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Methylenetetrahydrofolate Reductase Gene C677T Polymorphism and Lung Cancer: an Updated Meta-analysis

  • Hou, Xin-Heng;Huang, Yu-Min;Mi, Yuan-Yuan
    • Asian Pacific Journal of Cancer Prevention
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    • v.13 no.5
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    • pp.2025-2029
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    • 2012
  • Objective: Methylenetetrahydrofolate reductase (MTHFR) catalyzes the metabolism of folate and nucleotides needed for DNA synthesis and repair. Variations in MTHFR functions likely play roles in the etiology of lung cancer (LC). So far, several studies between MTHFR C677T polymorphism and LC provide controversial or inconclusive results. Methods: To better assess the purported relationship, we performed a meta-analysis of 14 publications. Eligible studies were identified by searching the Pubmed, Embase, Web of Science and Google Scholar databases. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated to assess the association. Results: Overall, no significant association was detected between the MTHFR C677T polymorphism and LC risk, the same as in race subgroup. However, in the stratified analysis by histological type, significantly increased non-small-cell lung cancer (NSCLC) risk was indicated (T-allele vs. C-allele: OR = 1.11, 95%CI = 1.03-1.19; TT vs. CC: OR = 1.24, 95%CI = 1.09-1.41; TC vs. CC: OR = 1.11, 95%CI = 1.03-1.20 and TT+TC vs. CC: OR = 1.09, 95%CI = 1.03-1.15). At the same time, ever-smokers who carried T-allele (TT+TC) had a 10% decreased LC risk compared with CC genotype carriers. Conclusions: Our study provided evidence that the MTHFR 677T null genotype may increase NSCLC risk, however, it may protect ever-smokers against LC risk. Future studies with large sample sizes are warranted to further evaluate this association in more detail.

Optimal Conditions for Improving Enzyme Preteatment Efficiency in Sludge Reduction Process. (슬러지 저감시 효소 전처리의 효율 향상 및 최적화 연구)

  • 김정래;심상준
    • Microbiology and Biotechnology Letters
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    • v.32 no.2
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    • pp.166-171
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    • 2004
  • In this study, we introduced enzymatic pretreatment method, together with ozone treatment for sludge digestion. We optimized the amount of enzyme and ozone, respectively for the successful sludge pretreatment. As a result, we found that as more enzyme is used, higher sludge hydrolysis efficiency was obtained. When we treated sludge by ozone ranging from 0.01g $O_3$/g SS to 0.04 g $O_3$/g SS without enzyme treatment, 0.04 g $O_3$/g SS showed the highest increase of SCOD. Meanwhile, when protease was used together with the same ozone dosage ranges, 0.03g $O_3$/g SS ozonation resulted in the highest increase of SCOD. The sludge pretreatment was optimized by controlling the amount of enzyme and ozone.

Cr-doped Tialite Pigments (크롬을 사용한 Tialite계 안료)

  • Kim, Yeon-Ju;Lee, Byung-Ha
    • Korean Journal of Materials Research
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    • v.21 no.9
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    • pp.515-519
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    • 2011
  • The purpose of this study was to determine the optimal firing condition and composition for $Al_2TiO_5$ crystal, which is suitable for stable coloration in glazes at high temperatures, using $Cr_2O_3$ as chromophore for the synthesis of $Al_2TiO_5$ system pigments. $Al_2TiO_5$ has a high refractive index and good solubility of chromophore in the $Al_2TiO_5$ lattice, making this structure a good candidate for the development of new ceramic pigments. Pigments were synthesized by using $Al_2O_3$ and $TiO_2$ mainly. Various amounts of $Cr_2O_3$ such as 0.01, 0.02, 0.03, 0.04 and 0.05 mole were also added. Each compound was synthesized at $1300^{\circ}C$, $1400^{\circ}C$, and $1500^{\circ}C$ for 2 hours and cooled naturally. The crystal structure, solubility limit, and color of the synthesized pigments were analyzed by XRD, SEM, Raman spectroscopy, UV and UV-vis. The changes in color as the result of applying 6 wt% of the synthesized pigments to lime barium glaze were expressed as CIE-L*a*b* values. A $Cr_2O_3$ 0.03 mole doped $Al_2TiO_5$ brown pigment was successfully synthesize at $1400^{\circ}C$, and the values of CIE-L*a*b* parameters were L* = 44.62, a* = 3.10, and b* = 17.25. In the case of the pigment synthesized at $1500^{\circ}C$, the brown color was obtained at 0.01 mole and 0.02 mole $Cr_2O_3$, and the CIE-L*a*b* values were 55.34, 1.73, 28.64, and 49.39, 0.51, 21.33, respectively. At $1500^{\circ}C$, the maximum limit of solid solution was 0.03 mole $Cr_2O_3$. The glazed sample showed green color, and the values of the CIEL* a*b* parameters were L* = 45.69, a* = -0.98, and b* = 20.38.

