• Bulletin of the Korean Chemical Society
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• v.31 no.11
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• pp.3348-3352
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• 2010

Novel 4'-ethyl-5'-norcarbocyclic adenosine phosphonic acid analogues were synthesized from propionaldehyde 5 through a de novo acyclic synthetic route using reiterative Grignard additions and ring-closing metathesis (RCM) as key reactions. The synthesized nucleoside phosphonic acids analogues 17, 18, 19, and 21 were subjected to antiviral screening against human immunodeficiency virus.

• Biomedical Science Letters
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• v.20 no.1
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• pp.43-47
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• 2014

To understand the effect of prenatal stress on sex-specific changes in embryonic and placental growth, a synthetic glucocorticoid (dexamethasone) was administered intraperitoneally at a dosage of 1 mg/kg body weight (BW) (Dex1) or 10 mg/kg BW (Dex10) to pregnant ICR mice at the gestational days 7.5, 8.5 and 9.5 post coitum (p.c.). Embryos and placentas were then harvested at days 11.5 and 18.5 p.c., and their body weight and size were measured following the determination of sex through PCR using Sry specific primers in tail tissues. As a result, female embryos presented reduced fetal body weight and size in Dex1- and Dex10-treated groups than those of control group at the embryonic day 11.5 p.c. Interestingly, the growth seems to be recovered at day 18.5 as there was no difference in growth between control and dexamethasone treated groups. In the case of males, Dex1 induced a decrease in fetal weight in day 11.5 and this pattern was maintained until day 18.5, whereas their growth was not affected by Dex10 treatment. Placental growth showed similar patterns to fetal growth in both sexes but the extent of reduction was not statistically significant in most cases. Placental weights in Dex1- and Dex10-treated group were decreased significantly in male only. The results imply that the effect of prenatal stress is largely sex dependent due to different strategies for growth and survival in a stressful environment.

• Journal of KIBIM
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• v.5 no.3
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• pp.11-18
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• 2015

Integrated Project Delivery (IPD) is a new trend in the building industry and a key feature of IPD is the use of BIM to support project collaboration. Therefore, engineers should learn the use of BIM and IPD in the construction industry. In this study, the authors draw necessary components for developing an IPD course curriculum through analyzing a project case and current courses provided by universities in Korea. The authors make several suggestions for effective IPD education in universities.

• Bulletin of the Korean Chemical Society
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• v.31 no.9
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• pp.2514-2518
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• 2010

A very simple synthetic route of a novel SATE prodrug type of 6'-fluoro-6'-methyl-5'-noradeonosine carbocyclic nucleoside phosphonic acid is described. The key fluorinated alcohol intermediate 7 was prepared from the epoxide intermediate 6a via selective ring-opening of epoxide. Coupling of 7 with $N^6$-bis-Boc-adenine under a Mitsunobu reaction followed by phosphonation and deprotection afforded the carbocyclic phosphonic acid. The chemical stability of the bis(SATE) derivative 13 was measured at neutral (pH 7.2) and slightly acidic (Milli-Q water, pH 5.5) pH. The antiviral activity test of the SATE prodrug 13 and its parent nucleoside phosphonic acid 11 were evaluated against HIV-1.

• Journal of Navigation and Port Research
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• v.44 no.5
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• pp.430-437
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• 2020

This paper analyzes the profitability of the Private Finance Initiative(PFI) ports and proposes the application plans of the R-project(Rehabilitate project) for old ports to attract and activate private investment in the port industry. The R-project of old ports can reduce the government's financial budget and provide improved facilities for users more quickly than the public sector comparator. Before suggesting the R-project for old ports, the profitability of the currently operating 11 companies of the PFI ports are analyzed using the four ratios of profitability, and the results show that all the companies indicate low profitability, except for the top three companies. To apply the R-project, the three types of R-project ports are categorized as maintaining the function of the port, changing the function of the port, and mixing the function of the port. Additionally, three obstacles and improvement measures are suggested; attracting private business, legal issues, and administrative procedures. This study is conducive to the policy making for the port renewal and the activating PFI for the port industry.

• International conference on construction engineering and project management
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• 2009.05a
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• pp.1615-1617
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• 2009

The water resources project of 320 Ha second stage reclamation, in which including an University City, out of 800 Ha Ndata Farm, Malawa, had been under studied in this research. The challenge of C value of runoff coefficient was obtained as 0.8, by introducing the attenuation factors method, proposed by second author, an IDF dimensionless method customary used in Taiwan, proposed by the third author, is translated further to solve the project design rainfall; Rational Method, thus, obtains 11.5 CMS as the 5 year recurrence storage. The final job, completed by the third author's on-site performance, includs field alignments and discussions with the trustee, Malawa President H. E. Dr. Bingu Wa Mutharika, when a special concern of anti-theft. In order to provide sufficient supply up to an amount of 44,000 M3 during April to November, the sketch package includes 6 measurements: one water barrage, one sluice gate, one intake, one sediment reservoir, one water reservoir, and 3199 Km long gravity-driving hydraulic pipe.

