• Korean Journal of Acupuncture
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• v.27 no.1
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• pp.23-30
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• 2010

목적 : 본 연구는 간접구의 안전성에 대한 기초 데이터를 확보하기 위하여 수행되었다. 연구설계 : 50명의 건강한 성인을 무작위 배정으로 두 그룹으로 나누어 4주간 (일주일에 3회) 신궐혈과 관원혈에 뜸을 시술하였다. 시험군에 비하여 대조군은 열이 전달되지 않도록 단열제로 처리한 뜸으로 동일한 부위에 시술하였다. 첫 시술 1시간 전과 마지막 시술 1시간 후에 공복상태에서 채혈을 하여 혈액학적 검사를 시행하였다. 결과 : 혈액학적 검사에서 적혈구와 총 백혈구 및 백혈구의 종류별 절대수치와 상대수치에서 두 그룹 간에 특별한 차이가 없었다. 또한 혈청학적 검사에서 총 단백질, 알부민, AST, ALT, ALP, GGT, LDH, 요소질소, 크레아티닌, 총콜레스테롤 및 중성지방의 비교에서도 그룹 간에 차이가 없었다. 결론 : 본 연구는 건강한 사람에서 간접구의 시행 후 혈액학적 안전성을 처음으로 보고하는 것으로서, 향후 뜸의 연구를 수행시 중요한 비교 자료로 사용될 수 있을 것이다.

• The Journal of Internal Korean Medicine
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• v.26 no.4
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• pp.941-945
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• 2005

연구목적 : 선양낭성암은 모든 두경부 종양에서 불과 1% 미만의 희소암으로, 본 논문에서는 하악 선양낭성암 기원의 간에 전이성 거대 종양을 가진 증례를 통해 선양낭성암에서의 한방 치료의 유효성평가와 함께 이에 대한 계속적인 연구를 유도해내는 계기로 삼고자 한다. 연구방법 : 본 연구에서는 한약물치료, 침치료, CT검사 및 혈액학적 검사를 포함한 모든 치료와 검사결과를 추적 조사하였다. 치료로 청간탕과 화침법을 사용하였으며, 청간탕은 1일 3회 복용, 화침은 월 1회 시술하였다. 또한, 혈액학적 검사는 월 1회 하였으며, CT검사는 19개월간의 치료기간 중 2회에 걸쳐 수행되어졌다. 연구결과 : 재검사시의 CT소견과 내원당시의 CT소견을 비교하였을 때, 큰 변화가 없이 잘 유지하였으며, 비록 일부의 혈액학적 검사소견이 약간 악화되었지만, 환자의 주증상은 빠르게 경감되었다. 결론 : 본 증례는 진행성 선양낭성암 환자에게서 한방치료가 삶의 질 개선과 생존을 향상을 위한 고식적 목적의 치료에 유용하게 사용되어질 수 있는 가능성을 제시해 준다.

• Tuberculosis and Respiratory Diseases
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• v.42 no.5
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• pp.654-659
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• 1995

Background: Tuberculosis has commonly been associated with various hematologic changes. A difference between the changes found in pulmonary tuberculosis and those found in miliary tuberculosis has been discussed. Up to now some worker were investigated hematological changes associated with pulmonary tuberculosis but was not investigated those associated with miliary tuberculosis in korea. Therefore we examimed the peripheral blood and bone marrow findings in miliary tuberculosis patients to determine hematologic changes. Methods: We performed blood sample at admission and bone marrow biopsy within 7days after admission. For evaluation of the hematologic findings, full blood counts and marrow differential counts were defined by the criteria outlined by Dacie and Lewis. Results: 1) Peripheral blood findings: Pancytopenia in 10% of patients, anemia in all patients, leukocytosis in 10% of patients, leukopenia in 20% of patients, thrombocytopenia in 30% of patients, lymphocytopenia in 90% of patients, monocytosis in 40% of patients and neutrophilia in 10% of patients were found at peripheral blood. 2) Bone marrow findings: Lymphocytopenia in 30% of patients, lymphocytosis in 20% of patients, plasmacytosis in 40% of patients, monocytosis in 100% of patients, and hypocellularity in 30% of patients were found at bone marrow. Erythropoiesis was decreased in 30% of patients. Granulopoiesis was decreased in 20% of patients and increased in 20% of patients. Bone morrow granuloma occured in 25% of patients. Conclusion: Hematologic changes of miliary tuberculosis were seen tendency of cytopenic pattern but monocyte was increased at peripheral blood and bone morrow. This findings would provide additional information for the differential diagnosis of miliary tuberculosis.

• Journal of the Korean Society of Food Science and Nutrition
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• v.44 no.9
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• pp.1286-1294
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• 2015

The acute and subchronic toxicity of 1 kGy gamma-irradiated orange was evaluated in ICR mice. For acute toxicity, groups of 30 male and 30 female ICR mice were orally administered 1 kGy gamma-irradiated orange (0, 1,000, and 2,000 mg/kg). The mortality, clinical sign, body weight changes, and necropsy findings of ICR mice were observed for 14 days. No significant changes in body weight or abnormal gross findings were observed in relation to 1 kGy gamma-irradiated orange. Hematological and serum biochemical parameters were within normal ranges. According to the results, 1 kGy gamma-irradiated orange had no special toxic effects in male and female ICR mice at 2,000 mg/kg. For subchronic toxicity, groups of 36 male and 36 female ICR mice were given a diet of 1 kGy gamma-irradiated orange for 13 weeks (control, non-irradiated, and irradiated imported orange). During the experimental period, mortality, clinical signs, body weight change, food consumption, organ weight, and histopathological examination did not show any changes in comparison to the control group. Several hematological and serum biochemical parameters showed statistically significant changes, but these changes were within normal range. These results indicate that 1 kGy gamma-irradiated orange did not cause any toxic effects in male and female ICR mice and therefore can be considered as safe.

