• 제목/요약/키워드: Abnormally

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Motor Evoked Potential and Somatosensory Evoked Potential Studies in Acquired Demyelinating Polyneuropathy (후천성 탈수초성 다발신경병증에서의 운동유발전위 및 체성감각유발전위 연구)

  • Kwon, Hyung-Min;Hong, Yoon-Ho;Oh, Dong-Hoon;Lee, Kwang-Woo
    • Annals of Clinical Neurophysiology
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    • v.6 no.1
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    • pp.20-25
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    • 2004
  • Background and Objectives: The proximal and distal nerve segments are preferentially involved in acquired demyelinating polyneuropathies (ADP). This study was undertaken in order to assess the usefulness of motor evoked potential (MEP) and somatosensory evoked potential (SSEP) in the detection of the proximal nerve lesion in ADP. Methods: MEP, SSEP and conventional NCS were performed in 6 consecutive patients with ADP (3 AIDP, 3 CIDP). MEP was recorded from abductor pollicis brevis and abductor hallucis using magnetic stimulation of the cortex and the cervical/lumbar spinal roots. SSEP were elicited by stimulating the median and posterior tibial nerves. Latency from cortex and cervical/lumbar roots, central motor conduction time (CMCT), EN1-CN2 interpeak latency were measured for comparison. Results: MEP was recorded in 24 limbs (12 upper and 12 lower limbs) and SSEP in 24 limbs (12 median nerve, 12 posterior tibial nerve). F-wave latency was prolonged in 25 motor nerves (25/34, 73.5%). Prolonged CML and PML were found in 41.7% (10/24) and 45.8% (11/24), respectively. Interside difference (ISD) of CMCT was abnormally increased in the upper extremity, 66.7% (4/6 pairs) in case of CML-PML. EN1-CN2 interpeak latency was abnormally prolonged in one median nerve (1/10) and LN1-P1 interpeak latency was normal in all posterior tibial nerves. Conclusions: MEP and SSEP may provide useful information for the proximal nerve and root lesion in ADP. MEP and SSEP is supplemental examination as well as complementary to conventional NCS.

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Chorea in Systemic Lupus Erythematosus: Evidence for Bilateral Putaminal Hypermetabolism on F-18 FDG PET (전신성 홍반성 루푸스에서 F-18 FDG PET상 기저핵 포도당대사 증가 소견을 보이는 무도병 1예)

  • Seo, Wook-Jang;Chung, Son-Mi;Koh, Su-Jin;Lee, Chang-Keun;Kim, Jae-Seung;Im, Joo-Hyuk;Yoo, Bin;Moon, Hee-Bom
    • The Korean Journal of Nuclear Medicine
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    • v.37 no.5
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    • pp.325-330
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    • 2003
  • Purpose: We describe a 54-year-old woman with systemic lupus erythematosus (SLE) who suddenly presented with chorea and had positive antiphospholipid antibodies. F-18 FDG PET showed abnormally increased glucose metabolism in bilateral putamen and primary motor cotex. Tc-99m ECD SPECT also showed abnormally increased regional cerebral blood flow in bilateral putamen. She was treated with corticosteroid and aspirin after which the symptoms improved. Four months later, follow up F-18 FDG PET showed improvement with resolution of hypermetabolism in bilateral putamen. This case suggests that striatal hypermetabolism is associated with chorea in SLE.

Mulberry Growth Promotion by Nitrogen Application under Abnormally Wet and Cool Weather Conditions (하추기 이상 저온하에서 뽕나무 발육부진요인과 추비에 의한 생육증진)

  • 이원주;윤명근
    • Journal of Sericultural and Entomological Science
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    • v.36 no.2
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    • pp.110-114
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    • 1994
  • Abnormally cool and wet weather conditions during the summer of 1993 offered an opportunity to evaluate the effects of abnormal weather conditions on mulberry growth and to develop cultivation practicies to reduce leaf yield loss under the similar abnormal weather conditions. Different methods of nutrient supplementation were evaluated in Suwon and Kongju. Nitrogen was supplemented by foliar spray of urea(1.7%) or composite chemical fertilizer Jamsibiryo #8, or by the application of ammonium sulfate(60kg/ha) to the soil. During the period between the late June and the early September which corresponds to the mulberry growing season after summer pruning, mean temperature was 1.4$^{\circ}C$ lower and precipitation 83mm higher than normal year. This weather condition in 1993 caused reduction in leaf yield by 16.4% than common year. Soil nitrogen content decreased due to higher precipitation. Leaf yield loss was reduced by the supplementation of nitrogen to the soil. Leaf nitrogen content increased with the foliar urea spray and nitrogen supplementation to the soil.

