• Proceedings of the Korean Society of Fisheries Technology Conference
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• 1998.06a
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• pp.359.2-360
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• 1998

• Korean Journal of Pharmacognosy
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• v.30 no.4
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• pp.368-376
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• 1999

Twenty-four Oriental herbal medicines including Platycodi Radix and Scutellariae Radix, etc., which have been used for the cure of hyperlipidemia, coronary heart, disease were evaluated for the 3-hydroxy-3-methylglutaryl coenzyme A(HMG-CoA) reductase inhibition and antioxidant effect on a free radical, 1,1-diphenyl-2-picrylhydrazyl(DPPH) in vitro, and antihyperlipidemic effect on hyperlipidemic rats induced by Triton WR-1339 in vivo. 80% MeOH extract of eight herbs including Scutellariae Radix, Coptidis Rhizoma, Paeoniae Radix Rubra, Moutan Cortex Radicis, Angelicae Gigantis Radix, Bambusae Caulis in Taeniam, Cinnamomi Ramulus and Crataegi Fructus inhibited the HMG-CoA reductase activities and exhibited a radical-trapping action on a stable free radical, DPPH. On Triton WR-1339-induced hyperlipidemic rats, four herbs including Scutellariae Radix, Angelicae Gigantis Radix, Bambusae Caulis in Taeniam and Cinnamomi Ramulus showed respectively the significant suppression of serum total cholesterol, triglyceride, phospholipid and LDL-cholesterol levels and serum transaminase(ALT and AST) activities. From these results, it is suggested that each 80% MeOH extract of Scutellariae Radix, Angelicae Gigantis Radix, Bambusae Caulis in Taeniam and Cinnamomi Ramulus have effective antihyperlipidemic action against hyperlipidemia.

• The Journal of Korean Medicine
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• v.18 no.2
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• pp.245-266
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• 1997

In order to study the effects of Guibitanggamibang on blood pressure and hyperlipidemia, experimental study were performed on hypertension in normal and SHR rats, and on hyperlipidemia induced by Triton WR-1339 in normal rats. Also the level of total cholesterol, triglyceride, LDL-cholesterol, HDL-cholesterol, phospholipid and transaminase(GOT, GPT) were measured. The results are summarized as follows: 1. After Guibitanggamibang was given to normal rats, the results showed that inhibitory effects on blood pressure and heart beat were not statistically significant. 2. After Guibitanggamibang was given to SHR rats, the results showed that inhibitory effects on blood pressure were statistically significant. 3. In the model of hyperlipidemia induced by 2% cholesterol food, Guibitanggarrubang had significantly-decreasing effects on total cholesterol, triglyceride, HDL-cholesterol, LDL-choleste rol, Transaminase(GOT, GPT) level in serum. 4. In the model of hyperlipidemia induced by Triton WR-1339, Guibitanggamibang had significantly-decreasing effects on total cholesterol, triglyceride, LDL-cholesterol, phospholipid, Transaminase(GOT, GPT) level in serum. 5. In the model of hyperlipidemia induced by Triton WR-1339, Guibitanggamibang had no significant effects on HDL-cholesterol level in serum. These results show that Guibitanggamibang(歸脾湯加味方) has significant inhibitory effects on blood pressure and hyperlipidemia and that it could be clinically applied for hypertension and hyperlipidemia.

• Journal of Society of Preventive Korean Medicine
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• v.8 no.2
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• pp.171-184
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• 2004

In order to study the effects of Gagamyounjo-Tang(加減潤燥湯) on the experimentally hypercoagulable state and hyperlipidemia in rats, we have made the hypercoagulable state in rats by injection of Bothrops jararaca venom (0.1ml/200g : Control group), and have administered solid extract of Gagamyounjo-Tang(加減潤燥湯)(132mg/200g : Sample group). After 1 hour we measured the platelet count, fibrinogen level, APTT, FDP and D-dimer. And we have made the hyperlipidemia in rats by injection of Triton WR-1339 for 3 days(30mg/200g/day : Control group), and have administered solid extract of Gagamyounjo-Tang(加減潤燥湯)(132mg/200g : Sample group), then we measured the total cholesterol, triglyceride, phoshpolipid and HDL-cholesterol levels. The results are summarized as follows : 1. In the hypercoagulable state, Sample group significantly decreased in platelet count compared with Control group(p<0.01), and significantly prolonged in APTT compared with Control group(p<0.05). 2. In the hyperlipidemia, Sample group significantly decreased in the total cholesterol, triglyceride and phoshpolipid compared with Control group(p<0.01), and significantly increased in HDL-cholesterol level compared with Control group(p<0.01). According to the above experimental results, Gagamyounjo-Tang(加減潤燥湯)is assumed to have curative effects against the hypercoagulable state in rats induced by Bothrops jararaca venom and the hyperlipidemia in rats induced by Triton WR-1339. And we can suppose that Gagamyounjo-Tang(加減潤燥湯) has a curative effect against the cerebrovascular accident caused by blood stasis.

