• Proceedings of the Korean Society of Applied Pharmacology
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• 1994.04a
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• pp.232-232
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• 1994

인삼이 면역계 질환의 일종인 과민성 반응에 대한 치료약으로서의 가능성을 연구하기 위해서 in viva와 in vitra실험을 수행하였다. in vitra실험으로서는 hyaluronidase의 활성을 지표로 삼았으며, in viva실험에서는 mouse이각, rat등피부, 복강 비만세포, 그리고 guinea pig의 ileum에서 면역반응에 대한 아답타겐의 작용을 관찰하였다. in uitra 실험에서는 hyaluronidase와 histamine 분비를 항알레르기 작용의 지표로 사용하였다. hyaluronidase의 경우 그 활성은 Cacl2로 활성화 시키기 전이나 후에 모두 아답타겐(100, 50, 및 10 mg/ml)에 의해서 현저하게 억제되었다. 한편 rat 복강 비만 세포에서의 histamine유리 시험에서는 아답타겐(0.5, 1, 5mg/ml)이 histamine유리가 증가되었다. Guinea pig의 ileum 평활근에서는 아답타겐이 평활근 자극 작용없이 항히스타민 효과률 나타내었다. in uiua 실험의 첫 단계로 우리는 혈관 투과성에 미치는 아답타겐의 효과를 mouse 이각과 rat 등피부에서 관찰하였다. Mouse이각에서의 실험에서는 hoistamine, serotonin, 그리고 LTC4로 challenge하여 관찰한 결과 histamine과 serotonin의 경우, 혈관투과성 항진은 아답타겐(50-400mg/m1)에 의해서 유의성있게 억제되었으나, rat 등 피부에서는 mouse에서와는 달리 48-hr PCA가 증가 되었고, histamine에 의한 혈관투과성 항진은 아답타겐에 의해 영향을 받지 않았다. 반면에 compound 48/80과 serotonin에 의한 혈관투과성 항진은 mouse 의 경우에서처럼 아답타겐에 의해 억제되었다.

• Journal of the Korean Society of Costume
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• v.58 no.9
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• pp.68-80
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• 2008

The purpose of this study is, as a prior stage to produce manufactured medical goods, to examine literature on the medicinal efficacy of natural dyes that can be used to produce medical goods, and to experiment the possibility of dyeing of some medicinal ingredients that have not been used as natural dyes until now. For this study, 44 types of medicinal ingredients such as Gyomaekchil(buckwheat), Nohoiyeob(aloe), Pogongyounng(dandelion), and Jibooja(broom cypress) were used. First, they were classified by a thermal sensation such as hot, warm, neutral, cool, and cold feeling, and by their characteristics of complex tastes such as sweet, sour, bitter, salty, pungent, astringent, and flat tastes. And then they were dyed with two types of mordant, resulting to a total of 132 types of dyed cloths. The 132 dyed cloths could be classified as five types of colors: 89 types(67.42%) of yellow series, 25 types(18.94%) of yellow-red series, 6 types(4.55%) of green-yellow series, 6 types(4.55%) of purple series, and 6 types(4.55%) of purple-blue series. The results of this study found that there were various medicinal ingredients that had efficacy to cure skin disorders and also could be used as natural dyes.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• v.9 no.2
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• pp.447-450
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• 2005

This paper describes an implementation of system based on ZIGBEE wireless communication technique to prevent for diseases of skin ailments and respiratory ailments as sensing the air pollutions that breaks out in the inside and purifying. ZIGBEE wireless communication technique has features - low battery consumption, low cost, acceptance of the maximum 256 node and simple protocol structure of below 32Kbyte. Hardware platform is implemented by using ATmega128L in ATmel corporation and 2.4GHz RF-IC CC2420 in Chipcon corporation and dust sensor(GP2Y1010AU) and gas sensor(GSBT11) that confirm degree of inside air pollution for ZIGBEE wireless communication technique.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.46 no.1
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• pp.23-29
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• 2020