• Korean Journal of Food Science and Technology
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• v.52 no.5
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• pp.555-559
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• 2020

In order to examine the toxicity of palatinose-L (Pal-L) bioconverted from sucrose, we performed a 14-consecutive day toxicity study with male and female Sprague-Dawley (SD) rats. We recorded clinical signs of toxicity, body weight, organ weights, hematology, blood biochemical, urinalysis, histological changes in organs, such as the liver and kidneys, and clinical chemistry analysis data for all SD rats. There were no significant changes in food/water consumption, body weight, and organ weights during the experimental period. Although there were some hematologic and urinalysis alterations, these changes were not considered toxicologically significant. In addition, histopathological examination of the liver and kidneys revealed no abnormal or toxicological changes between the control and Pal-L-treated rats of both sexes. Collectively, these results suggest that Pal-L was not indicated to have any toxicity in the SD rats when it was orally administered up to a dose of 1,000 mg/kg/day for 14 days.

• Journal of the Korean Society of Radiology
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• v.13 no.4
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• pp.531-537
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• 2019

The purpose of this study was to analyze the relationship between hematologic hyperlipemia index and severity of fatty liver abdominal ultrasonography. A total of 412 adults from January 1, 2017 to December 31, 2017 who underwent abdominal ultrasonography and hematologic data within 3 months of the ultrasound examination, were the target of the investigation. As a result of the study, the hematological values according to the degree of fatty liver were statistically significant in triglyceride, AST and ALT (p<.05), fatty liver was associated with gender, triglyceride, AST and ALT (p<.05). In conclusion, the degree of fatty liver was not directly related to the hematologic value of hyperlipidemia, but we confirmed the necessity of co-management with fatty liver and hyperlipidemia by confirming its relevance.

• The Microorganisms and Industry
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• v.18 no.2
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• pp.19-25
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• 1992

본문에서는 현재 주로 사용되고 있는 혈청학적 방법을 주로 소개하고자 한다. HIV 감염의 특성상 헌혈 혈액 등과 같이 많은 시료를 신속하게 검사하여야 하고 또한 검사결과가 개인에게 매우 중요한 의미를 지니므로 HIV에 대한 혈청학적 검사는 일차적으로 민감도가 높은 검색용 검사를 우선 시행하고 이차적으로 특이도가 높은 확인용 검사를 실시하여 판정하는 것을 원칙으로 하고 있다.

• Journal of Veterinary Clinics
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• v.15 no.1
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• pp.214-218
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• 1998

2세의 암컷 진돗개가 3개월간 혈액성 질분비물과와 외음부 종창을 주증으로 내원하였다. 질에 형성된 종괴는 조직병리학적 검사로 개 전파성 생식기 육종으로 진단되어 vincristine sulfate$(0.5 mg/M^{2})$을 1주 간격으로 3회 정맥주사를 실시하면서 혈액, 병리조직 검사 를 병행하였다. 종괴의 크기는 투여 후 1주부터 급격히 감소되었으며 조직소견상 종양세포는 세포질의 공포변성, 핵농축 및 붕괴, 혹은 apoptosis가 관찰되었다. 4주째 종괴는 완전히 소실 되어 치료를 중단하였고 혈액학적 검사 결과 부작용은 없었다. 마지막 투여후 10주째 건강한 새끼 4마리를 자연 분만하여 개 전파성 생식기 육종에서 vincristine 단독 투여로 우수한 치료 효과를 얻었다.

• Journal of Gastric Cancer
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• v.5 no.1
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• pp.29-33
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• 2005

Purpose: To determine the prognostic values of the hematologic parameters checked preoperatively in gastric cancer patients, we evaluated and compared the relationship between hematologic parameters and clinicopathologic factors of gastric cancer patient. Materials and Methods: The medical records of 357 consecutive patients who had undergone surgery for gastric cancer at the Department of Surgery, Hanyang University Hospital, between Dec. 2,000 and Dec. 2003 were reviewed. To exclude any adverse effect of invasive procedures to hematologic parameters, the samples taken immediately at outpatient department was used. The normal range of serum albumin was defined above 3.5 g/dl, serum hemoglobin above 12 g/dl, and serum platelet count under $400\times10^{3}{\mu}l$. Patients were defined as group 1 when any of these parameters was abnormal, and defined as group 2 when all parameters were normal. The relationships between hematologic parameters and survival rate were investigated. Results: The mean values of platelet count increased, but level of serum albumin and serum hemoglobin decreased significantly according to the advancement of the disease stage (P=0.000). The differences of depth of tumor invasion and lymph node metastasis between the group 1 and the group2 was statistically significant (P=0.001). Three-year survival difference between group 1 and group 2 was significant (P=0.037). Conclusion: The hematologic parameters checked preoperatively in patients of gastric cancer are simple and cheap, meanwhile reflect the general condition of the patients. Any presence of anemia, hypoalbuminemia, or thrombocytosis can predict the progression of the disease and poor survival rates.

• Journal of the korean veterinary medical association
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• v.24 no.1
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• pp.19-24
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• 1988

A lactating Holstein cow which did not have had responded to drug therapy during 2 months was clinically examined. Right atrial vegetative endocarditis was determined dy ultrasonographic diagnosis, and later it was confirmed at necropsy. An early systolic