• Asian Pacific Journal of Cancer Prevention
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• 제14권12호
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• pp.7537-7542
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• 2013

Background: Terpinen-4-ol, a monoterpene, is found as the main component of essential oil extracts from many plants. In this study apoptotic and autophagic types of cell death induced by terpinen-4-ol and associated mechanisms were investigated in human leukemic HL-60 cells. Materials and Methods: The cytotoxicity of human leukemic U937 and HL-60 cells was determined by MTT assay. Cytochrome c release, expression of Bax, Bcl-2, Bcl-xl and cleaved Bid were determined by Western blotting. Cell morphology was examined under a transmission electron microscope. LC3-I/II, ATG5 and Beclin-1 levels were detected by immunoblotting. Results: Terpinen-4-ol exhibited cytotoxicity to human leukemic HL-60 but not U937 cells. The apoptotic response to terpinen-4-ol in HL-60 cells was due to induction of cytochrome c release from mitochondria and cleavage of Bid protein after the stimulation of caspase-8. There was a slightly decrease of Bcl-xl protein level. The characteristic cell morphology of autophagic cell death was demonstrated with multiple autophagosomes in the cytoplasm. At the molecular level, the results from Western blot analysis showed that terpinen-4-ol significantly induced accumulation of LC3-I/II, ATG5 and Beclin-1, regulatory proteins required for autophagy in mammalian cells. Conclusions: Terpinen-4-ol induced-human leukemic HL-60 cell death was via both autophagy and apoptosis.

• 한국통신학회논문지
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• 제29권2B호
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• pp.167-173
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• 2004

본 논문은 비방사성유전체선로를 이용한 60㎓ 무선통신 송수신기 개발에 관한 것이다. 비방사성유전체선로를 이용하여 건발진기, 셔큘레이터, ASK변조기, 밸런스믹서, 3dB 방향성 결합기 및 대역통과 필터를 제작하였으며, 이를 이용하여 밀리미터파 대역인 60㎓에서 동작하고 전송대역폭은 2㎓ 정도이며, 송신출력 10mW이하에서 1Km이상의 통신이 가능한 무선통신송수신기를 제작하였다. 또한 제작된 무선통신송수신기에 대해 BER실험을 실시하였으며, 통신거리 1Km에서 155.52Mbps ATM(OC-3) 데이터 전송속도에서 BER은 10-11 정도였으며, 심한 강우시에는 BER 10-6 정도로 안정된 전송특성을 가지고 있음을 알 수 있었다.

• 생약학회지
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• 제40권2호
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• pp.118-122
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• 2009

Methanol extracts of Orostachys japonicus A. Berger (OAB) were found to exhibit apoptosis induction of HL60 human acute promyelocytic leukemia cells. Treatment of OAB exerted strong cytotoxicity against HL60 cells. OAB induced DNA fragmentation of HL60 cells in a dose dependent manner. Nitric oxide production were also increased in OAB-treated RAW264.7 macrophage cell lines. Treatment of OAB increased the expression of p53 and iNOS gene and the expression of p53, $NF-{\kappa}B$ and iNOS protein in cultured HL60 and RAW264.7 cells. These results suggest that OAB are effective on strong anti-cancer properties and can be useful as a chemo-preventive agents.

• 한국의류학회지
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• 제35권2호
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• pp.156-166
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• 2011

This study investigated the casual jacket design preferences of women aged 50s and 60s and suggested a prototype design for functional clothing. All age groups liked the casual jacket with a length between the waist and hip, a convertible collar, and a single-breasted design. Those in their 50s preferred fitted or semi-fitted casual jackets while those in their 60s preferred semi-fitted casual jackets. Although, there were significant differences between the preferred jacket designs and ready-made brand jacket designs, most brand jacket designs were casual, semi-fitted, middle-hip length, single-breasted, and with stand-rolled or convertible collars. The analysis of the sleeve styles in brand jackets showed that consumers needed designs that are more decorative. Fashion designers for senior citizens need to design elderly clothing that is comfortable, fashionable, functional, and considers a universal design for ease of clothing function. It will also make the senior citizen fashion market more appealing to consumers. To provide jacket designs for senior citizens, we suggested casual jacket designs for embedding a functional device as well as a new jacket design library for women in their 50s and 60s.

• 생명과학회지
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• 제8권2호
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• pp.162-166
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• 1998

전 골수성 백혈병 세초인 HL-60 세포를 model로 하여, 민간요법으로 사용되어져 부작용이 극히 적은 거승로 알려진 고려인삼의 구성 성분 중 주요성분이 ginseng (Panzx ginseng C.A. Meyer) saponin 및 ginsenoside Rh1, Rh2, Rh3, 비파 (Eriobotrya japonica L.) 잎의 성분들 중에서 항발암 및 항암성분으로 알려진 ursolic acid 및 oleanolic acid, 웅담중의 중요성분 성분인 lithocholoc acid 드잉 분화능력이 있는 지를 조사하고자 본 실험을 수행아였다. Retinoic acid를 처리한 결과 타 연구자들의 연구결과들처럼 높은 분화력을 관찰할 수 있었으며, dbcAMP 단독 처리군에서도 높은 분화효과를 나타냈었다. Dexamethasone 처리군에서는 분화효과를 거의 관찰할 수 없었으나,dexamethansone과 구조적으로 유사한 ursolic acid와 oleanolic acid는 보다 높은 분화력을 보였고 웅담성분의 중요성분인 lirhocholic acid는 높은 분화력을 나타냈었다. Ginseng saponin은 0.00375% (w/v)에서 20% 이상의 분화력을 보였으며, Ginsenoside Rh2와 Rh3는 높은 분화력을 나타냈다.

