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Sleep Patterns in Chronic Schizophrenic Patients Treated with Clozapine (Clozapine으로 치료 중인 만성 정신분열병 환자의 수면양상)

  • Shin, Il-Seon;Lee, Seung Hyun;Yoon, Bo-Hyun;Yoon, Jin-Sang
    • Korean Journal of Biological Psychiatry
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    • v.6 no.2
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    • pp.246-252
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    • 1999
  • Objectives : Daytime drowsiness or sedation and changes in night sleep are commonly seen in patients treated with clozapine. There is, however, very limited information on their degree and nature during the course of treatment. The purpose of this study was to understand the sleep patterns in chronic schizophrenic patients with clozapine treatment over a period of 24 weeks. Method : The sleep pattern was evaluated using a set of 5-point scale questionnaire, to record subjective impressions of the night sleep induction, maintenance and quality, and daytime drowsiness and fatigue. In addition, unusual experiences associated with night sleep were recorded. The sleep questionnaire was repeatedly administered at baseline and at 1, 2, 4, 8, 12 and 24 weeks of drug treatment. At present, data on 12 patients has been collected. Results : All the components of night sleep were significantly improved in the 1st through the 12th week after treatment with clozapine. Daytime drowsiness was significantly higher in the 1st to the 2nd week after the treatment and fatigue was also significantly higher in the 1st to the 4th week after the treatment. Eight patients experienced noticeable increases in salivation during night sleep, and of these, one also reported frequent nocturnal urination and even enuresis. However, all these adverse factors did not affect the major sleep patterns. Conclusions : These findings suggest that the beneficial effects of clozapine on night sleep might last much longer than the undesirable effect of daytime drowsiness and fatigue. In other words, tolerance of the hypnotic action of clozapine might develop late and tolerance of the daytime drowsiness and fatigue might be evident earlier.

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Correlation between Cognitive Functions and Psychotic Symptoms in Schizophrenic Patients (정신분열병 환자에서 인지기능 및 정신병적 증상의 상관관계)

  • Kim, Yong-Ku;Lee, Jung-Ae;Lee, So-Youn;Lee, Bun-Hee;Han, Chang-Su
    • Korean Journal of Biological Psychiatry
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    • v.13 no.3
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    • pp.191-201
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    • 2006
  • Objectives : The purpose of this study was to investigate whether the cognitive functions would be correlated with psychotic symptoms and whether antipsychotic treatments would affect the cognitive functions after 8 weeks. Methods : The thirty-five schizophrenic patients were conducted in this study. The psychopathology was measured using PANSS. The memory function, executive function, and sustained attention were measured using Memory Assessment Scale(MAS), Wisconsin Card Sorting Test(WCST), and Vigilance(VIG) and Cognitrone(COG) in Vienna Test System. After 8 weeks of antipsychotic treatment, we retested the cognitive tests. Results : 1) The cognitive tests after the 8 week's treatment showed significant improvements in memory and executive function in the schizophrenic patients. On the other side, sustained attention did not show improvement. 2) The change of PANSS were correlated with perseverative response, perseverative error and total correct in WCST at baseline. WCST scores at baseline were correlated with negative symptoms, but not positive ones. Conclusion : These study suggests that 1) the impaired sustained attention could be a vulnerability marker in schizophrenia, 2) memory & executive function deficit could be reversible after treatment, and 3) medication might have a benefit in improving the cognitive functions in schizophrenia. Furthermore, the data supports that the better premorbid executive function was, the more favorable was the treatment response in schizophrenic patients. Finally, this study indicates that executive function might be an index of treatment improvement.

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Degree-of-Association Judgments of Fragrances with Color Hues and Tones (색상과 톤에 의한 향 연상 강도 평가)

  • Kim, Yu-Jin
    • Science of Emotion and Sensibility
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    • v.13 no.3
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    • pp.559-572
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    • 2010
  • Color, an important visual cue, can cross-modally affect odor association and odor quality identification Here, this research investigates aspects of the cross-modal associations between color and fragrance in greater depth, delving into the topic of whether the degree-of-association of fragrances with hue and tone of colors varies systematically. For 33 color stimuli (10 hues, 3 tones, and 3 achromatic colors), 67 subjects judged the degree-of-association of four typical fragrance families (fresh, floral, oriental, and woody) on a 7-point scale. The statistical analysis showed that fragrance associations of the all families had characteristic distributions across ten hues of the color stimuli. The cross-modal relationship between color tone (especially, lightness attribute) and fragrance association appeared to be dimensional (e.g. a positive linear relationship between the floral family and the lightness). More specifically, as colors became warmer and brighter, the associated floral scents were stronger, while the woody scents was less associated. Brighter or more vivid cool colors were associated with stronger fresh scents. These findings confirm the systematic existence of synthetic interactions between vision and olfaction in perfumery.

