• Korean Journal of Community Nutrition
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• v.5 no.4
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• pp.779.2-780
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• 2000

• Tuberculosis and Respiratory Diseases
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• v.47 no.6
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• pp.824-835
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• 1999

Background: Sleep-related breathing disorders are commonly found in patients with chronic renal failure and particularly, sleep apnea may have an influence on the long-term mortality rates in these patients. Maintenance hemodialysis is the mainstay of medical measures for correcting the metabolic derangements of chronic renal failure but it is uncertain whether it may alleviate sleep disorders including sleep apnea. Methods: Forty seven patients on maintenance hemodialysis were surveyed with the sleep questionnaire about their clinical symptoms related to sleep disorders. Among them, 15 patients underwent the polysomnography and their blood levels of urea nitrogen, creatinine, electrolytes and the arterial blood gases in the nights before and following hemodialysis were measured. Results: Forty(85.1%) of the 47 patients complained of the symptoms associated with sleep-wake cycle disturbances, 55.3% experienced snoring and 27.7% reported witnessed apneas. The duration of REM sleep increased significantly in the nights after hemodialysis compared to the nights without hemodialysis(p<0.05) and the percentage of total sleep time comprising NREM sleep decreased significantly in the nights following hemodialysis compared to the nights before hemodialysis(p<0.05). The percentage of total sleep time consisting of the stage 1 and 2 NREM sleep showed the trend for a decrease in the nights after hemodialysis(p=0.051), while the percentage of total sleep time comprising the stage 3 and 4 NREM sleep did not change between nights. The obstructive sleep apnea was more predominant type than the central one in both nights and there were no differences in the apnea index and the apnea-hypopnea index between the nights. The decrease in the blood level of urea nitrogen, creatinine, potassium and phosphorus was observed after hemodialysis(p<0.05), but the differences of parameters measured during polysomnography between the nights did not correlate with the changes of biochemical factors obtained on the two nights. Arterial blood gas analysis showed that pH was significantly greater in the nights after hemodialysis than in the nights before hemodialysis(p<0.05), but there were no correlations between the parameters examined during polysomnography and the parameters of arterial blood gas analysis(p<0.05). Conclusion: These results suggest that chronic renal failure is an important systemic disorder which is strongly associated with sleep disorders. Maintenance hemodialysis, although it is a widely accepted measure to treat chronic renal failure, did not significantly modulate the sleep architecture and the severity of sleep apnea. Thus, taking the patients with chronic renal failure into account, it is advisable to try not only to find a substantial way for correcting metabolic derangements but also to consider the institution of more effective treatments for sleep disorders.

• Journal of the Korean Society for Nondestructive Testing
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• v.32 no.5
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• pp.494-501
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• 2012

In the present paper, the ultrasound blood images were measured at both the human radial artery(RA) and common carotid artery(CCA), depending on the age, and the pulsatility index of blood echogenicity(PIBE) was analyzed. In addition, the ultrasound blood images were measured at both RA and CCA of both the stroke patients and the control group, and PIBE was compared. PIBE of RA for the young group was similar with that for the old group ($0.13{\pm}0.11$ and $0.16{\pm}0.03$). PIBE of CCA for the young group, however, was larger than that for the old group ($0.70{\pm}0.21$ and $0.32{\pm}0.01$), and was more variable depending on the subject. Similarly, the fibrinogen concentrations of the patients ($336{\pm}61$ and $340{\pm}126mg/dl$) were more than that of the control group ($264{\pm}38$ and $257{\pm}43mg/dl$), for both RA and CCA. The results indicate the possibility of the ultrasonic test on the correlation between erythrocyte aggregation and stroke, and it is expected that the in-vivo EA measurement would be clinically useful.

