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Changes of Polyamine Metabolism and Delayed Neuronal Degeneration of Hippocampus after Transient Cerebral Ischemia in Mongolian Gerbils (뇌허혈 손상에 있어서 Polyamine 대사의 변동이 해마신경세포의 지연성괴사에 미치는 효과에 관한 연구)

  • Shin, Kyung-Ho;Shin, Hwa-Jung;Lee, Young-Jae;Kim, Hyung-Gun;Choi, Sang-Hyun;Chun, Yeon-Sook;Chun, Boe-Gwun
    • The Korean Journal of Pharmacology
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    • v.32 no.3
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    • pp.323-334
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    • 1996
  • Male Mongolian gerbils $(60{\sim}80g)$ were given DL-difluoromethylornithine (DFMO; 250mg/kg, ip) and methylglyoxal bis(guanylhydrazone) (MGBG; 50 mg/k, ip), respectively, 1 h prior to transient (7 min) occlusion of bilateral common carotid arteries (OBC7) and a daily dose of one of them for 6 days after recirculation, and the polyamine contents, activities of ornithine and S-adenosylmethionine decarboxylases (ODC and SAM-DC), and light microscopic findings of the hippocampus were evaluated. The hippocampal putrescine (PT) levels of the control gerbils treated with saline (STGr), markedly increased after OBC7, showing a peak level at 24 h after recirculation. The peak PT level was reduced in DFMO treated gerbils (DTCr) and in MGBG treated gerbils (MTGr). And 7 days after recirculation, the PT level of DTGr was decreased to about 75% of the PT level in the sham operated group (nonTGr) and to about 55% of the STGr level, respectively. The hippocampal spermidine (SD) level of STGr tended to decline, showing the lowest value at 8 h after recirculation. But the spermidine (SD) level of DTGr was somewhat higher at 8 h after OBC7 than those of STGr and MTGr The hippocampal spermine (SM) levels of all the experimental groups were little changed for 7 days after OBC. OBC7 markedly increased the hippocampal ODC activity. reaching a maximum (about 3 times higher than preischemic level) at 8 h and rapidly recovered to the control value by 24 h in STGr gerbils, and the OBC7-induced increase of ODC activity was significantly attenuated by DFMO or MGBG treatment. Whereas OBC7 induced a rapid decrease of the hippocampal SAMDC activity follwed by gradual recovery to the preischemic level, and the decrease of the SAMDC activity was slightly attenuated by DFMO or MGBG treatment. 7 Days after OBC7 the histological finding of the hippocampal complex stained with cresyl violet showed an extensive delayed neuronal damage in the CA1 region and to a lesser extent, in the dentate gyrus, sparing the CA3 region. And the neuronal death was aggevated by DFMO but significantly attenuated by MGBG. The immunochemical reactivity of hippocampus to anti-GFAP antibody was significantly increased in the CA1 region and to a lesser extent, in the dentate gyrus 7 days after OBC7, but was little changed in the CA3. And the increase of the anti-GFAP immunoreactivity was moderately enhanced by DFMO and significantly suppressed by MGBG. These results suggest that the polyamine metabolism may play a modulatory role in the ischemic brain damage.

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Business Application of Convolutional Neural Networks for Apparel Classification Using Runway Image (합성곱 신경망의 비지니스 응용: 런웨이 이미지를 사용한 의류 분류를 중심으로)

