• Science of Emotion and Sensibility
• /
• v.5 no.4
• /
• pp.51-57
• /
• 2002

The purpose of the study was to measure and compare driver's psychophysiological responses in different driving conditions through driving simulator. Twelve male adults(more than 1 year of driving experience) were assigned to four different driving conditions, such as normal speed(70㎞/h), sudden start(0㎞/h→70㎞/h), and sudden stop(70㎞/h→0㎞/h), and their simulator sickness, subjective pleasantness and arousal, EEG, ECG, skin temperature, and GSR were measured. Subjective and physiological evaluations were executed before and after driving in each condition. The results showed that subjective pleasantness and arousal increased in sudden stop and sudden start conditions, relative to stop and normal speed conditions. As the central nervous responses, beta wave increased and alpha wave decreased in sudden stop and sudden start conditions, relative to stop and normal speed conditions. With regard to the autonomic responses, heart rate and GSR increased, while skin temperature decreased in sudden stop and sudden start conditions, which means an activation of sympathetic nervous system. The results suggested that based upon observation of the distinctive psychophysiological changes by driving conditions, it is possible to evaluate the human sensibility in dynamic environment.

• Journal of Veterinary Clinics
• /
• v.27 no.5
• /
• pp.522-532
• /
• 2010

The aims of the present study were to characterize the effect of glucocorticosteroids (GCs) on the normal canine skin and to evaluate the effect of a lipid mixture (LM), containing cholesterol, pseudoceramide, and free fatty acid, on the steroid-induced damaged skin of dogs. Five beagles were involved and the skin of the back of each dog was topically applied with four kinds of GCs twice daily for 28 days. LM was applied after that period of GCs application. Transepidermal water loss (TEWL), skin hydration, and skin pH were assessed during experimental periods and histopathological evaluation was performed. TEWL was significantly increased, with a maximum increase obtained on day 28 (p < 0.01). Skin pH was significantly decreased, with a maximum decrease obtained on day 28 (p < 0.01). Skin surface hydration was significantly increased on day 3, but values of skin hydration were progressively decreased and finally reached those of baseline. In histology, as results of steroid application, losses of keratin layers in the stratum corneum and edematous changes in the upper parts of dermis, and consequently, thickness of the epidermis and the stratum corneum were decreased. In addition, the numbers of hair follicles were markedly decreased in steroid control as compared to intact control. However, these skin atrophic changes were markedly inhibited by treatment of LM as compared with steroid control in the present study. Moreover, all biophysical parameters were reached to the baseline after LM treatment. These results showed that the topically applied GCs induced skin barrier impairment and a LM should be effective on repair of disturbed skin barrier function in dogs. Therefore, it is concluded that a LM tested in the present study is expected to treat the steroid-induced skin damages.

• Journal of Oral Medicine and Pain
• /
• v.22 no.1
• /
• pp.137-143
• /
• 1997

두개하악장애는 가장 흔히 발병하는 질병중의 하나이다. 이때 저작계에 흔히 호소하는 주소가 근육의 통증이다. 통증의 정도를 측정하는 방법으로 촉진이 가장 널리 사용되고 있으나 정량화하기 어렵다는 단점이 있다. 따라서 통증 측정기 등과 같이 다양한 시도가 진행되고 있다. 근육이나 관절의 병적 소견은 해당조직의 혈액순환장애나 염증반응과 종종 관련이 있다. 이러한 상태는 신체의 표면과 밀접한 관계가 있어 피부온도에 영향을 미치며, 따라서 thermography로 측정할 수 있다. 피부온도의 측정은 질병의 활성 상태를 평가하는 데 유익하며, 또한 치료결과를 평가하는 데에도 효과적이다. 객관적 피부온도 측정장치가 있다면 턱관절이나 저작근의 이상상태를 평가하는데 매우 도움이 될 것이다. 따라서 본 연구의 목적은 경제적이면 양측성으로 특정 부위의 피부온도를 측정할 수 있는 기기를 사용하여 검사자내 및 검사자간 신뢰도를 측정하고 좌우 온도차이를 확인함으로써 향후 질환 및 치료 겨오가에 대한 임상적 평가시 객관적 측정방법의 하나가 될 수 있는 지를 알고자 하는 데 있다. 구강내 염증이나 이상이 없으며 두개하악장애가 없는 치과대학생 15명을 대상으로 조사하였다. 평균연령은 24.9세, 범위는 24-30세이었다. 사용한 기기는 미국산 YSI Precision 4000이다. 18-2$0^{\circ}C$의 일정한 실내온도에서 두 검사자가 각각의 검사를 알지 못하는 상태에서 별도로 정해진 부위에 검사를 시행하고, 약 1주일후 이전 검사에 대한 기억이 없어진 상태에서 두 검사자중 한 검사자가 다시 동일한 검사를 시행하였다. 측정치들을 이용하여 상관관계를 계산하고 이에 대한 유의성을 검정하였다. 1. 검사자내 상관관계(r)는 좌 .798(p=<.0001), 우 .757(p=<.0001)이었다. 2. 두검사자간 상관관계(r)는 좌 .958(p=<.0001), 우 .951(p=<.0001)이었다. 3. 좌우 측정치간의 차이는 유의한 차이가 없었다. 4. 근육부위별 측정에서는 inferior masseter muscle의 검사자간에서만 유의한 상관관계가 없었을 뿐 anterior masseter muscle, anterior temporalis 모두 검사자내 및 간에 유의한 상관관계를 나타내었다. 이상의 결과로 보아 정상인에 있어 근육내 발통점의 피부온도는 검사자간에는 특정부위에 따라 다소 차이가 있을 수 있으나 일반적으로 높은 재현성을 보여줌으로서 향후 교근 및 측두근의 임상연구 평가에 피부온도조사는 도움이 되리라 사료된다.