The skin is colonized by a large number of microorganisms with a stable composition of species. However, disease states of skin such as acne vulgaris, psoriasis, and atopic dermatitis have specific microbiome compositions that are different from those of healthy skin. The target modulation of the skin microbiome can be a potential treatment for these skin diseases. Quorum sensing (QS), a bacterial cell-cell communication system, can control the survival of bacteria and increase cell density. Also, QS affects the pathogenicity of bacteria such as biofilm formation and protease production. In this study, we confirmed anti-QS activity of Amorepacific patented ingredients, which are Lactobacillus ferment lysate (using Lactobacillus plantarum APsulloc 331261, KCCM 11179P) through bio-reporter bacterial strain Chromobacterium violaceum. The purple pigment production of C. violaceum controlled by QS was reduced 27.3% by adding 10 ㎍/mL of Lactobacillus ferment lysate (freeze dried). In addition, the Lactobacillus ferment lysate increased growth of Staphylococcus epidermidis 12% and decreased growth of Pseudomonas aeruginosa 38.5% and its biofilm formation 17.7% at a concentration of 10 ㎍/mL compared to the untreated control group. Moreover, S. epidermidis was co-cultured with the representative dermatological bacterium Staphylococcus aureus in the same genus, the growth of S. epidermidis was increased 134 % and the growth of S. aureus was decreased 13%. These results suggest that fermented lysate using Lactobacillus plantarum APsulloc 331261 may be useful as a cosmetic ingredient that can control the balance of skin microbiome.

• The Journal of the Korea institute of electronic communication sciences
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• v.13 no.3
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• pp.661-668
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• 2018

Biomedical signals using skin resistance have different characteristics according to stress diseases. Biological diagnostic devices for diagnosing stress diseases have been developed by using these characteristics, and devices have been developed so that the signals measured by the skin storage meter can be easily analyzed. Experts in the field will look directly at the output signal to determine the likelihood of any stress disorder. However, it is very difficult for a person to accurately determine whether a person to be measured has a stress disorder by analyzing a bio-signal measured by each person to be measured, and the result of the judgment is very likely to be wrong. In order to solve these problems, we implemented the function of determining the signal of a stress disorder by using the machine learning technique. SVM was used as a classification method in consideration of low computing ability of measurement equipment. Training data and test data were randomly generated for each disease using error range 5 based on 13 diseases. Simulation results showed more than 90% decision accuracy. In the future, if the measurement equipment is actually applied to the patients, we can retrain the classifier with the newly generated data.

• Journal of Chest Surgery
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• v.37 no.7
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• pp.613-616
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• 2004

Systemic lupus erythemotosus (SLE) is an autoimmune disorder with dermal, renal, and cardiac manifestations. It frequently has cardiovascular complications such as pericarditis, myocarditis, and valvular heart diseases. Valvular heart diseases in SLE comes mainly in the form of mitral or aortic insufficiencies. Report of aortic stenosis is extremely rare. Surgical treatments of valvular heart disease in SLE are not done frequently because of complications in other organs. Aortic stenosis developed in a 59 year-old woman with SLE, and aortic valve replacement was done successfully.

• The Journal of Korean Obstetrics and Gynecology
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• v.29 no.1
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• pp.14-34
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• 2016

