Journal of Pharmaceutical Investigation
- Volume 17 Issue 2
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- Pages.61-65
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- 1987
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
Synthesis and Antiinflammatory Activity of 4-Substituted-1,2-benzothiazine-3-carboxamide-1,1-dioxides
4-치환-1,2-Benzothiazine-3-carboxamide-1,1-dioxide의 합성 및 항염작용
- Suh, Jung-Jin (Yuhan Research Center) ;
- Hong, You-Hwa (Yuhan Research Center) ;
- Kim, Byung-Chae (Yuhan Research Center)
- Published : 1987.06.20
Abstract
4-Pivaloyloxy, 4-benzenesulfonyloxy and 4-p-toluenesulfonyloxy compounds of piroxicam (2a, 2b and 2c) and isoxicam(4a, 4b and 4c) were synthesized in fairly good yield. Antiinflammatory and ulcerogenic effects of the 6 compounds were determined. Antiinflammatory effect of 2a was comparable to that of piroxicam and ulcerogenic effect of 2a was less than that of piroxicam.
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