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Test Result on Embedded Steel Column-to-Foundation Connection for Modular Unit Structural System (유닛 모듈러 기둥 매입형 기초 접합부에 대한 실험 연구)

  • Lee, Sang Sup;Bae, Kyu Woong;Park, Keum Sung;Hong, Sung Yub
    • Journal of Korean Society of Steel Construction
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    • v.26 no.6
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    • pp.537-547
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    • 2014
  • A steel modular unit structural system has been used increasingly for mid and high-rise buildings, since the building can be easily constructed by assembling the pre-made modular unit structures. For this structural system, each modular unit structures have to be properly connected to the foundation to transfer the axial force and the bending moment that are generated from external load to the ground. In this study, a new type of the embedded steel column-to-foundation connection was proposed, and its flexural behavior was evaluated through a series of experimental study. Five full scale specimens for the proposed connections were constructed and tested. The effect of the main parameters that affect the flexural behavior of the proposed connection, such as embedment length and shape of end plate, were studied. From the results, it was found that the flexural stiffness of the proposed connection was higher than that of the semi-rigid connection for all test specimens, and 200 mm of embedment length was proper for the given test specimens in this study.

Development Trend of Environment Monitoring Payloads (환경감시탑재체 개발 동향)

  • Yeon, Jeoung-Heum;Kim, Seong-Hui;Ko, Dai-Ho;Lee, Seung-Hoon;Yong, Sang-Soon
    • Current Industrial and Technological Trends in Aerospace
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    • v.7 no.1
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    • pp.79-88
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    • 2009
  • Environment and climate changes affect all aspects of our society, and its researches are rapidly growing recently. The enhanced remote sensing technology made the satellite to be widely used in the environment monitoring applications with the increased worldwide interests. In this paper, recent development trends of environment monitoring payloads are researched. The major specifications, observational methods and objects of each payloads are surveyed and described. The environment monitoring payloads have been developed for the low-earth-orbit satellite to cover the entire earth area with single satellite. However, as the importance of time-scale resolution increases, payloads for geostationary orbit are under developing recently. Also, ultraviolet, visible, and infrared observation payloads are being developed depending on the monitoring objects. According to these trends, domestic environment monitoring payloads have to be developed with clear and careful mission analysis.

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A Study on the Dynamic Behaviour of Cut-and-Cover Tunnel by Shaking Table Test (진동대 실험을 이용한 개착식터널의 동적 거동특성에 관한 연구)

  • 정형식;조병완;이영남;이두화;이용준
    • Journal of the Korean Geotechnical Society
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    • v.17 no.6
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    • pp.173-180
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    • 2001
  • This research is aimed at investigating the dynamic response of cut-and-cover tunnel to seismic waves. We carried out shaking table test which is used a 1/40-scale(the width of prototype tunnel is about 14.2m, the height is about 8.5m) model for this research, and we analyzed the effect of depth of tunnel and slope of the ground in relation to the dynamic responses of tunnel. As a result of the test, the stress and acceleration along the tunnel decreased accordingly to the depth of increment, and this phenomenon is caused by the increase of the confining effect of ground. Also, the dynamic responses of tunnel showed a tendency to rise according as ground declined gently. In comparison the result of shaking table test with that of structural analysis on ordinary condition, we conclude that seismic waves do not affect cut-and-cover tunnel when the depth of tunnel is over the diameter of tunnel.

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Factors Influencing Airborne Concentration of Fungi, Bacteria and Gram Negative Bacteria in Kindergarten Classroom (유치원 교실에서 공기 중 박테리아와 곰팡이 발생에 영향을 미치는 요인)

  • Park Donguk;Jo Kyunga;Yoon Chungsik;Han Inyoung;Park Dooyong
    • Journal of Environmental Health Sciences
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    • v.30 no.5 s.81
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    • pp.440-448
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    • 2004
  • Airborne bacteria, gram negative bacteria (GNB) and fungi were measured in 70 class of 17 kindergartens. The objective of this study is to identify the factors influencing airborne concentrations of bacteria, GNB and fungi using multiple regression analysis. The average concentrations of bacteria and fungi exceeded $1,000\;CFU/m^3$. The average of GNB was $3.7{\times}10^2\;CFU/m^3$. This results indicated that air of kindergartens was contaminated with microbes such as bacteria and fungi. ANOVA test found that the concentrations of bacteria, GNB and fungi were significantly different by the characteristics of weather (rain, after rain, sunny) sampling date (July, August, September and October), the location of sampling site (ground level and basement) and the location of toilet (inside class, nearby class and away class). Multiple regression tests concluded that sampling date, the scale of city where kindergartens are located, the location of sampling site and ventilation efficiency can significantly affect the airborne concentration of bacteria, GNB and fungi. Most of these factors could be related moisture. Environmental factors that can cause the increment of moisture should be controlled in order to reduce airborne concentration of bacteria, GNB and fungi. Legal actions concerning prohibition on the presence of toilet inside class and ventilation criteria should be taken.

