• Korean Journal of Clinical Pharmacy
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• v.21 no.3
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• pp.208-214
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• 2011

목적: 이 연구의 목적은 한국인 성인 환자를 대상으로 아미카신 1일 1회 요법을 시행하였을 때의 약동학적 파라미터를 평가하고, 신기능에 따른 아미카신의 약동학적 파라미터를 비교함으로써 최적의 개인화 약물요법을 설계할 수 있도록 하는 것이다. 방법: 그람 음성균 감염에 대해 1일 1회 요법으로 아미카신을 투여 받았던 353명의 한국 성인 환자를 대상으로 항정상태에서 아미카신의 농도를 2회(약물 투여 전 1시간 이내, 약물투여 종료 후 0.5~1시간 이내) 측정하였다. 각 환자의 약동학적 파라미터(분포용적, 청소율, 반감기) 및 혈중 최고 농도, 최저 농도는 환자의 나이, 체중, 신장, 성별, 혈중 크레아티닌 농도, 투여된 약물용량, 측정된 약물의 혈중농도, 감염의 종류 등을 감안하여 산출하였다. 크레아티닌 청소율에 따라 환자를 4군으로 분류하여 아미카신의 약동학적 파라미터를 비교분석하였다. 결과: 본 연구에서 아미카신 혈중 최저, 최고 농도의 평균 ${\pm}$ 표준편차는 각각 $1.14{\pm}1.95mg/L$, $26.35{\pm}9.28mg/L$이며, 청소율, 분포용적 및 반감기의 평균 ${\pm}$ 표준편차는 각각 $55.40{\pm}23.72mL/hr/kg$, $0.35{\pm}0.12L/kg$, 그리고 $5.22{\pm}3.34hrs$로 산출되었다. 크레아티닌 청소율에 따른 아미카신의 청소율, 분포용적 및 반감기의 유의한 차이가 관찰되었다. 종합적으로 아미카신의 혈중 최저 농도는 크레아티닌 청소율이 40 mL/min 미만인 경우 40 mL/min 이상인 경우에 비해 유의하게 증가하였다. 결론: 아미카신의 약동학적 파라미터들은 신기능에 따라 유의한 차이가 있으므로 최적의 치료효과를 위해서는 환자의 크레아티닌 청소율에 따른 개인화 약물요법이 필요하다.

• Journal of the korean Society of Automotive Engineers
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• v.18 no.6
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• pp.23-32
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• 1996

차량에서 엔진은 가장 큰 질량 집중체(concentrated mass)이다. 만약 엔진이 적절하게 구속되지 않거나 절연되어 있지 않으면, 차체에 진동을 일으키는 원인이 된다. 엔진은 다양한 진동 교란을 받는데 엔진 마운트는 이러한 모든 것들을 고립시키는 역할을 해야 하며, 엔진은 정적인 장착 하중에 대한 지지와 전후, 좌우 및 수직 방향의 운동에 대해 적절한 강성을 가져야 한다. 또한 정숙성을 향상시키기 위해서는 엔진 마운트의 재료인 고무의 강성계수를 낮추는 것이 필요한데 이는 일반적으로 내구성의 저하를 가져온다. 따라서 개발과정에서 강성계수를 낮추는 변경을 하면 부품의 내구성을 보정함에 따르는 재평가 또한 필요하게 된다. 엔진 마운트에 쓰이는 고무부품의 해석은 엔진 마운트 시스템에 대한 진동 해석 및 내구수명의 예측과 병행해야 하며, 진동해석으로부터 얻은 하중 지지 능력 등의 모든 요구 특성을 만족하기 위해서는 고무 재료의 특성에 대한 지식, 엔진 마운트의 장착 위치에 대한 결정 능력과 함께 주어진 조건에 대한 형상의 최적 설계 능력 등이 요구된다. 본 연구에서는 기본적인 형상을 파라미터화하여 엔진 마운트의 형상을 최적화 하는 절차를 제안하였다. 현재 승용차에 널리 사용되고 있는 부시형(bush type) 엔진마운트를 적용 모델로 선택하였으며, 엔진 마운트의 기본적인 형상을 몇개의 파라미터를 사용하여 정의하고 설계 사양으로 주어지는 강성값과 각 파라미터들의 조합으로 구성되는 형상이 갖는 강성값의 차이가 최소가 되도록 파라미터 값들을 최적화하였다. 최적화된 파라미터 값들로 구성되는 형상을 내구 성능, 성형성등을 고려하여 최종 형상으로 결정한다. 내구성능의 예측은 금속부품의 내구수명 예측에 널리 이용되고 있는 방법이 방진 고무부품의 경우에도 적용 가능한지를 검토하고, 방진 고무부품에도 일반적으로 적용될수 있는 내구수명 예측방안의 개발 가능성을 타진해 보았다. 본 연구의 목표는 시제품을 제작하기 이전에 설계된 부품에 대한 스프링 상수 및 내구특성을 체계적으로 규명하여 제품 시험의 횟수를 줄이고, 보다 정밀한 제품을 제작할 수 있도록 하기 위한 것이다.