The Effect of a Piezoelectric Ultrasonic Scaler with Curette Tip on Root Substitute Removal in Vitro (큐렛형 팁을 장착한 압전방식 초음파 치석제거기가 치근대체물 삭제에 미치는 영향)

  • Lee, Young-Kyoo
    • Journal of Periodontal and Implant Science
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    • v.30 no.2
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    • pp.429-442
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    • 2000
  • Based on current evidence in the literature, it is known that endotoxin is a weakly adherent surface phenomenon and that power-driven instruments can be used to accomplish definitive root detoxification and maximal wound healing without overinstrumentation of root and without extensive cementum removal. And one of the newly developed curette tips used with low power of piezoelectric ultrasonic scaler, is effective to remove calculus and not to remove the excessive cementum. The purpose of this study is therefore, to assess the influence of ultrasonic power and various working parameters on root substitute removal when instrumentation is performed with the curette tip on piezoelectric ultrasonic scaler. This study assessed defect depth, width and area resulting from instrumentation using a piezoelectric ultrasonic scaler with a curette type tip in vitro to acrylic resin block as a root substitute. The working parameters was standardized by the sledge device which controls lateral force(0.5 N, 1 N, 2 N) and instrumentation time(5 sec, 10 sec, 20 sec) and power setting was adjusted 0,2,4,8 in P mode. Power setting had the greatest influence on defect depth compared to lateral force and instrumentation time(standardized regression parameter estimates${\pm}$standard error, $0.37{\pm}0.02$, $0.19{\pm}0.02$, $0.07{\pm}0.02$). The effects on defect area also greatest for power setting($0.57{\pm}0.03$) compared to lateral force and instrumentation time($0.33{\pm}0.03$, $0.12{\pm}0.03$). The effect of the power setting on the defect width($0.15{\pm}0.01$) is not so great as defect depth or defect area compared to lateral force($0.12{\pm}0.01$) and effect of instrumentation time is minimal($0.02{\pm}0.01$). It could be concluded that the power setting has the greatest influence on the defect depth and area in curette type tip with low power of piezoelectric ultrasonic device. Many parameters can be adjusted in various situation in clinical use of piezoelectric ultrasonic scaler but the power setting is the first parameter to be adjusted.

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The Relationship between Weight of Single Garments and Thermal Insulation with a Thermal Manikin (써멀마네킨을 이용한 단일의복의 중량과 보온력에 관한 연구)

  • Choi, Jeong-Wha;Lee, Hyo-Hyun
    • Journal of the Korean Society of Clothing and Textiles
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    • v.33 no.2
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    • pp.173-186
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    • 2009
  • The purpose of this study was to examine the relationship between the weight of seasonal garments worn by Korean women in their daily lives and thermal insulation. We selected a total of 121 garments(13 kinds of Under garments, 51 Upper garments, 32 Lower garments, 15 Headgear, 10 Gloves Footgear) based on our previous survey using questionnaire and interview. Thermal insulation of single garment was measured with a thermal manikin. Also we measured garment weight, covering area, thickness, air permeability on the each garment(chamber air temperature: $21.5{\pm}0.5^{\circ}C$, humidity: $50{\pm}5%R.H.$ air speed: 0.15m/s). The results are as follow: The very strong positive correlation(r=0.905, p<.01) was recognized between the weight of single garment and thermal insulation. The regression equation of thermal insulation can be represented as follows: Thermal Insulation(clo)=$0.03+0.0004{\times}Garment$ Weight(g)($r^2$=0.820, SEE =0.059). There are significant differences in the thermal insulation and garment weight by season and garment type(p<.05). The each garment category's thermal insulation and garment weight has as follows: Under garment(0.06clo, 89g), Blouse Shirt T-shirt(0.13clo, 200g), Cardigan Sweater Vest(0.14clo, 287g), Coat Jacket Jumper(0.41clo, 890g), Skirt(0.16clo, 276g), Trousers(0.20clo, 438g), Headgear(0.03clo, 102g), Gloves Footgear(0.03clo, 33g).

