• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.14 no.1
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• pp.151-166
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• 2019

New drug development requires 10 to 15 years of long time and more than $ 1 billion in funding, ranging from basic research${\rightarrow}$preclinical medicine${\rightarrow}$clinical medicine${\rightarrow}$product approval${\rightarrow}$sales. Many new drug development bio-venture companies will continue to pursue new drug development with funds secured through listing on the securities market. This study focuses on the impact of the listing on the market of bio-venture companies in the development of new drugs. It is necessary to determine whether the increase in registered patent, preclinical, clinical and technology transfer contracts at the time of listing (D) The results of this study are as follows. We also analyzed whether the registered patent, preclinical, and clinical effects had significant effect on technology transfer contracts at two years after listing and listing. The results of the analysis are as follows. First, Korea's new drug development bio-venture firms increased their registered patents but did not increase their pre-clinical, clinical and technology transfer contracts. Second, at the time of listing and two years after listing, pre-employment has a significant effect on Korea's technology transfer contracts and has a significant effect on overseas technology transfer contracts. However, registered patents and clinics have significant influence on technology transfer contracts. Korea 's new drug development bio-venture firms showed patent increase despite the stock market listing, but pre-clinical, clinical and technology transfer contracts did not increase. In order to strengthen technological commercialization of new drug development bio-venture companies in the future, it is required to establish R & D strategy for efficient use of IPO subscription funds, open innovation through strengthening industry-academia-partnerships, and more sophisticated preclinical and clinical strategy establishment.

• Journal of Wetlands Research
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• v.20 no.4
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• pp.353-362
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• 2018

The purpose of this study is to suggest a structure plan for improving the utilization of inactive storage in the dam for overcoming the drought. Inactive storage in the dam is composed of the emergency storage and dead storage. The emergency storage can be used for the case of emergency such as drought. But, in general, the dead storage for sedimentation is not used even for the emergency. Therefore, this study considers the part of dead storage that the sedimentation is not progressed yet can be used during the severe drought period and is called "drought storage in a dam". The accurate Sediment Level(SL) analysis for the computation of the drought storage should be performed and so the present and future SL in the dam reservoir is estimated using SED-2D linked with RMA-2 model of SMS. After the consideration of additionally available storage capacity based on the estimated SL, the drought storage is finally determined. Present data based on historical data, future predicted future climate factors by Representative Concentrarion Pathways(RCP) 8.5 scenario. Then, using the TANK model, dam inflows were determined, and future period such as SL and drought storage were suggested. As the results, we have found that the available drought storage will be reduced in the future when we compare the present drought storage with the future one. This is due to a increase variability of climate change. Therefore, we should take the necessary study for the increase of available drought storage in the future.

• Journal of Food Hygiene and Safety
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• v.33 no.6
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• pp.453-459
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• 2018

This study was performed to investigate the contamination levels of heavy metals (such as lead, cadmium, arsenic and mercury) and aflatoxin (such as $B_1$, $B_2$, $G_1$ and $G_2$) in commercial herbs for food and medicine. The concentrations of the heavy metals were measured by the ICP-MS and a mercury analyzer. The aflatoxins were analyzed by a HPLC-florescence coupled with photochemical derivatization. The detection ranges of the lead, cadmium, arsenic and mercury were found to be 0.006~4.088 mg/kg, 0.002~2.150 mg/kg, ND~0.610 mg/kg and ND~0.0139 mg/kg respectively. Among the total samples, the 3 samples (2.6%) were not suitable for the specification of cadmium by the MFDS (Ministry of Food and Drug Safety). The 13 samples of the total 117 samples were aflatoxin positive (11.1%). The amount of aflatoxin $G_1$ was $0.7834{\mu}g/kg$ in the Puerariae Radix and aflatoxin $G_2$ were $0.3517{\mu}g/kg$, $0.4881{\mu}g/kg$ in two samples of the Glycyrrhizae Radix et Rhizoma, respectively. The aflatoxins $B_2$ and $G_1$ were simultaneously detected in the 10 Angelicae Gigantis Radix. The detection ranges of aflatoxins $B_2$ and $G_1$ were $0.2324{\sim}1.0358{\mu}g/kg$ and $0.7552{\sim}1.6545{\mu}g/kg$ respectively in Angelicae Gigantis Radix. The results of the current study suggest that continuous monitoring is needed for the proactive management of commercial herbs for food and medicine safety.

