Biomedical Science Letters (대한의생명과학회지)
- Volume 13 Issue 4
- /
- Pages.287-291
- /
- 2007
- /
- 1738-3226(pISSN)
- /
- 2288-7415(eISSN)
Analysis of Clinical Biochemical Components in Sera of Tsutsugamushi Disease Patients
- Kim, Chong-Ho (Department of Clinical Pathology, Wonkwang Health Science College) ;
-
Park, Seung-Taeck
(School of Medicine, Wonkwang University) ;
- Oh, Geum-Ga (Department of Clinical Pathology, Namwon Medical Center)
- Published : 2007.12.31
Abstract
The factors and mechanisms by infection of Oriental Tsutsugamushi caused disease are not well understood. The onset of tsutsugamushi disease is characterized by chilliness, fever, malaise, headache and generalized aching. Infection of tsutsugamushi is the cause of impairment of function of a major organ often complicate the picture and immediately change the prognosis for the worse. Tsutsugamushi disease is reported that this disease is characterized by the histopathogenesis of liver, kidney, heart, and lung, but the variation of biochemical components in serum of tsutsugamushi disease patient are not clear. We analyzed total protein (TP), albumin (AL), aspartic aminotranferase (AST), alanine aminotransferase (ALT), alkaline phosphotase (ALP), urea nitrogen (UN), creatinine (CRE), glucose (GLD), cholesterol (CHOL) and total bilirubin (TB) in sera of patients with tsutsugamushi disease. In comparison with reference, total protein and albumin were abnormally decreased in 19.6% and 39.2% of patients, respectively. AST, ALT, ALP, creatinine, UN, glucose, cholesterol and total bilirubin were abnormally increased in 94.1 %, 72.5%, 25.5%, 15.7%, 9.8%, 62.7%, 25.5% and 6.0% of patients, respectively. The patients showed abnormal relative rate of protein electrophoretic fractions to total protein in serum compared to them of reference were 43.1% (albumin), 12.9% (
Keywords
- Tsutsugamushi;
- Albumin;
- Aspartic aminotranferase (AST);
- Alanine aminotransferase (ALT);
- Urea nitrogen (UN);
- Creatinine;
- Glucose