• Journal of the korean Society of Automotive Engineers
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• v.7 no.1
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• pp.48-54
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• 1985

One of the most probable reason of the apex seal damage in IR-2500 industrial Wankel (rotary) engine was believed to be the engine detonation. Both analytical and experimental studies were made with a view th find out engine detonation pressure. The stagnation detonation pressure $p_{03}$' was estimated based on the data from IR-2500 engine detonation tests, such as engine firing pressure, state of fresh charge at BDC and polytropic compression exponent. The estimated stagnation detonation pressure for the natural gas fueled IR-2500 engine was in excess of 3,700 psia. With natural gas liquid added to the natural gas the octane value of the fuel was lowered, thus, making the engine more prone to detonate. The estimated detonation pressure for the case with the mixed fuel was about 3,400 psia which was sufficiently high to break the apex seal. The subsequent engine lab tests performed on two identical engines with sole difference in the apex seal thickness between the two engines proved that the engine knock, in fact, was the villain of the apex seal failure.ilure.

• International Journal of Industrial Entomology and Biomaterials
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• v.5 no.1
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• pp.109-122
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• 2002

The purpose of this investigation is to evaluate the effects of the Nuegra on enhancement of the masculine and physical activities in general through measuring changes of the testosterone, FSH and subjective symptoms like fatigue, insomnia, urinary stream, muscular weakness, libido and erectile dysfunction. Total 168 male subjects were enrolled from 12 urology, internal medicine clinics and general practitioner, During the 6-week investigational period, 2 capsules of Nuegra were given to the subjects right after meal for 4 weeks, and 1 capsule of Nuegra was added each time in subjects with no or minimal effect. Testoster-one and FSH levels were measured at first visit and last visit, for evaluating masculine activities. To avoid bias and standardize the test results, only one clinic was assigned as a central lab, and all blood samples were transferred. General information and subjective symptoms were evaluated at first visit and at 2 weeks interval, week 2, 4 and 6 using VAS (Visual Analogue Scale). The mean age of the subjects were 51.8${\pm}$8.2 years old (range: 36.1-82.1). Based on the subjects who were tested on testosterone and FSH levels at day l and week 6, the means were 4.4${\pm}$1.4 nmol/L (range: 2.6-7.7), 8.6${\pm}$9.6 mIU/mL (range: 0.3-40.4), respectively at day 1. At week 6, the results were 4.9 ${\pm}$1.6 (2.6-8.9 range), 9.4${\pm}$13.1 (1.0-53.9 range), respectively. Marginally significant difference between pre-dose and post-dose was present. Statistically significant differences were revealed in general assessment for subjective symptoms, fatigue, insomnia, erectile dysfunction, etc. In fatigue, response rates were 39.6, 65.4 and 76.4% at week 2, 4 and 6, respectively (P < 0.0001). Response vates for erectile dysfunction were 13.4, 41.2 and 72.7% at week 2, 4, and 6 (P < 0.0001), respectively, Response rates for libido were 13.6, 51.6 and 73.5% at week 2, 4, and 6 (P < 0.0001), respectively. For urinary stream response rates were 26.9, 44.7 and 66.8% at week 2, 4, and 6 (P < 0.0001), respectively. VAS for muscular weakness did not show significant results that response rates were 40, 60 and 80% at week 2, 4, and 6 from 8.2 (P ＝ 0.24), respectively. Response rates for insomnia were 50, 60, 100% at week 2, 4, and 6 (P < 0.0001), respectively. The results shows that Nuegra tends to enhance masculine activities including libido, erectile dysfunction and urinary stream and also effective for improving general conditions especially insomnia, muscular weakness and fatigue. In conclusion, this investigation has demonstrated that Nuegra does not only have tendency to increase masculine activities through increased secretion of the testosterone and FSH but also improve general conditions such as erectile dysfunction, libido, fatigue and muscular power.