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Cutting Frequency Effects on Forage Yield and Stand Persistence of Orchardgrass and Alfalfa-Orchardgrass Fertilized with Dairy Slurry

  • Min, D.H.;Vough, L.R.
    • Asian-Australasian Journal of Animal Sciences
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    • v.13 no.5
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    • pp.630-635
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    • 2000
  • Previous research has not evaluated the effects of various rates and frequencies of manure application and frequencies of cutting on yield and stand persistence of cool-season grasses and alfalfa-grass mixtures. The primary objective of this study was to compare the effects of cutting management systems on herbage yield and stand persistence of orchardgrass (Dactylis glomerata L.) and an alfalfa (Medicago sativa L.)-orchardgrass mixture from various rates and frequencies of dairy slurry application. A randomized complete block design with treatments in a sub-subplot arrangement with four replicates was used. The main plot consisted of 2 cutting management systems (4 and 5 annual cuttings). The subplots were 9 fertility treatments: 7 slurry rate and frequency of application treatments, one inorganic fertilizer treatment, and an unfertilized control. The split-split-plots were the two forage species: orchardgrass and alfalfa-orchardgrass mixture. The study was initiated after 1st cutting in 1995. Cumulative yields of the 2nd and subsequent cuttings of both orchardgrass and alfalfa-orchardgrass in 1995 were higher for the 5-cutting system than the 4-cutting system. The 1995 growing season was abnormally dry. In 1996, an abnormally wet year, the reverse was true, total herbage yields being higher for the 4-cutting system than the 5-cutting system. Species response to fertility rate/frequency treatments was different in both years. Higher application rates early in the season and carryover of nutrients from late season applications the previous year appear to be responsible for the yield increases of those fertility treatments having significant yield differences between the cutting management systems. The stand ratings of orchardgrass were not affected by cutting management. In the spring of 1997, however, the stand ratings of alfalfa-orchardgrass in the 4-cutting management system were significantly greater than the 5-cutting management system. The very high manure application rate significantly reduced the stand ratings of alfalfa-orchardgrass in the 5-cutting system.

Analysis of Clinical Biochemical Components in Sera of Tsutsugamushi Disease Patients

  • Kim, Chong-Ho;Park, Seung-Taeck;Oh, Geum-Ga
    • Biomedical Science Letters
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    • v.13 no.4
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    • pp.287-291
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    • 2007
  • The factors and mechanisms by infection of Oriental Tsutsugamushi caused disease are not well understood. The onset of tsutsugamushi disease is characterized by chilliness, fever, malaise, headache and generalized aching. Infection of tsutsugamushi is the cause of impairment of function of a major organ often complicate the picture and immediately change the prognosis for the worse. Tsutsugamushi disease is reported that this disease is characterized by the histopathogenesis of liver, kidney, heart, and lung, but the variation of biochemical components in serum of tsutsugamushi disease patient are not clear. We analyzed total protein (TP), albumin (AL), aspartic aminotranferase (AST), alanine aminotransferase (ALT), alkaline phosphotase (ALP), urea nitrogen (UN), creatinine (CRE), glucose (GLD), cholesterol (CHOL) and total bilirubin (TB) in sera of patients with tsutsugamushi disease. In comparison with reference, total protein and albumin were abnormally decreased in 19.6% and 39.2% of patients, respectively. AST, ALT, ALP, creatinine, UN, glucose, cholesterol and total bilirubin were abnormally increased in 94.1 %, 72.5%, 25.5%, 15.7%, 9.8%, 62.7%, 25.5% and 6.0% of patients, respectively. The patients showed abnormal relative rate of protein electrophoretic fractions to total protein in serum compared to them of reference were 43.1% (albumin), 12.9% ($\alpha_1$-globulin), 58.8% ($\alpha_2$-globulin), 60.8% ($\beta$-globulin) and 70.6% ($\gamma$-globulin), respectively. These data suggest that infection of Oriental Tsutsugamushi causes impairment of function of a major organ and abnormal serum protein electrophoresis fractions to tsutsugamushi patients.

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Molecular biological characterization of the new virus isolated from abnormally swimming salmonid - Reverse transcriptase activity - (이상유영(異常遊泳) 증상(症狀)을 나타내는 연어과 어류(魚類)에서 분리(分離)된 새로운 바이러스의 분자생물학적(分子生物學的) 특성(特性) - 역전사효소 활성 -)

  • Oh, Myung-Joo
    • Journal of fish pathology
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    • v.9 no.2
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    • pp.177-183
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    • 1996
  • A new RNA virus isolated from abnormally swimming behavior has caused mortalities in salmonid fish (Oh et al., 1995 a), A reverse transcriptase (RTase) activity of the virus was determined by using poly r(A) : oligo d(T) as templete : primer. This RTase activity was associated with virus particles of buoyant density of 1.16 g/ml. The virus particles in sucrose fractions were enveloped and were about 85 nm diameter with central electron-dense core. The brain and kidney samples of artificially infected fish showed RTase activity. Virus particle associated proteins about 120, 80, 65, 61, 48, 42, 35, 30, 25, 19, and 15 kDa were observed when examined by polyacrylamide gel electrophoresis analysis. This study showed the presence of a new retrovirus in salmonid fish, which tentatively called RVS (Retrovirus of salmonid).