Prevention of Missing the Fee of Medical Supplies and Improvement Activity of Cost Cutting (진료재료대 수가누락방지 및 비용절감 개선활동)

  • Choi, Hyun-ju
    • Quality Improvement in Health Care
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    • v.21 no.1
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    • pp.52-61
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    • 2015
  • Objectives: Because recently hospital had to faced with financial hardship, we have to have more effective hospital management. The purpose of this study was to reduce loss costs of the hospital through the systematic management of medical supplies and increase operational efficiency. Methods: The team was composed of outpatient nursing staff, medical record administrator, nurses in medical insurance, medical computer center, dermatologists for this study. We surveyed for 114 people including outpatient nursing staff, nurse aids, medical assistant, physician assistant. Pre-survey period was 2013.03.11 ~ 03.30(2 weeks), and post-survey period was 2013.09.03 ~ 09.17(2 weeks). Result: We improved this way through the computational improvement, conservation campaigns, inventory management, staff training, replaced by low-cost medical supplies. The finding of this study were as follows: Comparing before and after the activity of outpatient nursing staff's degree of knowledge, performance, economic consciousness, the degree of knowledge, performance was increased, but there was no significant change in economic consciousness. Performance of Married person is higher than the unmarried, In addition, the high-position people were more the degree of knowleage, economic consciousness. After activity, correlation of goods and treatment, examinations is increasing, but statistically there was no mean. Conclusion: This study revealed that knowledge in a short period of activity, but also can improve, perform the same change in behavior is not easy. This one shows the intensive training required to sustained and systematic behavioral changes, such as changes in behavior, perform rituals to help the economy. Expensive medical supplies to replace a similar effect as the cost of materials just to have a lot of cost savings. Therefore, more medical supplies change is necessary to develop alternative treatment and cost cutting.

Growth Characteristics of Lily by the Treatment of Aeration in vitro (기내 통기처리에 의한 백합의 생육특성)

  • 구대회
    • Korean Journal of Plant Tissue Culture
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    • v.26 no.4
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    • pp.241-244
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    • 1999
  • The effect of Milliwrap and Uniwrap attached to the lid on the growth and acclimation of lily growing in vitro was investigated. Milliwrap treatment increased the plant height 1.6 and 1.2 times higher than control in 'Dame Blanche' and '94-36', respectively, plant height of 'Dame Blanche' was 6.1㎝ and '94-36' line was 13.4 ㎝. Two treatments slightly inhibited the fresh weight in 'Dame Blanche', whereas Milliwrap and Uniwrap enhenced the fresh weight more than 30% in '94-36'. Leaf width (1.0 ㎝) of Milliwrap treatment was most wide, which was 2.5 times higher than that of control. In the fresh weight of bulblets, the fresh weight per bulblet of treatment was higher than control in '94-36', but the number of bulblets per scale were few in the treatment to control. In the air composition of culture vessel, ethylene content (0.03 ppm) was low in the Milliwrap treatment compared with the control. CO₂ content of control was higher than treatments as 0.11% and it was about 3 times to air condition of out side. The acclimation ratio of Milliwrap treatment was higher as 85.1% and control was similar with Uniwrap treatment.