Potential Exposure to Air Pollutants for Driver and Its Control Using Commercial Air Cleaning Device Inside Vehicle (차량 운전자의 공기오염물질 잠재적 노출 및 차량용 공기청정기에 의한 제어)

  • Kim Dae-Won;Kim Moon-Hyeon;Yang Won-Ho
    • Journal of Environmental Health Sciences
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    • v.30 no.5 s.81
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    • pp.481-486
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    • 2004
  • Vehicle occupant exposure to air pollutants has been a subject of concern in recent years because of higher levels of air pollutants inside gasoline or diesel-using vehicle, comparing to the surrounding atmosphere. Contrary to previous studies, fuel of vehicles operated in this study was liquefied petroleum gas (LPG). This study examined the potential exposure and removal efficiency of selected volatile organic compounds (VOCs), nitrogen dioxide ($NO_2$) and respirable suspended particle (RSP) by commercial air cleaning device inside vehicle under different ventilation conditions. Vehicle concentrations inside of benzene, toluene, m,p-xylene, $NO_2$ and RSP were lower under the low ventilation condition. This was indicated that outdoor air pollutants could affect the vehicle air quality inside in case metropolitan cities such as Daegu. The urban vehicle concentrations inside of benzene, toluene, m,p-xylene, $NO_2$ and RSP with air cleaning device were higher than those without air cleaning device. This means that the use of air cleaning device equipped with activated carbon filter, which was used in this study, in the interior of vehicles could be expected to reduce the vehicle occupants exposure to air pollutants effectively. In batch type reactor of laboratory scale, removal efficiencies of air cleaning device used were $97.0\%,\;95.7\%,\;94.6\%\;and\;85.5\%$ respectively in benzene, toluene, m,p-xylene and $NO_2$.

A Study on the Promotion for Convention Industry in Korea (국내 컨벤션산업의 육성전략에 관한 연구)

  • 신현대
    • The Journal of Information Technology
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    • v.3 no.4
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    • pp.107-128
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    • 2000
  • Many Countries in the world are struggling to foster the industry of international convention while attracting various international convention on the politics, economy society, culture, religion and sports. The needs of international conventiones are increasing now becourse of the expansion of international visitors exchanges and it affect on the promotion of national economy development of tour industry internal and overseas public relation of the countries. The important point in this situation is to make a consensus between public organization in eluding goverment related civil industry and academic society and set up and process the long term and short-term strategy basis on the consensus. First related facilities should be enlarged and inproved and maketing activities to hold the conventions that are propec to their facilities should be fostered. Second it is imporment to try to hold the international convention through in troducing our related abilities and facilies if the world and through Positive public realations and marketing activities in the world. Third to perform the inducde international conventions successfully the gualities of related personnel should be improved and the experts such as conventions Planner and simultaneous interprefec should be nurtured. Fourth related enterpries should be supported step by step by goverment level to foster their activifies on holding and operating the international conventions. Fifth the tourism effect can b promoted by harmonizing the tourism and international convention through building large scale convention centers in the cities. Therefore to develop the international conventions industry more positively and effectively publicity work and activity to hold of the goverment posifive and creative effort of related enterprise and people's active participation are all needed.

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A Study on the Evaluation of the Cognition of the Circulation Efficiency in Geriatric Hospital (노인요양병원 진료부의 경로인지 효율성 평가에 관한 연구)

  • Bae, Sun-mi;Kim, Suk-Tae
    • Korean Institute of Interior Design Journal
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    • v.25 no.6
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    • pp.40-51
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    • 2016
  • The aim of this study is to quantitatively deduce the circulation efficiency and space arrangements of the outpatient department in geriatric hospitals in terms of spatial structure and to find a methodology that could promote the improvement of accessibility and spatial cognition while using the facilities. All space units of the selected twelve geriatric hospitals were located on the first floor. The study adopted the psychological distance concept of space syntax to the unitized spaces, and presented a set of indices, such as TD, PN, RF, PNT and TRF. These indices were calculated according to the standard clinical use procedures. The study evaluated the effectiveness of circulation. The analysis of circulation was based on the four major geriatric illnesses that were selected in this study. The study established the standard clinical use procedure with consideration of the medical treatment, examinations and space units of outpatient departments. The results are as follows: 1) Based on the statistical data, four major geriatric illnesses are examined, and space requirement and standard procedures are established. Development indicators are applied in order to quantitatively deduce the efficiency of spatial cognition. 2) The percentage of the risk of cognitive decline(TRF) has an inversely proportional correlation to the circulation efficiency(PNT) at a certain point. TRF is more influenced by the clinical use procedure than the scale. 3) The arrangement of the waiting space and types of corridor greatly affect the percentage of the risk of cognitive decline. 4) Vulnerable facilities are selected on the basis of the evaluation, and two alternatives that could promote the circulation efficiency are presented. The result of the reanalysis showed that cognitive efficiency had much improved compared to the existing facilities.