• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.34 no.3
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• pp.250-265
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• 2008

Distraction osteogenesis is a well-established clinical treatment for limb length discrepancy and skeletal deformities. Appropriate mechanical tension-stress is believed not to break the callus but rather to stimulate osteogenesis. In contrast to fracture healing, the mode of bone formation in distraction osteogenesis is primarily intramembranous ossification. Although the biomechanical, histological, and ultrastructural changes associated with distraction osteogenesis have been widely described, the basic biology of the process is still not well known. Moreover, the molecular mechanisms in distraction osteogenesis remain largely unclear. Recent studies have implicated the growth factor cascade is likely to play an important role in distraction. And current reserch suggested that mechanical tension-stress modulates cell shape and phenotype, and stimulates the expression of the mRNA for bone matrix proteins. The purpose of this study is to examine the pattern of expression of growth factors($TGF-{\beta}1$, IGF-I, bFGF) and extracellular matrix proteins(osteoclacin, osteonectin) related to osteogenesis by osteodistraction of the mandible in rabbits. 24 rabbits is used for this experiment. Experimental group are gradual distraction(0.7mm, twice/day), acute distraction(1.4mm, twice/day) and control group is only osteotomized. After 5 days latency, osteotomic site is distracted for each 7 days and 3.5 days. Consolidation period is 28 days. The animal is sacrificed at the 3th, 7th, 14th, 28th. The distracted bone is examined by immunohistochemical analysis and RT-PCR analysis. The results obtained from this study were as follow : No significant difference was found on clinical examination according to distraction rate, but gradual distraction was shown to improve regenerate bone formation on radiographic and histologic examination. Growth factors and extracelluar matrix proteins expression increased in distraction group than control group. From these results, it could be stated that graudal distraction is shown to improve and accelerate bone formation and mechanical stress like distraction has considerable effects on osteogenesis related factors. And rabbit is the most appropriate animal model for further reseach on the molecular mechanisms that mediate osteodistraction. It is believed that understanding the biomolecular mechanisms that mediate distraction osteogenesis may guide the development of targeted strategies designed to improve distraction osteogenesis and accelerate bone healing.

• Journal of Chest Surgery
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• v.13 no.4
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• pp.422-434
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• 1980

Since 1968 up to the end of October 1980, 448 valves were replaced in 354 patients in Seoul National University Hospital. There were 238 mitral, 38 aortic, 7 tricuspid, 45 aortic with mitral, 23 tricuspid with mitral, and 3 triple valve replacement aortic mitral and tricuspid cases. Annual increase of mitral valve replacement cases and decrease of operative maortality were remarkable. Recently operative mortality of mitral valve replacement is about 5%. Sex ratio of mitral valve replacement is almost equal and there were 12 cases of pediatric patients (5%) among 238 cases, and patients under the age of 20 years were 34 (14.3%). Mitral valve replacement was done for 199 single mitral, 38 double valve and one triple valve lesions. Among 238 mitral valve replacement paients left atrial thrombus in 23(9.7%), atrial fibrillation in 132 (55.5%), and reoperation after blind mitral commissurotomy in 12(5%) cases were noted. In recent cases bioprosthetic valves, mainly lonescu-shiley valve were utilized to overcome the difficulties of postoperative late complications in anticoagnuation, especially for the rural patients and pediatric cases, in addition to the hemodynamic advantages of lonesocu valve. Among 354 patients 16 cases were congenital heart anomaly related, 5 ventricular septal defect related aortic and 4 Ebstein related tribuspid valve replacement cases. There were 2 congenital anomaly related mitral valve replacements, one for congenital mitral insufficiency of 7 years old boy and one for corrected transposition of the great vessels associated with mitral insufficiency. Among total 354 valve replacements 49 operative deaths (13.3%) were noted and in 238 mitral valve replacement 24 operative deaths occurred (10.1%). In 39 patients among 354 total valve replacements late complications were found. In 238 mitral valve replacement cases late complications were noted in 26 patients, among whom 16 cases expired. Main late complications were thrombe-embolism, subacute becteerial endocarditis, arrythmia cerebral hemorrhage due to unsatisfactory anticoagulation, and congestive heart failure in the incipient period of valve replacement were also noted. In mitral valve replacement cases long-term survival rate was 83.2% who showed marked clinical improvement. Ther were no evidences of calcification during the 2 years follow-up period for the lonescu-valve replacement cases among 19 pediatric patients. In conclusion 238 cases of mitral valve replacement were done with 24 operative deaths and 26 late complication cases among whom 16 expired. The long term survival was 83.2% of the cases. In pediatric cases in place of coumadin anticoagulation Persantin **** 75 and aspirin were administered after valve replacement. In adult cases who have difficulaties with coumadin anticoagulation and for those even with bioprosthetic heart valve replacement who needs long-term or permanent anticoagulation persantin 75 and aspirin combination regimen were administered with antisfactory results.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.9 no.2
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• pp.165-173
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• 1998

