• Journal of Yeungnam Medical Science
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• v.11 no.2
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• pp.352-362
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• 1994

To evaluate the effects of pregnancy-induced hypertension (PIH) to the iron status of fetuses, umbilical cord blood of 35 newborn infants borne by PIH mothers and of 37 normal term infants delivered at Yeungnam University Hospital from September 1, 1993 to September 30, 1994, were studied. The serum hemoglobin concentration of women with PIH was significantly higher than normal full-term pregnant women. There was no significant difference in serum hemoglobin concetration between women with PIH and normal full-term pregnant women and their newborn infants. There was no significant difference in serum hemoglobin concentration beween infants of women with PIH and normal full-term infants. The serum iron concentration of newborn infants of women with PIH was higher and the serum ferritin concentration of newborn infants of women with PIH was lower than normal full-term infants, but there were no significant difference between the two groups. The serum total iron-binding capactity and unsaturated iron-binding capacity of infants of women with PIH were significantly higher than normal full-term infants. The newborn infants of PIH women seemed that they might have occult depletion of iron store and need meticulous follow up during early neonatal period.

• Tuberculosis and Respiratory Diseases
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• v.66 no.2
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• pp.104-109
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• 2009

Background: Anemia is quite common in lung cancer patients and known to decrease the quality of life. Darbepoetin alfa is an erythropoiesis-stimulating protein approved for administration to cancer patients. This study examined the efficacy and safety of darbepoetin alfa in lung cancer patients with a hemoglobin concentration <10 g/dl during chemotherapy. Methods: Lung cancer patients (n=178) received darbepoetin alfa at doses of 1.91 ${\mu}g/kg$ per week until the hemoglobin concentration increased to >10 g/dl. The efficacy and safety were measured by comparing the hemoglobin concentration and assessing the adverse events. Results: After chemotherapy, the hemoglobin concentration decreased to 9.03${\pm}$0.64 g/dl. With the darbepoetin alfa treatment, the hemoglobin concentration increased to 10.09${\pm}$1.17 g/dl after 4 weeks reaching a peak hemoglobin concentration of 10.45${\pm}$1.18 g/dl. The changes in hemoglobin after 4 and 8 weeks with treatment were 1.08${\pm}$1.24 g/dl and 1.38${\pm}$1.59 g/dl (p<0.01). At least a 1 g/dl or more increase in hemoglobin was observed in 62.4% of patients. There were no serious adverse effects except for some mild reactions. Conclusion: Darbepoetin alfa administered to lung cancer patients appears to be an effective, well-tolerated treatment for chemotherapy induced anemia.

• Clinical and Experimental Pediatrics
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• v.45 no.3
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• pp.362-369
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• 2002

Background : Anemia is still the most common nutrient deficiency worldwide, especially in adolescence because of an insufficient supply of iron, an increased iron requirement due to accelerated physical growth and blood loss due to menstruation in girls. This study was designed to assess the anemia and serum iron status of middle school girls. Methods : Hematologic examinations, physical examinations and questionnaires were performed for middle school girls in 1990, 1997, 1999 and 2000. Anemia was defined as a serum hemoglobin level of less than 11.5 g/dL. Iron deficiency was defined as a serum ferritin level of less than 10 ng/mL. Iron deficiency anemia was defined as anemia plus one of the following; MCV less than 78 fL, Ferritin level less than 10 ng/mL or Transferrin saturation rate less than 10%. Results : There was no significant difference in mean Hb between urban and rural areas and decreases in mean Hb as with age. The prevalence of anemia decreased by year; 13.5% in 1990, 6.9 % in 1997, 6.0% in 1999, and 5.7% in 2000. It was high in high school girls(10.1% in 1997 and 12.6% in 2000). The prevalence of iron deficiency decreased by year; 36.1% in 1990, 13.9% in 1997, 13.3% in 1999, and 23.2% in 2000. It was 21.3% in 1997 high school girls and 37.8% in 2000. The prevalence of iron deficiency anemia(IDA) decreased by year; 10.0% in 1990, 4.6% in 1997, 8.3% in 1999, and 6.1% in 2000. It was 11.6% in 1997 high school girls and 18.6% in 2000. Conclusion : Although the prevalence of iron deficiency decreased during this period, the prevalence of anemia in the elder adolescence girls was high. Two things are recommended; first, it is necessary to screen for anemia in middle school girls and high risk groups, second, it is important to evaluate the knowledge of nutrition and to enforce effective nutritional education, leading to subjects receiving adequate nutrition.

