Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Vincristine Therapy for Canine Transmissible Venereal Tumor in a Jindo Dog

Vincristine을 이용한 진도견의 전파성 생식기 육종 치료

  • Published : 1998.03.01
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Abstract

2세의 암컷 진돗개가 3개월간 혈액성 질분비물과와 외음부 종창을 주증으로 내원하였다. 질에 형성된 종괴는 조직병리학적 검사로 개 전파성 생식기 육종으로 진단되어 vincristine sulfate$(0.5 mg/M^{2})$을 1주 간격으로 3회 정맥주사를 실시하면서 혈액, 병리조직 검사 를 병행하였다. 종괴의 크기는 투여 후 1주부터 급격히 감소되었으며 조직소견상 종양세포는 세포질의 공포변성, 핵농축 및 붕괴, 혹은 apoptosis가 관찰되었다. 4주째 종괴는 완전히 소실 되어 치료를 중단하였고 혈액학적 검사 결과 부작용은 없었다. 마지막 투여후 10주째 건강한 새끼 4마리를 자연 분만하여 개 전파성 생식기 육종에서 vincristine 단독 투여로 우수한 치료 효과를 얻었다.

Keywords

References

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