The Experimental Study on the Animal Stroke Model of Oriental Medicine

한의학적 중풍 동물 모델 설정을 위한 실험적 연구

  • 채한 (경희대학교 한의과대학 생리학교실) ;
  • 이현삼 (경희대학교 동서의학대학원 신경과학교실) ;
  • 홍무창 (경희대학교 한의과대학 생리학교실)
  • Published : 2000.01.01

Abstract

The purpose of the present study was to explore the proper method for animal stroke model of Oriental medicine To this end, brain ischemia was induced by distal middle cerebral artery occlusion(dMCAO) and proximal middle cerebral artery occlusion(pMCAO) and evaluated with the method of Triphenyl Tetrazolium Chloride (TTC) staining and Swimming Behavior Test. Results demonstrated that first, infarct size and volume of pMCAO group were significantly bigger that those of dMCAO group. Second, analysis of swimming behavior test revealed that the percentage of left turning angles of pMCAO was significantly bigger than that of dMCAO. Third, during swimming behavior test, there were peculiar traces of small successive circles that represent motor dysfunction and conscious disturbance among dMCAO group. The results of the study thus indicate that non-invasive intraluminal method of pMCAO was the appropriate animal stroke model for Oriental medicine in the light of brain ischemia as hemiplesia and conscious disturbance.

Keywords

References

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