• Proceedings of the Korean Society of Applied Pharmacology
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• 1993.04a
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• pp.56-56
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• 1993

새로운 cell cycle 특이적 억제제의 스크리닝 방법의 확립과 이를 이용하여 cell cycle 억제제의 검색 및 세포분열 및 성장을 억제하는 작용의 분석과 이들의 항암작용 및 세포성장 및 분열 억제 작용의 signal transduction mechanism을 규명한다. 이상의 연구를 수행하기 위해 흰쥐 재생간 조직 및 흰쥐 일차 배양 간세포를 연구 모델로 하여 스크리닝 방법을 확립하고, 세포 분열 및 성장 억제제의 연구 대상 약물로는 기존의 천연물 및 미생물의 2차 대사 산물을 분리 정제한 물질등을 사용하여 그 작용 효능을 연구한다. 1) 흰쥐 부분 간 절제 수술 26시간 후 핵 단백질을 분리 2) MPF activity 측정 3) MPF 활성 저해제 생산 균주의 1차 탐색

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2009.05a
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• pp.99-102
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• 2009

LES(Large eddy simulation) of breakup and atomization of a liquid jet into cross turbulent flow was performed. Two phase flow between a gas phase and a liquid phase was modeled by a mixed numerical scheme of both Eulerian and Lagrangian methods for gas and liquid phases respectively. The first and second breakup of liquid column was observed. The penetration depth in cross flow was comparable with experimental data for several variant of a liquid-gas momentum flux ratio by varying liquid injection velocities. SMD(Sauter Mean Diameter) distribution downstream of jet was analyzed.

• Korean Journal of Biological Psychiatry
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• v.7 no.2
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• pp.152-158
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• 2000

Background : No association between schizophrenia and dopamine D4 receptor polymorphisms have been reported. Despite these results, it is premature to exclude the association. It has been suggested that the susceptibility to develop schizophrenia could result from variation at a number loci which may interact or coact with each other. Therefore, we investigated a possible association of combinations of exon III 48bp polymorphism[D4E3] and exon I 12bp polymorphism of the DRD4 gene [D4E1] with schizophrenia. Methods : 207 unrelated Korean schizophrenic patients and 191 healthy controls were recruited. DRD4 genotype was established using the polymerase chain reaction. Statistical analysis consisted of ${\chi}^2$ tests for Hardy-Weinberg proportions and genotypic and allelic frequencies in the patients and control groups. Results : There were no statistically significant differences in the each polymorphisms between schizophrenics and controls. And all genotype frequencies were within Hardy-Weinberg expectations. When the combinations of the polymorphism in schizophrenia and controls were compared, however, there were significant differences at $A1A2^*2/4$ in the distributions of the combinations of D4E1 and D4E3(p<0.01). Conclusions : These findings suggest that the certain combination of D4E1 and D4E3($A1A2^*2/4$) has the protective role to a susceptibility for schizophrenia.

• Nuclear Engineering and Technology
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• v.2 no.4
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• pp.255-262
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• 1970

More detailed calculations of extension to general anisotropic transport equation with fission are studied. These calculations involve that the operator can be splitted into scattering and fission operators when we prove the completeness of general anisotropy. Applying these operators to the equation makes it easy to extract the slowing-down transient of zero-measure, and completely solves the transport equation. In addition, the number of the eigenvalues of the second anisotropy is classified with Cs unknown, B$_1$and B$_2$known constants.

• Korean Journal of Psychosomatic Medicine
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• v.9 no.1
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• pp.16-27
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• 2001

