• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.20 no.2 s.33
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• pp.116-131
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• 2007

황기건중탕은 보비익기(補裨益氣) 및 거습열(祛濕熱)하는 효능(效能)으로 신체(身體)의 허약(虛弱)을 개선하며 염증(炎症)을 유발할 수 있는 외사(外邪)의 침입을 방어하여 인체의 면역기능(免疫機能)을 강화하는 처방으로 면역관련 세포중 하나인 microglial cell를 대상으로 면역세포에 황기건중탕이 어떠한 효능을 발휘하는 지를 살펴보았다. 물로 전탕(煎湯)한 황기건중탕을 여과한 후 실험한 결과 BV2 microglial cells에서 LPS로 자극하여 염증을 유발하는 주요 물질인 NO의 분비를 세포독성 없이 억제하였다. 또한NO를 생성하는 효소인 Cox-2의 발현도 감소시켰다. 그리고 기타 염증전구 물질들이 $TNF-{\alpha}$, $IL-1{\beta}$, IL-12도 황기건중탕의 용량이 증가함에 따라 의존적으로 감소함을 알 수 있었다. 이러한 결과를 보아 황기건중탕은 면역관련세포인 microglial cell에서 염증 관련 인자들의 분비 및 생성을 억제를 통하여 면역관련 상태를 개선시키는 것으로 사료된다.

• Journal of Korean Medical classics
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• v.18 no.2 s.29
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• pp.70-84
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• 2005

장석순(張錫純)$(1860{\sim}1933)$시청말민초시기적의가(是淸末民初時期的醫家), 통과대기소저(通過對其所著)${\ulcorner}$의학충중참서록(醫學衷中參西錄)${\lrcorner}$적제오기제삼권중(的第五期第三卷中), 관우(關于)'논간병치법'(論肝病治法)내용적연구(內容的硏究), 소득출적결론시(所得出的結論是), 기대간병적치법가개괄위평간법(其對肝病的治法可槪括爲平肝法), 산간법(散肝法), 화간법(化肝法), 유간법(柔肝法), 진간법(鎭肝法), 염간법(斂肝法), 보간법(補肝法), 완간법등팔법(緩肝法等八法). 평간법인위(平肝法認爲), 인지원기찰근우신, 맹아우간이유약역손(萌芽于肝而柔弱易損), 고불가관파간기(故不可關破肝氣). 차내경중(且內經中)'궐음불치(厥陰不治), 구지양명(求之陽明)'여금궤중(與金櫃中)'당선실비(當先實脾)', 도이서조간기위관건(都以舒調肝氣爲關鍵), 인차이승강탕여배비서간탕등립방(因此以昇降湯與培脾舒肝湯等立方), 차작위평간약중시료계지(且作爲平肝藥重視了桂枝). 산간법인위(散肝法認爲), 간위목장(肝爲木臟), 구유직향이성향상신전(具有直向而性向上伸展), 소이부응기성(所以符應其性), 이용신미산지(而用辛味散之), 즉가위보법(卽可爲補法). 작위산간약(作爲散肝藥), 기선용인진여맥아(其善用茵蔯與麥芽). 화간법시재간체증대(化肝法是在肝體增大), 혹간중유열(或肝中有熱), 혹간기울체(或肝氣鬱滯), 혹옹창시(或壅脹時), 작위산간달울지법(作爲散肝達鬱之法), 사용료시호(使用了柴胡), 유향(乳香), 몰약(沒藥), 차이활혈약당좌약사용적치법(且以活血藥當佐藥使用的治法), 우기중시료삼칠근(尤其重視了三七根). 유간법시근거(柔肝法是根據)'간악조희윤(肝惡燥喜潤), 조칙간체판경이간화간기즉망동(燥則肝體板硬而肝火肝氣卽妄動), 윤칙간체유화이간화간기장영정(潤則肝體柔和而肝火肝氣長寧靜)'적이론(的理論), 인위재치료중가선용당귀(認爲在治療中可選用當歸), 작약(芍藥), 백자인(柏子仁), 현삼(玄蔘), 구기자(枸杞子), 아교(阿膠), 별갑(鱉甲), 단불가장기사용(但不可長期使用). 기진간법시(其鎭肝法是), 재치료경간(在治療驚癎), 전광(癲狂), 현운(眩暈), 뇌충혈제증시(腦充血諸證時), 작위대표처방선용료진간식풍탕(作爲代表處方選用了鎭肝熄風湯). 염간법시근거기(斂肝法是根據其)'범인원기지탈(凡人元氣之脫), 개탈재간(皆脫在肝)'적독특이론(的獨特理論), 이내복탕등작위대표처방진행치료적방법(以來復湯等作爲代表處方進行治療的方法), 차대제양사용료산수유(且大劑量使用了山茱萸). 보간법시재간기허약이실기조달시사용적치법(補肝法是在肝氣虛弱而失其條達時使用的治法), 인위황기시보간적주약. 완간법시의거(緩肝法是依據)‘간고급(肝苦急), 급식감이완지(急食甘以,緩之)'지설이정적치법(之說而定的治法), 인위단미감초시대표약(認爲單味甘草是代表藥).

