Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
권호 표지

Clinical and Immunohistochemical Characteristics of Malignant Aortic Body Tumor in a Pekingese Dog

페키니즈에서 발생한 악성 대동맥체 종양의 임상양상과 면역조직화학적 특성

  • Kim, Won-Jung (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University) ;
  • Kim, Seung-Gon (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University) ;
  • Lee, Chang-Min (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University) ;
  • Kim, Dae-Young (Department of Veterinary Pathology, College of Veterinary Medicine, University of Missouri-Columbia) ;
  • Park, Hee-Myung (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University)
  • Accepted : 2014.07.28
  • Published : 2014.10.31
Download PDF
⟨ Previous Next ⟩

Abstract

A 12-year-old castrated male Pekingese dog was presented with weakness, exercise intolerance, and an episode of coughing started 2 weeks earlier upon presentation. Physical examination revealed a grade II/VI left systolic heart murmur. Echocardiographic examination revealed a pericardial effusion and a mass at the heart base located beside the left atrium. The mass beside the left atrium was also visible on the thoracic radiograph after drainage of the pericardial effusion. An aortic body tumor was definitely diagnosed based on postmortem histopathological examination and immunohistochemical staining for specific markers. The dog lived 234 days after diagnosis with only medical management and without recurrence of the pericardial effusion.

12살령 중성화 수컷 페키니즈 개가 허약, 운동불내성과 2주전부터 시작한 기침을 주증으로 내원하였다. 신체검사에서 좌측 수축기성 심잡음(grade II/VI) 이 확인되었고, 심장초음파 검사에서 심낭수와 좌심방 주변 심기저부에 종괴가 관찰되었다. 심낭수천자 후에는 흉부방사선 상에서도 좌심방 옆으로 종괴가 확인되었다. 사후 부검을 통한 조직학적 검사 및 면역조직화학 염색을 통해 대동맥체 종양으로 진단되었다. 본 환축은 진단 후 내과적 치료만을 받았으며, 심낭수의 재발 없이 234일을 생존하였다.

Keywords

References

  1. Aresu L, Tursi M, Iussich S, Guarda F, Valenza F. Use of S-100 and chromogranin A antibodies as immunohistochemical markers on detection of malignancy in aortic body tumors in dog. J Vet Med Sci 2006; 68: 1229-1233. https://doi.org/10.1292/jvms.68.1229
  2. Aupperle H, Marz I, Ellenberger C, Buschatz S, Reischauer A, Schoon HS. Primary and secondary heart tumors in dogs and cats. J Comp Path 2007; 136: 18-26. https://doi.org/10.1016/j.jcpa.2006.10.002
  3. Brown PJ, Rema A, Gartner F. Immunohistochemical characteristics of canine aortic and carotid body tumors. J Vet Med A 2003; 50: 140-144. https://doi.org/10.1046/j.1439-0442.2003.00498.x
  4. Doss JC, Grone A, Capen CC, Rosol TJ. Immunohistochemical localization of chromogranin A in endocrine tissue and endocrine tumors of dogs. Vet Pathol 1998; 35: 312-315. https://doi.org/10.1177/030098589803500413
  5. Ehrhart N, Ehrhart EJ, Willis J, Sisson D, Constable P, Greenfield C, Manfra-Maretta S, Hintermeister J. Analysis of factors affecting survival in dogs with aortic body tumors. Vet Surg 2002; 31: 44-48. https://doi.org/10.1053/jvet.2002.29989
  6. McGavin MD, Zachary J. Pathologic basis of veterinary medicine. 4th ed. Philadelphia: Mosby Elsevier. 2007: 739-740.
  7. Noszczyk-Nowak A, Nowak M, Paslawska U, Atamaniuk W, Nicpon J. Cases with manifestation of chemodectoma diagnosed in dogs in department of internal diseases with horse, dogs, and cats clinic, veterinary medicine faculty, university of environmental and life science, Wroclaw, Poland. Acta Vet Scand 2010; 52: 35-41. https://doi.org/10.1186/1751-0147-52-35
  8. Park C, Yoo JH, Kim DY, Park HM. Spontaneously occurring chemodectoma in a Yorkshire terrier dog. J Vet Clin 2008; 25: 187-191.
  9. Rajagopalan V, Jesty SA, Craig LE, Gompf R. Comparison of presumptive echocardiographic and definitive diagnoses of cardiac tumors in dogs. J Vet Intern Med 2013; 27: 1092-1096. https://doi.org/10.1111/jvim.12134
  10. Ware WA, Hopper DL. Cardiac tumors in dogs: 1982-1995. J Vet Intern Med 1999; 13: 95-103.
  11. Yamamoto S, Fukushima R, Hirakawa A, Abe M, Kobayashi M, Machida N. Histopathological and immunohistochemical evaluation of malignant potential in canine aortic body tuomrs. J Comp Path 2013; 149: 182-191. https://doi.org/10.1016/j.jcpa.2012.12.007
  12. Yates WDG, Lester SJ, Mills JHL. Chemoreceptor tumors diagnosed at the western college of veterinary medicine 1967-1979. Can Vet J 1980; 21: 124-129.