• The Korean Journal of Blood Transfusion
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• v.29 no.3
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• pp.229-239
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• 2018

The circulatory system is closely related to the inter-relationship between the anatomy of the heart and blood vessels, and the fluid dynamic properties of blood. The physical properties of blood, which affect blood flow, are called hemorheologic factors. Hemorheologic factors, such as blood viscosity and erythrocyte aggregation, are influenced mainly by hematocrit. A higher hematocrit level results in an increase in blood viscosity, erythrocyte aggregation, which impedes the circulation itself, and tissue oxygenation. An excess of serum ferritin causes injury to vascular endothelial cells and erythrocytes via oxygen free radicals. In addition, an excess of blood can aggravatee the adverse effects of the hemorheologic parameters and induce atherogenesis, microcirculatory disturbances, and major cardiovascular events. A preventive and therapeutic approach with a phlebotomy or blood donation has been stimulated by the knowledge that blood loss, such as regular donations, is associated with significant decreases in key hemorheologic variables, including blood viscosity, erythrocyte aggregation, hematocrit, and fibrinogen. Major cardiovascular events have been improved in regular blood donors by improving blood flow and microcirculation by decreasing the level of oxidative stress, improving the hemorheologic parameters, and reducing the serum ferritin level. Confirmation of the positive preventive and therapeutic effects of blood donations on cardiovascular disease by a well-designed and well-controlled Cohort study may be good news to patients with cardiovascular disease or at risk of these diseases, as well as patients who require a transfusion.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.22 no.5
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• pp.42-50
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• 2021

The purpose of this study was to identify and analyze the communication behavior styles of hemodialysis nurses based on the structured Q-methodology. The Q-population was formulated based on literature reviews and in-depth interviews with 10 hemodialysis nurses who were working in hospitals in Seoul and Anyang-si, Gyeonggi Province. A total of 50 Q-samples, which were believed to best represent the communication behavior styles of hemodialysis nurses, were selected from the Q-population by the author and a professor majoring in nursing. 30 P-samples were selected from hemodialysis nurses who were working in primary, secondary, and tertiary hospitals in Seoul. Q-sorting was performed by P-samples and data was analyzed through the pc-QUANL program. The results suggested that there are four types of communication behavior styles of hemodialysis nurses, namely: "type I: listening and speaking courteously with an active mind", "type II: listening and speaking courteously with a receptive mind", "type III: advising with an explanation" and "type IV: super-reasonable with a defensive mind". It is expected that the analytical results described here may provide basic information that can be used to develop educational material for hemodialysis nurses.

• Journal of Life Science
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• v.33 no.2
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• pp.208-215
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• 2023

In recent decades, the field of aging research has progressed from the genetic and cellular levels to in vivo models of blood exchange. Since genes capable of extending the lifespan in C. elegance have been reported, various potential target molecules have been discovered through genomics, proteomics, metabolomics, and transcriptomics. Accordingly, research on the interactions between target molecules has also been increasing. The parabiosis method, in which two experimental animals are surgically combined, was introduced, and a factor that could reverse the aging phenomenon was discovered using this method. The parabiosis method is used to find more accurate and effective aging-reversal factors that could exist in young blood. As more new evidence has been revealed, the parabiosis method has established a new paradigm for aging research. Moreover, a device capable of exchanging blood elaborately in laboratory animals was published in 2022 and presented new results necessary for aging reversal. Since GDF11, was reported, many other anti-aging candidates that are soluble factors in blood, such as β2m, TIMP2, VCAM1, Gpld1, and clusterin, have been discovered. In addition, mcicroglia cells and neuroinflammation have been directly proven to be aging factors. These latest research results were obtained by parabiosis, the newly designed device for plasmapheresis, and injecting young blood or conditioned blood methods. In this review, we discuss the latest research results using the device and young blood administration in old mice.

• Korean Journal of Animal Reproduction
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• v.23 no.2
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• pp.159-163
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• 1999

Recent development of the molecular biology techniques has made it possible to characterize and analyze early diagnoses of genetic disorders and economic trait loci. In this study, porcine genomic DNA was extracted from both clotted and dried blood to analyze the porcine estrogen receptor (ER) gene by polymerase chain reaction (PCR). By the methods reported here, genomic DNA extracted from clotted or dried blood was efficient enough to detect ER gene by PCR. Moreover, the PCR-RFLP (restriction fragment length polymorphism) of ER gene was identified by PvuII restriction enzyme. Thus the results obtained from this study show that the clotted and dried blood was useful for identification of the certain genotype in a rapid manner with low cost. Importantly, this study implies that the whole blood can be economically utilized in studies of endocrinology, molecular biology, and genetics by obtaining both serum and DNA simultaneously in an efficient manner.

