호
• /
• pp.129-140
• /
• 2021

목적 : 본 연구에서는 자폐스펙트럼장애(ASD) 영유아와 영유아의 어머니를 대상으로 수면문제 경계선 및 임상 수준과 정상 수준 간 사회성숙도와 문제행동의 차이를 검증하였다. 연구방법 : 서울시에 소재한 종합병원의 소아정신과, 발달장애 클리닉, 재활의학센터 등에서 2010년부터 2015년까지 ASD로 진단된 만 1-5세 영유아와 영유아 어머니 102명을 대상으로 축적된 자료를 활용하였으며 유아행동평가척도(CBCL 1.5-5)와 사회성숙도 검사(SMS) 자료를 최종분석에 사용하였다. 결과 : ASD 영유아의 수면문제 수준은 T점수에서 56.58로 나타났다. 수면문제는 CBCL 1.5-5의 하위척도들과 유의한 상관관계를 나타냈으나, 사회지수와 유의한 상관관계를 나타내지 않았다. 본 연구에서는 수면문제 경계선 및 임상 수준 집단과 정상 수준의 2개 집단으로 나누었다. 집단 간 사회성숙도의 차이를 검증한 결과, 경계선 및 임상 수준 집단이 정상 수준 집단보다 SMS의 사회지수가 낮았다. 또한, 정서적 반응성, 불안/우울, 신체증상, 위축 등 내재화 문제와 주의집중문제, 공격행동 등 외현화 문제가 심각했다. 이외 DSM 전반적 발달문제, DSM 주의력결핍/과잉행동장애, DSM 반항행동문제 등 외현화 DSM 장애 증상이 유의하게 심각했다. 결론 : 수면문제 경계선 및 임상 수준 집단은 정상 수준 집단과 비교하여 유의하게 낮은 사회성숙도와 심각한 문제행동을 나타낸다는 것을 확인하였다.

• Journal of Chest Surgery
• /
• 제33권8호
• /
• pp.648-654
• /
• 2000

Background: Cardiopulmonary bypass during open heart surgery causes systemic inflammatory respose. IL-10 is an anti-inflammatory cytokine that inhibits inflammatory process and protects organ function by down regulation of pro-inflammatory cytokine release and maintenance of blood level balance with pro-inflammatory cytokines. Mateial and Method: Plasma IL-10 levels were measured and analyzed in 22 patients who underwent open heart surgery (11 cases of coronary artery bypass graft, 11 cases of valve replacement) under cardiopulmonary bypass since 1988 January to July at Department of Thoracic and Czardiovascular surgery, Yeungnam University Hospital. 1g of methylprednisolone was administrated to thirteen patients randomly. Blood samp.es were taken and collected at the time of induction of anesthesia, 10 min before cardiopulmonary bypass, 10 min after starting of CPB, 10 min aftr aortic cross clamping, 10 min after ACC release, and 10 min, 2 hours, and `5 hours after CPB respectively. The plasma levels of IL-10 were determined by enzyme-linked immunosorbent assays(ELISA). Wilcoxon-Raule Sum test was used for statistical analysis. Result: In all 22 patients, cardiopulmonary bypass time was used for statistical analysis. Result: In all 22 patients, cardiopulmonary bypass time was 171$\pm$41.4 min and aortic cross clamp time was 118$\pm$36.5 min. Peak IL-10 level was achieved at 10 min after ACC(361.0$\pm$52.81pg/ml) and was decreased sharply at 2 hours after CPB. Peak IL-10 level was correlated positively with aortic cross clamp time(p=0.011); however, it did not correlated with bypass time(p=0.181). In valve replacement group, mean IL-10 level at peak point was 567.89$\pm$107.69 pg/ml and was significantly higher than that of coronary artery bypass group(205.67$\pm$192.70 pg/ml)(p<0.001). ACC time in valve replacement group was significantly longer than that of coronary artery bypass group(p<0.01), however, bypass time was not(p=0.212). Thirteen patients with steroid pretreatment before starting of CPB showed relatively higher plasma IL-10 level than in control group, however, no statistical significance was noted(p=0.19). Conclusion: plasma level of IL-10 was increased in association with cardiopulmonary bypass and revealed peak at 10 min after ACC release. IL-10 level was correlated positively with ACC time. Therefore, systemic inflammatory respeonse in association with cardiopulmonary bypass could be decreased by reducing ACC time during cardiac surgery.

