• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.7
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• pp.510-516
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• 2020

This study investigated the characteristics and factors affecting inpatient infants, children, and adolescents who experienced falling, using NHDIS data from 2008 through 2017, The study analyzed data of 116 patients who were under 18 and who experienced injuries (KSCD, S00-S99) by falling (KSCD, W00-W19). Frequency analysis, cross-tabulations, and multiple regression analysis were conducted, using SPSS 23. There were more boys than girls, and most of the falls occurred at the ages of over one to under six years old. Most of the children had respiratory diseases, and most had open wounds or bruises due to falling. Also, most of the falls were related to the bed. In the factor analysis, age (β=.318), the main diagnosis (β=.231), and injury (β=.169) except gender affected falling. This suggests that it is necessary to conduct fall prevention education for children, considering the developmental stage characteristics and age group. It is necessary to screen the risk group such as children with a disease with relatively less restriction of activities or with a hyperactive disorder, and to develop a related manual. Hopefully, the results will be used as the basic data for fall prevention education and creating a fall prevention manual according to the characteristics of children's developmental stage for patients who need hospitalization, their caregivers, and the relevant medical team.

• Korean Journal of Food Science and Technology
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• v.41 no.2
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• pp.191-195
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• 2009

We assessed the effect of surimi gel, which is prepared from the king oyster mushroom (pleurotus eryngii) and cuttlefish meat paste (KCP) on lipid metabolism and antioxidant activity in high-cholesterol-fed rats. Three groups of 3-week-old male Sprague-Dawley rats were fed on a diet containing 1 g cholesterol/kg for 6 weeks. We administered only a high-cholesterol diet to the control group, one group was fed on surimi gel containing cuttlefish paste and king oyster mushrooms, and another group was fed with general boiled fish meat paste (GFP), which is commonly sold in marketplaces. Plasma and hepatic lipid profiles were measured, and the antioxidant status of the liver was assessed. The plasma triglyceride concentration did not differ significantly among the groups. Supplementation with KCP resulted in lower plasma and hepatic cholesterol concentrations and atherogenic index as compared to the control group and GFP, whereas the plasma high-density lipoprotein-cholesterol concentration was elevated. Moreover, the KCP-supplemented animals evidenced greater bile acid excretion. The KCP groups evidenced significantly lower plasma and hepatic levels of thiobarbituric acidreactive substances as compared to the control group. Besides, hepatic antioxidant enzyme activities, including catalase and superoxide dismutase, were significantly higher in the KCP group. In conclusion, KCP was quite effective in improving the lipid metabolism and reducing oxidative stress by upregulating the hepatic antioxidant enzymes in high-cholesterol-fed rats.

• Journal of Nutrition and Health
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• v.45 no.4
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• pp.324-335
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• 2012

The purpose of this study was to examine the relationship of dietary self-efficacy and illness beliefs, perceived benefits, and perceived barriers for the reduction of sodium intake in the elderly. A cross-sectional study was performed on 252 elderly people, aged 65 yrs and above, living in Daejeon Metropolitan city and Jecheon city, Chungbuk from March 21 to March 30, 2011. Dietary self-efficacy of three factors (resisting relapse, reducing salt and behavioral skills), perceived benefits and barriers, accurate and inaccurate illness beliefs were measured by 5 or 4 point Likert scale. With the increasing education level of the elderly, dietary self-efficacy, and accurate illness belief score increased and perceived barrier score decreased. Perceived benefits score was higher in the subject living alone compared to those living with siblings or spouses. Among three factors of dietary self-efficacy, reducing salt was scored highest and behavioral skills scored lowest in the elderly. Recording meal diary and reading labels for salt content in the items of behavioral skills showed lower score than other items. Accurate illness beliefs and perceived benefits were more scored than inaccurate illness beliefs and perceived barriers respectively in the subjects. The subjects with higher accurate illness beliefs, lower inaccurate illness beliefs, higher perceived benefits, and lower perceived barriers for the reduction of sodium intake showed higher dietary self-efficacy. In summary, accurate illness beliefs and perceived benefits positively correlated with dietary self-efficacy for the reduction of sodium intake in the elderly, whereas inaccurate illness beliefs and perceived barriers are negatively correlated.

• Proceedings of the Korea Contents Association Conference
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• 2018.05a
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• pp.347-348
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• 2018