• Restorative Dentistry and Endodontics
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• v.23 no.1
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• pp.339-345
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• 1998

The purpose of this study was to evaluate the in vitro accuracy of Root ZX(Morita Co., Japan) which is the ratio type electronic apex locator. The 86 extracted human palatal roots of maxillary molar with fully formed apices were used. File lengths with the file tip just visible at the foramen were compared to those measured with Root ZX. For length measuring with Root ZX, saline test model with which the apical 1/3 of each root was submerged into normal saline were designed. The root canal lengths were determined with Root ZX and the radiographs were taken with a file in the canal. The distances from file tips of Root ZX lengths to apecies in radiographs also were measured with Profile projector PJ311(Mitutoyo Co., Japan). The results were as follows : 1. The root canal length determined with electronic apex locator was $0.78{\pm}0.53mm$ shorter than the length with visual measurement. 2. The file tip of Root ZX lengths was located at $0.85{\pm}0.49mm$ away from the apex in radiograph. 3. The accuracy of the Root ZX was 79.1% within 0.5mm of visual working length and 96.5% within 1.0mm.

• Restorative Dentistry and Endodontics
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• v.41 no.1
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• pp.6-11
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• 2016

Objectives: The purpose of this in vitro study was to evaluate the accuracy of working length (WL) determination of four electronic apex locators (EALs), namely, Root ZX (RZX), Elements diagnostic unit and apex locator (ELE), SybronEndo Mini Apex locator (MINI) and Propex pixi (PIXI) using Stainless steel (SS) and nickel-titanium (NiTi) hand files. The null hypothesis was that there was no difference between canal length determination by SS and NiTi files of 4 EALs. Materials and Methods: Sixty extracted, single rooted human teeth were decoronated and the canal orifice flared. The actual length (AL) was assessed visually, and the teeth were embedded in an alginate model. The electronic length (EL) measurements were recorded with all four EALs using SS and NiTi files at '0.5' reading on display. The differences between the AL and EL were compared. Results: The results obtained with each EAL with SS and NiTi files were compared with AL. A paired sample t test showed that there was a statistical significant difference between EAL readings with SS and NiTi files for RZX and MINI (p < 0.05). The accuracy of RZX, ELE, MINI and PIXI within ${\pm}0.5 mm$ of AL with SS/NiTi files were 93.3%/70%, 90%/91.7%, 95%/68.3%, and 83.3%/83.3%, respectively. Conclusions: The results of this study indicate that Root ZX was statistically more accurate with NiTi files compared to SS files, while MINI was statistically more accurate with SS files compared to NiTi files. ELE and PIXI were not affected by the alloy type of the file used to determine WL.

• The Journal of the Korean dental association
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• v.48 no.4
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• pp.297-307
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• 2010

Noncarious cervical lesions(NCCLs) are characterized as structural defects found on the tooth surface of the cement-enamel junction. Loss of tooth structure through noncarious mechanisms may vary in etiology and clinical presentation for each individual but presently many clinician now classify this as tooth failure of abfraction due to the stress applied in the cervical area of the tooth under oral physiological and pathological loads. In the current study, we investigated the stress distribution of maxillary premolar with NCCL using simulated 3D finite element analysis. The results were as follows: 1. In the sound maxillary premolar, the stresses were highly concentrated at cervical enamel surface of the mesiobuccal line angle, asymmetrically. 2. Once the lesion has been formed, the highest stress concentration was observed around the apex of the wedge shaped lesion. 3. In four types of NCCL, the patterns of stress distribution were similar and the peak stress was observed at mesial corner and also stresses concentrated at lesion apex. 4. Lesion cavity modification of rounding apex, reduced stress of lesion apex. 5. When restoring the notch-shaped lesion, material with high elastic modulus worked well at the lesion apex and material with low elastic modulus worked well at the cervical cavosurface margin.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.18
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• pp.7589-7595
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• 2014