  • Seo, Yian;Shin, Kyung-shik
    • Journal of Intelligence and Information Systems
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    • v.24 no.3
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    • pp.1-19
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    • 2018
  • Large amount of data is now available for research and business sectors to extract knowledge from it. This data can be in the form of unstructured data such as audio, text, and image data and can be analyzed by deep learning methodology. Deep learning is now widely used for various estimation, classification, and prediction problems. Especially, fashion business adopts deep learning techniques for apparel recognition, apparel search and retrieval engine, and automatic product recommendation. The core model of these applications is the image classification using Convolutional Neural Networks (CNN). CNN is made up of neurons which learn parameters such as weights while inputs come through and reach outputs. CNN has layer structure which is best suited for image classification as it is comprised of convolutional layer for generating feature maps, pooling layer for reducing the dimensionality of feature maps, and fully-connected layer for classifying the extracted features. However, most of the classification models have been trained using online product image, which is taken under controlled situation such as apparel image itself or professional model wearing apparel. This image may not be an effective way to train the classification model considering the situation when one might want to classify street fashion image or walking image, which is taken in uncontrolled situation and involves people's movement and unexpected pose. Therefore, we propose to train the model with runway apparel image dataset which captures mobility. This will allow the classification model to be trained with far more variable data and enhance the adaptation with diverse query image. To achieve both convergence and generalization of the model, we apply Transfer Learning on our training network. As Transfer Learning in CNN is composed of pre-training and fine-tuning stages, we divide the training step into two. First, we pre-train our architecture with large-scale dataset, ImageNet dataset, which consists of 1.2 million images with 1000 categories including animals, plants, activities, materials, instrumentations, scenes, and foods. We use GoogLeNet for our main architecture as it has achieved great accuracy with efficiency in ImageNet Large Scale Visual Recognition Challenge (ILSVRC). Second, we fine-tune the network with our own runway image dataset. For the runway image dataset, we could not find any previously and publicly made dataset, so we collect the dataset from Google Image Search attaining 2426 images of 32 major fashion brands including Anna Molinari, Balenciaga, Balmain, Brioni, Burberry, Celine, Chanel, Chloe, Christian Dior, Cividini, Dolce and Gabbana, Emilio Pucci, Ermenegildo, Fendi, Giuliana Teso, Gucci, Issey Miyake, Kenzo, Leonard, Louis Vuitton, Marc Jacobs, Marni, Max Mara, Missoni, Moschino, Ralph Lauren, Roberto Cavalli, Sonia Rykiel, Stella McCartney, Valentino, Versace, and Yve Saint Laurent. We perform 10-folded experiments to consider the random generation of training data, and our proposed model has achieved accuracy of 67.2% on final test. Our research suggests several advantages over previous related studies as to our best knowledge, there haven't been any previous studies which trained the network for apparel image classification based on runway image dataset. We suggest the idea of training model with image capturing all the possible postures, which is denoted as mobility, by using our own runway apparel image dataset. Moreover, by applying Transfer Learning and using checkpoint and parameters provided by Tensorflow Slim, we could save time spent on training the classification model as taking 6 minutes per experiment to train the classifier. This model can be used in many business applications where the query image can be runway image, product image, or street fashion image. To be specific, runway query image can be used for mobile application service during fashion week to facilitate brand search, street style query image can be classified during fashion editorial task to classify and label the brand or style, and website query image can be processed by e-commerce multi-complex service providing item information or recommending similar item.

Welfare Activation Strategy for a Urban Park Users (도시공원 이용자들을 위한 공원복지 활성화전략 -부산도시공원 이용자를 중심으로-)

  • Kim, Kyo-Jung
    • The Journal of the Korea Contents Association
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    • v.12 no.10
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    • pp.195-204
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    • 2012
  • The purpose of this study is to suggest the improvement plan for the welfare in the park through the empirical test on the park facilities, which are the hardware, and the service contents, which are the software, in the urban parks of Busan. Therefore, to identify the welfare of the parks in Busan, this study took 7 urban parks as samples according to the plate method of experts, and conducted the questionnaire survey from 1,500 persons using these parks. The IPA analysis results on the importance and the satisfaction of the users on the form of use, facilities and the contents of the park are as follows. First, the convenient facilities, which are the hardware of the park, are represented as a intensive management item. Second, the importance and the satisfaction for all the facilities and the contents of each park are significant differences. according to the location of each park and the characteristics of each principal park users. Such results mean that the Busan urban park operation does not satisfy the expectation of the park users for the welfare facilities in the parks. Therefore, it implies that to activate the urban parks and to improve the quality of life than the present, the aceessibility of the local residents to the information should be reinforced through the development of contents to reflect the region and the desires of the users and through building and managing the homepage of the urban parks.

A Dynamical Load Balancing Method for Data Streaming and User Request in WebRTC Environment (WebRTC 환경에 데이터 스트리밍 및 사용자 요청에 따른 동적로드 밸런싱 방법)

  • Ma, Linh Van;Park, Sanghyun;Jang, Jong-hyun;Park, Jaehyung;Kim, Jinsul
    • Journal of Digital Contents Society
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    • v.17 no.6
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    • pp.581-592
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    • 2016
  • WebRTC has quickly grown to be the world's advanced real-time communication in several platforms such as web and mobile. In spite of the advantage, the current technology in WebRTC does not handle a big-streaming efficiently between peers and a large amount request of users on the Signaling server. Therefore, in this paper, we put our work to handle the problem by delivering the flow of data with dynamical load balancing algorithms. We analyze the request source users and direct those streaming requests to a load balancing component. More specifically, the component determines an amount of the requested resource and available resource on the response server, then it delivers streaming data to the requesting user parallel or alternately. To show how the method works, we firstly demonstrate the load-balancing algorithm by using a network simulation tool OPNET, then, we seek to implement the method into an Ubuntu server. In addition, we compare the result of our work and the original implementation of WebRTC, it shows that the method performs efficiently and dynamically than the origin.

