• 한국전산유체공학회:학술대회논문집
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• 2007.10a
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• pp.243-248
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• 2007

A three-dimensional (3D) unstructured hydrodynamic solver for transient two-phase flows has been developed. A two-fluid three-field model was adopted for the two-phase flows. The three fields represent a continuous liquid, an entrained liquid, and a vapour field. The hydrodynamic solver is for the 3D component of a nuclear system code and the component-scale analysis tools for transient two-phase flows. The finite volume method and unstructured grid are adopted, which are useful for the flows in a complicated geometry. The semi-implicit ICE (Implicit Continuous-fluid Eulerian) numerical scheme has been adapted to the unstructured non-staggered grid. This paper presents the numerical method and the preliminary results of the calculations. The results show that the numerical scheme is robust and predicts the phase change and the flow transitions due to boiling and flashing problems well.

• Korean Management Science Review
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• v.24 no.1
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• pp.91-111
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• 2007

In this paper an effective two-phase approach adopting modified p-median mathematical model is proposed for grouping machines and parts in cellular manufacturing(CM). Unlike the conventional methods allowing machines and parts to be improperly assigned to cells and families, the proposed approach seeks to find the proper block diagonal solution where all the machines and parts are properly assigned to their most associated cells and families in term of the actual machine processing and part moves. Phase 1 uses the modified p-median formulation adopting new inter-machine similarity coefficient based on the non-binary production data-based part-machine incidence matrix(PMIM) that reflects both the operation sequences and production volumes for the parts to find machine cells. Phase 2 apollos iterative reassignment procedure to minimize inter-cell part moves and maximize within-cell machine utilization by reassigning improperly assigned machines and parts to their most associated cells and families. Computational experience with the data sets available on literature shows the proposed approach yields good-quality proper block diagonal solution.

• Current Optics and Photonics
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• v.3 no.4
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• pp.285-291
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• 2019

We have studied the behavior of light in the intermediate regime between a single nanoslit and an infinite nanoslit array. We first calculated the optical characteristics of a small number of nanoslits using finite element numerical analysis. The phase variance of the proposed nanoslit model shows a gradual phase shift between a single nanoslit and ideal nanoslit array, which stabilizes before the total array length becomes ${\sim}0.5{\lambda}$. Next, we designed a transmission-enhanced Fresnel zone plate by applying the phase characteristics from the small-number nanoslit model. The virtual-point-source method suggests that the proposed Fresnel zone plate with phase-invariant nanoslits achieves 2.34x higher transmission efficiency than a conventional Fresnel zone plate. Our report describes the intermediate behaviors of a nanoslit array, which could also benefit subwavelength metallic structure research of metasurfaces.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.30 no.7 s.250
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• pp.757-764
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• 2006

Isothermal cyclic stress-strain deformation and thermomechanical deformation (TMD) of 429EM stainless steel were analyzed using a rheological model employing a bi-linear model. The proposed model was composed of three parameters: elastic modulus, yield stress and tangent modulus. Monotonic stress-strain curves at various temperatures were used to construct the model. The yield stress in the model was nearly same as 0.2% offset yield stress. Hardening relation factor, m, was proposed to relate cyclic hardening to kinematic hardening. Isothermal cyclic stress-strain deformation could be described well by the proposed model. The model was extended to describe TMD. The results revealed that the hi-linear thermomechanical model overestimates the experimental data under both in-phase and out-of-phase conditions in the temperature range of $350-500^{\circ}C$ and it was due to the enhanced dynamic recovery effect.

