• Journal of the Korea Society of Computer and Information
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• v.23 no.7
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• pp.81-90
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• 2018

In this paper, reducing lense Vignetting effect and adaptive learning rate method are proposed to complement Scribner's neural network for nuc algorithm which is the effective algorithm in statistic SBNUC algorithm. Proposed reducing vignetting effect method is updated weight and bias each differently using different cost function. Proposed adaptive learning rate for updating weight and bias is using sobel edge detection method, which has good result for boundary condition of image. The ordinary statistic SBNUC algorithm has problem to compensate lense vignetting effect, because statistic algorithm is updated weight and bias by using gradient descent method, so it should not be effective for global weight problem same like, lense vignetting effect. We employ the proposed methods to Scribner's neural network method(NNM) and Torres's reducing ghosting correction for neural network nuc algorithm(improved NNM), and apply it to real-infrared detector image stream. The result of proposed algorithm shows that it has 10dB higher PSNR and 1.5 times faster convergence speed then the improved NNM Algorithm.

• Genomics & Informatics
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• v.21 no.4
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• pp.45.1-45.11
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• 2023

Nonalcoholic fatty liver disease (NAFLD) is a common type of chronic liver disease, with severity levels ranging from nonalcoholic fatty liver to nonalcoholic steatohepatitis (NASH). The extent of liver fibrosis indicates the severity of NASH and the risk of liver cancer. However, the mechanism underlying NASH development, which is important for early screening and intervention, remains unclear. Weighted gene co-expression network analysis (WGCNA) is a useful method for identifying hub genes and screening specific targets for diseases. In this study, we utilized an mRNA dataset of the liver tissues of patients with NASH and conducted WGCNA for various stages of liver fibrosis. Subsequently, we employed two additional mRNA datasets for validation purposes. Gene set enrichment analysis (GSEA) was conducted to analyze gene function enrichment. Through WGCNA and subsequent analyses, complemented by validation using two additional datasets, we identified five genes (BICC1, C7, EFEMP1, LUM, and STMN2) as hub genes. GSEA analysis indicated that gene sets associated with liver metabolism and cholesterol homeostasis were uniformly downregulated. BICC1, C7, EFEMP1, LUM, and STMN2 were identified as hub genes of NASH, and were all related to liver metabolism, NAFLD, NASH, and related diseases. These hub genes might serve as potential targets for the early screening and treatment of NASH.

• The Bulletin of The Korean Astronomical Society
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• v.40 no.1
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• pp.44.1-44.1
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• 2015

We present joint constraints on the number of effective neutrino species $N_{eff}$ and the sum of neutrino masses ${\Sigma}m_{\nu}$, based on a technique which exploits the full information contained in the one-dimensional Lyman-${\alpha}$ forest flux power spectrum, complemented by additional cosmological probes. In particular, we obtain $N_{eff}=2.91{\pm}0.22$ (95% CL) and ${\Sigma}m_{\nu}$ < 0.15 eV (95% CL) when we combine BOSS Lyman-${\alpha}$ forest data with CMB (Planck+ACT+SPT+WMAP polarization) measurements, and $N_{eff}=2.88{\pm}0.20$ (95% CL) and ${Sigma}m_{\nu}$ < 0.14 eV (95% CL) when we further add baryon acoustic oscillations. Our results tend to favor the normal hierarchy scenario for the masses of the active neutrino species, provide strong evidence for the Cosmic Neutrino Background from $N_{eff}{\approx}3$($N_{eff}=0$ is rejected at more than $14{\sigma}$), and rule out the possibility of a sterile neutrino thermalized with active neutrinos (i.e., $N_{eff}=4$) - or more generally any decoupled relativistic relic with $${\Delta}N_{eff}{\sim_=}1$$ - at a significance of over $5{\sigma}$, the strongest bound to date, implying that there is no need for exotic neutrino physics in the concordance ${\Lambda}CDM$ model.

