• Bulletin of the Korean Chemical Society
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• 제33권9호
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• pp.2861-2866
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• 2012

Results of the comparisons of various density functional theory (DFT) methods with different basis sets for predicting the molecular geometry of TPOP24N-Oxide macrocycle, an oxoporphyrin N-oxide, are reported in this paper. DFT methods, including M06-2X, B3LYP, LSDA, B3PW91, PBEPBE, and BPV86, are examined. Different basis sets, such as 6-$31G^*$, 6-31+G (d, p), 6-311+G (d, p), and 6-311++G (d, p), are also considered. The M06-2X/6-$31G^*$ level is superior to all other density functional methods used in predicting the geometry of TPOP24N-Oxide. The geometries of regioisomeric chlorin N-oxide and oxoporphyrin N-oxide are reported using M06-2X/6-$31G^*$ method. The geometry effects of oxoporphyrin and chlorin N-oxide regioisomers are increased ${\beta}-{\beta}$ bond lengths by N-oxidation because the bond overlap index due to charge transfers is decreased. In N-oxidation ring (II, III), angles that include ${\beta}-{\beta}$ bond length increase as the bond overlap index of ${\beta}-{\beta}$ bond is decreased by N-oxidation. The potential energy surfaces of chlorin N-oxide and oxoporphyrin N-oxide are explored by M06-2X/6-$31G^*$, and single-point calculations are performed at levels up to M06-2X/6-311++G (d, p). Total and relative energies are then calculated. The results indicate that chlorin 24 N-oxides are more stable than chlorin 22 N-oxides in chlorin N-oxide regioisomers. Moreover, TPOP24N-Oxide is less stable than TPOP22N-Oxide.

• 한국임상약학회지
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• 제29권2호
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• pp.101-108
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• 2019

Background: High doses of methotrexate (MTX) are often used in various chemotherapy protocols to treat acute lymphoblastic leukemia (ALL) and non-Hodgkin's lymphoma (NHL) in children, but its delayed elimination increases the occurrence of adverse events, such as bone marrow suppression. The aim of this study was to investigate the elimination of MTX at 24 and 48 hours. Methods: We retrospectively analyzed electronic medical records of ALL or NHL pediatric patients who received $5g/m^2$ MTX infusion over 24 hours (between June, 2012 and July, 2018) at the Yonsei University Health System, Korea. The delayed elimination of MTX concentrations was assessed with 100 or $150{\mu}M$ MTX at 24 hours, and 2 or $5{\mu}M$ at 48 hours. Results: Among the 85 MTX cycles administered, 23 cycles were classified in delayed elimination group, and 62 cycles showed normal elimination. At 24 hours, the delayed elimination group with MTX concentration > $100{\mu}M$ showed higher percentage than group with MTX concentration < $100{\mu}M$ (45.8% vs. 19.7%, p = 0.015). However, no differences were observed at $150{\mu}M$ MTX (p = 0.66). At 48 hours, the delayed elimination was higher than the normal elimination at both concentration baselines (p < 0.001 at $2{\mu}M$, p = 0.024 at $5{\mu}M$). Conclusions: MTX concentrations greater than $100{\mu}M$ show high probability of delayed elimination at 24 hours. When MTX levels are above normal, leucovorin and hydration regimens should be continued to prevent delayed elimination.

• 한국환경과학회지
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• 제24권11호
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• pp.1463-1471
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• 2015

The surface modified activated carbons (SMACs) were prepared with various $P_2O_5$ concentrations using two activated carbons (ACs: waste citrus peel-based activated carbon and coconut-based activated carbon). The characteristics and adsorptivity of bisphenol A (one of phenolic endocrine disrupting chemicals) were compared between ACs and SMACs. The contents of C, H and N of SMACs were similar to those of ACs, but the content of $P_2O_5$ for the former increased greatly than for the latter, due to the impregnation of $P_2O_5$ into the pores. The specific surface area, total pore volume, average pore diameter and iodine adsorptivity for the former decreased due to the impregnation of $P_2O_5$ into the pores, compared to those for the latter. The adsorptivity of bisphenol A for the former were higher than that for the latter, although specific surface area, total pore volume, average pore diameter and iodine adsorptivity for the former were lower than those for the latter.