• Journal of Korea Technical Association of The Pulp and Paper Industry
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• v.30 no.3
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• pp.46-56
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• 1998

The objective of this study was to investigate the relationship between water vapor diffusion properties and the pore structure of paper. Gas-phase molecular diffusivity of water vapor through pores was determined based on the kinetic theory of gas. A mathematical model was derived to characterize the dimensional changes of the pore caused by the fiber-swelling mechanism. A modified-Fickean diffusion model was designed to simulate the water-vapor diffusion phenomena in porous paper web. Structural characterisocs of paper pores including the tortuosity and the shape factor was studied on a theoretical basis of Knudsen flow diffusion. Results are summarized as follows: 1. The theoretical water vapor diffusivity in gas-phase was 0.092$cm^2$ /min, 2. Porosity was inversely proportional to the degree of wet-swelling of paper, 3. Solid-phase water-diffusivity of fiber was 1.2 $ \times 10^{-5}cm^2/min$, 4. Modified diffusion model was fairly consistent to the experimental data (from part I), and 5. The Fickean pore tortuosity, ranging from 1,000 to 2,500, was in inverse proportion to the porosity of paper, and the Knudsen shape factor and length-angle factor for micro-pores in paper were 0.5~3.5 and about 340, respectively.

• Journal of Korean Society for Atmospheric Environment
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• v.26 no.1
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• pp.94-102
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• 2010

Water content of $PM_{2.5}$ (particles in the atmosphere with a diameter of less than or equal to a nominal $2.5{\mu}m$) was estimated by using a gas/aerosol equilibrium model, SCAPE2, for the particles collected at Seoul and Gosan, Korea. From measured and analyzed characteristics of the particles, the largest difference between Seoul and Gosan is the proportions of total ammonia (t-$NH_3$=gas phase $NH_3$+particle phase ${NH_4}^+$), total nitric acid (t-$HNO_3$=gas phase $HNO_3$+particle phase ${NO_3}^-$) and sulfuric acid ($H_2SO_4$). Even though both sites have sufficient t-$NH_3$ to neutralize acidic species such as $H_2SO_4$, t-$HNO_3$, and t-HCl (total chloric acid=gas phase HCl+particle phase $Cl^-$), equivalent fraction of t-$NH_3$ and t-$HNO_3$ are higher at Seoul and $H_2SO_4$ is higher at Gosan. Based on the modeling result, it is identified that the $PM_{2.5}$ at Seoul is more hygroscopic than Gosan if the meteorological conditions are the same. To reduce water content of $PM_{2.5}$, and thus, mass concentration, control measures for ammonia and nitrate reduction are needed for Seoul, and inter-governmental cooperation is required for Gosan.

• Korean Journal of Optics and Photonics
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• v.35 no.4
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• pp.143-149
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• 2024

We analyze the effect of atmospheric fluctuation on laser beam propagation, using a single-phase screen model and a multi-phase screen model. When a laser beam (wavelength 1064 nm, radius 10 mm, collimated by 25.4 mm optics) propagates 3 km, atmospheric fluctuation with structure constant C_n² in the range of 10^-17 to 10^-14 is generated by the single- and multi-phase screen models. The results of short-term and long-term exposures are analyzed in terms of the beam profile, power in the bucket, and beam radius at the receiver plane. The power in the bucket and beam radius increase as the structure constant increases. When the structure constant is less than 2×10^-15, the results of the single- and multi-phase screen models are similar, within a difference of 1.5 %. However, when the structure constant is greater than 2×10^-15, the difference between the two models increases, and the multi-phase screen model is appropriate under this condition.

• Korean Journal of Clinical Pharmacy
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• v.26 no.4
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• pp.312-317
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• 2016