• The Journal of Pediatrics of Korean Medicine
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• v.24 no.3
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• pp.58-67
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• 2010

Objectives: The objective of this study was to evaluate the correlations between the Weak Children Questionnaire result and K-CBCL score. Also, this study was designed to define the cut off values of Heart Weak Scores by using 'K-CBCL' which represents the total behavior problems scores 50T in order to detect Heart Weak in Children Methods: 271 elementary school students in Daejeon answered the questionnaire and the data was analyzed. Results: There were high correlations between Heart Weak Score and K-CBCL which in a total behavior problems scores. The cut off values of Heart Weak Score, K-CBCL, a total behavior problems scores 50T, were calculated by ROC curve analysis. To diagnose as a Heart Weak Children, the correspondent cut off values for Heart Weak Score were 11 in boys and 8 in girls. Conclusions: To diagnose as a Heart Weak in Children, the correspondent cut off values for Heart Weak Score were 11 in boys and 8 in girls.

• Journal of Veterinary Clinics
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• v.31 no.5
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• pp.407-411
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• 2014

A 12-year-old castrated male Pekingese dog was presented with weakness, exercise intolerance, and an episode of coughing started 2 weeks earlier upon presentation. Physical examination revealed a grade II/VI left systolic heart murmur. Echocardiographic examination revealed a pericardial effusion and a mass at the heart base located beside the left atrium. The mass beside the left atrium was also visible on the thoracic radiograph after drainage of the pericardial effusion. An aortic body tumor was definitely diagnosed based on postmortem histopathological examination and immunohistochemical staining for specific markers. The dog lived 234 days after diagnosis with only medical management and without recurrence of the pericardial effusion.

• The Journal of Pediatrics of Korean Medicine
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• v.15 no.1
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• pp.267-270
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• 2001

소아천식은 기도의 만성 염증 및 과민반응을 특징으로 나타내고 있어 염증을 일으키거나 알레르기 반응을 일으키는 물질로부터 차단하는 방법이 효과적임을 현대의학에서 이미 밝히고 있다. 한의학에서는 천증(喘證)에 본디 뿌리 깊은 근원(천유숙근(喘有夙根))이 있다고 간주하여 허약한 체질은 내적인 요인이고, 풍한침습(風寒侵襲)은 유발요인이며, 담음복폐(痰飮伏肺)와 신기휴허(腎氣虧虛)는 재발의 근본이라고 하였다. 본 연구에서는 소아 천식에 구마황(灸麻黃), 은행(銀杏), 건강(乾薑), 오미자(五味子), 백전(白前), 구백부(灸百部), 소자(蘇子) 등을 사용하였고, 경우에 따라 황기(黃?) 혹은 선령비(仙靈脾)를 추가하여 正氣(正氣)를 강화시키는 목적으로 사용하였다. 약리학적 연구에 따르면 마황과 건강, 오미자 등은 모두 기도의 염증세포 침윤(浸潤)를 억제하고 항알레르기 효과가 있으며, 건강과 오미자는 또한 히스타민에 대한 길항효과(拮抗效果)도 있는 것으로 알려져 있다. 은행 추출물은 혈소판 활성화 수용체에 대한 길항작용을 갖고 있으므로 이러한 물질들로 인한 기관지의 경련을 방지하여 천식증상을 왕화시킨다. 구백부(灸百部)는 지해(止咳)효과가 뛰어나다. 소아천식에 대한 치료는 표본동치(標本同治)의 원칙을 지키며, 증상이 완화된 단계에서도 중약 투여를 1-2개월 지속시키는 것이 중요하다. 소아에게 있어서 천식증상이 완화된 후 어혈(瘀血) 상태가 성인에 비해 심하지는 않지만, "구병필어(久病必瘀)"의 결과에 유의할 필요가 있다. 천식이 장기간 지속되면 필히 혈액순환 장애가 수반되므로 천궁(川芎)이나 단삼(丹蔘) 등의 활혈제(活血劑)를 가미하여 사용하면 효과를 높일 수 있다. 결론적으로 소아의 천식은 항염증, 평천(平喘), 화담(火痰), 지해(止咳)와 더불어 보신익기화어(補腎益氣化瘀)의 약물을 병행하여 사용하는 것이 바람직하며, 단순한 중약 투여는 일부 양약에 의한 소아성장에 미치는 영향을 피할 수 있어 더 많은 임상연구가 이어져야 한다.

