• Environmental Analysis Health and Toxicology
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• v.19 no.3
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• pp.287-294
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• 2004

Diabetic complication is one of major risk factors leading to vascular disease such as atherosclerosis, stroke, coronary heart disease and etc. Several factors affecting the acceleration of diabetic vascular complication have been known such as hypertension, hyperlipidemia, immune complex and genetic factors. To screen and develop new therapeutics agents for diabetic vascular complication, it is strongly needed to develop animal models for diabetic complications. However in rodents models, diabetic complications is not well developed. Furthermore to assess the possibility of new therapeutics for diabetic vascular complications, diabetic animal models which have the risk factors of diabetic complications is needed. We aim to develop and establish an diabetic animal model which have diabetic complications with hyperlipidemia which is one of risk factors for diabetic complications. We induced insulin -dependent diabetes by intra. venous injection of streptozotocin (35 mg/kg/day) in RICO rats which is a spontaneous animal model for hyperlipidemia. Our models (STZ RICO) showed hyperglycemia, persistent high level of plasma cholesterol and triglyceridemia with severe diabetic renal changes until 28 weeks after induction of diabetes. STZ-RICO rats could be used for the evaluations of newly developed diabetic drugs.

• Korean Journal of Agricultural Science
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• v.43 no.4
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• pp.623-633
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• 2016

A total of 6,973 steer growth records of Hanwoo breeding bull's progeny test data collected from 1989 to 2015 were analyzed to identify the most appropriate growth curve among three growth curve models (Gompertz, Logistic and von Bertalanffy). The Gompertz growth curve model equation was $W_t=990.5e^{{-2.7479e}^{-0.00241t}}$, the Logistic growth curve model equation was $W_t=772(1+8.3314e^{-0.00475t})^{-1}$, and the von Bertalanffy growth curve model equation was $W_t=1,196.4(1-0.646e^{-0.00162t})^3$. The Gompertz model parameters A, b, and k were estimated to be $990.5{\pm}10.27$, $2.7479{\pm}0.0068$, and $0.00241{\pm}0.000028$, respectively. The inflection point age was estimated to be 421 days and the weight of inflection point was 365.3 kg. The Logistic model parameters A, b, and k were estimated to be $772.0{\pm}4.12$, $8.3314{\pm}0.0453$, and $0.00475{\pm}0.000033$, respectively. The inflection point age was estimated to be 445 days and the weight of inflection point was 385.0 kg. The von Bertalanffy model parameters A, b, and k were estimated to be $1196.4{\pm}18.39$, $0.646{\pm}0.0010$, and $0.00162{\pm}0.000027$, respectively. The inflection point age was estimated to be 405 days and the weight of inflection point was 352.0 kg. Mature body weight of the von Bertalanffy model was 1196.4 kg, the Gompertz model was 990.5 kg, and the Logistic model was 772.0 kg. The difference between actual and estimated weights was similar in the Logistic model and the von Bertalanffy model. The difference between market weight and estimated market weight was the lowest in the Gompertz model. The growth curve using the von Bertalanffy model showed the lowest mean square error.

• Nuclear Medicine and Molecular Imaging
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• v.42 no.1
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• pp.1-7
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• 2008

PET allows non-invasive, quantitative and repetitive imaging of biological function in living animals. Small animal PET imaging with $[^{18}F]$FDG has been successfully applied to investigation of metabolism, receptor-ligand interactions, gene expression, adoptive cell therapy and somatic gene therapy. Experimental condition of animal handling impacts on the biodistribution of $[^{18}F]$FDG in small animal study. The small animal PET and CT images were registered using the hardware fiducial markers and small animal contour point. Tumor imaging in small animal with small animal $[^{18}F]$FDG PET should be considered fasting, warming, and isoflurane anesthesia level. Registered imaging with small animal PET and CT image could be useful for the detection of tumor. Small animal experimental condition of animal handling and registration method will be of most importance for small lesion detection of metastases tumor model.

• Reproductive and Developmental Biology
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• v.37 no.1
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• pp.41-49
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• 2013

Ovarian cancer is the most lethal world-wide gynecological disease among women due to the lack of molecular biomarkers to diagnose the disease at an early stage. In addition, there are few well established relevant animal models for research on human ovarian cancer. For instance, rodent models have been established through highly specialized genetic manipulations, but they are not an excellent model for human ovarian cancer because histological features are not comparable to those of women, mice have a low incidence of tumorigenesis, and they experience a protracted period of tumor development. However, the laying hen is a unique and highly relevant animal model for research on human ovarian cancer because they spontaneously develop epithelial cell-derived ovarian cancer (EOC) as occurs in women. Our research group has identified common histological and physiological aspects of ovarian tumors from women and laying hens, and we have provided evidence for several potential biomarkers to detect, monitor and target for treatment of human ovarian cancers based on the use of both genetic and epigenetic factors. Therefore, this review focuses on ovarian cancer of laying hens and relevant regulatory mechanisms, based on genetic and epigenetic aspects of the disease in order to provide new information and to highlight the advantages of the laying hen model for research in ovarian carcinogenesis.