일본 뇌염 바이러스(Japanese encephalitis virus)는 작은빨간집모기(Culex spp.)를 매개로 사람에게 감염될 수 있으며, 인체에 치명적인 질병을 유발한다. 일본 뇌염 바이러스의 혈청형(serotype)은 1종류이지만, 유전형(genotype)은 5종류(GI, GII, GIII, GIV, GV)로 분류되고 있다. 현재 일본 뇌염 바이러스 백신은 아시아 지역에서 감염 빈도가 높은 유전형 3(GIII)에 대한 백신이며, 사백신(inactivated vaccine)과 약독화 백신(attenuated vaccine)이 주로 사용되고 있다. 본 연구에서는 기존 백신의 부작용을 줄이고 한계점을 개선하기 위하여, 생물정보학 데이터베이스를 활용한 접근법을 통해 펩타이드 백신 후보군을 선별하였다. 5가지의 유전형 중에서도 감염 빈도가 가장 높은 유전형 3(GIII) 및 최근 감염빈도가 서서히 늘어나고 있어 주의가 요구되고 있는 유전형 1(GI)을 연구 대상으로 선정하였다. 여러 종류의 생물정보학 데이터베이스를 활용하여 백신으로 활용가치가 높은 것으로 보고되고 있는 외피 단백질(envelope protein)에 대한 아미노산 상동성을 분석하고, 이를 바탕으로 공통 적용이 가능한 동시에 면역원성이 높은 펩타이드 3종을 백신 후보군으로 선별하였다. 더 나아가 이들의 3차원 구조 모델링을 통해 보다 백신으로 활용 가능성이 높은 펩타이드를 최종 도출하였다.

• Journal of the East Asian Society of Dietary Life
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• v.17 no.5
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• pp.644-652
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• 2007

In this study, we examined family history of chronic diseases, food group intake and physical activity in $5^{th}\;and\; 6^{th}$ grade elementary school children. Food group intake was compared with the KDRI food guides for children. The measurements of daily physical activity, television viewing, computer use, and daily servings of five food groups, including grains, meats, dairy products, fruits, and vegetables, were based on child and parent self-reports. As indices of obesity, the obesity index(%) and BMI(Body Mass Index) were used. The results were as follows. In boys, 83.2% were normal weight with 7.4% slightly obese, 7.4% moderately obese, and 2.0 were highly obese while the percentages of normal and slightly obese in girls were 89.9% and 6.2% respectively (p<0.05). The boys had more hours of daily physical activity(p<0.05) and more hours of computer usage(Internet searching or games)(p<0.05) than the girls. Slightly over 50% of the subjects met the daily recommended servings of grains, dairy products, fruits, and vegetables according to the KDRI food guides. However, only 26% of boys and 27% of girls met the recommended daily servings of protein foods such as meats, beans, and eggs. Thirty two percent(32%) of girls consumed high fat snacks everyday while 32% consumed high sugar snacks every day. The girls consumed more vegetables(p<0.05) and more high sugar snacks(p<0.05) than the boys. The children with family histories of obesity showed greater obesity rates(p<0.05) and sedentary lifestyles(p< 0.05) than those children without a family history of obesity. Children with family histories of high blood pressure consumed more sewings of vegetables and high fat snacks than the controls(p<0.05). The children with family histories of obesity consumed more high sugar or high fat snacks than the controls(p<0.05).

• Korean Journal of Poultry Science
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• v.29 no.1
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• pp.59-75
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• 2002

The present study was conducted to compare the disease resistance to fowl typhoid among White Leghorn (WL) known as possessing greater genetic resistance to Salmonella, Rhode Island Red (RIR) susceptible to the disease and their mating crossbreed, WL ${\times}$RIR. Also, it was carried out to compare fowl typhoid-resistance among Hyline white${\times}$Hyline brown(HwHb), Hw${\times}$lsa brown(Hwlb), Isa white${\times}$lb(Iwlb), Iw${\times}$ Hb(IwHb) and Ib ${\times}$ Iw(IbIw) in order to select crossbreed chickens which have disease resistance to fowl typhoid and simultaneously produce the brown eggs which our domestic consummers prefer There was no death of WL chickens challenged with Sal. gallinarum at each 2, 5 and 8 wk of age, while average 86.2 to 64.1% of RIR chickens tested died at the same challenge age during the test period of 2 weeks. Their maiting crossbreed, WL ${\times}$ RIR were intermediate between the two breeds. weight gains of tested chickens were significantly higher in WL and WL ${\times}$RIR without difference between them than RIR. In recovery rate of tested strain of Sal. gallinarum from braun, heart, fiver, spleen and cecum of chickens challenged, WL ${\times}$RIR fell between the other two breeds, with somewhat higher rate then WL but much lower then RIR. In the disease resistance determination test using HwHb, Hwlb, Iwlb, IwHb and IbIw$.$ crossbreed chickens experimentally infected with Sal. gallinarum, it was recognized that all of crossbreeds tested developed marked resistance to fowl typhoid, based on the results judged by the measurement parameters of mortality, weight gain, recovery rate of challenged strain of bacteria, and positive rate of agglutination antibody, and HwHb had a tittle higher disease resistance then ethers.

• The KIPS Transactions:PartB
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• v.18B no.2
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• pp.67-72
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• 2011

Single nucleotide polymorphisms (SNPs) are a very important tool for the study of human genome structure. Cluster analysis of the large amount of gene expression data is useful for identifying biologically relevant groups of genes and for generating networks of gene-gene interactions. In this paper we compared the clusters of SNPs within asthma group and normal control group obtained by using hierarchical cluster analysis method with entropy distance. It appears that the 5-cluster collections of the two groups are significantly different. We searched the best set of SNPs that are useful for diagnosing the two types of asthma using representative SNPs of the clusters of the asthma group. Here support vector machines are used to evaluate the prediction accuracy of the selected combinations. The best combination model turns out to be the five-locus SNPs including one on the gene ALOX12 and their accuracy in predicting aspirin tolerant asthma disease risk among asthmatic patients is 66.41%.

