• 생명과학회지
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• 제26권2호
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• pp.174-180
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• 2016

Dicumarol는 전동싸리 식물에서 추출한 coumarin 유도체로 vitamin K 의존적으로 항응고 작용를 한다. 그러나, dicumarol에 의한 MMP-9의 발현 및 활성화 조절에 대한 연구는 수행되지 않았다. 본 연구에서 dicumarol이 인간 신장암 Caki세포에서 PMA 매개의 MMP-9의 발현과 활성화를 조절 할 수 있는지 확인하였다. Dicumarol는 PMA유도 MMP-9의 활성을 억제하였고, MMP-9의 mRNA RT-PCR 및 promoter assay를 통하여 전사단계에서 조절됨을 확인하였다. Dicumarol에 의한 MMP-9 발현 조절에 NF-κB와 AP1 전사인자의 전사 활성 저해에 의하여 야기됨을 확인하였다. NQO1 siRNA를 이용한 knock-down 실험에서 dicumarol이 PMA유도의 MMP-9 활성 억제에 NQO1의 관련성을 확인 할 수 없었다. Dicumarol는 PMA에 의한 세포이동 및 침윤을 억제하였는데, 이러한 현상은 MMP-9의 발현 및 활성을 조절함으로써 일어날 수 있음을 확인하였다.

• Journal of Communications and Networks
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• 제15권4호
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• pp.352-361
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• 2013

Combining multiple-input multiple-output orthogonal frequency division multiplexing (MIMO-OFDM) with a massive number of transmit antennas (massive MIMO-OFDM) is an attractive way of increasing the spectrum efficiency or reducing the transmission energy per bit. The effectiveness of Massive MIMO-OFDM is strongly affected by the channel state information (CSI) estimation method used. The overheads of training frame transmission and CSI feedback decrease multiple access channel (MAC) efficiency and increase the CSI estimation cost at a user station (STA). This paper proposes a CSI estimation scheme that reduces the training frame length by using a novel pilot design and a novel unitary matrix feedback method. The proposed pilot design and unitary matrix feedback enable the access point (AP) to estimate the CSI of the signal space of all transmit antennas using a small number of training frames. Simulations in an IEEE 802.11n channel verify the attractive transmission performance of the proposed methods.

• Molecules and Cells
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• 제38권2호
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• pp.151-155
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• 2015

Matrix metalloproteinase (MMP)-9 degrades type IV collagen in the basement membrane and plays crucial roles in several pathological implications, including tumorigenesis and inflammation. In this study, we analyzed the effect of flavonols on MMP-9 expression in phorbol-12-myristate-13-acetate (PMA)-induced human fibrosarcoma HT-1080 cells. Galangin and kaempferol efficiently decreased MMP-9 secretion, whereas fisetin only weakly decreased its secretion. Galangin and kaempferol did not affect cell viability at concentrations up to $30{\mu}M$. Luciferase reporter assays showed that galangin and kaempferol decrease transcription of MMP-9 mRNA. Moreover, galangin and kaempferol strongly reduce $I{\kappa}B{\alpha}$ phosphorylation and significantly decrease JNK phosphorylation. These results indicate that galangin and kaempferol suppress PMA-induced MMP-9 expression by blocking activation of NF-${\kappa}B$ and AP-1. Therefore, these flavonols could be used as chemopreventive agents to lower the risk of diseases involving MMP-9.

• 한국정보통신학회논문지
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• 제10권8호
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• pp.1393-1400
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• 2006

본 논문은 확률접근 기반의 네트워크 자원할당 방식에서 네트워크의 대표적인 서비스 품질 척도인 대기시간과 블러킹 확률이 특정 임계값을 넘지 않으면서 최소화가 되도록 접근 확률을 최적화하는 방법에 대하여 연구하였고 그에 따른 성능분석을 하였다. 확률 접근에 의한 제어 방식은 시스템에서 서비스 받고 있는 메시지의 수, 시스템에서 대기하고 있는 메시지의 수, 문턱 값, 컷오프 값 등의 시스템 상태에 따라 접근확률을 다르게 하여 자원의 할당을 동적으로 제어하는 방식이다. 접근 확률을 최적화하는 문제는 무한개의 균형 방정식을 포함하는 문제로서 Neuts의 행렬기하기법(matrix geometric method)을 통하여 유한개의 균형 방정식을 가지는 최적화 문제로 변환하였다. 또한 유한개의 균형방정식은 비선형 최적화 문제로 모델링이 되는데 이것을 다시 변수 치환 기법을 이용하여 설형 최적화 문제로 변환하여 최적의 접근 확률을 구하였다. 수치해석을 통하여 주어진 조건하에 최적의 접근 확률을 구한후 트래픽의 대기시간, 블러킹 확률 및 시스템 최대 이용률을 구하였고 버퍼의 문턱 값을 제어하여 시스템의 이용률이 증가하는 것을 보였다.

• International Journal of Control, Automation, and Systems
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• 제1권1호
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• pp.11-18
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• 2003

The parametric approaches to sliding mode design are newly proposed for the class of multivariable systems. Our approach is based on an explicit formula for representing all the slid-ing modes using the Lyapunov matrices of full order. By manipulating Lyapunov matrices, the sliding modes which satisfy the design criteria such as the quadratic performance optimization and robust stability to parametric uncertainty, etc., can be easily obtained. The proposed ap-proach enables us to adopt a variety of Lyapunov- (or Riccati-) based approaches to the sliding mode design. Applications to the quadratic performance optimization problem, uncertain systems, systems with uncertain state delay, and the pole-clustering problem are discussed.