Objectives : This study was aimed to investigate stress and coping strategy in the families of schizophrenic patient, and changes of knowledge, stress and coping strategy after brief program of family education compared with control group Methods : The education group consisted of twenty four people who were families with schizophrenic patients and attended the brief program of family education. The control group consisted of twenty two people with schizophrenic inpatients. Self-report questionnaires such as Family Coping Questionnaire(FCQ), Patient Rejection Scale(PRS), Worry Questionnaire, Knowledge Questionnaire, Beck Depression Inventory(BDI), and State-Trait Anxiety Inventory(STAI) were administered to the education group and the control group, twice at the pre-test and post-test. Results : 1) In the education group, scores of worry questionnaire, BDI and STAI-S at the post-test were significantly lower than those at the pre-test. Social interests score of FCQ and knowledge questionnaire score at the post-test were significantly higher than those at the pre-test. In FCQ factors, social interests associated with avoidance strategy score at the post-test was significantly higher than that at the pre-test. However, in the control group, there was no significant difference in all questionnaires. 2) In the education group, significant positive correlation existed between calculated differences of worry questionnaire and STAI-S, and between worry questionnaire and STAI-T, whereas significant negative correlation existed between positive communication of FCQ and PRS, and between knowledge questionnaire and STAI-S. In the control group, significant negative correlation existed between information of FCQ and PRS, and between positive communication of FCQ and PRS. 3) In the education group, significant positive correlation existed between calculated differences of worry questionnaire and age of patient, whereas significant negative correlation existed between knowledge questionnaire and duration of illness. However, in the control group, there was no significant correlation. Conclusion : The brief program of family education was effective in increasing knowledge about schizophrenia, decreasing worry and anxiety about the patients in families with schizophrenic patient. In the education group as knowledge about schizophrenia increased, anxiety about schizophrenic patient decreased, but there was no significant correlation in the control group. As relative's rejection feeling about schizophrenic patient decreased, positive communication strategy increased in both groups. However, the control group was more affected by rejection feeling than the education group.

• Journal of the Korean Chemical Society
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• v.17 no.4
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• pp.298-305
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• 1973

Following results were obtained for the mechanical degradation of polystyrene (for polystyrene itself and when blended with rubber) by roll mastication. 1) The rate of mechanical degradation for polystyrene itself can be represented by the second-order rate equation proposed by Goto. $-\frac{dP_t}{dt} = k_s(P_t-P_{\infty})^2$ Where Pt is the degree of polymerization of the degraded polymer at t minutes and $P{\infty}$ is the final degree of polymerization. 2) The mechanical degradation of polystyrene component in the polystyrene-rubber (SBR, BR) blend system occurred similarly as that of polystyrene itself. 3) Under the experimental conditions the mechanical degradation rate of the polystyrene component of the polystyrene-rubber, (SBR, BR) blend system followed approximately the same second-order equation as that for polystyrene itself.

• Korean Journal of Biological Psychiatry
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• v.13 no.4
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• pp.279-288
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• 2006

Objectives : We investigated the association of SNP A and P1763 polymorphisms on dystrobrevin binding protein 1(DTNBP1) gene with smooth pursuit eye movement(SPEM) abnormality in Korean schizophrenic patients. Methods : We measured SPEM function in 217 Korean schizophrenics(male 116, female 101) and divided them into two groups, one is a good SPEM function group and the other is a poor SPEM function group. We then analyzed SNP A polymorphism and P1763 polymorphism on DTNBP1 gene from their DNAs extracted from their blood. We compared the differences of genotype and allele distributions of the two polymorphisms on DTNBP1 gene between the two groups. Results : The Ln S/N ratio(mean${\pm}$SD) of the good SPEM function group was $4.39{\pm}0.33$ and the ratio of poor SPEM function group was $3.17{\pm}0.71$. There were no statistically significant differences of age and male/female ratio between the two groups. There were no significant differences of genotype or allele distributions of the SNP A polymorphism and P1763 polymorphism on DTNBP1 gene between the two schizophrenic groups divided by SPEM function. Conclusion : The results suggest that SNP A polymorphism and P1763 polymorphism on DTNBP1 gene might not be related to SPEM function abnormality in schizophrenia.