• Nuclear Medicine and Molecular Imaging
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• v.43 no.1
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• pp.35-39
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• 2009

Purpose: Increased FDG uptake in the bone marrow has been reported in patients taking erythropoietin or granulocyte-colony stimulating factor (G-CSF). The aim of this study is to investigate the correlation between F-18 FDG uptake in the bone marrow and bone marrow finding, hematological parameters. Materials and Methods: Twenty patients who had diffuse FOG uptake at the bone marrow and received hematological examinations, bone marrow biopsy within 10 days before or after PET/CT were enrolled in this study. Among them, 11 patients were excluded; 4 patients received G-CSF or erythropoietin before PET/CT. Seven patients showed definite pathology in a bone marrow biopsy. The parameters included the measurement of WBC, hemoglobin, platelet and cellularity of the bone marrow. Results: Bone marrow FDG uptake was correlated with a low hemoglobin but not WBC, platelet. Histopathologic findings in marrow biopsies were various: normal finding (n=3), hyperplasia of granulocytic cells (n=2), eosinophilic hyperplasia (n=1), reactive lymphoid nodules (n=1), hypercelluar marrow (n=1), hypocelluar marrow (n=1). All patients except two, showed normal marrow celluarity. Conclusion: FOG uptake by bone marrow correlated with anemia but not WBC, platelet, bone marrow cellularity.

• Journal of environmental and Sanitary engineering
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• v.15 no.3
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• pp.37-43
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• 2000

The purpose of this experimental study examine characteristics of blood pigments removal of butchery wastewater by heat processed eggshell, compare activated carbon with its efficiency. Calcined eggshell were classified into four kinds of mesh as HPES-32(Heat Processed Eggshell 32 $mesh=500{\mu}m$), HPES-48($300{\mu}m$), HPES-150($180{\mu}m$) and HPES-150($106{\mu}m$). And two contacting process of CMFA(Complete Mixing Float Adsorption) and FLFA(Fixing layer Flow Adsorption) Were used for getting removal efficiency of blood pigments. In case of using CMFA process, the removal efficiency of blood pigments was occurred as HPES-80>HPES-150>HPES-32, but in case of using FLFA process was occurred as HPES-150>HPES-80>HPES-48>HPES-32. The two results between CMFA and FLFA were differ in strength of removal efficiency of blood pigments.

• Proceedings of the Korean Information Science Society Conference
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• 2011.06c
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• pp.172-175
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• 2011

본 연구에서는 현장검사 (Point-of-Care Testing, POCT)를 목적으로 측방 유동 검사 스트립의 피크들을 분리하는 템플릿 정합법을 제안한다. 템플릿은 스트립의 제어 리건드 선과 대상 리건드 선 간격으로 떨어져 있는 두 개의 펄스로 구성된다. 이 템플릿을 스캔신호와 정합시켜 최대 응답 위치에서 피크들의 중심을 찾고, 주어진 위치에서 피크들을 분리한다. 제안한 방법을 바디텍메드사의 당화 혈색소 면역 검사 스트립과 동사의 형광 스트립 리더기에 적용하여 농도 측정 성능에 미치는 영향을 기존에 구현된 방법과 비교 검토하였다. 실험 결과 본 연구에서 제안한 방법은 장치나 검사 스트립에 종속적인 매개변수가 필요한 기존 방법과 동등한 성능을 보였다.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.12 no.1
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• pp.10-15
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• 2009

Purpose: The manner of rectal bleeding of auto-amputated polyps (AP) is similar to juvenile polyps (JP) or Meckel's diverticula (MD). We conducted this study to characterize the clinical spectrum of AP. Methods: Fourteen patients were enrolled this study who were diagnosed AP due to painless rectal bleeding. The clinical data of AP was assessed and then compared with the clinical data of JP and MD retrospectively. Results: The prevalence of AP was 10.4% (14/135) and high in younger patients compared with that of JP (p=0.042 below 2 years). Whereas JP was more common in patients aged 2 to 5 years (p=0.005). Male was predominant in AP (p=0.008 AP vs JP). The manner of rectal bleeding in AP group was sudden and transient. There was no significant difference in time interval between onset of rectal bleeding and diagnosis between the 3 groups. However AP was diagnosed in 9 patients (64.3%) within 7 days after onset of rectal bleeding, but JP was diagnosed in 5 patients (4.1%) in the same period (p<0.001). All of AP were located in the rectum and the sigmoid colon. The mean hemoglobin was 11.3${\pm}$1.5 g/dL in AP, 11.8${\pm}$1.3 g/dL in JP, and 8.4${\pm}$1.2 g/dL in MD (p<0.001, only significant in MD). Conclusion: AP may be considered in male older than 1 year with transient and sudden onset or increase of painless rectal bleeding without drop of hemoglobin level.

• Clinical and Experimental Pediatrics
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• v.46 no.9
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• pp.883-888
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• 2003