• Journal of the Society of Cosmetic Scientists of Korea
• /
• v.23 no.2
• /
• pp.118-151
• /
• 1997

Allergic contact dermatitis is a common skin disease resulting from specific immumologic sensitization to topically applied various allergen. Purpose of this study was to investigate skin morphologic chganges by light microscopic, changes of protein band by SDS-PAGE in the skin treated on the surfactant. Furthermore, lectin histochemistry is used to know the chagnges of the terminal sugar of the glycoconjugate in the skin treated on the surfactant. The results were as follows : The 1 day of treated group was indicated the enlargement of capillary, the 3 days of treated group was showed that the cytoplasm was eosinophlic by the pyknotic of nucleus. The 6 days of treated group was observed hyperkeratinoid, increased of inflammation cells to epithelium. The 9 days of treated group was appeares that serum crust was sheded and formed a acanthosis. But dermis layer was cytoplasmic vaculation and enlargement of intercellular space. The 12 days treated group made up new epidermis layer of seven layer and of observed an decreased in quantity of inflammation cells. The mast cell of degranulated type was increased in treated surfactnat. It was secreating granules hold histamin, serotonin and heparin. Accordingly, protein band of electrophortic phase was observed a sudden changes since 3 days treated group. At observeation of the cell-surface glycoconjugates, LCA, PNA, SBA and WGA lectin positive cells but inducated lectin negative cells in Con-A. Furthermore, PNA and SBA showed stroger positive reaction as treated surfactant group.

• Science of Emotion and Sensibility
• /
• v.21 no.1
• /
• pp.177-186
• /
• 2018

The mechanism of emotion is complex and influenced by a variety of factors, so that it is crucial to analyze emotion in broad and diversified perspectives. In this study, we classified neutral and negative emotions(sadness, fear, surprise) using arousal evaluation, which is one of the psychological evaluation scales, as well as physiological signals. We have not only revealed the difference between physiological signals coupled to the emotions, but also assessed how accurate these emotions can be classified by our emotional recognizer based on neural network algorithm. A total of 146 participants(mean age $20.1{\pm}4.0$, male 41%) were emotionally stimulated while their physiological signals of the electrocardiogram, blood flow, and dermal activity were recorded. In addition, the participants evaluated their psychological states on the emotional rating scale in response to the emotional stimuli. Heart rate(HR), standard deviation(SDNN), blood flow(BVP), pulse wave transmission time(PTT), skin conduction level(SCL) and skin conduction response(SCR) were calculated before and after the emotional stimulation. As a result, the difference between physiological responses was verified corresponding to the emotions, and the highest emotion classification performance of 86.9% was obtained using the combined analysis of arousal and physiological features. This study suggests that negative emotion can be categorized by psychological and physiological evaluation along with the application of machine learning algorithm, which can contribute to the science and technology of detecting human emotion.

