• Title/Summary/Keyword: 홍어 콜라겐 펩타이드

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Anti-inflammatory Effect of Skate Collagen Peptide through Attenuation of Oxidative Stress (홍어 콜라겐 펩타이드의 산화적 스트레스 완화를 통한 항염증효과)

  • Jeong, Kap Seop;Noh, Jeong Sook
    • Journal of the Korean Applied Science and Technology
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    • v.35 no.4
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    • pp.1369-1378
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    • 2018

  • The purpose of this study was to investigate the effect of skate skin collagen peptide (SCP) according to its molecular weight (<1,000 Da or >1,000 Da) which was divided using the ultrafilatration method. The 200 mg/kg collagen peptide was administrated to obesity-induced db/db mice for 8 weeks. As the results, in collagen peptide-treated groups, body weight gain was decreased, the plasma and hepatic concentration of reactive oxygen species decreased and oxidative stress was alleviated. In addition, SCP-treated group showed the significant reduction of the protein expressions of nuclear transcription factors($NF-{\kappa}B$), enzymes(COX2, iNOS), and inflammatory cytokine(IL-6) in hepatic tissue, compared with those of the obese control group. There was a slight difference depending on the molecular weight of collagen peptide, but overall it was not significant. Therefore, SCP effectively inhibited the obesity-induced inflammatory response through attenuation of oxidative stress in the liver.

  • https://doi.org/10.12925/jkocs.2018.35.4.1369 인용 PDF KSCI HTML

Development of High Functional Collagen Peptide Materials using Skate Skins (홍어껍질을 이용한 고기능성 콜라겐 펩타이드 소재 개발)

  • Baek, Jang-Mi;Kang, Keon-Hee;Kim, Sang-Ho;Noh, Jeong-Sook;Jeong, Kap-Seop
    • Journal of Environmental Science International
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    • v.25 no.4
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    • pp.579-588
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    • 2016

  • The aim of this study was to investigate and development collagen peptide materials from skate skin. Protein and fat content of collagen peptide showed about 95% and 0.1%, respectively. Average molecular weight of collagen peptide was measured as 1,015. In the analysis of amino acid, glycine and hydroxy proline content in collagen peptide was 19.32% and 16.25%, respectively, showing a typical characteristics of the collagen peptide. In obese db/db mice ingested 500 mg/day of collagen peptide for 18 days, the amounts of food and water intake were decreased considerably, contents of triglyceride, total cholesterol were decreased significantly in white adipose tissue of db/db mice. The final yield of collagen peptide was 17.23% in the optimized process for mass production. These results indicate that collagen peptide from skate skin may serve as candidates of fat reduction in adipose tissue and could be used as functional food and cosmetic ingredients.

  • https://doi.org/10.5322/JESI.2016.25.4.579 인용 PDF KSCI