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Antagonistic Activities of Bacillus spp. Strains Isolated from Tidal Flat Sediment Towards Anthracnose Pathogens Colletotrichum acutatum and C. gloeosporioides in South Korea

  • Han, Joon-Hee;Shim, Hongsik;Shin, Jong-Hwan;Kim, Kyoung Su
    • The Plant Pathology Journal
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    • v.31 no.2
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    • pp.165-175
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    • 2015
  • Anthracnose is a fungal disease caused by Colletotrichum species that is detrimental to numerous plant species. Anthracnose control with fungicides has both human health and environmental safety implications. Despite increasing public concerns, fungicide use will continue in the absence of viable alternatives. There have been relatively less efforts to search antagonistic bacteria from mudflats harboring microbial diversity. A total of 420 bacterial strains were isolated from mudflats near the western sea of South Korea. Five bacterial strains, LB01, LB14, HM03, HM17, and LB15, were characterized as having antifungal properties in the presence of C. acutatum and C. gloeosporioides. The three Bacillus atrophaeus strains, LB14, HM03, and HM17, produced large quantities of chitinase and protease enzymes, whereas the B. amyloliquefaciens strain LB01 produced protease and cellulase enzymes. Two important antagonistic traits, siderophore production and solubilization of insoluble phosphate, were observed in the three B. atrophaeus strains. Analyses of disease suppression revealed that LB14 was most effective for suppressing the incidence of anthracnose symptoms on pepper fruits. LB14 produced antagonistic compounds and suppressed conidial germination of C. acutatum and C. gloeosporioides. The results from the present study will provide a basis for developing a reliable alternative to fungicides for anthracnose control.

Dislication Loop Models for Plastic Deformation of the AI-5.5 at.%Mg alloy (AI-5.5at.%MG합금의 소성변형을 규명하기 위한 전위환 모델의 고찰)

  • An, Seong-Uk;Jeong, Seung-Bu
    • Korean Journal of Materials Research
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    • v.4 no.3
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    • pp.349-356
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    • 1994
  • For the deformation, life time prediction and improvement of the life time in high temperature materials it's very important to know the mechanism of deformation. For these mechanisms the dislocation loop models of Orlova et al. and Mills et al. are used often now. But they show controversial differencies, even if they have unertaken similar experimental tests with the same alloy of A1-5.5at.% Mg. In this work also the similiar tests of them have done under the same temperature of 573 K ; (1) The specimen was deformed by $\sigma$= 30MPa and $\varepsilon$=0.03. (2) Direct after creep deformation of $\sigma$= 30MPa and $\sigma$= 0.03 the stress reduction tests to 15, 10 and OMPa have been performed. (3) To study the loop models dislocation structure and dislocation density ( p ) have been observed.

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An Effect of Incremental Dental Health Care Program in School Dental Clinic (학교구강보건실 계속구강건강관리사업의 효과)

  • Yang, Jung-Seung;Shim, Hyung-Soon
    • Journal of Korean society of Dental Hygiene
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    • v.5 no.1
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    • pp.29-38
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    • 2005
  • In 2001, as a subject of this study, the first grade 165 kids in Yomju elementary school had been guided in pit and fissure sealant, fluoride rinse, group tooth brushing, and Dental health education as a part of oral disease preventive program. From the data, this author has estimated incremental dental health care program in school dental clinic in order to make it more effective and enlarge it. For that purpose, the program has been continued at six month intervals for two years. The retention condition of pit and fissure sealant in first molar and DMF rate had been investigated. The conclusions are as follows: 1. Full and partial retention of pit and fissure sealant was measured as 80.69% in maxillary right first molar, 83.20% in maxillary left first molar, and 86.72% in mandibular right first molar, and 86.28% in mandibular left first molar. 2. Retention of pit and fissure sealant in first molar was measured as 76.55% in maxillary right first molar, 81.03% in maxillary left first molar, 80.65% in mandibular left first molar, and 82.03% in mandibular right first molar. 3. Among Yomju elementary school students, DMF rate was measured as 8.7%, and DMFT index as 1.03. However, in Yangdong elementary school students the former was measured as 13.8% and the latter as 1.76. When the DMF rate difference between Yomju and Yangdong elementary school kids was considered, the oral health condition of the former was much better than that of the latter because the former had received incremental dental health care program for two years and on the other hand, the latter had not. So it is necessary that we should enlarge school dental clinic, improve and keep students' oral health.

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