• Journal of the Korean Society for Nondestructive Testing
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• v.29 no.5
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• pp.415-420
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• 2009

This paper reports the results of a case study for the evaluation of surface damage by using acoustic nonlinearity of surface wave. In this study, the experimental system was constructed to measure the acoustic nonlinear parameter of surface wave in an Aluminum 6061 T6 specimen of which surface was damaged by the three point bending fatigue test, and magnitudes of nonlinear parameter measured before and after the fatigue test were compared. Especially, since the surface fatigue damage by the three point bending is concentrated at the central position of loading, the change in the nonlinear parameter around this position was monitored. Experimental results showed that the measured nonlinear parameter at the outside of this position after the fatigue test was almost same as the initial value before the fatigue test, since the fatigue damage at this position was little. However, clear increase in the nonlinear parameter was noticed after the fatigue test at the central position of specimen where the surface fatigue damage is expected to be concentrated.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.12 no.1
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• pp.62-67
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• 2011

Grinding process is executed in the final machining stage to meet the quality requirements. In generally the ground surface of workpiece is affected by dressing condition as well as grinding condition. In order to estimate the roughness of workpiece, the several roughness models have been researched. These models defined the specific parameters and considered the several parameters which affect to roughness as multiply relationship among them. However, the multiply relationship among parameters is not enough to show the complicated grinding mechanism. Therefore, the neural network algorithm is used in this paper to predict the ground roughness for the plunge grinding. The proposed structure is composed of the initial roughness as well as final roughness model. The input parameters of proposed neural network are referred with the existing roughness model's. The performance of the proposed model is verified through experiments.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.30 no.11B
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• pp.698-706
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• 2005

In this paper, we investigate the parameters of the IEEE 802.11e MAC protocol, CWmin and AIFS, in terms of their capability of QoS control. The delay and the bandwidth performances are selected as the QoS medics to examine the characteristics of those parameters. A policy on MAC parameters usage, thereby, is proposed. We regard the MAC-level traffic classification as the differentiation in the channel accessibility, and thus the delay differentiation is referred to a main issue of the class-level QoS control. Realizing the tight relationship between the delay performance and the parameter AIFS, we derive an analytical expression of their relationship through an analysis of the MAC mechanism. Various simulations are examined which show the validity of our assertions, and a policy on the parameters usage is proposed based on those observations.

• Journal of the Institute of Electronics Engineers of Korea SC
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• v.42 no.3 s.303
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• pp.41-46
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• 2005

In this paper, we proposed noninvasive and continous measurement of blood pressure using pulse transit time(PTT) and physical characteristic parameters and verified its clinical effectiveness. PTT can be obtained by electrocardiogram and phtoplethysmogram. There are many researches for estimating blood pressure using PTT which can be used for individual. However, it is not enough for extracting general regression equation which can estimate blood pressure for unspecified people. In this study, we suggested the regression equatin using PTT and physical characteristic parameters related to blood pressure and did measure blood pressure of many people. we compared the performance between two methods. As the results, we knew that the regressin model using PTT combined with physical characteristic parameters can estimate blood pressure more acurately and is closer to American National Standards Institute of the Association of the Advancement of Medical Instrument(ANSI/AAMI).

• Transactions of the Korean Society of Mechanical Engineers A
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• v.41 no.9
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• pp.817-823
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• 2017

In the past, research has been conducted on the development of an adaptive cruise control algorithm considering fuel efficiency, and an adaptive cruise control system considering fuel efficiency have been developed. However, research on optimizing vehicle and adaptive cruise control parameters in order to maximize performances is insufficient. In this study, the design optimization of vehicle and control parameters considering fuel efficiency, trackability, ride comfort and safe distance is performed. This paper proposes performance measures of vehicle behavior and develops an adaptive cruise control system. In addition, based on the screening of vehicle parameters that significantly influence performances, kriging surrogate models are constructed through a sequential design of experiment, and kriging surrogate model-based design optimization is performed to maximize fuel efficiency and satisfy target performances.

• Journal of the Korea Society for Simulation
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• v.23 no.3
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• pp.11-17
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• 2014

The central composite design (CCD) is often used to estimate the second-order linear model. This paper uses a correlation induction strategy of common random numbers (CRN) in simulation experiment and utilizes the induced correlations to obtain better estimates for the second-order linear model. This strategy assigns the CRN to all design points in the CCD. An appropriate selection of the axial points in CCD makes the weighted least squares (WLS) estimator be equivalent to ordinary least squares (OLS) estimator in estimating the linear model parameters of CCD. We analytically investigate the efficiency of this strategy in estimation of model parameters. Under certain conditions, this correlation induction strategy yields better results than independent random number strategy in estimating model parameters except intercept. The simulation experiment on a selected model supports such results. We expect a suggested random number assignment is useful in application of CCD in simulation experiments.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.35 no.4
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• pp.393-400
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• 2011

In this study, a procedure for the inverse estimation of the fatigue life parameters of springs which utilize the field fatigue life test data is proposed to replace real test with the FEA on fatigue life prediction. The Bayesian approach is employed, in which the posterior distributions of the parameters are determined conditional on the accumulated life data that are routinely obtained from the regular tests. In order to obtain the accurate samples from the distributions, the Markov chain Monte Carlo (MCMC) technique is employed. The distributions of the parameters are used in the FEA for predicting the fatigue life in the form of a predictive interval. The results show that the actual fatigue life data are found well within the posterior predictive distributions.

• Korean Journal of Remote Sensing
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• v.35 no.6_4
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• pp.1363-1372
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• 2019

In this study, we tried to analyze the fusion parameters required to produce a high-resolution multispectral image using an image fusion technique and to suggest global fusion parameters. We analyzed the linear regression coefficients that can simulate the panchromatic image, and the fusion coefficients required for producing the fusion image. When the fusion images were produced using the representative fusion parameters, it was confirmed that the difference in DN value between each fusion image was quantitatively smaller than when the optimal fusion parameters were used. Therefore, this study can minimize the regional characteristics reflected in the fused image.