• 대한화학회지
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• 제40권7호
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• pp.526-530
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• 1996

3-Imino-1, 2, 5-thiadiazolidine 1, 1-dioxide와alkylamine 의 반응에 의하여 3-(N-alkylamino)-4, 5-dihydro-1, 2, 5-thiadiazole 1, 1-dioxide를 제조하였다. 이 헤테로고리 화합물의 주요 분광학적 성질과 X-선 결정학외절에 의한 분자구조를밝혔다. 3-(N-benzylamino)-4, 5-dihydro-4-(4'-methoxyphenyl)-1, 2, 5-thiadiazole 1, 1-dioxide의 단결정은 단사정계, 공간군은 $P2_1a$, $a=22.512(3)(1)\AA$, $b=9.831(2)\AA$, $c=7.194(4)\AA$, $\beta=96.65(2)$, 그리고 Z=4이다.

• 대한약학회:학술대회논문집
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• 대한약학회 2000년도 NEW STRATEGY FOR DRUG DEVELOPMENT IN POST-GENOMIC ERA(대한약학회)
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• pp.212.1-212.1
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• 2000

• 대한화학회지
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• 제48권4호
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• pp.385-393
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• 2004

Benzofuroxan과 ethyl acetoacetate를 반응시켜 2-ethoxycarbonyl-3-methylquinoxaline 1,4-dioxide (8)를 합성하고, 이것을 hydrazine hydrate 또는 selenium dioxide와 반응시켜 2-hydrazinocarbonyl-3-methylquinoxaline 1,4-dioxide (9) 또는 2-ethoxycarbonyl-3-formylquinoxaline 1,4-dioxide (10)를 합성하였다. 화합물 9를 alkanoyl chloride류, benzoyl chloride류, heteroacyl chloride류 및 benzenesulfonyl chloride류와 반응시켜 3-methyl-2-(substituted hydrazinocarbonyl)quinoxaline 1,4-dioxide류 (11-14)를 합성하였다. 화합물 9를 sodium nitrite와 반응시켜 2-azidocarbonyl- 3-methylquinoxaline 1,4-dioxide (15)를 합성한 다음, 이것을 디옥산/알코올류 용매하에서 환류시켜 Curtius 자리옮김반응에 의한 N-(3-methyl-1,4-dioxoquinoxalin-2-yl)-alkyl carbamate류 (16)를 합성하였다. 그리고 화합물 15를 치환 아닐린류와 반응시켜 2-(3-substituted phenylureido)-3-methylquinoxaline 1,4-dioxide류 (17)를 합성하였다. 한편 화합물 10을 benzoic hydrazide 또는 치환 아닐린류와 반응시켜 quinoxaline 1,4-dioxide류 (18, 19)를 각각 합성하였다. 그리고 합성한 화합물들에 대한 제초력과 살균력도 조사하였다.

• Bulletin of the Korean Chemical Society
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• 제13권5호
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• pp.462-463
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• 1992

• 대한화학회지
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• 제39권10호
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• pp.834-836
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• 1995

• Biomolecules & Therapeutics
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• 제4권4호
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• pp.408-410
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• 1996

3, 4-Dihydro-3-oxo-2H-1, 2, 4-benzothiadiazine-1, 1-dioxides were synthesized as conformationally rigid analogues of sulfonylurea hypoglycemic agents. All the compounds prepared showed hyperglycemic activity. The hyperglycemic activity was enhanced for the diabetic rats in which the blood glucose level was increased by 30-70%.

• 약학회지
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• 제44권6호
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• pp.494-498
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• 2000

Noble 7,7'-substituted (or unsubstituted) 4-oxo-1,1',2,2'-dibenzothiazine-3,3'-dicarboxylic acid methyl ester 1,1,1',1'-tetraoxide 3,4'-yl ethers 2a-h were synthesized through the dehydration of 7-substituted (or unsubstituted) 4-hydroxy-1,2-benzothiazine-3-carboxylic acid methyl ester 1,1-dioxides 1a-h using silver(I) oxide for the development of new nonsteroidal antiinflammatory drugs (NSAIDs). Optimal reaction was proceeded through stirring of distilled acetone using 100 mol% of silver(I) oxide at room temperature for 24-68 hrs.

• Journal of Pharmaceutical Investigation
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• 제17권2호
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• pp.61-65
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• 1987

4-Pivaloyloxy, 4-benzenesulfonyloxy and 4-p-toluenesulfonyloxy compounds of piroxicam (2a, 2b and 2c) and isoxicam(4a, 4b and 4c) were synthesized in fairly good yield. Antiinflammatory and ulcerogenic effects of the 6 compounds were determined. Antiinflammatory effect of 2a was comparable to that of piroxicam and ulcerogenic effect of 2a was less than that of piroxicam.

• 대한화학회지
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• 제31권5호
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• pp.464-470
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• 1987

파라위치에 메톡시, 메틸, 아세틸 및 니트로기를 가진 아닐린유도체를 출발물질로 하여 6-substituted benzofuroxan 유도체를 합성하고, 이들과 4-아미노페놀을 반응시켜 7-Substituted 2-aminophenazine-5,10-dioxides류를 합성하였다. 그리고 benzofuroxan과 4-아미노페놀을 반응시켜 2-Aminophenazine-5,10-dioxide도 합성하였다. 이들 phenazine 유도체의 항균성을 희석법에 의하여 최소 발육저지 농도로서 조사하였는데, 전자를 주는 치환기를 가진 phenazine dioxide 유도체들이 전자를 당기는 치환기를 가진 phenazine dioxide유도체들 보다 항균성이 더 강하였다. 이 사실로부터 phenazine dioxide 유도체에서 치환기의 전자효과와 항균성사이에는 직접적인 연관성이 있다는 것을 알았다.

• 약학회지
• /
• 제31권1호
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• pp.40-41
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• 1987

4-Hydroxy-2H-1, 2-benzothiazine-3-carboxylic acid 1a was reacted with 2 equivalents of dicyclohexylcarbodiimide (DCC) to give 2-cyclohexyl-3-cyclohexylimino-4,5-dihydro-1H-imidazo [1,5-b][1,2] benzothiazine-10, 10a-dyhydro-1,10-dione 5,5-dioxide 2a and dicyclohexylurea (DCU). On the other hand 2-substituted-4-hydroxy-2H-1, 2-benzothiazine-3-carboxylic acid 1,1-dioxide 1b or c was reacted with DCC to give 2-cyclohexylimino-3-cyclohexyl-5-alkyl-4-oxo-2,5H-1,3-oxazino [5,6-c]-1,2-benzothiazine 6,6-dioxide 2b or c and DCU.