Apurinic/apyrimidinic endonuclease 1 (APEX1) is a multifunctional protein which plays a central role in the BER pathway. APEX1 gene being highly polymorphic in cancer patients and has been indicated to have a contributive role in Apurinic/apyrimidinic (AP) site accumulation in DNA and consequently an increased risk of cancer development. In this case-control study, all exons of the APEX1 gene and its exon/intron boundaries were amplified in 530 breast cancer patients and 395 matched healthy controls and then analyzed by single-stranded conformational polymorphism followed by sequencing. Sequence analysis revealed fourteen heterozygous mutations, seven 5'UTR, one 3'UTR, two intronic and four missense. Among identified mutations one 5'UTR (rs41561214), one 3'UTR (rs17112002) and one missense mutation (Ser129Arg, Mahjabeen et al., 2013) had already been reported while the remaining eleven mutations. Six novel mutations (g.20923366T>G, g.20923435G>A, g.20923462G>A, g.20923516G>A, 20923539G>A, g.20923529C>T) were observed in 5'UTR region, two (g.20923585T>G, g.20923589T>G) in intron1 and three missense (Glu101Lys, Ala121Pro, Ser123Trp) in exon 4. Frequencues of 5'UTR mutations; g.20923366T>G, g.20923435G>A and 3'UTR (rs17112002) were calculated as 0.13, 0.1 and 0.1 respectively. Whereas, the frequency of missense mutations Glu101Lys, Ser123Trp and Ser129Arg was calculated as 0.05. A significant association was observed between APEX1 mutations and increased breast cancer by ~9 fold (OR=8.68, 95%CI=2.64 to 28.5) with g.20923435G>A (5'UTR), ~13 fold (OR= 12.6, 95%CI=3.01 to 53.0) with g.20923539G>A (5'UTR) and~5 fold increase with three missense mutations [Glu101Lys (OR=4.82, 95%CI=1.97 to 11.80), Ser123Trp (OR=4.62, 95%CI=1.7 to 12.19), Ser129Arg (OR=4.86, 95%CI=1.43 to 16.53)]. The incidence of observed mutations was found higher in patients with family history and with early menopause. In conclusion, our study demonstrates a significant association between germ line APEX1 mutations and breast cancer patients in the Pakistani population.

• Journal of Korean Academy of Oral and Maxillofacial Radiology
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• v.25 no.2
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• pp.501-511
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• 1995

The purpose of this study was to evaluate the position and shape of mental foramen in periapical radiographs. For this study, periapical radiographs of premolar areas were obtained from the 200 adults. Accordingly, the positional and shape changes of mental foramen were evaluated. The authors obtained radiographs according to changes in radiation beam direction in periapical radiographs of premolar areas, and then evaluated the positional and shape changes of mental foramen. The following results were obtained: 1. Shapes of mental foramen were observed elliptical(34.3％), round or oval(28.0％), unidentified(25.5％) and diffuse(12.2％) type in descending order of frequency. 2. Horizontal positions of mental foramen were most frequently observed at the 2nd premolar area(55.3％), the area between the 1st premolar and 2nd premolar(39.6％), the area between the 2nd premolar and 1st molar(3.4％), the 1st premolar area(1.0％), the area between the canine and 1st premolar(0.7％) in descending order of frequency. 3. Vertical positions of mental foramen were most frequently observed at the inferior to apex(67.1％), and at apex(24.8％), overlap with apex(6.4％), superior to apex(1.7％) in descending order of frequency. 4. Shapes of mental foramen were more obviously observed at the upward 10° positioned periapical radiographs. And according to the changes of horizontal and vertical position, they were observed similar to normally positioned periapical radiographs.

• Restorative Dentistry and Endodontics
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• v.28 no.1
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• pp.64-71
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• 2003

The purpose of this study was to compare the initial apical file(IAF) first Ole that fits to the apex in each canal before and after early flaring to analyze if the size of file to fit to the apex would increase after flaring. Eighty anterior teeth with complete apical formation and patent foramens were selected. The samples were randomly divided into 4 groups(GG, OS, GT, PT Group) of 20 teeth each. A file was fit to the apex in each canal and that size recorded. Radicular flaring were completed using different types of instruments. After flaring a file was again fit to the apex in the same manner as before and its size recorded. The results of this study were as follows : 1. The mean diameter of IAF before flaring(file diameters in $mm{\times}10^{-2}$) was $19.81{\pm}8.32$ before and $25.94{\pm}9.21$ after(p<0.05). 2. The increase in diameter of IAF was approximately one file size for all groups. 3. Ranking of increasing diameter of IAF were GG>CT>OS>PT group. There was a statistically significant difference between before and after flaring(p<0.05). 4 Ranking of the time for flaring were GG>GT>OS>PT group. There was a statistically significant difference between GG group and other groups(p<0.05). 5. In the case without change of IAF diameter, they showed decrease in force after flaring when IAF was pulled out from root canal(p<0.05). This study suggested that early radicular flaring increases the file size that is snug at the apex, and awareness of that difference gives the clinician a better sense of canal size. Early flaring of the canal provides better apical size information and with this awareness, a better decision can be made concerning the appropriate final diameter needed for complete apical shaping.