• 한국생물공학회:학술대회논문집
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• 한국생물공학회 2003년도 생물공학의 동향(XII)
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• pp.611-614
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• 2003

p-KG03의 고유점도는 65.22 및 50.75 $d{\ell}/g$ 이며, 사슬강도성은 0.170이였고, 특성화 농도는 0.114 g/l이었다. p-KG03은 non-Newtonic fluid로 Power-Low Model에 의한 pseudoplastic한 물성을 갖으며, 유체성으로 p-KG03 1%의 constancy index (K)는 2,172 cp, flow behavior index (n)는 0.52이었다. 특히 pH, 염 및 열에 안정하며 기존 다당류와의 혼합이용 가능성이 있을 것으로 생각된다.

• 대한치과교정학회지
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• 제30권1호
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• pp.101-114
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• 2000

한국인 성인에서 연령 증가에 따른 연조직 측모 변화 양상을 규명하기 위하여 남자 17명과 여자 8명을 대상으로 24세와 32세에 촬영된 측모 두부X-선 규격사진을 비교, 분석한 결과 다음과 같은 결론을 얻었다. 1. 관찰 기간 동안, 남녀 모두 경조직에서는 통계적으로 유의한 변화가 없었다 (p>0.05). 2. 연조직의 전후적 계측치에서 남자는 턱부위 (Pog', Gn')의 유의한 증가를, 여자는 하순 (LI)의 유의한 감소를 관찰할 수 있었다 (p<0.05). 3. 연조직의 수직적 계측치에서 남녀 모두 상순의 길이 (Sn-Sto) 가 증가하는 경향을 보였으나 통계적 유의성은 남자에서만 나타났고 하안면 고경 (Sn-Gn') 은 남녀 모두에서 유의하게 증가하였다 (p<0.05). 4. 연조직 두께는 남녀 모두 전체적으로 증가하는 경향을 보였으며 특히 턱부위 (Pog', Gn') 에서 유의한 증가가 있었다 (P<0.05).

• 한국수산과학회지
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• 제32권1호
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• pp.56-61
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• 1999

참메기, Silurus asotus를 대상으로 수온 ($15^{\circ}C,\;20^{\circ}C,\;25^{\circ}C$ 및 $30^{\circ}C$)과 광주기 (24L:0D, 12L:12D 및 0L:24D)에 따른 산소 소비량의 변화를 연속적인 컴퓨터 모니터링 시스템을 이용하여 조사하였다. 평균 무게 280g의 참메기의 산소 소비량은 수온의 증가에 따라 증가하였고, $15^{\circ}C$에서 $35.2\~96.4mg\;O_2/kg$ fish/hr, $20^{\circ}C$에서$78.6\~127.9mg\;O_2/kg$ fish/hr, $25^{\circ}C$에서$120.1\~231.7mg\;O_2/kg$ fish/hr, $30^{\circ}C$에서 $197.5\~352.3mg\;O_2/kg$ fish/hr으로 나타났다(p<0.05). 광주기에 따른 산소 소비량은 암기 조건에서 보다 명기 조건에서 산소소비량이 더 높게 나타났다. 또한, 24L:0D와 12L:12D와 비교하여 0L:24D에서 평균 산소 소비량이 낮게 나타났다(p<0.05). 산소 소비량의 최대값과 최소값의 차이는 수온이 상승함에 따라 증가하였고, 12L:12D에서 가장 큰 것으로 나타났고, 새벽녁과 저녁 무렵에 산소 소비량의 급격한 변화를 나타내었다. 특히, 12L:12D의 조건에 두었을 때 명기와 암기에 대한 뚜렷한 반응을 보였다.

• 한국식생활문화학회지
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• 제24권4호
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• pp.391-400
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• 2009

This study was conducted to investigate bone density and food behavior of middle-aged (<65-years-of-age) and oldaged women (${\geq}$65-years-of-age) in the Seoul area of Korea. Average height and weight, body mass index, body fat percentage, and waist-hip ration (WHR) of the middle-aged participants were 158.0 cm, 58.4 kg, 23.3, 29.7%, and 0.88. Corresponding measurements for old-aged participants were 152.6 cm, 56.3 kg, 24.1, 33.1%, and 0.93. T- and Z-scores for middle-aged women were -1.20 and -0.21, and those of old-aged women were -2.02 and -0.49. Osteopenia and osteoporosis percentage of middle- and old-aged women were 41.2% and 14.7%, and 45.2% and 37.1%, respectively. Significant differences were evident concerning between-meal, overeating, exercise, and nutritional supplementation among the two groups. Middle-aged women displayed a positive relationships between bone density and the parameters of height (p<0.05), weight (p<0.05), exercise (p<0.05), consumption of soybean and soybean-processed food (p<0.05), and negative relationships between bone density and the parameters of WHR (p<0.001), consumption of meat and meatprocessed food (p<0.05), and tea drinking (p<0.05). In old-aged women group, positive relationships were evident for bone density and the parameters of height (p<0.05), weight (p<0.05), exercise (p<0.05), nutritional supplementation (p<0.05), and consumption of soybean and soybean-processed food (p<0.05). The results reveal a link between healthy bones and desirable food behavior, indicating the importance of a practical and systematically organized food behavior education program for middle- and old-aged Korean women.

