• Archives of Pharmacal Research
• /
• v.19 no.6
• /
• pp.475-479
• /
• 1996

Diethylcarbamazine (DEC, 1-diethylcarbamyl-4-methylpiperazine) is an antiparasitic piperazine derivative used in the treatment of lymphatic filariasis caused by Wuchereria bancrofti, Brugia malayi or grugia timori. DEC-N-oxide is a major metabolite in humans and has antifilarial activity. In carrying out pharmacokinetic studies, gas chromatographic analysis of DEC in plasma can be complicated by the presence of the metabolite, since the thermally unstable DEC-N-oxide is converted back to a material which coelutes with DEC under the conditions of the analysis. We now report a method to separate DEC-N-oxide from DEC in plasma using solid phase extraction with subsequent gas chromatographic analysis using a nitrogen specific detector. One-diethylcarbamyl-4-ethylpiperazine (E-DEC) was the internal standard. The standard curve of DEC was linear in the range of 10 to 200 ng/ml as described by Y=0.0350+0.0128X, $R^2=0.999$. The limit of quantitation was 4 ng/mL. Reproducibility at 10, 100 and 200 ng/mL concentration points of the standard curve gave coefficient variations of 6.1%, 7.8% and 1.6%, respectively. The recovery following solid phase extraction was 99.3% for DEC and 94.8% for the internal standard. This sensitive and specific analytical method is suitable for pharmacokinetic studies of DEC.

• Analytical Science and Technology
• /
• v.34 no.6
• /
• pp.259-266
• /
• 2021

Cannabis (Marijuana) is one of the most widely used drugs in the world, and its distribution has been controlled in South Korea since 1976. Identification of 11-nor-Δ⁹-carboxy-tetrahydrocannabinol (THCCOOH) in urine can provide important proof of cannabis use, and it is considered scientific evidence in the forensic field. In this study, we describe a simultaneous quantitative method for identifying THCCOOH and THCCOOH-glucuronide in urine, using simple liquid-liquid extraction (LLE), and liquid chromatography-tandem mass spectrometry (LC-MS/MS). THCCOOH-D₃ and THCCOOH-glucuronide-D₃ were used as internal standards. Validation results of the matrix effect, as well as recovery, linearity, precision, accuracy, process efficiency, and stability were all satisfactory. No carryover, endogenous or exogenous interferences were observed. The limit of detection (LOD) of THCCOOH and THCCOOH-glucuronide were 0.3 and 0.2 ng/mL, respectively. The developed method was applied to 28 authentic human urine samples that tested positive in immunoassay screening and gas chromatography/mass spectrometry (GC/MS) tests. The ranges of concentrations of THCCOOH and THCCOOH-glucuronide in the samples were less than LOQ~266.90 ng/mL and 6.43~2133.03 ng/mL, respectively. The concentrations of THCCOOH-glucuronide were higher than those of THCCOOH in all samples. This method can be effectively and successfully applied for the confirmation of cannabinoid use in human urine samples in the forensic field.

• Journal of the Korean Geotechnical Society
• /
• v.22 no.8
• /
• pp.77-88
• /
• 2006

In this study, the lateral behavior of Pile-Bent structures subjected to lateral loading was evaluated by a load-transfer approach. An analytical method based on the Beam-Column model and nonlinear load transfer curve method was proposed to consider material non-linearity (elastic and yielding) and $P-{\Delta}$ effect. Special attention was given to the lateral deflection of Pile-Bent structures depending on different soil properties, lateral load, slenderness ratio based on pier length and reinforcing effect of casing. From the results of the parametric study, it is shown that the increase of lateral displacement in a pile is much less favorable for an inelastic analysis than for an elastic analysis. It is found that for inelastic analysis, the maximum bending moment is located within a depth approximately 3.5D(D: pile diameter) below ground surface, but within 1.5D when $P-{\Delta}$ effect is considered. It is also found that the magnitude and distribution of the lateral deflections and bending moments on a pile are highly influenced by the inelastic analysis and $P-{\Delta}$ effect, let alone soil properties around an embedded pile.