• 융합보안논문지
• /
• 제22권4호
• /
• pp.3-9
• /
• 2022

최근 4차 산업혁명 환경이 도래하면서 어느 조직이든 데이터의 개방과 공유, 융합이 활발하게 이루어지고 있다. 그런데 데이터의 개방과 공유는 필연적으로 보안 취약성을 초래할 수밖에 없으며 오히려 4차 산업혁명 환경에서 운영되는 조직의 존폐까지 영향을 미칠 수 있는 위협요인으로 대두되는 양면성이 있다. 특히 군이라는 조직에서 보안 문제는 군자체가 아닌 국가의 위협이 될 수 있으므로 항상 높은 수준의 보안 기강 유지가 필수적으로 요구된다. 이에 본 논문에서는 군(軍) 보안수준에 영향을 미칠 수 있는 요인을 추출하여 보안수준 발전대책을 모색하기 위해 계획 행동이론, 억제이론, 보호 동기 이론 등을 적용한 구조방정식 모형을 통해 14개 변수를 선별하였고 각 이론과 변수의 영향력을 검정하였다. 그 결과 평소 보안규정 교육과 평가를 통해 체화된 보안지식은 행동에 영향을 미친다는 계획 행동이론을 채택할 수 있었고, 억제이론과 보호 동기 이론은 기각 수준의 유의미성을 나타냈다. 또한, 3년간의 보안감사 결과 측정된 값을 통해 군(軍) 보안수준에 가장 큰 영향을 미치는 변수는 지휘 관심과 정신보안이라는 사실도 확인되었다. 결론적으로 군(軍) 보안수준을 높이기 위해서는 보안교육과 신상필벌, 보안시스템 고도화 등과 함께 지휘 관심과 정신보안 태세를 확고히 해야 한다는 내용이 발전대책으로 제시되었다.

• Journal of Korean Neurosurgical Society
• /
• 제52권4호
• /
• pp.293-299
• /
• 2012

Objective : To evaluate the surgical efficacy of and factors associated with decompressive craniectomy in patients with an internal carotid artery (ICA) territory infarction. Methods : Seventeen patients (8 men and 9 women, average age 61.53 years, range 53-77 years) were treated by decompressive craniectomy for an ICA territory infarction at our institute. We retrospectively reviewed medical records, radiological findings, and National Institutes of Health Stroke Scale (NIHSS) at presentation and before surgery. Clinical outcomes were assessed using the Glasgow Outcome Scale (GOS). Results : Of the 17 patients, 15 (88.24%) achieved a poor outcome (Group A, GOS 1-3) and 2 (11.76%) a good outcome (Group B, GOS 4-5). The mortality rate at one month after surgery was 52.9%. Average preoperative NIHSS was $27.6{\pm}10.88%$ in group A and $10{\pm}4.24%$ in group B. Mean cerebral infarction fraction at the septum pellucidum level before surgery in group A and B were 33.67% and 23.72%, respectively. Mean preoperative NIHSS (p=0.019) and cerebral infarction fraction at the septum pellucidum level (p=0.017) were found to be significantly associated with a better outcome. However, no preexisting prognostic factor was found to be of statistical significance. Conclusion : The rate of mortality after ICA territory infarction treatment is relatively high, despite positive evidence for surgical decompression, and most survivors experience severe disabilities. Our findings caution that careful consideration of prognostic factors is required when considering surgical treatment.