• Proceedings of the Korea Water Resources Association Conference
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• 2016.05a
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• pp.432-432
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• 2016

말라리아는 Plasmodium 속 원충으로 인하여 적혈구와 간 세포내에 발병하는 감염병으로, 매년 약 3-5억의 발병과 100만 명 이상의 사망자로 인하여 세계보건기구(WHO)가 선정한 6대 열대병 중에서도 가장 중요한 질환으로 고려되고 있다. 우리나라에서도 법정전염병 제3군으로 지정된 중요한 감염병이다. 국내에서는 지난 2000년 이후 감소 추세를 보이던 국내 말라리아 환자발생(현역 군인 포함)이 2005년 1,324명, 2006년 2,021명, 2007년 2,192명으로 2007년 국내 말라리아 환자는 전년대비 8.5%의 증가를 보이고 있다. 일반적으로, 매개체를 통한 감염병은 생태계 내에서의 상호 작용에 영향을 받기 때문 기후 인자와도 큰 영향을 받는 것으로 알려져 있다. 특히, 모기 매개 질병은 기후의 영향을 크게 받으며, 기온, 강수량, 습도 등의 수문기상 요소가 중요한 영향을 미치며, 그 중에서도 말라리아는 매개체에 의한 전염병 중 가장 중요하게 다루어지는 전염병인 동시에 기후변화에 가장 민감한 질병이다. 이 때문에 말리리아와 기후 인자 및 기후변화를 연관 지으려는 연구가 다수 수행되어 왔으며, 특히 최근에는 습지와 기후 인자와 말라리아의 상관관계를 분석하는 등의 다각적인 분석도 이루어지고 있다. 또한, 최근에 기후변화가 현실적인 문제로서 부각되면서 말라리아의 발생 문제에 대한 연구도 다각적으로 수행되고 있다. 본 연구에서는 기후 인자 및 기후변화와 상관성이 높은 감염병 중에서 국내 발병자 수가 많아서 분석이 용이한 말라리아를 주요한 감염병으로 선정하고, 말라리아의 발생과 기후 인자와의 상관관계를 살펴보고, 이를 바탕으로 기후 인자에 따른 말라리아의 발생을 모의할 수 있는 모형을 구축하고, 실제 적용성을 검증하였다. 이를 위하여 2001년부터 2011년까지의 월간 말라리아 감염병 발생 현황과 전국 기상대의 기후인자를 수집하였다. 말라리아와의 상관 분석을 위해서 포함된 기후인자는 평균기온($^{\circ}C$), 상대습도(%), 강수량(mm)을 이용하여 연관성을 분석하였으며, 이를 회귀 모형화 하였다. 연구결과, 구축된 회귀 모형이 말라리아 발생자료에 대한 설명력이 있는 것으로 나타났다.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.12
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• pp.314-321
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• 2019

Based on data obtained from the Korea National Health and Nutrition Examination Survey (KNHANES) conducted by Korea Centers for Disease Control & Prevention (KCDC), this study analyzed the relationship between existence of the spouse, number of family members, and disease afflictions of the Korean elderly, and factors affecting their quality of life. The collected data were analyzed by Chi-square test, t-test and One-way Anova, using the SPSS / WIN 25. Our comparative analysis on the health status and quality of life revealed that individuals in the singles group had significantly more diseases than the married group. The singles group considered their health was subjectively poor, whereas the quality of life of the married group was higher. Analyzing the characteristics of chronic disease and activity restriction showed significantly higher prevalence of several diseases in the singles group. Besides, the singles group revealed significantly higher limitations of activity. Taken together, our results reveal a difference in the health status, quality of life, and the presence of chronic diseases in accordance to existence of the spouse, indicating that having a spouse increases the level of health and quality of life of the elderly.

• Applied Microscopy
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• v.37 no.3
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• pp.167-174
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• 2007

Heat shock protein (HSP) 70 functions as a molecular chaperon and reduces stress-induced denaturation and aggregation of intracellular proteins. Erythropoietin (EPO) plays an important role during acute renal failure repair process by rapidly correcting anemia and enhancing renal tubular regeneration. The purpose of this study was to examine the effect of EPO treatment on renal HSP70 expression. Male Sprague-Dawley rats were injected rHUEPO. Kidney were preserved by in vivo perfusion with paraformaldehyde-lysine-periodate (PLP) and processed for immunohistochemistry and electron microscopy. In control kidney, HSP70 was expressed in the cortex, outer medulla and inner medulla. Especially, HSP immunoreactiviy was mainly founded in descending thin limb of outer medulla and inner medullary collecting duct. In EPO treated kidney, HSP70 expression markedly increased in the descending thin limb of outer medulla and newly detected in cortical collecting duct. Electron microscopy showed the presence of HSP immunoreactivity on the intracelluar vesicles and Golgi complex of descending thin limb and cortical collecting duct. These findings suggest that EPO treatment leads to new production of HSP70 in renal tubular cells, and induction of HSP70 by rHuEPO is causally related to protective function.