• Journal of the Society of Disaster Information
• /
• v.14 no.3
• /
• pp.379-386
• /
• 2018

Purpose: This study was to the fragility evaluation of I-shape curved beam structure subjected to strong ground motions including Gyeongju and Pohang earthquakes Method: In particular, to conduct the analytical model, ABAQUS and ANSYS platform was used in this study. Furthermore, the analytical model using 3D Finite Element Model (FEM) was validated, in comparison to the theoretical solutions at the location of 025L, 05L, and 0.75L in static loading condition. In addition, in order to evaluate the seismic fragility of the curved beam structure, 20 seismic ground motions were selected and Monte-Carlo Simulation was used for the empirical fragility evaluation from 0.2g to 1.5g. Result: It was interesting to find that the probability of the system failure was found at 0.2g, as using 190 MPa limit state and the probability of the failure using 390 MPa limit state was starting from 0.6g. Conclusion: This study showed the comparison of the theoretical solution with analytical solution on I-shaped curved beam structures and it was interesting to note that the system subjected to strong ground motions was sensitive to high frequency earthquake. Further, the seismic fragility corresponding to the curved beam shapes must be evaluated.

• Therapeutic Science for Rehabilitation
• /
• v.9 no.4
• /
• pp.33-43
• /
• 2020

Objective: This study used a mixed methods analytical approach to analyze the level of depression in and quality of life of patients who had been exposure to Agent Orange. Methods: Data on the general characteristics, depression level, and the quality of life of 29 patients who were hospitalized because of exposure to Agent Orange were collected. Focus group interviews were conducted with 17 of these 29 patients. Regarding mixed methods, the sequential integrated design model proposed by Teddlie and Tashakkori (2003) was employed. The analytical methods were as follows: (1) general characteristics were examined using frequencies and proportional distributions; (2) depression scores and quality of life scores were assessed using descriptive statistical analysis; and (3) content analysis was used to examine the focus group interview data. Results: The average K-GDS depression score was 19.24 points, and the average WHOQOL-BREF quality of life score was 57.66 points. The focus group interview data yielded 3 topics were named "deployment route", "the manner of exposure to Agent Orange", and "life after Agent Orange exposure". Conclusion: There is an urgent need to increase public awareness, develop a public policy response, and conduct additional research on ground occupational therapy programs that include physical therapy.

• Journal of Korean Society for Atmospheric Environment
• /
• v.23 no.1
• /
• pp.39-49
• /
• 2007

In this study, the performance characteristics of solid phase microextraction (SPME) were investigated for three major odorous groups that consist of 10 individual compounds ([1] volatile organic compounds (VOC): benzene, toluene, p-xylene and styrene, [2] reduced sulfur compounds (RSC): hydrogen sulfide, methyl mercaptan, dimethylsulfide (DMS), dimethyldisulfide (DMDS), and carbon disulfide, and [3] amine: trimethylamine (TMA)). For the purpose of a comparative analysis, two types of SPME fiber ([1] polidimethylsiloxane/divinilbenzene (P/D) and [2] $Carboxen^{TM}$/polidimethylsiloxane (C/P)) were test ε d against each other for a series of standards prepared at different concentration levels (100, 200, and 500 ppb). To compare the analytical performance of each fiber, all standards were analyzed for the acquisition of calibration data sets for each compound. The results of P/D fiber generally showed that its calibration slope increased as a function of molecular weight across different VOCs; however, those of C/P fiber showed a fairly reversed trend. Besides, we confirmed that the application of SPME is limited to many sulfur compounds; only two compounds (DMS and DMDS) are sensitive enough to draw calibration results out of SPME. The calibration data for RSC show generally enhanced slop values for C/P relative to P/D fiber. However, in the case of TMA, we were not able to find a notable difference in their performance.