• Toxicological Research
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• 제25권4호
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• pp.159-173
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• 2009

Nuclear factor erythroid derived 2-related factor-2 (Nrf2) is a master transcription regulator of antioxidant and cytoprotective proteins that mediate cellular defense against oxidative and inflammatory stresses. Disruption of cellular stress response by Nrf2 deficiency causes enhanced susceptibility to infection and related inflammatory diseases as a consequence of exacerbated immune-mediated hypersensitivity and autoimmunity. The cellular defense capacity potentiated by Nrf2 activation appears to balance the population of $CD4^+$ and $CD8^+$ of lymph node cells for proper innate immune responses. Nrf2 can negatively regulate the activation of pro-inflammatory signaling molecules such as p38 MAPK, NF-${\kappa}B$, and AP-1. Nrf2 subsequently functions to inhibit the production of pro-inflammatory mediators including cytokines, chemokines, cell adhesion molecules, matrix metalloproteinases, COX-2 and iNOS. Although not clearly elucidated, the antioxidative function of genes targeted by Nrf2 may cooperatively regulate the innate immune response and also repress the expression of pro-inflammatory mediators.

• 한국CDE학회논문집
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• 제3권1호
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• pp.48-56
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• 1998

Finite element analysis is very important in the design and analysis of mechanical engineering. The process of FEA encompasses shape modeling, mesh generation, matrix solving and post-processing. Some of these processes can be tightly integrated with the current software architectures and data sharing mode. However, complete integration of all the FEA process itself and the integration to the manufacturing processes is almost impossible in the current practice. The barriers to this problem are inconsistent data format and the enterprise-wise software integration technology. In this research, the information model based on STEP AP209 was chosen for handling finite element analysis data. The international standard for the FEA data can bridge the gap between design, analysis and manufacturing processes. The STEP-based FEA system can be further tightly integrated to the distributed software and database environment using CORBA technology. The prototype FEA system DICESS is implemented to verify the proposed concepts.

• 열처리공학회지
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• 제6권3호
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• pp.159-165
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• 1993

Creep tests of the TiC particulate reinforced Al composite have been conducted in the temperature ranges from 200 to $500^{\circ}C$. The steady-state cree rate of the composite depended strongly on the temperature and ap' plied stress. The stress exponent for the steady state creep rate of the composites was approximately 17.5 and the activation anergy was calculated to be 390KJ/mol. The steady-state creep equation could be written as $\acute{\varepsilon}_{ss}$ $$(s^{-1})=1.5{\times}10^{-9}\;{\sigma}^{17.5}\exp(-390000/RT)$$. Fracture surface examination showed that the fracture mode of the particulate reinforced composite was ductile by plastic tearing of the aluminum matrix and TiC particle interfaces were offered as sites for crack.

• Journal of Microbiology and Biotechnology
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• 제30권3호
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• pp.325-332
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• 2020

Methyl linderone (ML), a cyclo-pentenedione, was isolated from the fruit of Lindera erythrocarpa Makino (family Lauraceae). This plant has well-known anti-inflammatory effects; however, the anti-cancer effects of ML have not yet been reported. Thus, in the present study we investigated the effects of ML on the metastasis of human breast cancer cells. We used 12-O-tetradecanoyl phorbol-13-acetate (TPA)-stimulated MCF-7 cells as the cell model to study the effects of ML on invasion and migration. ML was found to reduce the invasion and migration rate of TPA-stimulated MCF-7 cells. Moreover, it inhibited two metastasis-related factors, matrix metalloproteinase-9 (MMP-9) and interleukin-8 (IL-8), at the mRNA and protein expression levels, in TPA-treated MCF-7 cells. The mechanism by which ML exerted these effects was through the inhibition of translocation of activator protein-1 (AP-1) and signal transducer and activator of transcription-3 (STAT3), mediated via phosphorylation of extracellular signal-regulated kinase (ERK). Taken together, our findings indicated that ML attenuated the TPA-stimulated invasion and migration of MCF-7 cells by suppressing the phosphorylation of ERK and its downstream factors, AP-1 and STAT3. Therefore, ML is a potential agent for the treatment of breast cancer metastasis.

• 한국통신학회논문지
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• 제40권3호
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• pp.459-468
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• 2015

본 논문에서는 하나의 AP가 다수의 사용자를 지원하는 상향링크 다중사용자 하이브리드 빔포밍 시스템을 고려한다. 상향링크 다중사용자 하이브리드 빔포밍 시스템의 성능은 채널에 아날로그 빔이 결합된 형태의 유효 채널에 의해서 결정된다. 따라서 시스템의 성능을 최대화하기 위해서는 채널의 정보를 획득하고 획득된 채널 정보를 이용해서 아날로그 빔을 적절히 선택해야 한다. 본 논문에서는 상향링크 다중사용자 하이브리드 빔포밍 시스템에 적합한 채널 추정 방법과 저복잡도 아날로그 빔 선택 알고리즘을 제안한다. 또한 수학적으로 계산 복잡도 분석을 통해서 제안하는 저복잡도 아날로그 빔 선택 알고리즘이 최적의 아날로그 빔 선택 알고리즘에 비해서 복잡도가 훨씬 작은 것을 보여준다. 모의 실험 결과를 통하여 동일한 조건 하에서 제안된 저복잡도 아날로그 빔 선택 알고리즘이 최적의 아날로그 빔 선택 알고리즘에 비해 줄어든 계산 복잡도에 비하여 성능 면에서 열화가 거의 없는 것을 확인한다.