• 한국항행학회논문지
• /
• 제19권5호
• /
• pp.370-378
• /
• 2015

데이터획득/처리장치는 수리온의 2차양산 항공기에 최초 적용하기 위해 개발한 항공기 구성품으로서 엔진, 동력전달, 유압 등 항공기의 주요 계통의 정보를 처리, 타 계통 및 조종사에게 제공한다. 그러나 항공기 생산시험비행 중 해당 구성품과 관련된 여러 결함이 발생하였으며, 장비의 중요성을 고려할 때 긴급하고 확실한 개선이 요구되었다. 본 논문에서는 항공기에서 발생한 결함을 유형별로 분석하고 그 결과를 바탕으로 동작회로와 소프트웨어 전반에 걸쳐 원인분석 및 개선형상을 검증한 결과를 기술하였다. 특히 결함주입기법 기반의 항공기 연동시험을 통해 구성품 장비단위 뿐 아니라 체계단위에서 효과적으로 개선형상을 검증하였으며 이를 통해 수리온 비행안전성 및 품질 신뢰성을 크게 향상시킬 수 있었다.

• 대한한의학회지
• /
• 제29권1호
• /
• pp.117-133
• /
• 2008

Objectives : Since ancient times, Koreans have applied medicinal spabaths for treatment of various diseases. The objective of this study was to investigate the effect of strontium, one of the common ingredients of such baths, experimentally on acute skin barrier damage. Materials and Methods : Male hairless mice, average weight 20g, were divided into six groups. Each group consisted of five mice. The first was the normal, non-treated group. The second was the control group with acute skin barrier damage intentionally induced by TS. The third was the Ba-Sr1 group bathed in 1mg/L strontium chloride before and after inducing acute skin barrier damage by TS. The fourth was the Ba-Sr7 group bathed in 7mg/L strontium chloride before and after inducing acute skin barrier damage by TS. The fifth was the Sr1 group bathed in 1mg/L of strontium chloride only after intentionally inducing acute skin barrier damage by TS. The sixth was the Sr7 group bathed in 7mg/L of strontium chloride only after intentionally inducing acute skin barrier damage by TS. External changes of skin, skin erythema level, transepidermal water loss level, and GOT and GPT level of each group were checked immediately before and after TS, 3 hrs, 5 hrs and 24 hrs after inducing acute skin barrier damage. Then, tissue samples were made and examined for damage to epithelial cells, stratum corneum, change of mucous polysaccharide in dermis and amount of mast cells. Statistical analysis was performed by one way-ANOVA, Scheffe and Duncan for a post hoc test and pairwise comparison for comparing for difference between each time. Statistical significance was achieved if the probability was less than 5% (p<0.05) Results : 1. From skin erythema and TEWL level indicating the function of the skin barrier, we can know that it is helpful to the skin barrier to bathe in a water solution including a low concentration of strontium. 2. In the control group with acute skin barrier damage induced by TS, skin barrier damage persisted until 3-5 hrs and recovered after 5-24 hrs. Differently from the control group, in the case of taking a bath in a water solution including strontium, skin barrier damage recovered after only 3-5 hrs. Therefore, the bath with a water solution including strontium can promote recovery of the skin barrier. 3. Bathing in water solution including a higher concentration of strontium was more beneficial to recovery of skin barrier damage. 4. There was no influence on serum GOT and GPT from bathing in a water solution including strontium. Conclusions : The strontium was effective for recovery and mitigation of acute skin barrier damage induced by tape stripping. I suggest that strontium (Sr) can be used as an external treatment medicine, addedinto bath water to treat acute skin barrier damage.

• Communications for Statistical Applications and Methods
• /
• 제19권3호
• /
• pp.405-414
• /
• 2012

층화확률추출은 모집단을 어떤 층화기준에 의해 여러 층으로 분할한 다음 각 층으로부터 독립적으로 표본을 임의추출하는 방법으로 여러 가지 장점을 가지고 있어 실제 조사에서 많이 활용되고 있다. 본 연구에서는 대규모 표본조사에서 많이 사용하고 있는 층화확률추출을 사용하여 추출된 표본을 통해 모평균에 대한 붓스트랩 추정량과 신뢰구간 및 가설검정 등 통계적 추론에 대하여 연구하였다. 층화모집단에서의 모평균의 추정량과 관련된 극한 분포이론들을 기초로 붓스트랩 일치성을 근거로 층화 모평균에 대해 표준 붓스트랩 방법, 백분위수 붓스트랩 방법, 스튜던트화 붓스트랩 방법을 활용한 신뢰구간과 붓스트랩 가설검정 방법을 제안하였으며, 모의실험을 통해 신뢰구간 추정 방법들의 유효성을 확인하였다.