• International Journal of High-Rise Buildings
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• v.11 no.3
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• pp.181-187
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• 2022

POSCO E&C has completed Parc.1 project successfully. The construction period was 42months, and 1.5 million workers were participated till completion. To meet schedule management and quality control, POSCO E&C has adopted a lot of technologies such as GPS measurement, 3D scanning, vibration control, stack effect control, column shortening control, etc

• Biomedical Science Letters
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• v.11 no.3
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• pp.311-318
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• 2005

Grp78, discovered as one of the putative target genes of Hoxc8, is a highly conserved stress protein and functions as a molecular chaperone in the endoplasmic reticulum (ER). In order to see the stage-specific expression pattern of Grp78 during development, mouse embryos from day 7.5 to 17.5 p.c. were isolated, and RT-PCR as well as in situ hybridization was performed. When RT-PCR was performed using Grp78 specific primers, periodic expression pattern was detected. And also a region-specific expression pattern was detected with a strong expression in the trunk part of day 11.5 p.c. embryo, like that of Hoxc8. When in situ hybridization was performed, Grp78 was revealed to be expressed in the endoderm, somite, neuroepithelium cells of neural tube in early embryos. In the case of late embryos, Grp78 expression was detected in the liver, segmental bronchus within cranial lobe of lung, ossification center within the cartilage primordium of rib and vertebra, submandibular gland, as well as metanephros. These expression patterns are very much similar to those of Hoxc8. Since Hoxc8 has been reported to regulate apoptosis during organogenesis, it might be possible that the apoptotic function could have been conveyed through the expression of Grp78, implying that the Grp78 is one of the Hoxc8 downstream target genes.

• Journal of Korean Society of Forest Science
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• v.96 no.3
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• pp.348-356
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• 2007

The purpose of this study is to give the results of economic feasibility of industrial forest plantations, and also A/R CDM project in Indonesia to investors. In order to analyze economic feasibility of the industrial forest plantation and A/R CDM project, this study comparatively analyzes the feasibility based on three following scenarios: industrial plantation type; A/R CDM type; combination type of industrial plantation and A/R CDM project. In the aspect of IRR, the combination type has 11 % while the industrial plantation type has 8%. If the price of timber increases USD $5/m^3$ (from the standard price: USD $30/m^3$ to USD $35/m^3$), IRR of the industrial plantation type will increase from 8% to 14%. This result shows us that the IRR of the industrial plantation type is very sensitive to the price of timber. There is no economic feasibility of A/R CDM project if the price of lCER is under USD 5. In addition, IRR of the A/R CDM project type is the same to IRR of industrial plantation type (8%) when the price of lCER is USD 10. Finally, the total investment expenditure on 12,000ha of the combination type is approximately 13 billion won while the industrial plantation type is 13.6 billion won. It takes 11 year to reach the turning point in terms of profitability of the combination type while the industrial plantation takes 13 year. Thus, the economic feasibility of the combination type is higher than the other types(industrial plantation type and A/R CDM project type).

• Land and Housing Review
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• v.11 no.3
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• pp.11-19
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• 2020

This study aims to examine the relationship between the improvement of the income distribution index from the late 1980s to the 1990s and large-scale housing supply projects such as the 2 million housing construction project. Looking at Korea's economic development in terms of income growth and distribution, GDP has continuously increased since the establishment of the government, especially in the late 1980s. The Gini Index, a representative income inequality index, rapidly deteriorated in the early 1970s, and gradually improved from the late 1980s. The 2 million housing construction project, announced in 1988, supplied a third of the existing nationwide housing stock of 6.5 million units in three years. The project cost was 65 trillion won, equivalent to 50% of Korea's GDP at the time. This study questioned whether the ratio of the number of employed workers in the construction industry was a variable directly affecting the Gini Index. To verify this, the causal relationship between the proportion of employed workers in the construction and manufacturing industries and the Gini Index from 1979 to 2008 was statistically analyzed. For this, the ARIMA model was established for each variable, and the correlation of their residuals was verified. The 2 million housing construction project had the effect of improving income inequality in terms of rising wages for production workers and creating jobs for the low-educated and low-income class. During the project period, the number of middle-income earners increased sharply, and the income gap between the high-income and low-income earners greatly decreased. The expansion of the construction volume can be used as a powerful and direct policy tool for improving income distribution. However, the effect may be limited. When the proportion of workers exceeds the threshold, the effect is weakened.