Purpose : The etiology of hemolytic anemia can be classified as either cellular or extracellular defects of red blood cells. The aim of this study was to investigate the clinical and laboratory findings of hemolytic anemia concerning its etiological classification. Methods : Clinical and laboratory findings of the patients with hemolytic anemia treated from January 1987 to May 2002 at Severance Hospital were analyzed retrospectively. They were divided into two groups based on the types of red cell defects(group I : erythrocytic defect, group II : extraerythrocytic defect). Results : Twenty one cases were included in group I, thirty four cases in group II, and three cases were unclassified. In group I, nineteen cases(90.5%) were diagnosed as hereditary spherocytosis and were proved to have red cell membrane disorders while two cases(9.5%) were shown to have red cell enzyme deficiencies. In group II, thirteen cases(38.2%) were noted as autoimmune hemolytic anemia, eleven cases(32.4%) as traumatic or microangiopathic hemolytic anemia, four cases(11.8%) as drug induced hemolytic anemia, two cases(5.9%) were related with systemic lupus erythematosus and one case(2.9%) with malignancy. Hemoglobin at the time of diagnosis(7.5 g/dL vs. 6.2 g/dL, P<0.05) and the incidence of splenomegaly(85.7% vs. 18.2%, P<0.05) were higher in group I though blood urea nitrogen(9.0/0.4 mg/dL vs. 27.8/1.6 mg/dL, P<0.05) was higher in group II. Conclusion : Comparing the clinical features of pediatric hemolytic anemia, we concluded as following : In cases associated with extraerythrocytic defect, blood tests revealed significant initial lower hematocrit with higher level of BUN and Cr while cases with erythrocytic defect, splenomegaly were more common noted.

• Journal of agricultural medicine and community health
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• v.27 no.1
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• pp.165-181
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• 2002

The purpose of this survey was to assess the nutritional status of preschool children a county of Jeju Island. This study used health examinations results for preschool aged children, performed by the public health center of Pukjeju-gun in Jeju-do for over three years from 1999 to 2001, of children in kindergartens and children homes. The target children totaled 5,990 from the ages three to six. For a control group, 316 children from the nearby Jeju-city areas were included as well. The items of this research included height, weight, and hemoglobin values. 1. The average height of boys from ages three to six were 96.35cm, 102.14cm, 109.94cm, 111.00cm respectively, and girls were 94.96cm, 100.93cm, 108.33cm, 110.54cm respectively. The average weights of boys from ages three to six were 15.42kg, 16.93kg, 19.65kg, 19.67kg respectively, and the weight of girls were 14.90kg, 16.45kg, 18.88kg, 19.50kg respectively. 2. The percentages of children who did not reach 90% of the Korean standard height were 4.3% in boys 4.1% in girls. The percentages of children with less than 80% of the Korean standard weight were 7.6% in boys and 6.8% girls. The percentages of children over 120% of Korean standard weight were 10.4% in boys and 11.4% in girls. 3. As for the obesity level, the percentage of boys under-weighed(under 10% for standard weight for height) were 11.6% and girls, 9.5%, and the percentages of boys and girls with obesity($\geq$20%) were 3.6% and 4.4% respectively. 4. The mean hemoglobin value of boys were 11.83g/$d\ell$ and girls, 11.83g/$d\ell$. These were lower than the value of average normal Korean children (12.5g/$d\ell$). The mena hemoglobin values of the children in Pukjeju-gun were considerably lower than that of the children living in Jeju-city(12.3g/$d\ell$) as well. Anemia of Children of Pukjeju-gun were estimated at 38.1%(male) and 37.2%(female), by using Hemoglobin level(<11.5g/$d\ell$ 5. The rates of children included within the normal range of obesity level in Jeju-city and Pukjeju- gun were boys 80.2%, 71.6% in boys, and 77.4%, 72.4% in girls. The percentage of children living in PukJeju-gun included within the normal range were considerably low. 6. There were no changes in the Body Mass Index (BMI) during the three years from 1999 to 2001, but the percentage of children with anemia significantly increased. Health care for preschool aged children, especially in the rural areas, is very important. Centering on public health centers, it is necessary to systematically promote health care in the rural areas.

• Journal of Yeungnam Medical Science
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• v.11 no.1
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• pp.42-48
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• 1994

Among the erythrocyte membrane defects, hereditary spherocytosis is the most common. The erythrocyte membrane defect results from a deficiency of spectrin, the most important structural protein in red cell. Hereditary spherocytosis often presents with hemolytic anemia, jaundice, moderate splenomegaly. Diagnosis is established by the presence of spherocytes in the peripheral blood, reticulocytosis, an increased osmotic fragility, and a negative Coombs test. In children, splenectomy is usually performed after age 6 years but can be done at a younger age if warranted by the severity of the anemia and the need for frequent transfusions. In the period December 1987 to Agust 1993, 9 patients with hereditary spherocytosis underwent splenectomy and the following results were obtained. 1. Nine patients were comprised of five males and four females. 2. Five patients(55.6%) had been admitted to our hospital during age 6-10 years. 3. Four of the nine patients had autosomal dominant inheritance with variable expression. The other five patients had no known inheritance. 4. The diagnosis of the spherocytosis was based on the increased osmotic fragility and increased autohemolysis of the erythrocytes, as well as on the appearance of spherocytes in the peripheral blood smear. 5. In all cases splenectomy was performed. Two patients had concomitant gall stones and choledocholithiasis, respectively. One patient with concomitant gall stones underwent simultaneous cholecystectomy and splenectomy. The other patient associated with choledocholithiasis underwent splenectomy, cholecystectomy, choledocholithotomy, and T-tube drainage. 6. Complete hematologic recovery was obtained by the splenectomy in all cases. 7. Postoperative complication was not occurred.