Secure Management Method for Private Key using Smartphon's Information (스마트폰 고유정보를 이용한 안전한 개인키 관리 방안)

  • Kim, Seon-Joo
    • The Journal of the Korea Contents Association
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    • v.16 no.8
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    • pp.90-96
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    • 2016
  • The 3390 million people, around 83% of the adult population in Korea use smartphone. Although the safety problem of the certificate has been occurred continuously, most of these users use the certificate. These safety issues as a solution to 'The owner of a mobile phone using SMS authentication technology', 'Biometric authentication', etc are being proposed. but, a secure and reliable authentication scheme has not been proposed for replace the certificate yet. and there are many attacks to steal the certificate and private key. For these reasons, security experts recommend to store the certificate and private key on usb flash drive, security tokens, smartphone. but smartphones are easily infected malware, an attacker can steal certificate and private key by malicious code. If an attacker snatchs the certificate, the private key file, and the password for the private key password, he can always act as valid user. In this paper, we proposed a safe way to keep the private key on smartphone using smartphone's unique information and user password. If an attacker knows the user password, the certificate and the private key, he can not know the smart phone's unique information, so it is impossible to use the encrypted private key. Therefore smartphone user use IT service safely.

Temporal Analysis of Opinion Manipulation Tactics in Online Communities (온라인 공간에서 비정상 정보 유포 기법의 시간에 따른 변화 분석)

  • Lee, Sihyung
    • Journal of Internet Computing and Services
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    • v.21 no.3
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    • pp.29-39
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    • 2020
  • Online communities, such as Internet portal sites and social media, have become popular since they allow users to share opinions and to obtain information anytime, anywhere. Accordingly, an increasing number of opinions are manipulated to the advantage of particular groups or individuals, and these opinions include falsified product reviews and political propaganda. Existing detection systems are built upon the characteristics of manipulated opinions for one particular time period. However, manipulation tactics change over time to evade detection systems and to more efficiently spread information, so detection systems should also evolve according to the changes. We therefore propose a system that helps observe and trace changes in manipulation tactics. This system classifies opinions into clusters that represent different tactics, and changes in these clusters reveal evolving tactics. We evaluated the system with over a million opinions collected during three election campaigns and found various changes in (i) the times when manipulations frequently occur, (ii) the methods to manipulate recommendation counts, and (iii) the use of multiple user IDs. We suggest that the operators of online communities perform regular audits with the proposed system to identify evolutions and to adjust detection systems.

Web Site Keyword Selection Method by Considering Semantic Similarity Based on Word2Vec (Word2Vec 기반의 의미적 유사도를 고려한 웹사이트 키워드 선택 기법)

  • Lee, Donghun;Kim, Kwanho
    • The Journal of Society for e-Business Studies
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    • v.23 no.2
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    • pp.83-96
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    • 2018
  • Extracting keywords representing documents is very important because it can be used for automated services such as document search, classification, recommendation system as well as quickly transmitting document information. However, when extracting keywords based on the frequency of words appearing in a web site documents and graph algorithms based on the co-occurrence of words, the problem of containing various words that are not related to the topic potentially in the web page structure, There is a difficulty in extracting the semantic keyword due to the limit of the performance of the Korean tokenizer. In this paper, we propose a method to select candidate keywords based on semantic similarity, and solve the problem that semantic keyword can not be extracted and the accuracy of Korean tokenizer analysis is poor. Finally, we use the technique of extracting final semantic keywords through filtering process to remove inconsistent keywords. Experimental results through real web pages of small business show that the performance of the proposed method is improved by 34.52% over the statistical similarity based keyword selection technique. Therefore, it is confirmed that the performance of extracting keywords from documents is improved by considering semantic similarity between words and removing inconsistent keywords.