• Journal of Korean Society of Forest Science
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• v.107 no.4
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• pp.486-496
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• 2018

Pine wilt disease (PWD) in Gyeonggi province was first detected in Gwangju in 2007, and ever since has caused extensive damage. Insect vector and host tree in Gyeonggi province are Monochamus saltuarius and Pinus koraiensis, respectively, which are different from the southern region that consist of Monochamus alternatus and Pinus densiflora. Consequently, spread and mortality characteristics may be different, but our understanding is limited. In this research, we utilized the spatial data of newly infected trees in Gyeonggi province from 2008 to 2015 to analyze how it is related to various environmental and human factors, such as elevation, forest type, and road network. We also analyzed the minimum distance from newly infected tree to last year's closest infected tree to examine the dispersal characteristics based on new outbreak locations. Annual number of newly infected trees rapidly increased from 2008 to 2013, which then stabilized. Number of administrative districts with infected trees was 5 in 2012, 11 in 2013, and 15 in 2014. Most of the infected trees was Pinus koraiensis, with its proportion close to 90% throughout the survey period. Mean distance to newly infected trees dramatically decreased over time, from 4,111 m from 2012 to 2013, to approximately 600 m from 2013 to 2014 and 2014 to 2015. Most new infections occurred in higher elevation over time. Distance to road from newly infected trees continuously increased, suggesting that natural diffusion dispersal is increasingly occurring compared to human-influenced dispersal over time.

• Korean Journal of Environmental Biology
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• v.36 no.4
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• pp.517-524
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• 2018

The purpose of this study was to investigate the density of thrips, and insecticidal resistance for effective control of Western flower thrips in greenhouse. The presence and density of the thrips was investigated using yellow colored-sticky trap in a cucumber field from May to August in Cheon-an. The results of the investigation revealed the existence of the following thrips species; Frankliniella occidentalis, F. intonsa, Thrips palmi, T. tabaci, Scirtothrips dorsalis, Microcephalothrips abdominalis, and T. nigropilosus. The predominant pest was found to be the western flower thrips. To survey the western flower thrips insecticidal resistance, we established the discriminating concentration (DC), recommended concentration (RC) and $2{\times}$recommended concentration ($2{\times}RC$) of nine insecticides; Emamectin benzoate EC, spinetoram SC, Chlorfenapyr EC, Spinosad SC, Cyantraniliprole EC, Acetamiprid WP, Dinotefuran WG, thiacloprid SC and thiamethoxam SC. The bioassay of about five local populations was conducted using the leaf-dipping method. In all local populations, insecticidal resistance in western flower thrips had not developed in emamectin benzoate EC (RC, $10.8{\mu}L\;L^{-1}$), chlorfenapyr EC (RC, $50.0{\mu}L\;L^{-1}$), spinetoram SC (RC, $25.0mg\;L^{-1}$), and spinosad SC (RC, $50.0mg\;L^{-1}$). However, insecticidal resistance in RC was found to have developed in cyantraniliprole EC (RC, $50.0{\mu}L\;L^{-1}$) and four insecticides of neonicotinoid type. Insecticidal activity of 95% or more was observed in each population when cyantraniliprole EC tested in $2{\times}RC$. However, the neonicotinoid types showed different insecticidal activity in $2{\times}RC$.