• Journal of the Korean Society of School Health
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• v.6 no.2
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• pp.69-75
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• 1993

The questionaire survey in this study was obtained from 1256 upper elementary children in a certain elementary school in In-Cheon city from May 1 to May 31 1993. The purpose of this study was to promote an understanding on the Actual condition of oral health management and to plan a desirable solution for oral health program by surveying the current status of oarl health management. The survey was carried out by using the questionaire after being modified and complemented which was used for the survey of the study on the actual condition of oral health management by Sin Seon Hang (1989). The major results are summarized as follows: 1. General tooth brushing of respondents. 1) As for frequency, 2 times it day is highest. 2) After breakfast meal and below 3 minutes is high. 3) Respondents brushed only teeth with the direction of up and down, left and right side. 4) The period of using for one tooth brush is from 4 months to 6 months. 2. The degree of recognition on oral health knowledge is low. 3. 1) The degree of dental examine's experience with scaling experience are 26.83%. 2) Respondents who experience dental treatment are 57.88%. 3) In oral disease, dental caries is highest. 4) Great difficulty of going to the dentists' is psychological thread and next is lack of time.

• Asia Pacific Journal of Corpus Research
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• v.1 no.1
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• pp.31-60
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• 2020

This paper investigates changes in relativization in Singapore English broadsheet newspapers from 1993 to 2016. One of the first diachronic studies in Singapore English (SgE), it also explores corresponding data from the diachronic Siena-Bologna (SiBol) news corpus. As SgE is in the endonormative stabilization phase in Schneider's (2007) Dynamic Model of postcolonial Englishes, divergence from British English (BrE) is to be expected. In this study, the dataset is a new Singapore English Newspaper (SEN) corpus compiled from local news articles in 1993, 2005 and 2016, and the corpus tool employed is Sketch Engine. The results reveal changes in relativization practices in SEN over the given period, many of which occur in a similar pattern as those identified in SiBol, albeit at varying rates of change. Most significant of these include a sharp decline in the which relativizer in restrictive relative clauses with non-animate antecedents, complemented by a rise in that. The change has been so rapid that although which relative clauses were more common than that clauses in 1993, that has subsequently overtaken which for both the corpora. One shift in SEN that is different from SiBol is the increase in frequency of non-restrictive relative clauses in SgE. The likely motivators for the changes in the two varieties are identified as colloquialization, densification and prescriptivism. The effect each of these factors could have had on the varieties are discussed, as well as the implications that the findings have on our understanding of the evolutionary status of SgE as a postcolonial variety.

• The Korean Journal of Emergency Medical Services
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• v.5 no.1
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• pp.23-35
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• 2001

This study was done to examine the relationship between stress and coping methods of 86 emergency medical technicians with the 1st or 2nd grade qualifications who serve at 36 fire stations in Gwangju and Jeonnam region from Aug. 1 to Aug. 31, 2001. Data collection was done by questionnaire. The research instruments used the stress measure tool developed by Cho Hee et al.(1999) and revised and complemented by the researcher to measure firemen's stress, and health instrument revised by Suh Mi Hye et al(1993). Data were analyzed by t-test, ANOVA, and Pearson's correlation using SPSS. The results of this study were as follows : 1. The mean score of perceived stress was 3.4. The mean score of coping methods was 2.11. 2. The levels of stress according to the general characteristics of subjects were significantly different at marital status(t=7.054, p=.009) and in relation with organization(t=3.989, p=.049). 3. The relationship between levels of stress and health status was significantly correlated(r=.325, p=.000), and so the hypothesis of this research, "the less levels of stress, the better health status is." was supported. 4. The relationship between stress and health status was significantly different at crisis status(r=.393, p=.000), relation with organization(r=.348, p=.001), the characteristics of subjects(r=.387, p=.000), special knowledge and technology(r=.337, p=.001), and the roll complication as a professional(r=.343, p=.001).

• Molecules and Cells
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• v.26 no.3
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• pp.291-298
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• 2008

Human karyopherin ${\beta}3$, highly homologous to a yeast protein secretion enhancer (PSE1), has often been reported to be associated with a mediator of a nucleocytoplasmic transport pathway. Previously, we showed that karyopherin ${\beta}3$ complemented the PSE1 and KAP123 double mutant. Our research suggested that karyopherin beta has an evolutionary function similar to that of yeast PSE1 and/or KAP 123. In this study, we performed yeast two-hybrid screening to find a protein which would interact with karyopherin ${\beta}3$ and identified apolipoprotein A-I (apo A-I), a secretion protein with a primary function in cholesterol transport. By using in vitro binding assay, co-immunoprecipitation, and colocalization studies, we defined an interaction between karyopherin ${\beta}3$ and apo A-I. In addition, overexpression of karyopherin ${\beta}3$ significantly increased apo A-I secretion. These results suggest that karyopherin ${\beta}3$ plays a crucial role in apo A-I secretion. These findings may be relevant to the study of a novel function of karyopherin ${\beta}3$ and coronary artery diseases associated with apo A-I.