• The Journal of the Korea Contents Association
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• v.10 no.12
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• pp.378-386
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• 2010

The concern regarding inability to perform CPR properly was widespread, and few studies, however, have queried bystanders regarding their responses to an actual emergency. This study assessed how often CPR was performed by CPR-trained bystanders and what factors were associated with the performance and nonperformance of CPR by trained bystanders. From a 2,000 sample survey of the National Emergency Medical Center in Korea (2008), it extracted object persons who actually experienced an emergency situation, and examined closely the relationship of CPR education experience and CPR performance in an emergency. 169 completely interviewed, 23(13.6%) had CPR education experience and performed CPR in an actual emergency, 40(23.6%) had CPR education experience but didn't performed, 12 (7.1%) didn't have CPR education experience but performed, and 94(55.6%) neither had CPR education experience nor performed. Specifically, within bystanders who had CPR education experience, those who CPR was performed were different from those who CPR was not on medical emergency-related characteristics such as CPR knowledge(p=0.001), 1339 emergency phone number(p=0.006) and 1339 emergency services(p=0.001). Consequently, to consider social characteristics or an economic condition, various CPR teaching strategies should be prepared to continuously propel.

• The Korean Journal of Emergency Medical Services
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• v.12 no.1
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• pp.69-80
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• 2008

During New year's day and Thanksgiving holiday, the 1339 Information Center in Gwangju and Jeonnam received an emergency medical situation and carried out the analysis as follows ; 1. The reason for the higher phone guidance(72%) of the hospital was based on the simple query for the pain control rather than emergency care. This was explained by the unfamiliar environment of the holiday movers. Pharmaceutical guidance(12.6%) in rural area was also given during the holidays. 2. The disease counselling(2.4%) and emergency treatment instruction(First Aid)(1.6%) decreased because of the small number of request for the diseases. This explained the decrease of the disease counselling. 3. The phone calls increased 8-13 times more than usual. Five-day holidays could have more emergency patients than three-day holidays. During New year's day and Thanksgiving day, the number of received phone calls was 6,444(25.7%) and this accounted for one fourth of the total number in 2007. 4. The number of the patients increased on New year's day and Thanksgiving day because most of the medical institutions and pharmacy were off duty. 5. The patients were centered in Internal medicine and pediatrics. This showed the food-borne diseases and air-borne infection such as common cold. 6. During Thanksgiving day, ophthalmologic patients having viral keratoconjunctivitis(Apollo eye disease) increased 8 folds than in New year's day. It was estimated from the continuous epidemic of Apollo eye disease. 7. There broke out the traffic accidents, food poisoning, infectious diseases, dermatological diseases due to seasonal and environmental changes during the holiday move.

• The Korean Journal of Emergency Medical Services
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• v.12 no.2
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• pp.59-69
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• 2008

Purpose : This study aims to provide basic data to establish an effective emergency medical service system by analyzing health educator' understanding and use of emergency medical service system at schools. Method : 93 questionnaires from 200 elementary, middle and high school nurses in the city D were collected from May 26 to July 7, 2008 and ${\chi}^2$ analysis and frequency analysis were carried out with SPSS win PC 14.0. Results : 1. As for emergency contact points, 3(3.30%) answers 'they do not have any knowledge', 40(43.96%) said 'they have some idea' and 48(52.75%) said 'they do know about it'. Among 24 respondents who have less than five years of working experience, 2(8.33%), 16(66.67%) and 6(25.00%) answered 'have no knowledge', 'a little knowledge' and 'clear knowledge on it' respectively. As for 9 who have 6-10 years of career, 1(12.50%), 4(50.00%) and 3(37.50%) answered 'have no knowledge', 'a little knowledge' and 'clear knowledge on it' respectively. Among 32 respondents who have 11~20 years, there were no respondents with no knowledge on the given question, and 9(29.03%) said they have some understanding and 22(70.97%) answered they have clear understanding on the topic. From this result, it can be said that there is statistically meaningful differences among different working year groups with ${\chi}^2=16.583$ and p= .010. 2. As for 119 emergency contact in the given district, 24(29.63%), 30(37.04%) and 27 (33.33%) answered 'do not know', 'know' and 'know very well' respectively. As for the question to ask whether they know Emergency Medical Information Center 1339, 66(70.97%) answered 'Yes' and 27(29.03%) answered 'No'. When it comes to emergency contact numbers and list of hospitals, 59(63.44%) said 'they have some list', 20(21.51%) answered 'they have well established contact network' and 14(15.05%) said 'they have none'. 3. As for the use of 119 service at the time of emergency at schools, 59(63.44%), said 'Yes' and 12(12.90%) answered 'No'. Among those who said 'yes', 29(31.18%), 24(25.81%) and 5(5.38%) answered they have used the service 1-2, 3-5 and 6-10 times respectively. Conclusion : In order to ensure health educator to effectively deal with emergency situations at schools, there should be special activities to enhance health educator' understanding on 119 and Emergency Medical Information Center 1339 and at the same time, a system should be established to connect schools, 119 in a given district, hospitals and Emergency Medical Information Center 1339.