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Detection of Abnormally High Amygdalin Content in Food by an Enzyme Immunoassay

  • Cho, A-Yeon;Yi, Kye Sook;Rhim, Jung-Hyo;Kim, Kyu-Il;Park, Jae-Young;Keum, Eun-Hee;Chung, Junho;Oh, Sangsuk
    • Molecules and Cells
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    • v.21 no.2
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    • pp.308-313
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    • 2006
  • Amygdalin is a cyanogenic glycoside compound which is commonly found in the pits of many fruits and raw nuts. Although amygdalin itself is not toxic, it can release cyanide (CN) after hydrolysis when the pits and nuts are crushed, moistened and incubated, possibly within the gastrointestinal tract. CN reversibly inhibits cellular oxidizing enzymes and cyanide poisoning generates a range of clinical symptoms. As some pits and nuts may contain unusually high levels of amygdalin such that there is a sufficient amount to induce critical CN poisoning in humans, the detection of abnormal content of amygdalin in those pits and nuts can be a life-saving measure. Although there are various methods to detect amygdalin in food extracts, an enzyme immunoassay has not been developed for this purpose. In this study we immunized New Zealand White rabbits with an amygdalin-KLH (keyhole limpet hemocyanin) conjugate and succeeded in raising anti-sera reactive to amygdalin, proving that amygdalin can behave as a hapten in rabbits. Using this polyclonal antibody, we developed a competition enzyme immunoassay for determination of amygdalin concentration in aqueous solutions. This technique was able to effectively detect abnormally high amygdalin content in various seeds and nuts. In conclusion, we proved that enzyme immunoassay can be used to determine the amount of amygdalin in food extracts, which will allow automated analysis with high throughput.

Activity of Protein Kinase C in Abnormally Proliferated Vascular Endothelial Cells (비정상적인 세포증식이 유도된 혈관 내피세포에서 Protein Kinase C에 대한 활성 분석)

  • Bae, Yong Chan;Park, Suk Young;Nam, Su Bong;Moon, Jae Sul;Choi, Su Jong
    • Archives of Plastic Surgery
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    • v.34 no.1
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    • pp.13-17
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    • 2007
  • Purpose: To understand the pathogenesis of the disease that presents abnormally proliferated vascular endothelial cells, a model of DMH(1,2-dimethylhydrazine)-induced abnormal proliferation of HUVECs(Human Umbilical Vein Endothelial Cells) was made. We indirectly determined that Protein Kinase C(PKC) restricts the cellular proliferation and inhibits the manifestation of growth factor by using several inhibiting substances of the transmitter through our previous studies. Thereupon, we attempted to observe direct enzymatic activities of PKC and its correlation with the abnormal proliferation of vascular endothelial cells. Methods: $10^5$ HUVECs cells were applied to 6 individual well plates in three different groups; A control group cultured without treatment, a group concentrated with $0.75{\times}10^{-8}M$ DMH only, and a group treated with DMH & $5{\times}10^{-9}M$ Calphostin C, inhibitor of PKC. In analyzing the formation of intracellular PKC enzyme, protein separation was performed, and separated protein was quantitatively measured. PKC enzyme reaction was analyzed through Protein Kinase C Assay System (Promega, USA), and the results were analyzed according to Beer's law. Results: Enzymatic activity of PKC presented the highest in all reaction time of a group concentrated only with DMH, and the lowest in the control group. The group treated with DMH and the inhibitor revealed statistically lower enzymatic activity than group only with DMH in all reaction time, although higher than the control group. Conclusion: From the enzymatic aspect, most active and immediate reaction of the PKC was observed in the group concentrated with DMH only. The group treated with DMH & PKC inhibitor showed meaningful decrease. Accordingly, PKC holds a significant role in DMH-induced abnormal proliferation of vascular endothelial cells.

A Study on the Leakage Evaluation for Power Plant Valve Using Infrared Thermography Method (적외선열화상에 의한 발전용 밸브 누설명가 연구)

  • Lee, Sang-Guk
    • Journal of the Korean Society for Nondestructive Testing
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    • v.30 no.2
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    • pp.110-115
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    • 2010
  • This study was conducted to estimate the feasibility using thermal image measurement that is applicable to internal leak diagnosis for the power plant valve. Abnormal heating of valve surface associated with high temperature steam f10w toward valve outlet side in the condition of low temperature is a primary indicator of leakage problems in high temperature and pressure valves. Thermal imaging enables to see the invisible thermal radiation that may portend impending damage before their condition becomes critical. When steam flow in valve outlet side in the condition of low temperature is converted into heat transmitted through the valve body due to the internal leakage in valve. The existence of abnormally increasable leakage rate in the valve will result in abnormally high levels of heat to be generated that can be quickly identified with a thermal image avoiding energy loss or damage of valve component. From the experimental results, it was suggested that the thermal image measurement could be an effective way to precisely diagnose and evaluate internal leak situation of valve.