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Characterization of Single Nucleotide Polymorphisms in 55 Disease-Associated Genes in a Korean Population

  • Lee, Seung-Ku;Kim, Hyoun-Geun;Kang, Jason-J.;Oh, Won-Il;Oh, Berm-Seok;Kwack, Kyu-Bum
    • Genomics & Informatics
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    • v.5 no.4
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    • pp.152-160
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    • 2007
  • Most common diseases are caused by multiple genetic and environmental factors. Among the genetic factors, single nucleotide polymorphisms (SNPs) are common DNA sequence variations in individuals and can serve as important genetic markers. Recently, investigations of gene-based and whole genome-based SNPs have been applied to association studies for marker discovery. However, SNPs are so population-specific that the association needs to be verified. Fifty-five genes and 384 SNPs were selected based on association with disease. Genotypes of 337 SNPs in candidate genes were determined using Illumina Sentrix Array Matrix (SAM) chips by an allele-specific extension method in 364 unrelated Korean individuals. Allelic frequencies of SNPs were compared with those of other populations obtained from the International HapMap database. Minor allele frequencies, linkage disequilibrium blocks, tagSNPs, and haplotypes of functional candidate SNPs in 55 genetic disease-associated genes were provided. Our data may provide useful information for the selection of genetic markers for gene-based genetic disease-association studies of the Korean population.

Performances of Current-Waveform Modulated Single-Phase Induction Machine (전류파형을 변조한 단상유도전동기구의 특성에 관한 연구)

  • 황영문;김철우;박용규
    • 전기의세계
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    • v.24 no.1
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    • pp.55-62
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    • 1975
  • A single-phase induction motor with it's stator winding splitted into two series windings, of which the terminals of one winding is switched pulsationally by a thyristor type ON-OFF device so that the motor may operate as a pulsational shaded-pole motor, can modulate current waveforms of it's two series windings. In view of current waveform modulation method, a single-phase single-winding motor operates as a two-phase induction motor with asymmetrical axis windings where the starting torque can be obtained effectively without an auxiliary capacitor attached and it's running speed controlled by shifting phase between current waveforms differently. Equivalent circuit for analysis is modified from a double revolving field equivalent circuit of a single-phase induction motor with asymmetrical windings whose angle is 45.deg.C elet. degrees. Analysis and test results show that ON-OFF action of the pulsational shaded-pole winding has the same effect of a series capacitor, and then at heavy loads this motor operates with a small amonut of the input current than that having the fixed shaded-pole winding.

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Growth of long persistent $SrAl_2O_4:Eu^{2+},\;Dy^{3+}$ phosphor single crystals by the Verneuil method (베르누이법 의한 장잔광성 $SrAl_2O_4:Eu^{2+},\;Dy^{3+}$ 단결정 성장)

  • Nam, Kyung-Ju;Choi, Jong-Keon
    • Journal of the Korean Crystal Growth and Crystal Technology
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    • v.15 no.6
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    • pp.225-228
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    • 2005
  • We have grown the long persistent $SrAl_2O_4:Eu^{2+},\;Dy^{3+}$ phosphor single crystal by Verneuil method. The obtained single crystals were long persistent phosphorescence peaking at ${\lambda}=520nm$ with a size of about 5 mm diameter, 55 mm length. The melting temperature of $SrAl_2O_4:Eu^{2+},\;Dy^{3+}$ measured $T_{mp}=1968^{\circ}C$. The optimum composition was $SrCO_3:Al(OH)_3:Eu_2O_3:Dy_2O_3$ = 1 : 2 : 0.015 : 0.02. Flow rate of $H_2:O_2$ is about 4 : 1. Growthing rate is about 5 mm/hr. The spectra of the phosphorescence from the crystals are quite similar to those obtained with sintered powders used for luminous pigments. The crystalline structure of long persistent $SrAl_2O_4:Eu^{2+},\;Dy^{3+}$ phosphor single crystal was determined by X-ray diffraction.

Surgery for Bilateral Large Intracranial Traumatic Hematomas : Evacuation in a Single Session

  • Kompheak, Heng;Hwang, Sun-Chul;Kim, Dong-Sung;Shin, Dong-Sung;Kim, Bum-Tae
    • Journal of Korean Neurosurgical Society
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    • v.55 no.6
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    • pp.348-352
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    • 2014
  • Objective : Management guidelines for single intracranial hematomas have been established, but the optimal management of multiple hematomas has little known. We present bilateral traumatic supratentorial hematomas that each has enough volume to be evacuated and discuss how to operate effectively it in a single anesthesia. Methods : In total, 203 patients underwent evacuation and/or decompressive craniectomies for acute intracranial hematomas over 5 years. Among them, only eight cases (3.9%) underwent operations for bilateral intracranial hematomas in a single session. Injury mechanism, initial Glasgow Coma Scale score, types of intracranial lesions, surgical methods, and Glasgow outcome scale were evaluated. Results : The most common injury mechanism was a fall (four cases). The types of intracranial lesions were epidural hematoma (EDH)/intracerebral hematoma (ICH) in five, EDH/EDH in one, EDH/subdural hematoma (SDH) in one, and ICH/SDH in one. All cases except one had an EDH. The EDH was addressed first in all cases. Then, the evacuation of the ICH was performed through a small craniotomy or burr hole. All patients except one survived. Conclusion : Bilateral intracranial hematomas that should be removed in a single-session operation are rare. Epidural hematomas almost always occur in these cases and should be removed first to prevent the hematoma from growing during the surgery. Then, the other hematoma, contralateral to the EDH, can be evacuated with a small craniotomy.