• The Journal of Pediatrics of Korean Medicine
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• v.28 no.2
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• pp.1-22
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• 2014

Objectives The purpose of this study is to investigate the relationship between weak children and growth indices. Methods One hundred twenty-six of the first and the second grade elementary school students who didn't have to develop yet their secondary sexual characteristics answered the questionnaire. Their bone age and body composition were measured. Results 1. According to the Weak Children questionnaire analysis, respiratory problem was one of the biggest problems in the weak children group (35.7%), followed by digestive problems (23.0%), psycho-neurological problems (22.2%), neuromotor problems (9.5%), and urogenital problems (8.7%). 2. From the comparison between growth indices of weak children and that of normal children are as follows: 1) The group of children who had problem in their digestive system had lower growth indices than the normal average children group. The growth indices includes mean height, weight, total body water, protein mass, mineral mass, body fat, skeletal muscle mass, body fat percentage, body mass index (BMI), and basal metabolic rate (BMR). 2) The children who had urogenital weakness had lower mean height, RH (Recent Height), RH - MPH {Recent Height(%) - Mid-Parental Height(%)}, RUS (Radius, Ulna and Short bone) score, weight, protein mass, body fat, BMI, and visceral fat than the normal children group. 3. The results of the multiple comparisons of growth indices and weak children groups are as follows: 1) Digestive weak children were the lowest in total body water, protein mass, mineral mass, skeletal muscle mass, and basal metabolic rate. 2) Urogenital weak children were the lowest in height, RH, RH - MPH, RUS score, and weight. Conclusion These results showed that children's growth is strongly correlated to their own growth problems, especially to those children who have digestive and urogenital problems. Therefore, this may be an effective way for children growth treatment in Korean medicine to treat weak symptoms.

• Korean Journal of Health Education and Promotion
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• v.25 no.1
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• pp.39-53
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• 2008

Objectives: The purpose of this study was to investigate the effects of muscle strength exercise on physical function and quality of life in the frail elderly. Methods: Subjects were 401 frail elderly people selected by the screening tool developed by Japan department of Health, Labor and welfare. The program was carried out for twice a week for 12 weeks. Data were analyzed with paired t-test and t-test using STATA program. Results: 1) Muscle strength exercise for the frail elderly showed statistically significant effects on improving grip strength, single leg stand, TUG(Time up to go) and quality of life. 2) The grip strength and single leg stand indicators showed statistically significant effects between the over 75 years old and the under 75 years old. However, TUG and quality of life indicators didn't show statistically significant effects between the over 75 years old and the under 75 years old. Conclusions: The muscle strength exercise for the frail elderly people was very effective on improving grip strength, single leg stand, TUG and quality of life and especially, it was more effective in the over 75 years old than in the under 75 years old.

• Journal of Veterinary Clinics
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• v.24 no.2
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• pp.244-246
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• 2007

Clinical and histopathologic features of idopathic polymyositis in twenty-month-old Alaskan malamute dog are described. The clinical signs were progressive exercise intolerance with acute exacerbation of weakness, muscle atrophy, synchronous pelvic limb gait, short stiff steps and tip-toeing as like walking on eggshells. Physical and clinical examination revealed no evidence of neurologic, skeletal and secondary muscular disorders associated with other diseases. Therefore muscle biopsy was performed at the most severe muscle atrophy lesions to confirm by histopathology. Histopathologic findings documented mononuclear cell infiltration and necrosis of muscle fiber and it was diagnosed as idiopathic polymyositis. Initial treatment was focused on pain relief. Prednisone at immunosuppressive dose (2 mg/kg) was administered orally twice daily. After 3 weeks of starting treatment, the patient showed improvement of gait, appetite, exercise as well as gradually return to normal state of hematologic and serum chemistry profiles.

• FLOWER RESEARCH JOURNAL
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• v.16 no.2
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• pp.93-101
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• 2008

Research materials used were 55 kinds of flower teas proven in medicinal efficacy based on publications in oriental medicinal science. Efficacy in oriental medical science of the selected plants was classified into 11 groups, exterior-relieving herbs, removing dampness by promoting diuresis herbs, heatclearing herbs, purgative herbs, tonic herbs, qi-activating herbs, herbs as blood-tonics, herbs warming the intestine, qi-regulating herbs, herbs for removing dampness by means of aromatics, and herbs activating blood. Moreover, they were assorted by fever (hot, warm, slightly warm, common, cool, and cold), flavor (sweet, bitter, spicy, sour, and salty), and toxicity (toxic or nontoxic). Generally, flower teas have been known to be drinkable by all people. However, it is important to select proper flower teas considering physical constitution and health condition of the individual. One should be cautious in drinking flower teas containing toxic ingredients and weak people should be prohibited drinking them. Further clinical study on efficacy of flower teas will contribute to commercialization of these teas.

• Journal of Korean Philosophical Society
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• v.143
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• pp.87-118
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• 2017

In this paper, I will show several theoretical nonconformities which can be found in P. Singer's concept of human beings. As we know, P. Singer is a well-known animal liberalist. On the one hand, Singer regards man as a subordinate being to nature and on the other, as a transcendent being. This is the first inconsistency of Singer's concept of man. His second inconsistency is related to his position on the power of reason. He believes that it is the product of evolution, and at the same time that it is a power to resist the blindness of evolution. Thirdly, he also exposes the contradictory attitude in evaluation on man's moral ability. Considering these three contradictions, it becomes clear that Singer has failed to prove his claim that there is no qualitative difference between human beings and animals. Despite the popularity of his theory, I believe the theoretical foundation of Singer's animal liberation theory is rather weak. The reason for revealing the weakness of Singer's theory is not to return to the practice of mercilessly handling animals but to show that it is wrong to undermine human dignity under the guise of animal welfare.