• Proceedings of the Korean Society of Veterinary Clinics Conference
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• 2008.05a
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• pp.132-132
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• 2008

• Food Science of Animal Resources
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• v.38 no.3
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• pp.442-450
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• 2018

Liquid egg products can be contaminated with Salmonella spp. during processing. A predictive model for the growth of Salmonella spp. in unpasteurized liquid eggs was developed and validated. Liquid whole egg, liquid yolk, and liquid egg white samples were prepared and inoculated with Salmonella mixture (approximately 3 Log CFU/mL) containing five serovars (S. Bareilly, S. Richmond, S. Typhimurium monophasic, S. Enteritidis, and S. Gallinarum). Salmonella growth data at isothermal temperatures (5, 10, 15, 20, 25, 30, 35, and $40^{\circ}C$) was collected by 960 h. The population of Salmonella in liquid whole egg and egg yolk increased at above $10^{\circ}C$, while Salmonella in egg white did not proliferate at all temperature. These results demonstrate that there is a difference in the growth of Salmonella depending on the types of liquid eggs (egg yolk, egg white, liquid whole egg) and storage temperature. To fit the growth data of Salmonella in liquid whole egg and egg yolk, Baranyi model was used as the primary model and the maximum growth rate and lag phase duration for each temperature were determined. A secondary model was developed with maximum growth rate as a function of temperature. The model performance measures, bias factor ($B_f$, 0.96-0.99) and $r^2$ (0.96-0.99) indicated good fit for both primary and secondary models. In conclusion, it is thought that the growth model can be used usefully to predict Salmonella spp. growth in various types of unpasteurized liquid eggs when those are exposed to various temperature and time conditions during the processing.

• Journal of Animal Environmental Science
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• v.16 no.1
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• pp.29-40
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• 2010

The purpose of the study is to review current studies for economic values on livestock products produced by animal welfare. In order to review the topic, published research papers and reports were reviewed in the world. As the result of the study, the studies for the topic are not researched actively. The main ideas for the studies were consumer survey on meats and egg. Data were questionnaire, Lexis-Nexis databases, consumptions and prices on meats, auction data. Tools for analyses were Random parameters logit and latent class model, WTP analysis, Roterdam model, Pearson's Chi test, Mann-Whitney V-test, Kruskal-Wallis test, structural equation model, regression model, Target-costing, and conjoint analysis.

• Journal of the Korean Applied Science and Technology
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• v.30 no.4
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• pp.622-634
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• 2013

The multi-origin of obesity and its associated diseases made it's a complex area of biomedical science research and severe health disorder. From the 1970s to onwards this health problem turned to an epidemic without having any report of declining yet and it created a red alert to the health sector. Meanwhile, many animal models have been developed to study the lethal effect of obesity. In consequence, many drugs, therapies and strategies have already been adopted based on the findings of those animal models. However, many complicated things based on molecular and generic mechanism has not been clarified to the date. Thus, it is important to develop a need based animal model for the better understanding and strategic planning to eliminate/avoid the obesity disorder. Therefore, the present review would unveil the pros and cons of presently established animal models for obesity research. In addition, it would indicate the required turning direction for further obesity and obesity based disease research.

• Proceedings of the Korean Society of Veterinary Clinics Conference
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• 2007.10a
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• pp.624-624
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• 2007

• The Journal of Korean Medicine
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• v.20 no.4
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• pp.82-92
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• 2000

The purpose of the present study was to explore the proper method for animal stroke model of Oriental medicine To this end, brain ischemia was induced by distal middle cerebral artery occlusion(dMCAO) and proximal middle cerebral artery occlusion(pMCAO) and evaluated with the method of Triphenyl Tetrazolium Chloride (TTC) staining and Swimming Behavior Test. Results demonstrated that first, infarct size and volume of pMCAO group were significantly bigger that those of dMCAO group. Second, analysis of swimming behavior test revealed that the percentage of left turning angles of pMCAO was significantly bigger than that of dMCAO. Third, during swimming behavior test, there were peculiar traces of small successive circles that represent motor dysfunction and conscious disturbance among dMCAO group. The results of the study thus indicate that non-invasive intraluminal method of pMCAO was the appropriate animal stroke model for Oriental medicine in the light of brain ischemia as hemiplesia and conscious disturbance.