Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Effect of Orostachys japonicus A. Berger on Apoptosis Induction of Human Leukemia HL60 Cells

와송의 HL60백혈병세포의 Apoptosis유도 효과

  • Oh, Chan-Ho (Department of Food & Biotechnology, Woosuk University) ;
  • Bae, Jin-Beom (Department of Food & Biotechnology, Woosuk University) ;
  • Kim, Nam-Seok (Department of Food & Biotechnology, Woosuk University) ;
  • Jeon, Hoon (College of Pharmacology, Woosuk University) ;
  • Han, Kwang-Soo (Department of Alternative Medicine, Woosuk University) ;
  • Lee, Moon-Jun (College of Environmental & Bioresource Sciences, Chonbuk National University) ;
  • Kwon, Jin (Department of Prosthetics and Orthotics, Korea National College of Rehabilitation and Welfare)
  • 오찬호 (우석대학교 식품생명공학과) ;
  • 배진범 (우석대학교 식품생명공학과) ;
  • 김남석 (우석대학교 식품생명공학과) ;
  • 전훈 (우석대학교 약학대학) ;
  • 한광수 (우석대학교 대체의학과) ;
  • 이문준 (전북대학교 환경생명자원대학) ;
  • 권진 (한국재활복지대학 의료보장구과)
  • Published : 2009.06.30
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Abstract

Methanol extracts of Orostachys japonicus A. Berger (OAB) were found to exhibit apoptosis induction of HL60 human acute promyelocytic leukemia cells. Treatment of OAB exerted strong cytotoxicity against HL60 cells. OAB induced DNA fragmentation of HL60 cells in a dose dependent manner. Nitric oxide production were also increased in OAB-treated RAW264.7 macrophage cell lines. Treatment of OAB increased the expression of p53 and iNOS gene and the expression of p53, $NF-{\kappa}B$ and iNOS protein in cultured HL60 and RAW264.7 cells. These results suggest that OAB are effective on strong anti-cancer properties and can be useful as a chemo-preventive agents.

Keywords

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