• Journal of the Korean Applied Science and Technology
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• v.29 no.2
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• pp.214-223
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• 2012

This study was carried out to investigate the feeding effects of microcapsulated inulin (MI) from Jerusalem artichoke (Helianthus tuberosus L.) on blood lipid, fatty acid composition and cholesterol of egg in laying hens. Hyline brown layers of 25 weeks old were subjected to one of the following treatments for 4 weeks: a control group without MI, 800 ppm, 900 ppm, and 1,000 ppm. Compared with control group, levels of triacylglyceride and cholesterol in blood and egg cholesterol decreased significantly in groups MI groups. Egg saturated fatty acid was lower in MI groups than control group but not unsaturated fatty acid was significantly high in MI groups as compared to the group without MI. The results suggest that the addition of microcapsulated inulin to a laying hens' diet can improve egg quality by reducing blood lipids.

• Journal of Veterinary Clinics
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• v.16 no.2
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• pp.248-252
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• 1999

본 연구는 진도개, 풍산개 및 잡종견의 혈액학 및 혈액화학치의 차이를 비교하고자 본 실험을 수행하였다. 총 80두가 본 조사에 이용되었으며 경기도지방, 제주도, 서울 및 전남지방을 대상으로 실시하였다. 각각 진도개 30두, 풍산개 20두 및 잡종견 30두로 구성되었으며 성비는 각 군간에 차이가 없었다(진도개: 수캐=16, 암캐=14, 풍산개 : 수캐=9, 암캐=11, 잡종견: 수캐=15, 암캐=15). 연령은 진도개, 풍산개 및 잡종견 각각 1.3$\pm$0.9(년), 1.3$\pm$1.0(년), 1.3$\pm$ 1.6(년)이었다. 체종분포는 진도개, 풍산개 및 잡종견은 각각 9.0$\pm$4.5 kg, 9.8$\pm$4.0 kg, 8.4$\pm$4.7 kg이었다. 잡종견의 백혈구와 호중구수가 다른 두품종에 비해 유의성있게 높았다 (p<0.05). 풍산개의 림프구와 호산구수는 진도개와 잡종견의 수보다 높았다(p＜0.05). 하지만 풍산개의 단핵구 수는 진도개와 잡종견보다 유의성있게 낮았다(p<0.05). 진도개의 콜레스테롤과 무기인 수준은 풍산개와 잡종개의 수준보다 낮았다. 잡종견의 중성지방(triglyceride)의 수준은 진도개와 풍산개의 수준보다 낮았다. 잡종견의 나트륨 농도는 진도개와 풍산개의 수준보다 낮았으며 진도견의 칼륨농도는 풍산개와 잡종견의 농도와 비교하여 높았다. 바베시아 검사에서 모든 품종에서 음성이었으며 심장사상충 검사결과 양성율은 잡종견, 진도견과 풍산견 각각 20%, 10%, 10%이었다.

• Journal of the Korean Vacuum Society
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• v.14 no.3
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• pp.165-170
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• 2005

There is an increasing interest in developing novel coating to improve the blood compatibility of medical implants. Diamond-like carbon(DLC) and titanium nitride(TiN) films have been proposed as potential biomedical coatings due to their chemical k physical properties and moderate biocompatibility. To study the correlation between blood compatibility and physical properties of the films, the fibrinogen adsorption on the surface as well as morphology & wettability were investigated. The quantity of fibrinogen adsorption are Tower for TiN than DLC, which correlates with a higher hydrophilicity of TiN film. To reduce the quantity of fibrinogen adsorption on the film, plasma treatment and furnace annealing were performed, respectively. With the use of oxygen plasma and furnace annealing, the amount of fibrinogen adsorption on TiN film was remarkably reduced, while there was no decrease of the quantity with DLC.