• Elastomers and Composites
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• 제51권1호
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• pp.49-55
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• 2016

Nanosized cobalt disulfide ($CoS_2$) particles were synthesized with 0.08 M cobalt chloride hexahydrate ($CoCl_2{\cdot}6H_2O$) and 0.2 M sodium thiosulfate pentahydrate ($Na_2S_2O_3{\cdot}5H_2O$) dissolved in distilled water under microwave irradiation. $[C_{60}]Fullerene-CoS_2$ nanocomposites were prepared with nanosized $CoS_2$ particles and [$C_{60}$]fullerene as heated by $700^{\circ}C$ for 2 h in an electric furnace. X-ray diffraction (XRD), scanning electron microscopy (SEM) and transmission electron microscopy (TEM) identified the heated $[C_{60}]fullerene-CoS_2$ nanocomposites. Heated $[C_{60}]fullerene-CoS_2$ nanocomposites were investigated the activity of photocatalytic degradation as a catalyst in various organic dyes like acid yellow 23, methylene blue, methyl orange, and rhodamine B with ultraviolet light at 254 nm by UV-vis spectrophotometer.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 2008년도 춘계 학술발표회 제20권1호
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• pp.517-520
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• 2008

본 연구에서는 균열 철근콘크리트에서의 철근의 부식 저항성 평가를 실험적 방법에 의해 수행하였다. 실험 배합으로서 보통포틀랜드시멘트(OPC), 30% 치환률의 플라이애쉬(30% PFA), 60% 치환률의 고로슬래그미분말(60% GGBS), 10% 치환률의 실리카퓸(10% SF)이 적용된 콘크리트보를 사용하였으며, 부식저항성 실험은 만능시험기를 사용하여 0.3mm의 균열을 도입하여 측정하였다. 실험결과, 혼합콘크리트 균열 철근보의 60일 양생 후의 부식저항성 순서는 OPC > 10%SF > 30% PFA > 60% GGBS로 나타남을 확인하였다. 또한, 무게감량법에 의한 부식량 측정결과도 OPC의 경우가 가장 높은 부식저항성을 가지면서 최소의 부식을 발생시키고 있음을 확인하였다. 실험결과로써 건전부 콘크리트보에서의 부식저항성이 균열부 콘크리트에서의 부식저항성보다 높게 나타나고 있음을 확인할 수 있었고, 또한, 이성분계 콘크리트보다 OPC 콘크리트가 부식 저항이 더욱 높음을 확인하였다.

• 약학회지
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• 제47권5호
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• pp.319-324
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• 2003

This study examined the inhibitory effect of extracts of Trichosanthes kirilpwii sorted according to the parts on the growth of HL-60 cells. The growth of HL-60 leukemia cells was markedly inhibited by the treatment of the 80％ methanol extract of roots (10 $\mu\textrm{g}$/mι), stems (50$\mu\textrm{g}$/mι), pips (10$\mu\textrm{g}$/mι), and gourds (100 $\mu\textrm{g}$/mι), or the ethylacetate fraction of leaves (100 $\mu\textrm{g}$/mι). when the HL-60 cells were treated with the extracts of T. kirilpwii sorted according to the parts, DNA fragmentation and sub-G1 hypodiploid cells were observed. Moreover, T. kirilpwii extracts increased the level of the expression of the active form of caspase-3 and the activation of caspase-3 was demonstrated by the cleavage of poly(ADP-ribose) polymerase, a vital substrate of effector caspase. The results suggest that the inhibitory effect of extracts of T. kirilpwii sorted according to the parts on the growth of HL-60 cells seems to arise from the induction of apoptosis.

• 한국건축시공학회:학술대회논문집
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• 한국건축시공학회 2011년도 춘계 학술논문 발표대회 1부
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• pp.73-75
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• 2011

In this study, prediction of later-age compressive strength of ultra-high strength concrete, based on the accelerated strength of concrete cured in 50, 60℃ warm water was investigated. W/B of 32, 23.5, 19% 3 levels were examined. And the specimens were cured in 50, 60℃ warm water. The results showed reliable accuracy by regression relation between 28day strength cured by standard curing method and accelerated strength of the concrete cured in warm water. And the specimens cured in 50, 60℃ showed more high strength development. So 60℃ curing could be considered in order to reduce the measurement error. As a result, the feasibility of 50, 60℃ warm water curing method at high strength level was confirmed.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2007년도 하계학술대회 논문집 Vol.8
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• pp.505-506
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• 2007

Organic photovoltaic effects were studied in a device structure of ITO/CuPc/Al and ITO/CuPc/$C_{60}$/BCP/Al. A thickness of CuPc layer was varied from 10 nm to 50 nm, we have obtained that the optimum CuPc layer thickness is around 40 nm from the analysis of the current density-voltage characteristics in CuPc single layer photovoltaic cell. From the thickness-dependent photovoltaic effects in CuPc/$C_{60}$ heterojunction devices, higher power conversion efficiency was obtained in ITO/20nm CuPc/40nm $C_{60}$/Al, which has a thickness ratio (CuPc/$C_{60}$) of 1:2 rather than 1:1 or 1:3. Light intensity on the device was measured by calibrated Si-photodiode and radiometer/photometer of International Light Inc(IL 14004).