• 사물인터넷융복합논문지
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• 제9권2호
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• pp.33-40
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• 2023

본 연구는 간호대학생을 대상으로 아로마 블렌딩 오일 흡입이 학업스트레스와 수업집중력에 미치는 효과를 검정하기 위한 비동등성 플라시보 대조군 전후 시차설계의 유사실험연구이다. 연구의 대상자는 Y시에 소재하는 K대학교 간호학과 2학년 학생으로 처치군 24명, 플라시보 대조군 24명이었다. 2022년 11월 4일부터 2022년 12월 3일까지 자료를 수집하였고, 자료는 SPSS 23.0 Program을 이용하여 분석하였다. 동질성 검정은 chi-square test, independent t-test, 실험 후 집단 간 종속변수의 차이는 independent t-test, 집단 내 종속변수의 차이는 paired t-test로 분석하였다. 10일간 아로마 블렌딩 오일을 흡입한 처치군은 호호바 오일을 흡입한 플라시보 대조군보다 학업스트레스는 유의하게 감소하였고(t=-8.79, p<.001), 수업집중력 유의하게 증가하였다(t=24.44, p<.001).

• Asian Pacific Journal of Cancer Prevention
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• 제14권11호
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• pp.6733-6738
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• 2013

Multiple genetic studies have confirmed association of 8q24 variants with susceptibility to prostate cancer (PCa). As PCa risk SNPs may also influence disease outcome, we studied here eight 8q24 risk alleles, and evaluated their role in PCa clinical covariates in northern Chinese men. Blood samples and clinical information were collected from ethnically Chinese men from Northern China with histologically-confirmed PCa (n=289) and from age-matched normal controls (n=288). Eight 8q24 SNPs were genotyped by polymerase chain reaction-high- resolution melting analysis in 577 subjects. We examined the prevalence distribution of 8q24 risk alleles and analyzed the associations between the risk allele and PCa and clinical covariates to infer their impact on aggressive PCa. Three of the eight SNPs were associated with PCa risk in northern Chinese men, including rs16901966 (OR 1.31, 95% CI 1.01-1.70, p=0.042), rs1447295 (OR 1.47, 95% CI 1.09-1.98, p=0.011) and rs10090154 (OR 1.55, 95% CI 1.14-2.12, p=0.005). Haplotype analysis based association with the risk alleles revealed significant differences between cases and controls (OR 1.43, 95%CI 0.99-2.06, p=0.049). The risk alleles rs16901966, rs1447295 and rs10090154 were associated with age at diagnosis and tumor stage as compared with controls, while rs16901966 was associated with aggressive PCa (OR 1.43, 95% CI 1.01-2.03, p=0.042). The evidence for 8q24 SNPs with PCa risk in northern Chinese men showed rs16901966, rs1447295 and rs10090154 at 8q24 (region 1, region 2) to be strongly associated with PCa and clinical covariates. The three SNPs at 8q24 could be PCa susceptible genetic markers in northern Chinese men.

• 충청수학회지
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• 제24권4호
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• pp.807-824
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• 2011

It has been proved that if $\mathbb{X}^{(s,s)}$ is the union of two linear star-configurations in $\mathbb{P}^2$ of type $s{\times}s$, then $(I_{\mathbb{X}^{(s,s)}})_s{\neq}\{0\}$ for s = 3, 4, 5, and $(I_{\mathbb{X}^{(s,s)}})_s=\{0\}$ for $s{\geq}6$. We extend $\mathbb{P}^2$ to $\mathbb{P}^n$ and show that if $\mathbb{X}^{(s,s)}$ is the union of two linear star-configurations in $\mathbb{P}^n$, then $(I_{\mathbb{X}^{(s,s)}})_s=\{0\}$ for $n{\geq}3$ and $s{\geq}3$. Using this generalization, we also prove that the secant variety $Sec_1(Split_s(\mathbb{P}^n))$ has the expected dimension 2ns + 1 for $n{\geq}3$ and $s{\geq}3$.