• Journal of Physiology & Pathology in Korean Medicine
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• v.21 no.6
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• pp.1424-1431
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• 2007

This study was designed to observe the effects of the Phellinus linteus-Barley corn water extract (PLBC) on the improvement of the blood biochemical aspects; serum AST, ALT, LDH, ALP, Phospholipid, Trigryceride, Total Cholesterol, HDL, LDL, of Triton WR-1339(TX)-induced hiperlipidemic rats. Experimental groups were designed to normal control group(Normal), hiperlipidemic control group(Control), hiperlipidemic control group treated with Barley corn water extract(1000mg/1kg ; BC), hiperlipidemic control group treated with Phellinus linteus-Barley corn water extract (500, 1000, 1500mg/1kg; PLBC-1, PLBC-2, and PLBC-3, respectively). Serum AST levels of BC and all PLBC treated groups were significantly decreased (p<0.005) compared to Control group. Serum ALT levels of BC and PLBC-2 groups were decreased (p<0.05), PLBC-1 and PLBC-3 groups were significantly decreased (p<0.005) compared to Control group. Serum LDH levels of BC group was decreased but no significant, PLBC-1 and PLBC-2 groups were decreased (p<0.05), PLBC-3 group was significantly decreased (p<0.025) compared to Control group. Serum ALP levels of BC and PLBC-1 groups were decreased (p<0.05), PLBC-2 group was decreased but no significant, PLBC-3 group was significantly decreased (p<0.005) compared to Control group. Serum Phospholipid levels of BC group was decreased but no significant, PLBC-1 group was decreased (p<0.025), PLBC-2 and PLBC-3 groups were significantly decreased (p<0.005) compared to Control group. Serum Triglyceride levels of BC group was increased but no significant, PLBC-1 group was decreased but no significant, PLBC-2 and PLBC-3 groups were significantly decreased (p<0.005) compared to Control group. Serum Total cholesterol levels of BC group was decreased (p<0.05), PLBC-1, PLBC-2 and PLBC-3 groups were significantly decreased (p<0.005) compared to Control group. Serum HDL levels of BC group was increased (p<0.05), PLBC-1 and PLBC-2 groups were significantly increased (p<0.005), PLBC-3 group was increased (p<0.025) compared to Control group. Serum LDL levels of BC, PLBC-1 and PLBC-2 groups were decreased but no significant, PLBC-3 group was significantly decreased (p<0.005) compared to Control group. These results suggested that Phellinus linteus-Barley corn water extract improve Triton WR-1339(TX)-induced hiperlipidemic symptom in rats.

• Korean Journal of Food Science and Technology
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• v.40 no.6
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• pp.691-695
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• 2008

The objective of this study was to evaluate the effects of glycoprotein isolated from Morus indica L. (MIL) on plasma cholesterol levels and on the activities of hepatic detoxicant enzymes in ICR mice. MIL glycoprotein evidenced good scavenging activities against lipid peroxyl radicals. When the mice were treated with Triton WR-1339, the levels of total cholesterol (TC) and low-density lipoprotein (LDL)-cholesterol in plasma increased significantly by 53.9 and 47.5 mg/dL, respectively, as compared to the controls. However, when pretreated with MIL glycoprotein $(100{\mu}g/mL)$, ICR mice showed marked reductions to 55.4 and 47.0 mg/dL, as compared to Triton WR-1339 treatment alone. Interestingly, high density lipoprotein cholesterol levels were unchanged. These results indicate that the MIL glycoprotein is capable of scavenging lipidperoxyl radicals, lowering plasma lipid levels, and increasing the activities of detoxicant enzymes in the mouse liver.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2013.05a
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• pp.1339-1340
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• 2013