• Information Systems Review
• /
• v.16 no.3
• /
• pp.1-23
• /
• 2014

This research uses the Analytical Hiararchy Process (AHP) to scientifically and systematically calculate the weightings of attributes as well as dimensions considered for assessing an informational website. The present paper aims at observing and using the computed weightings to comparatively examine the perceptions of customer users and business users. We use the 3C-D-T (i.e., Content, Community, Commerce, Design, and Technology) framework to conduct a case study where we review and assess restaurant websites and calculate attribute weightings on these websites. Data used for website review was collected in two phases. Data in the first phase was collected from customer users, and data in the second phase was from business users who had registered in the same websites. Users were instructed to perform a pairwise comparison of the relative importance of website attributes. Our data analysis revealed that the customer users and business users demonstrated different views on the relative importance of the individual attributes. Based on the findings, we suggested that business users of restaurants should adapt their views to the customers' views to minimize perceptional differences, thereby increasing customer satisfaction and accomplishing successful business outcomes.

• Journal of the Korea Concrete Institute
• /
• v.22 no.3
• /
• pp.381-388
• /
• 2010

In this study, characteristics of the seismic response of the non-earthquake resistant reinforced concrete (RC) frame were identified. The test building is designed to withstand only gravity loads and not in compliance with modern seismic codes. Smooth bars were utilized for the reinforcement. Members are provided with minimal amount of stirrups to withstand low levels of shear forces and the core concrete is virtually not confined. Columns are slender and more flexible than beams, and beam-column connections were built without stirrups. Through the modeling of an example RC frame, the feasibility of the fiber elementbased 3D nonlinear analysis method was investigated. Since the torsion is governed by the fundamental mode shape of the structure under dynamic loading, pushover analysis cannot predict torsional response accurately. Hence, dynamic response history analysis is a more appropriate analysis method to estimate the response of an asymmetric building. The latter method was shown to be accurate in representing global responses by the comparison of the analytical and experimental results. Analytical models without rigid links provided a good estimation of reduced stiffness and strength of the test structure due to bond-slip, by forming plastic hinges closer to the column ends. However, the absence of a proper model to represent the bond-slip poased the limitations on the current inelastic analysis schemes for the seismic analysis of buildings especially for those with round steel reinforcements. Thus, development of the appropriate bond-slip model is in need to achieve more accurate analysis.

• Journal of the Korean Geotechnical Society
• /
• v.30 no.12
• /
• pp.41-49
• /
• 2014

The 3D numerical analysis is carried out to investigate the settlement behavior of flexible mat foundations subjected to vertical loads. Special attention is given to the improved analytical method (YS-MAT) that reflects the mat flexibility and soil spring coupling effect. The soil model captures the stiffness of the soil springs as well as the shear interaction between the soil springs. The proposed method has been validated by comparing the results with other numerical methods and a field measurement on mat foundation. Through comparative studies, the settlement of the proposed method was in relatively good agreement with those of a field measurement and other numerical methods. The results permit us to estimate the response of the mat foundation subjected to vertical loads that should be taken into account in the combination of mat flexibility and soil continuity characteristics.

• KSCE Journal of Civil and Environmental Engineering Research
• /
• v.5 no.3
• /
• pp.107-115
• /
• 1985

For the finite deflection analysis of plates with initial deflections subjected to uniaxial compression, the formulation of incremental finite strip method is made and has been incorporated into a computer program. A new in plane displacement function varying along the load: direction has been derived from the out-of-plane displacement function by considering the curvature of a plate. Either incremental load type analysis or incremental displacement type analysis may be selected to solve incremental equibrium equations in the program. The following results have been obtained: 1. Incremental displacement type analysis is superior to incremental load type analysis in that the former converges more rapidly than the latter. 2. The finite strip method using the new displacement function gives as accurate results as analytical method and other finite element methods.