• Korean Journal of Heritage: History & Science
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• v.46 no.3
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• pp.212-228
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• 2013

Stone cultural heritages are repaired by the use of metal stiffeners. The problem is that this type of repair has been based on the experience of workers without specific guidelines and has caused various problems. This is to suggest the structural reinforcement and behavioral characteristics of metal rods to minimize the secondary damage of materials and have the specimens tested and verified to establish the guidelines on how to insert metal stiffeners. When only epoxy resin is applied to the cut surface, only 70% of the properties of the parent material are regenerated and it is required to structurally reinforce the metal stiffener for the remaining 30%. The metal rod is under the structural behavior after the brittle failure of stone material and the structural behavior does not occur when the metal stiffener is below 0.251%. When it accounts for over 0.5%, it achieves structural reinforcement, but causes secondary damage of parent materials. The appropriate ratio of metal stiffener for the stone material with the strength of $1,500kgf/cm^2$, therefore, should be between 0.283% and 0.377% of the cross section of attached surface to achieve reversible fracture and ductility behavior. In addition, it is more effective to position the stiffeners at close intervals to achieve the peak stress of metal rod against bending load and inserting the stiffener into the upper secions is not structurally supportive, but would rather cause damage of the parent material. Thus, most stiffeners should be inserted into the lower part and some into the central part to work as a stable tensile material under the load stress. The dispersion effect of metal rods was influenced by the area of reinforcing rods and unrelated to their diameter. However, it ensures stability under the load stress to increase the number of stiffeners considering the cross section adhered when working on large-scale structures. The development length is engineered based upon the diameter of stiffener using the following formula: $l_d=\frac{a_tf_y}{u{\Sigma}_0}$. Also, helically-threaded reinforcing rods should be used to perform the behaviors as a structural material.

• Journal of Korean Society of Forest Science
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• v.108 no.3
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• pp.429-439
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• 2019

The objectives of this study were to gauge the extent of the forestry business through establishing the definition of forestry industry from the perspective of economic convergence and to analyze key components that affect each growth phase of a forestry business entity by classifying them. A total of 1,397 "sixth-sector industry" management entities were certified by the Ministry of Agriculture, Food, and Rural Affairs in South Korea from 2012-2017. Of these, 259 (18.5%) were in the forestry sector. In this study, the 259 forestry management entities were further classified into three phases based on sales distribution: entrance, development, and maturity. The entrance phase (<100 million KRW), development phase (>100 million and <1 billion KRW), and maturity phase (>1 billion KRW) constituted 33.2%, 55.4%, and 12.4% of the total 259 entities, respectively. The results showed that most of the management entities were either in the entrance or development phases, and only a small portion was in the maturity phase. To identify the key variables that affect each of the phases, chi-square analysis was used. We designed the "sixth-sector industry" type as an independent variable, whereas selected region, business organization, manager age group, forest product, processing type, and service type were designated as dependent variables. The results of the analysis showed that the processing and service types influenced all three developmental phases. Moreover, as the phase advanced, processing type showed a higher proportion of health-functional ingredients, such as powder or extract from forest products, which enable to develop and produce a variety of products. Service type also changed from simple experience to integrated experience tourism and finally to tourism education. Distribution and sales channel also turned out to be a significant factor during the development phase. This study provides the basic information needed to guide government support in the implementation of a formal forestry business through convergence as well as to increase the efficiency of business management.

• The Journal of Korean Society for Radiation Therapy
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• v.31 no.1
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• pp.67-74
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• 2019

Purpose: The purpose is to correct for position errors caused by long treatment times. By correcting the target motion that can occur during lung SBRT using IntraFraction CBCT. Methods and materials: We analyzed retrospectively the IFM data of 14 patients with two treatment arc in the treatment plan for lung cancer with stereotactic radiotherapy. An IntraFraction Motion was applied to the Arccheck phantom to acquire the Gamma index data. Results : IntraFraction Motion during the first treatment arc is in the left-right(LR), superiorinferior(SI), anterior-posterior(AP) directions were $0.16{\pm}0.05cm$, 0.72 cm(max error), $0.2{\pm}0.14cm$, 1.26 cm, $0.24{\pm}0.08cm$, 0.82 cm and rotational directions was $0.84{\pm}0.23^{\circ}$, $2.8^{\circ}$(pitch), $0.72{\pm}0.23^{\circ}$, $2.5^{\circ}$(yaw), $0.7{\pm}0.19^{\circ}$, $2^{\circ}$(roll). IntraFraction Motion during the second treatment arc is in the LR, SI, AP directions were $0.1{\pm}0.04cm$, 0.37 cm, $0.14{\pm}0.17cm$, 2 cm, $0.12{\pm}0.04cm$, 0.5 cm and rotational directions was $0.45{\pm}0.12^{\circ}$, $1.3^{\circ}$, $0.37{\pm}0.1^{\circ}$, $1^{\circ}$, $0.35{\pm}0.1^{\circ}$, $1.2^{\circ}$. Gamma index pass rates were $82.64{\pm}10.51%$, 48.4 %. Conclusions : In this study, we examined the validity of IntraFraction Motion correction in lung SBRT and the efficiency of IntraFraction CBCT. Due to the nature of SBRT treatment, IFM may increase due to the increased treatment time. It is believed that the increase in IFM with the increase in treatment time can be improved with the use of FFF Beam and additional position correction using CBCT during treatment.