• The Journal of Korean Academy of Prosthodontics
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• v.31 no.3
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• pp.303-316
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• 1993

The purpose of this study was to analysis the stress distribution induced by three unit PFM bridges and various cantilever bridges replacing maxillary latersal incisor. The simplified two-dimensional photoelastic models used for this study was contructed in the folio- wing way. CR/R ratio was designed to be 1 : 1, 1 : 1.25 and 1 : 1.5. The pontics of cantilever bridge supported by maxillary canines consisted of wrap-around type, rest-extension type, and simple type. 3-unit PFM bridge was constructed with traditional method. 1kg vertical static load was applied on the center of the incisal edge of the pontic. The stress pattern was examined and recorded by photography. The results obtained were as follows ; 1. The magnitude of stress on the abutment root apex area of a traditional 3-unit bridge was the lowest. 2. The model of cantilevered pontic with a rest showed the relatively well distributed stress around the abutment tooth. The model with simple pontic generated the greatest stress concentration in the supporting structure of the abutment tooth. 3. As the height of bone level reduced, the rotational and vertical force increased around the abutment tooth. 4. The stress concentration of the 3-unit bridges occured on the root apex and stress concentration of the cantilever briage occured on the root apex and cervix area, 5. In the case of the cantilever bridge, stress concentrated distally on the root apex area of the abutment tooth and additional stress was observed mesially on the upper part of the root. Especially in the case of the simple pontic, was phenomenon was more apparent than the others. 6. Force applied to cantilevered pontic was transmitted to the adjacent central incisor through the contact surface. Stress was markedly observed on the mesial cervix area in the case of simple pontic and on the root apex area in the case of wrap-around type and rest-extension type.

• The Journal of Advanced Prosthodontics
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• v.2 no.3
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• pp.92-96
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• 2010

PURPOSE. The aim of this study was to evaluate the thickness of buccal and palatal alveolar bone and buccal bony curvature below root apex in maxillary anterior teeth of Korean adults using Cone-beam CT images. MATERIALS AND METHODS. The 3D image was reconstructed with dicom file obtained through CBCT from 20 - 39 year old Korean subjects (n = 20). The thickness of buccal and palatal plate, root diameter, the buccal bony curvature angle below root apex and the distance from root apex to the deepest point of buccal bony curvature were measured on maxillary anterior teeth area using OnDemand3D program. RESULTS. Mean thickness of buccal plate 3 mm below CEJ was $0.68{\pm}0.29\;mm$ at central incisor, $0.76{\pm}0.59\;mm$ at lateral incisor, and $1.07{\pm}0.80\;mm$ at canine. Mean thickness of palatal plate 3 mm below CEJ was $1.53{\pm}0.55\;mm$ of central incisor, $1.18{\pm}0.66\;mm$ of lateral incisor, $1.42{\pm}0.77\;mm$ of canine. Bucco-lingual diameter 3 mm below CEJ was $5.13{\pm}0.37\;mm$ of central incisor, $4.58{\pm}0.46\;mm$ of lateral incisor, and $5.93{\pm}0.47\;mm$ of canine. Buccal bony curvature angle below root apex was $134.7{\pm}17.5^{\circ}$ at central incisor, $151.0{\pm}13.9^{\circ}$ at lateral incisor, $153.0{\pm}9.5^{\circ}$ at canine. Distance between root apex and the deepest point of buccal bony curvature of central incisor was $3.67{\pm}1.28\;mm$ at central incisor, $3.90{\pm}1.51\;mm$ at lateral incisor, and $5.13{\pm}1.70\;mm$ at canine. CONCLUSION. Within the limitation of this study in Korean adults, the thickness of maxillary anterior buccal plate was very thin within 1mm and the thickness of palatal plate was thick, relatively. The buccal bony curvature below root apex of maxillary central incisor was higher than that of lateral incisor and canine and it seems that the buccal bony plate below root apex of central incisor is most curved.