A Decision-support System for Care Plan in Long-term Care Insurance (의사결정나무기법을 활용한 노인장기요양보험 표준급여모형 개발)

  • Han, Eun-Jeong;Lee, Jung-Suk;Kim, Dong-Geon;Kwon, Jinhee
    • The Korean Journal of Applied Statistics
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    • v.27 no.5
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    • pp.667-679
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    • 2014
  • National Health Insurance Service(NHIS) provide care-plans for beneficiaries in the long-term care insurance(LTCI) systems that help them use LTC services appropriately. The care-plan includes recommendations for the most adequate type of care (gold standard) for beneficiaries. This study develops a decision-support system to determine the appropriate type of care plan. To develop a model, we used a data set that well-trained assessors in the NHIS investigated as a gold standard for beneficiaries: nursing home care, home-visit care, home-visit bathing, home-visit nursing, or day and night care. The decision-support system was established through a decision-tree model, because it may be easy to explain the algorithm of a decision-support system to working groups and policy makers. Our results might be useful in evidence-based care planning in an LTCI system and contribute to the efficient use of LTC services.

Measurement of Ambulatory Patients' Satisfaction and Its Influencing Factors in a Tertiary Hospital (병원 외래 방문 환자의 만족도 평가 및 관련 요인에 대한 연구 - 한 3차 병원 방문 환자를 중심으로 -)

  • Lee, Sang-Il
    • Journal of Preventive Medicine and Public Health
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    • v.27 no.2 s.46
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    • pp.366-376
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    • 1994
  • Patients' evaluation of hospital care is one of the most important aspects of quality assessment. Survey allows patients to judge sujectively the events that occur during their hospital visit if performed properly. This study describes the result of a research effort to develop outpatient questionnaire that has sufficient validity and reliability to be used to measure patients' perception of satisfaction in Korea and to investigate influencing factors on patients' satisfaction. Self-administered questionnaire was developed for outpatient and the survey was conducted covering 827 outpatients in a tertiary hospital. It was confirmed by factor analysis that patients evaluate several components of ambulatory care distinctly ; hospital environment, administration and ancillary services, and medical care. We found strong evidence of construct validity and internal consistency for the above three dimensions of hospital process. On the contrary, reliability of overall outcome measures was low. It suggests that three items concerning overall outcome measures have some different meanings in patients' perception. Using logistic regression analysis it was found that previous health status, cost evaluation, and improvement in health status have significant influences on the level of patients' overall satisfaction and that patient's sex, experience of previous visit, expectation for improvement, cost evaluation, and improvement in health status are strongly related with intention to recommend hospital. In spite of some limitations the results of this study can be used helpfully as baseline informations for developing self-administered questionnaire and for exploring the influencing factors on patients' satisfaction. Further comprehensive research efforts should be made on the measurement of ambulatory patients' satisfaction and its related factors in current Korean situation.

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A Study on the Intelligence Information System's Research Identity Using the Keywords Profiling and Co-word Analysis (주제어 프로파일링 및 동시출현분석을 통한 지능정보시스템 연구의 정체성에 관한 연구)

  • Yoon, Seong Jeong;Kim, Min Yong
    • Journal of Intelligence and Information Systems
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    • v.22 no.4
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    • pp.139-155
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    • 2016
  • The purpose of this study is to find the research identity of the Korea Intelligent Information Systems Society through the profiling methods and co-word analysis in the most recent three-year('2014~'2016) study to collect keyword. In order to understand the research identity for intelligence information system, we need that the relative position of the study will be to compare identity by collecting keyword and research methodology of The korea Society of Management Information Systems and Korea Association of Information Systems, as well as Korea Intelligent Information Systems Society for the similar. Also, Korea Intelligent Information Systems Society is focusing on the four research areas such as artificial intelligence/data mining, Intelligent Internet, knowledge management and optimization techniques. So, we analyze research trends with a representative journals for the focusing on the four research areas. A journal of the data-related will be investigated with the keyword and research methodology in Korean Society for Big Data Service and the Korean Journal of Big Data. Through this research, we will find to research trends with research keyword in recent years and compare against the study methodology and analysis tools. Finally, it is possible to know the position and orientation of the current research trends in Korea Intelligent Information Systems Society. As a result, this study revealed a study area that Korea Intelligent Information Systems Society only be pursued through a unique reveal its legitimacy and identity. So, this research can suggest future research areas to intelligent information systems specifically. Furthermore, we will predict convergence possibility of the similar research areas and Korea Intelligent Information Systems Society in overall ecosystem perspectives.