• Journal of the East Asian Society of Dietary Life
• /
• v.19 no.5
• /
• pp.750-760
• /
• 2009

In this study, the various effects of Salicornia herbacea, including antioxidative function, antibiotic, and anti-inflammatory effect, and the effect of sebiparous reduction due to intervention of the DHT hormone were investigated using. The result of this study Based on this analysis, the serum total cholesterol, triglyceride, and WBC were found to be significantly decreased and SOD, Ca, K, and Zn were shown to be significantly increased significantly in the group that received the SH pill group after trial fora 12 week trials. Testosterone and DHT were increased in the SH pill group, but it was not statistically significant. In the case of the skin condition measurements, the number of blackhead pores, skin oiliness, keratin and, MIC were significantly decreased, and the pH was decreased to normal pH in the SH pill group. Therefore, it was confirmed that overall skin condition was improved due to Salicornia herbacea diet. The results of this research result can contribute so demonstrate the potential of actively using that the Salicornia herbacea can be actively developed as a health supplement, and a medication.

• Science of Emotion and Sensibility
• /
• v.7 no.3
• /
• pp.51-56
• /
• 2004

Arousal level has been well defined by autonomic responses. However, entire emotion including both valence and arousal level is often questioned to be completely described by only autonomic responses. This study is to find the autonomic physiological parameters which were used emotion evaluation, 15 undergraduate students were asked to watch eight video clips from diverse movies and comedy shows for experiencing emotions. The subjectively experienced emotion were grouped by three factors. Two dimensional emotion model having the pleasant-unpleasant and arousal-non arousal factors were mapped with three physiological responses(GSR, PPG, SKT). The results may suggest that PPG and GSR may be used as arousal index while SKT may pleasant index. And the complex relation of physiological responses to emotional experiences are discussed.

• The Journal of Dong Guk Oriental Medicine
• /
• v.7 no.1
• /
• pp.33-41
• /
• 1998

Lymph node tissues of BALB/C mouse treated with DNCB were immunohistochemically observed to investigate the activation of cell mediated immunity in lymph node of murine with allergic contact dermatitis. The inguinal region of BALB/C mice were sensitized by one application of $25{\mu}l$ of 5% 2,4-dinitrochlorobenzene(DNCB) onto an abdominal skin and 2 weeks later, the mice were challenged with $4{\mu}l$ of 2.5% DNCB. The inguinal lymph node were obtained at hour 24, 48, and 72 after 2nd DNCB treatment and embedded with paraffin, and then stained by following ABC method that used monoclonal antibody including L3T4(CD4), Ly2(CD8), IL-2R(CD25). The distribution of helper T lymphocytes, cytotoxic T lymphocytes and IL-2 receptors began to increase at hour 24 after after 2nd DNCB treatment and these increase appeared in paracortical area and medullary sinius. These increase were greatest at hour 48. These results indicated that the IL-2 secretion began to increase by activation of helper T lymphocytes in lymph node of DNCB re-exposure area and subsequently to activate suppress T lymphocytes.

• Tuberculosis and Respiratory Diseases
• /
• v.61 no.2
• /
• pp.150-156
• /
• 2006

Background: Gefitinib (ZD 1839, Iressa) is a new anticancer agent; more specifically, it is a selective epidermal growth factor receptor tyrosine kinase inhibitor that is, widely used for various solid cancers, including lung cancer. Cutaneous adverse reactions induced by gefitinib have recently been reported; however, not much on this topic has been reported in the Korean literature. Method: We studied cutaneous adverse reactions of gefitinib in 23 patients who suffered with non-small cell lung cancer at Chonnam National University Hwasun Hospital from October 2004 to September 2005. Result: The patients ranged from 23-72 years old, and there were 17 patients with adenocarcinoma, 5 with squamous cell carcinoma and 1 with bronchioloalveolar carcinoma. The most common adverse reaction was acneiform eruptions in 15 patients (65.2%). This reaction appeared within 2 months after medication, and it didn't correlate with the therapeutic response and tumor type. Pruritus was the second most common reaction (39.1%), which was mild and generalized, especially around eyelid area. Xerosis (26.1%), exfoliation on palm and sole (21.7%), and paronychia (21.7%) followed. Hair breakage and intertrigo were rare adverse reactions. Conclusion: Various cutaneous adverse reactions were observed in patients with non-small cell lung carcinoma after gefitinib treatment. The skin complications could be alleviated with dermatologic consultations and treatments, skin complications could be alleviated.

• Journal of the Korean Chemical Society
• /
• v.37 no.4
• /
• pp.396-400
• /
• 1993

The structure-activity relationship of photo-skinsensitizing psoralens has been investigated by the MM2, FMO, molecular connectivity methods. The molecular complexes between DNA and photoskinsensitizing psoralens are discussed in terms of their differing abilities to complex and react with psoralen interstrand cross linking DNA base. The photoskinsensitiziers are analyzed with respect to the sterographics models of the active sites of the psoralens and frontier orbital density is closely correlated with photo-skinsensitizing carcinogenic activity.