• Journal of the Korea Organic Resources Recycling Association
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• v.27 no.3
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• pp.49-61
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• 2019

Swine manure has been recognized as a organic sources for composting and many research was conducted to efficiently utilize and treat. This study was to evaluate a feasibility for producing swine manure compost under various treatment with mixture of swine manure and saw dust. Treatments were designed as follows; non aerated composting pile(REF), aerated composting pile of $100L/m^3$(EXP1), and aerated composting pile of $150L/m^3$(EXP2). The total days of fermentation were 28 days and each samples were collected at every 7 days from starting of composting. Temperature sensors were installed under 30~40cm from the surface of composting pile. Inner temperature in composting piles of EXP1 and EXP2 was rapidly increased to $67{\sim}75^{\circ}C$ within 1~2 days. The elevated temperatures found during the thermophilic phase are essential for rapid degradation of organic materials. While swine manure composted, moisture content, total nitrogen, EC of EXP1, EXP2 in sample at 28 days were lower than those of REF. But, pH and organic matter of EXP1, EXP2 in sample at 28 days were higher than those of REF. After finishing fermentation experiment, maturity was evaluated with germination test. Calculated germination index(GI) at REF, EXP1 and EXP2 were 23.49, 68.50 and 51.81, respectively. The values of germination index were higher at EXP1 and EXP2 which is aerated composting piles than REF which is non aerated composting pile. According to the results, composting process by aerated static pile compost had significant effect on the reduction of required period for composting. Supplying adequate amount of air to compost swine manure will greatly reduce composting period.

• Journal of Korean Society of Forest Science
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• v.108 no.1
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• pp.29-39
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• 2019

The objective of this study was to suggest a suitable amount of fertilizer using the changes in growth performances and soil properties for improving survival and quality of Zelkova serrata trees in a harvested Pinus rigida plantation. One-year-old containerized seedlings of Z. serrata were planted with the density of 3000 seedlings $ha^{-1}$ in end of March 2011 at Gwangneung experimental forest, Pocheon. Solid compound fertilizer (N:P:K=3:4:1) were applied yearly in three amounts (control: no fertilization, F1: $180kg\;ha^{-1}$, and F2: $360kg\;ha^{-1}$) every May from 2011 to 2013. We analyzed soil properties before (2011) and after (2012 and 2017) fertilization. And we measured the root collar diameter and height of Z. serrata trees from 2011 to 2016, and then calculated H/D ratio and stem volume. Soil properties at Z. serrata plantation did not show difference according to fertilization level in every investigation year. As time passed after planting, however, concentrations of total nitrogen and available phosphorus were increased from decreased. The growth of root collar diameter, height and stem volume of Z. serrata trees at F2 plot were significantly higher those at the other plots after only 2 years of fertilization. Because Z. serrata tree demand to more nutrient during the early growing period. The survival rate of Z. serrata trees at control plot was significantly lower than that at the other plots. This might be due to Z. serrata trees at control plot had not the upper hand from competition with vegetation at the early in planting. However, the growth of height and stem volume of Z. serrata trees between F1 and F2 plots did not show difference over 6 years after planting. Consequently, we could suggest that Z. serrata trees need to F1 fertilization level for considering improving survival and quality of Z. serrata trees and economical efficiency of plantation managements after harvesting P. rigida plantation.