• The Korean Journal of Zoology
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• v.35 no.4
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• pp.518-525
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• 1992

본 연구에서는 horizontal clinostat과 원심분리 방법의 이용으로 각각 저중력 상태($\mu$G)와 고중력 상태(3G)를 유도하여, 중력장의 변화가 양서류 수정란의 초기 형태 형성에 미치는 영향을 북방산개구리(Rano dybows비름를 대상으로 조사하였다. 중력장의 변화는 첫번째 수평 분열인 제3분열면의 위치에 영향을 미쳤다. 즉 저중력 상태에서는 분열면이 적도면 근처에서, 또 고중력 상태에서는 분열면이 동물극 근처에서 형성되었다. 이와 같은 변화는 포배기로 이어져 할강의 위치와 동물극 정단 세포층 수에 영향을 미쳤다. 즉 저중력에 노출된 포배는 정상배(1G)에 비해 할강이 중앙에 위치했으며 동물극 정단의 세포층 수가 증가하는 반면 고중력에 노출된 포배는 할강이 보다 동물극 폭에 위치했으며 동물극 정단의 세포층 수도 감소하였다. 그러나 낭배기에 도달하면 동물극 정단 세포층 수의 차이는 정상 상태로 조절되었다. 한편 중력장의 변화는 낭배기에 이르는 발생 속도와 원구상순부의 위치를 변경시켰다. 낭배기 이후의 발생 단계에서 중력에 의한 변화로는 tail fin circulation(stage 22)시기의 머리크기의 변화를 들 수 있다. 이상의 결과로 무미 양서류의 초기 형태 형성은 중력장에 의해 변형될 수 있으며 이러한 변화는 발생이 진행됨에 따라 조절되는 것으로 보인다.

• Korean Journal of Biological Psychiatry
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• v.9 no.1
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• pp.62-67
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• 2002

Objective:There is increasing evidence that free radical-mediated CNS neuronal dysfunction is involved in the pathophysiology of schizophrenia. This study was performed to examine the relationship between antioxidant defense system and schizophrenia by analyzing polymorphism of catalase gene, an antioxidant enzyme. Method:Genotype and allele frequencies in the promoter region in the catalase gene using restriction fragment length polymorphism were studied, comparing 155 Korean controls with 167 Korean schizophrenics. Results:No difference was found between the schizophrenics and the controls in genotype and allele frequencies of HinfI polymorphism in the catalase gene. Significant difference was found between the female schizophrenics and the female controls in the genotype distribution(${\chi}^2$=11.096, df=2, p=0.004). Conclusions:The results do not support an association between polymorphism of catalase gene and schizophrenia. However, this study suggests that HinfI polymorphism in the catalase gene could be associated with female schizophrenics.

• Korean Journal of Biological Psychiatry
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• v.15 no.2
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• pp.83-91
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• 2008

Objectives : Neurological soft signs have been regarded as endophenotypes associated with the genetic basis of schizophrenia. This study was to investigate the intra-familial correlations of the neurological soft signs according to their genetic loading. Methods : Schizophrenic patients(N=14) were included, who had one parent with a family history of schizophrenia and the other without it. Genetic loading was determined by the patient's family history of schizophrenia using the Family Interview for Genetic Studies(FIGS). These parents were subdivided into two groups. The first group was designated as 'presumed carriers'(N=9) of genetic loading, who had one or more schizophreic firstor second-degree relatives. The second group was designated as 'presumed non-carriers'(N=11) of genetic loading, who had no schizophrenic first- or second-degree relatives. Normal controls(N=12) consisted of people without schizophrenic relatives. NSS were evaluated using the Neurological Evaluation Scale-Korean Version (NES-K), and the intra-familial correlations of NSS were tested using the Intra-Class Coefficients(ICC) method. Results : The scores of Motor Coordination subdimension of NES-K were significantly correlated between the patients and their presumed carriers(ICC=.804, p=.016), but not significantly correlated between the patients and their presumed noncarriers. In other subdimensions of NES-K, no significant correlation were found between the patients and their parents regardless of the genetic loading. But, there were no statistically significant differences in the scores of Motor Coordination subdimension of NES-K between the patients and controls. Conclusion : This study did not prove that the neurological soft signs might be an endophenotype of schizophrenia that cosegregate with the genetic loading. The future study using more subjects than this would be needed.