Objective: Midazolam is mainly metabolized by cytochrome P450 (CYP) 3A. Inhibition or induction of CYP3A can affect the pharmacological activity of midazolam. The aims of this study were to develop a population pharmacokinetic (PK) model and evaluate the effect of CYP3A-mediated interactions among ketoconazole, rifampicin, and midazolam. Methods: Three-treatment, three-period, crossover study was conducted in 24 healthy male subjects. Each subject received 1 mg midazolam (control), 1 mg midazolam after pretreatment with 400 mg ketoconazole once daily for 4 days (CYP3A inhibition phase), and 2.5 mg midazolam after pretreatment with 600 mg rifampicin once daily for 10 days (CYP3A induction phase). The population PK analysis was performed using a nonlinear mixed effect model ($NONMEM^{(R)}$ 7.2) based on plasma midazolam concentrations. The PK model was developed, and the first-order conditional estimation with interaction was applied for the model run. A three-compartment model with first-order elimination described the PK. The influence of ketoconazole and rifampicin, CYP3A5 genotype, and demographic characteristics on PK parameters was examined. Goodness-of-fit (GOF) diagnostics and visual predictive checks, as well as bootstrap were used to evaluate the adequacy of the model fit and predictions. Results: Twenty-four subjects contributed to 900 midazolam concentrations. The final parameter estimates (% relative standard error, RSE) were as follows; clearance (CL), 31.8 L/h (6.0%); inter-compartmental clearance (Q) 2, 36.4 L/h (9.7%); Q3, 7.37 L/h (12.0%), volume of distribution (V) 1, 70.7 L (3.6%), V2, 32.9 L (8.8%); and V3, 44.4 L (6.7%). The midazolam CL decreased and increased to 32.5 and 199.9% in the inhibition and induction phases, respectively, compared to that in control phase. Conclusion: A PK model for midazolam co-treatment with ketoconazole and rifampicin was developed using data of healthy volunteers, and the subject's CYP3A status influenced the midazolam PK parameters. Therefore, a population PK model with enzyme-mediated drug interactions may be useful for quantitatively predicting PK alterations.

• Journal of computational fluids engineering
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• v.6 no.4
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• pp.8-14
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• 2001

The phenomena of two-phase suspension flows appear widely in nature and industrial processes. Hence, it is of great importance to understand the mechanism of the gas-solid two-phase flows. In the present study, the numerical simulation has been approached by utilizing the Eulerian-Lagrangian methodology for describing the characteristics of the fluid and particulate phases in a vertical pipe and a 90°square-sectioned bend. The continuous phase(gas phase) is described by the Eulerian formulation and a κ-ε turbulence model is employed to find mean and turbulent properties of the gas phase. The particle properties(velocity and trajectory) are then described by a Lagrangian approach and computed using the mean velocity and turbulent fluctuating velocity of the gas phase. The predictions are compared with measurements by laser-Doppler velocimeter for the validation. As a result, the calculated results show good agreements.

• Journal of the Korean Society of Clothing and Textiles
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• v.18 no.4
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• pp.524-535
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• 1994

The interaction and detergency between oily soil and surfactant solution were studied Samples used were tristearin, tripalmitin and their mixture as a triglyceride, myristic acid as a fatty acid and sodium dodecyl sulfate (SDS) as surfactant. The results were as follows: 1. The mixtures of model oily soils were formed of eutectic point and their melting point were lower than them of individual oily soils. 2. The formation of liquid crystalline (LC) phase was recognized in the triangle phase diagram for SDS~ water~model oily soil system. The areas of LC phase region were in the order of SHS~ water~myristir acid> SDS~ water~mixture of tristearin, tripalmitin and myristic acid (TS/TP/M)>SDS~water~mixture of tristearin and tripalmitin (TS/TP) 3. The LC phase region expanded to wide concentration range of SDS solution and high concentration range of model oily soil with increasing temperature. Particularity, the LC phase region expanded highly at $30~40^{\circ}C$ but when the temperature was elevated above $40^{\circ}C$, expanding tendency decreased. 4. In the system of myristic acid and TS/TP/M contacted with SDS solution, the LC phase was already formed at $28^{\circ}C$ and the region of the LC phase were expanded with increasing temperature. But in the system of TS/TP contacted with SDS solution, the LC phase was not formed in whole experiment temperature. 5. The detergency of myristic acid was very high ann it was recognized that the formation of the LC phase played an important role in the detergency. The detergency of TS/TP was very for low, but when TS/TF was mixed with myristic acid, the detergency of TS/TP increased. It is supposed that the LC phase was formed butween SDS solution and myristic acid promoted to penetration of SDS solution into the inner parts of TS/TP.