Objectives：This study was conducted to compare the cognitive characteristics and visual-motor coordination ability of children with Asperger’s disorder and with those of children with PDD NOS. Methods：27 children(13 in AS group and 14 in PDD NOS group) were individually assessed using the K-WISC and BGT, and the results of those tests were analyzed. Results：The mean FSIQ of the AS group was significantly higher than that of the PDD NOS group. There was also a large discrepancy between VIQ and PIQ in the PDD NOS, while there was not significant discrepancy in the AS. The AS was distinguished from PDD NOS group by significantly higher scores in Vocabulary and Comprehension subscales and lower score in Block design. Also, when compared with the PDD NOS, the AS showed more difficulties in visual-motor coordination. Conclusion：The AS showed relatively good verbal and learning ability, while the PDD NOS relatively superior ability in visuospatial function and visual-motor coordination. The findings indicated that the K-WISC and BGT might be useful assessment tool to differentiate the AS from PDD NOS.

• Journal of the Korean Society of Radiology
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• v.5 no.5
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• pp.245-253
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• 2011

The hazard level will be increased with the augmentation of the dose received by patients. Therefore, patients radiation dose have been analyzed by this study for the radiology clinics located at Seoul and Gyeongin area from August 2009 to September 2010. In the case of the front and rear directional inspection of skull, patient radiation dose was turned out to be 1.75mGy for radiology clinic, 3.00mGy for UK, 3.00mGy for Japan, and 5.00mGy for Germany, therefore, radiology clinic was the lowest. In the case of lateral directional inspection of skull, patient radiation dose was turned out to be 1.49mGy for radiology clinic, 1.50mGy for 3rd medical institution, therefore, radiology clinic was measured lower, and it was lower than 3.00mGy which is the recommended dose of IAEA. In order to reduce medical exposure of patient, optimization of efficient protection of radiation and reduction of medical radiation exposure are thought to be required by observing recommendation of international organization based on the result of this study.

• Journal of Korean Ophthalmic Optics Society
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• v.16 no.4
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• pp.425-431
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• 2011

Purpose: For better understanding refractive error in Korean children and teenagers, a follow-up study on the changes of refractive error was performed in 1~13-year-old subjects for ten years. Methods: Among the people who had visited an ophthalmologic hospital in Seoul to examine the visual acuity and to correct refractive error from 2000 to 2010 years, 223 subjects (364 eyes) having the corrected visual acuity over 0.7 had been investigated the changes of spherical equivalent power of the cycloplegic clinical refraction and manifest clinical refraction from the accumulated medical record data for ten years. Results: The changes of spherical equivalent power for ten years in 1 to 13 years old were shown the highest change at 7-year-old. And annual change of spherical equivalent power was shown the highest change at from 9-year-old to 10-year-old (-0.64${\pm}$0.64 D) followed by from 8-year-old to 9-year-old (-0.64${\pm}$0.81 D). Conclusions: The changes of refractive error for Korean children and teenagers aged 1 to 13 years in an optometric practice were shown the tendency to proceeding to myopia with age, especially the largest increase at from 7-year-old to 10-year-old, and this period is important for vision care.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.6
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• pp.425-431
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• 2020

The purpose of this study was to provide nurses with the basic data to prepare nurses for systematic job embeddedness, job stress, and burnout in small and medium-sized hospitals and to identify any correlations. The data were collected between 1 November 2018 and 28 February 2019. The factors and general characteristics influencing the job embeddedness were found to be position (t=3.53, p<.001), total career (F=3.46, p=.034), current career (F=5.59, p=.004), and turnover experience (t=-1.72, p=.008). The job embeddedness was negatively correlated with the awareness of burnout (r=-.570, p<.001) and job stress (r=-.349, p<.001). Burnout (β=-.570, p<.001) and job stress (β=-.552, p<.001) had significant effects on job embeddedness (F=46.21, p<.001); the explanatory power of these variables was 34.9%. In other words, nurses in hospitals with fewer than 200 beds experienced higher job stress because they were exhausted. This suggests that it has a negative effect on job arrival, which is the intention to remain in the current organization. Therefore, it is necessary to manage exhaustion and job stress appropriately for the job.