• 한국운동역학회지
• /
• 제26권2호
• /
• pp.143-151
• /
• 2016

Objective: The purpose of this study was to investigate the effect of fatigue induction on ground reaction force (GRF) components, postural stability, and vertical jump performance in Taekwondo athletes. Method: Ten Taekwondo athletes (5 men, 5 women; mean age, $22.30{\pm}2.62years$; mean height, $174.21{\pm}9.20cm$; mean body weight, $67.28{\pm}12.56kg$) participated in this study. Fatigue was induced by a short period of strenuous exercise performed on a motorized treadmill. The analyzed variables included vertical jump performance, static stability (mediolateral [ML], center of pressure [COP], anteroposterior [AP] COP, ${\Delta}COPx$, ${\Delta}COPy$, and COP area), postural stability index values (ML stability index [MLSI], AP stability index [APSI], vertical stability index [VSI], dynamic postural stability index [DPSI]), and GRF components (ML force, AP force, peak vertical force [PVF], and loading rate). To analyze the variables measured in this study, PASW version 22.0 was used to calculate the mean and standard deviation, while a paired t-test was used to evaluate the pre- versus post-fatigue results. Pearson's correlation coefficients among variables were also analyzed. The statistical significance level was set at ${\alpha}$ = .05. Results: Vertical jump performance decreased significantly after the induction of fatigue, while AP COP, ${\Delta}COPx$, COP area, APSI, VSI, and DPSI increased significantly. PVF and loading rate increased significantly after the induction of fatigue, while the postural stability variables (AP COP, ${\Delta}COPy$, COP area, APSI, VSI, DPSI) were similarly correlated with GRF components (PVF, loading rate) after fatigue was achieved (r = .600, $R^2$ = 37%). Conclusion: These results suggest that the induction of fatigue can decrease postural stability and exercise performance of Taekwondo athletes during training and competition sessions.

• Asian Pacific Journal of Cancer Prevention
• /
• 제16권18호
• /
• pp.8163-8171
• /
• 2016

Background: Breast cancer is the second most cause of death (1.38 million, 10.9% of all cancer) worldwide after lung cancer. In present study, we assess the knowledge, level of awareness of risk factors and screening practices especially breast self examination (BSE) among women, considering the non-feasibility of diagnostic tools such as mammography for breast screening techniques of breast cancer in the holy city Varanasi, Uttar Pradesh, India. Materials and Methods: A cross-sectional population based survey was conducted. The investigation tool adopted was self administrated questionnaire format. Data were analysed using SPSS 20 version and Chi square test to determine significant association between various education groups with awareness and knowledge, analysis of variance was applied in order to establish significance. Results: The attitude of participants in this study, among 560 women 500 (89%) responded (age group 18-65 years), 53.8% were married. The knowledge about BSE was very low (16%) and out of them 15.6% were practised BSE only once in life time. study shown that prominent age at which women achieve their parity was 20 yrs, among 500 participants 224 women have achieved their parity from age 18 to 30 yrs. Very well known awareness about risk factors of breast cancer were alcohol (64.6%), smoking (64%) and least known awareness risk factors were early menarche (17.2%) and use of red meat (23%). The recovery factors of breast cancer cases were doctors support (95%) and family support (94.5%) as most familiar responses of the holy city Varanasi. Conclusions: The study revealed that the awareness about risk factors and practised of BSE among women in Varanasi is extremely low in comparison with other cities and countries as well (Delhi, Mumbai, Himachal Pradesh, Turkey and Nigeria). However, doctors and health workers may promote the early diagnosis of breast cancer.