• The Journal of Korean Medical History
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• v.32 no.1
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• pp.1-10
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• 2019

The Taesangugeupbang (Emergency Prescriptions for Childbirth) is a medical text written by Li-Chengong of China in the early 14th century. It incorporates forms of obstetrics and gynecology in use in the Chosun Dynasty and is quoted in the Hyangyakjibsungbang (Compendium of Prescription from the Countryside), the Euibangyoochui (Classified Collection of Medical Prescriptions), and the Taesanjibyo (Collection of Essentials for Childbirth). The recent rediscovery of Taesangugeupbang manuscripts in Japan has enabled full-scale research of this text. This article is based on a study of these manuscripts and attempts to synthesize the text through the various documents. The article suggests that: (1) critical texts for understanding the Taesangugeupbang include the Uijeoggo (A Review of Medical Books), the Euibangyoochui, and the Taesanjibyo; (2) there is a possibility that the Taesangugeupbang had disappeared from use in Joseon by the late 15th century; (3) the Taesangugeupbang complemented the treatment regimen of other texts and influenced the development of early Chosun ophthalmology; (4) The Taesangugeupbang is quoted in many Joseon's medical texts and is related to the author's mentor.

• Journal of Life Science
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• v.27 no.1
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• pp.72-77
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• 2017

Inorganic iron is essential for various metabolic processes, including RNA synthesis, electron transport, and oxygen detoxification in microorganisms. Many bacterial pathogens compete for iron acquisition in diverse environmental condition such as host. Salmonella Typhimurium SL1344 also requires inorganic iron as a cofactor for growth. When a M9 minimal liquid medium was supplemented with ethylenediamine di-o-hydroxyphenylactic acid (EDDA) which acts as an iron-chelating agent, growth of Salmonella Typhimurium SL1344 in the supplemented medium was completely arrested by deficient of useful iron under iron-depleted condition. However, a number of siderophores, which are small, high-affinity iron chelating compounds secreted by microorganisms such as bacteria and fungi, were produced for utilization of restricted iron under iron-depleted condition. A M9 minimal liquid medium complemented with human transferrin (hTf)-iron complex turned completely off production of siderophores, but growth of Salmonella Typhimurium SL1344 maintained level similar to compare one complemented with iron (III) chloride (FeCl3). This means that human transferrin (hTf)-bound iron can utilize via directly interaction with Salmonella Typhimurium SL1344 without productions of siderophores. Through construction and analysis of negative mutant for utilization of human transferrin (hTf)-bound iron, we confirm that the bacterium can directly use human transferrin (hTf)-bound iron without extracellularly intermediated carriers such as siderophores.

• Journal of environmental and Sanitary engineering
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• v.5 no.1
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• pp.83-92
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• 1990

Adapting two step aeration system to a waste water treatment of W-paper manufactory as Full-Scale Plants, we drew a following conclusion from its practical working. 1. Because BOD removal efficiency was 20% in A-Stage, 90% in B-Stage and total removal efficiency was 97%. It worked treatment plant well and was suitable for effluent water standard as well. Because COD removal efficiency was 42% in A-stage, 71% in B-stage and the total removal efficiency was 94% COD control was possible in effluent water quality. 2. Treatment efficiency according to a load capacity was average 20% in 1.401 BOD kg/m3/d load of A-Stage and average 90% in 0.273 BOD kg/$\textrm {m}^3$ / d load of B-Stage. 3. Treatment efficiency according to a ratio of F/M was 2.657--5.024 kg BOD/kg MLSS/d in A-Stage and BOD removal efficiency was 16-261 in the same stage. The ratio of F/M was 0.068-0.094 kg BOD /kg MLSS/d and BOD removal efficiency ratio was 85-94%. Therefore treatment efficiency could be kept stably and volume of aeration tank could be reduced wholly. 4. Treatment efficiency according to MLSS appeared BOD 20%. COD 42%, in A-Stage and removal efficiency appeared BOD 90%, COD 71% in B-Stage. They were suitable for plan condition. 5. Because of working of complemented treatment plant by AB-Process. 20,000,000 Won a month was saved than the ordinary working cost. Therefore, it was assumed that invested cost could be recollected in 19 months or so consequently.