• Therapeutic Science for Rehabilitation
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• v.3 no.1
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• pp.47-55
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• 2014

Objective : The purpose of this study is to assess effects of evjenth-hamberg stretching on upper-extremity function and ADL performance ability of patient with subacute stroke patients Methods : The object of this study K-hospital located in daegu, 39-year-old man who have receiving inpatient treatment with stroke. The subject during the period of four weeks, five times a week, and thirty minutes for one session, evjenth-hamberg stretching exercise of affected side. Before and after the intervention in order to compare upper-extremity function was assessed using manual function test(MFT), motor activity log(MAL) and ADL performance ability was assessed by functional independence measure(FIM). Results : Upper-extremity function of the object score improved from each 3 in MAL, the ADL performance ability score increased from 73 to 94. Conclusion : The result of this study evjenth-hamberg stretching in patients with subacute stroke upper-extremity function and ADL performance ability to promote was found that the effect. The evjenth-hamberg stretching in the occupational therapy, if appropriately utilized more on the functional recovery of patients is expected to be helpful.

• Journal of Nutrition and Health
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• v.48 no.4
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• pp.371-379
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• 2015

Purpose: This study was conducted to evaluate the factors influencing inadequate energy intake among Korean elderly. Methods: Our study included 1,869 elderly people (over 60 years old) who completed a dietary survey from the fifth Korean NHANES (2010). Factors that could affect the nutritional status of the elderly included age, family status, socio-economic factors (education, family income, livelihood security, employment), and health related factors (having chronic disease, functional status, diet therapy, depression, and suicidal thoughts). Energy and protein intake were assessed using the dietary intake data from 24hr recall method. Results: The percentage of people who consumed energy less than 75% of EEA for Koreans was 23.7% in men, 31.1% in women. The carbohydrate contribution to the total energy intake in the inadequate energy intake group was significantly higher than that in the adequate intake group (p < 0.05). Factors significantly related to inadequate energy intake after adjusting for age, family status, education, family income, employment, functional status, and suicidal thoughts were education (OR: 1.480 in men, 1.614 in women) and employment (OR: 1.751 in men, 1.464 in women), age 70 years or older in men (OR: 1.475), and living with family but without spouse in women (OR: 1.496). Conclusion: In summary, the results imply that energy intake of elderly would be affected by the status of social environment with aging and nutrition-related policy for Korean elderly should be based on the social status as well as health related conditions.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.6
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• pp.106-112
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• 2016

The purpose of this study was to examine the differences in the direct medical expenditure of community residents according to their physical activity level. The quota sampling method was used to select samples from a youth community center, senior center, community cultural center, and community recreational sports center in G city in Gyeongbuk-do. Of the 773 questionnaires distributed, 716 were completed. The questionnaires consisted of the demographic characteristics, regular exercise and physical activity levels, health status and medical costs. While the beneficial effect of regular exercise and physical activity on dental costs was not (significant), its effect on the costs of visiting hospital services was (significant). The mean differences in the total monthly direct medical expenditures on outpatient services and medicine for those with very high, high, moderate, low, and very low levels of physical activity were 7,500, 26,299, 47,517, 9,314, and 9,9978 won, respectively. The result of this study supported the findings of previous studies that regular exercise and physical activity. are not associated with the reduction of medical expenditure.

• Radiation Oncology Journal
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• v.9 no.1
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• pp.17-25
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• 1991

This study was undertaken to find the effect of radiation therapy on the healing ability of surgical wounds and on this basis, to find the proper time interval between the radiation therapy and surgery. Two hundred and fifty-two mice were used and a single dose of 2000 cGy was given in each instances to the hind limb of mice. Incisional wounds were produced after varying intervals in the previously irradiated areas and then they were followed up at regular intervals by the measurement of tensile strength. The wounds which received surgery immediately, 1 or 2 weeks after irradiation revealed marked delay and the wounds which received surgery 12, 16 or 20 weeks after irradiation demonstrated slight delay in wound healing in terms of tensile strength measurement. But the wounds which received irradiation 4 or 8 weeks before surgery did not differ much in the wound healing process from that of the control group. Histopathologic studies of the wounds demonstrated epithelization in most instances as quickly as in the control wounds. The appearance of fibroblasts and collagen fibers has delayed momently and appeared to have close correlation with the tensile strength healing curves.