The Mirror Characteristics of Dielectric Multilayer Optimized at 1.55${\mu}{\textrm}{m}$ Wavelength (1.55${\mu}{\textrm}{m}$에서 최적화된 유전체 다층막의 미러 특성)

  • 박태성;정홍배;김명진;윤대원
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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    • 1995.11a
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    • pp.183-186
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    • 1995
  • The fabrication of dielectric multilayer mirror(DMM) optimized at the wavelength of 1.55$\mu\textrm{m}$ and its spectral properties were investigated. The materials used in the fabrication of DMM are TiO$_2$-SiO$_2$, which have the advantage of yielding high reflectance for relatively small numbers of layers. The optical constants of TiO$_2$single film were obtained by using a modified envelope method. The reflectances of DMMs with 3,7,11 and 23 layers were 58%, 89%, 97% and 99.9% at the wavelength of 1.55$\mu\textrm{m}$, respectively.

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Kinetic Parameter Analysis of Hydrogen Diffusion Reaction for Hydrogen Storage Alloy of Fuel Cell System (연료전지의 수소저장용 합금에 대한 수소확산반응의 속도론적 해석)

  • Kim, Ho-Sung
    • Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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    • v.20 no.2
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    • pp.45-49
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    • 2006
  • Electrochemical hydrogenation/dehydrogenation properties were studied for a single particle of a Mm-based(Mm : minh metal) hydrogen storage alloy($MmNi_{3.55}Co_{0.75}Mn_{0.4}Al_{0.3}$) for fuel cell and Ni-MH batteries. A carbon fiber microelectrode was manipulated to make electrical contact with an alloy particle, and the potential-step experiment was carried out to determine the apparent chemical diffusion coefficient of hydrogen atom($D_{app}$) in the alloy. Since the alloy particle we used here was a dense, conductive sphere, the spherical diffusion model was employed for data analysis. $D_{app}$ was found to vary the order between $10^{-9}\;and\;10^{-10}[cm^2/s]$ over the course of hydrogenation and dehydrogenation process. Compared with the conventional composite film electrodes, the single particle measurements using the microelectrode gave more detailed, true information about the hydrogen storage alloy.

Spinal Arteriovenous Fistula with Progressive Paraplegia after Spinal Anaesthesia

  • Baltsavias, Gerasimos;Argyrakis, Nikolaos;Matis, Georgios K.;Mpata-Tshibemba, Stephanie
    • Journal of Korean Neurosurgical Society
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    • v.55 no.2
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    • pp.106-109
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    • 2014
  • A case of an iatrogenic spinal arteriovenous fistula with progressive paraplegia in a young woman is reported. The fistula was eventually created after repetitive lumbar punctures performed in the process of spinal anaesthesia. Her symptoms were progressed to paraplegia over a period of 2 years. The digital subtraction angiography demonstrated a single-hole fistula, involving the anterior spinal artery and vein. The lesion was occluded by embolization with immediate improvement. The potential mechanism is discussed.

Design of Double-clad, Dispersion-Compensated Fiber at$\lambda=1.55\mu\textrm{m}$ : Step & Triangular Index Profile ($\lambda=1.55\mu\textrm{m}$에서 계단형, 삼각형 분포-이중클래드 분산보상 광섬유의 설계)

  • 김수아;김창민
    • Journal of the Korean Institute of Telematics and Electronics D
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    • v.34D no.11
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    • pp.54-63
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    • 1997
  • The 1-D finite-element mehtod is applied for designing double-clad otpical fibers with dispersion-compensation capability. design parameters allowing only a $LP_{01}$ single mode are treated and macro-bending loss are taken into consideration. Design parameters are extracted to have the compensation ratio $(L_{SMF}/L_{DCF})$ of 6.2 for core structure with step-index profile, and of 5.2 for core with triangular-index profile.

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Development of an RSFQ 4-bit ALU

  • Kim, J.Y.;Baek, S.H.;Kim, S.H.;Jung, K.R.;Lim, H.Y.;Park, J.H.;Kang, J.H.;Han, T.S.
    • 한국초전도학회:학술대회논문집
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    • v.14
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    • pp.55-55
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    • 2004
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