Objectives: The objective of this study was to evaluate the effects of cytotoxicity, skin regeneration, anti-wrinkle, whitening and skin moisturizing of Oncheongeum (OCE).Methods: The cytotoxicity of OCE lyophilized aqueous extracts (yield=13.82%) was observed against human normal fibroblast cells and B16/F10 murine melanoma cells by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium Bromide (MTT) assay, and skin regeneration and anti-wrinkle effects were also evaluated through the assay of collagen type I synthesis compared to the transformation of the growth factor (TGF)-β1, hyaluronidase, collagenase and matrix metalloproteinase (MMP)-1 inhibitory assays compared to oleanolic acid (OA), and elastase inhibitory effects compared to phosphoramidon disodium salt (PP). In addition, OCE’s whitening effects were measured by a tyrosinase inhibitory assay and melanin formation test in B16/F10 murine melanoma cells compared to arbutin, and skin moisturizing effects were observed through a mouse skin water content test, respectively. Results: No OCE treatment-related cytotoxic effects appeared on human normal fibroblasts and B16/F10 murine melanoma cells. OCE concentration-dependently increased the collagen Type I synthesis on human normal fibroblast cells, and also effectively inhibited hyaluronidase, elastase, collagenase and MMP-1 activities. In addition, OCE inhibited melanin production of B16/F10 murine melanoma cells and activity of tyrosinase. And significant and dose-dependent increases of skin water content were detected in OCE-treated mouse skin compared to vehicle control skins. Conclusions: OCE showed favorable and sufficient effects in skin regeneration, anti-wrinkle, whitening and skin moisturizing in this experiment. But more detail mechanisms and studies on the skin protective efficiency of in vivo are needed with the screening of active biological compounds in individual OCE herbs.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.46 no.1
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• pp.73-80
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• 2020

Psychological stress can affect the physiological condition of the skin and cause various cutaneous disorders. The stress hormone cortisol is secreted by various skin cells such as fibroblasts, keratinocytes, and melanocytes. Tight junctions (TJs) are cell-cell junctions that form a barrier in the stratum granulosum of mammalian skin. TJs can also affect other skin barriers and are affected by chemical, microbial, or immunological barriers. Stress can cause damage to the skin barrier. Interestingly, to our knowledge, there has not been any research demonstrating the involvement of TJs in this process. In this study, cortisol was used to treat keratinocytes to determine its role in regulating TJs. We found that cortisol damaged skin barrier function by regulating the gene expression and structure of TJ components. Cortisol also inhibited the development of the granular layer in a skin equivalent model. These results suggest that cortisol affects the skin barrier function by the regulation of TJs.

• The Journal of the Korea Contents Association
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• v.5 no.6
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• pp.230-237
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• 2005

In this paper, we are suggested a method that's a major topics in sports medicine. It is disease control, control and management of chronic degenerative disease, and promotion of health. We are analyze physical activity to scientific and quantitative a trainee at Wu-Shu gymnasium, for a suggested method. We are measured a quantity of physical activity by SenseWear-PRO2-Armband which develop body-media company. Armband include to skin temperature sensor, near-body temperature sensor, accelerometer, heat flux sensor, galvanic skin response sensor. Acquired data was recorded to storage in Armband. We are analyzed using InnerView Wearer Software in the Stored data to skin temperature, calorie expenditure, quantity of physical activity. The result of this analyzed, we are know that a man of long-term exercise expenditure energy at short time and if liveliness of physical activity was Increase in expenditure energy with increase skin temperature. Also, we are know that the heat flux after increase expenditure energy with increase skin temperature. And, know that GSR was not affected a factors that physical activity, expenditure energy, increase skin temperature, and others.

• Journal of Digital Contents Society
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• v.19 no.7
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• pp.1397-1403
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• 2018

Today, modern people perceive skin care as part of their physical health care, and acne is a common skin disease problem that is found on the face. In this paper, an effective acne detection algorithm using CIE $L^*a^*b^*$ color space has been proposed. It is red when the pixel value of the component image $a^*$ is a positive number, so it is suitable for detecting acne in skin image. First, the skin image based on the RGB color space is subjected to light compensation through color balancing, and converted into a CIE $L^*a^*b^*$ color space. The extracted component image $a^*$ was normalized, and then the skin and acne area were estimated with the threshold values. Experimental results show that the proposed method detects acne more effectively than the conventional method based on brightness information, and the proposed method is robust against the reflected light source.