• Korean Journal of Plant Resources
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• v.35 no.4
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• pp.417-427
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• 2022

In this study, we investigated in vitro immuno-stimulatory and anti-obesity activity of fruit (LIF), leaves (LIL) and stems (LIS) from Lonicera insularis Nakai in mouse macrophages RAW264.7 cells and mouse pre-adipocytes 3T3-L1 cells. LIF, LIL and LIS increased the production of immunostimulatory factors such as nitric oxide (NO), inducible nitric oxide synthase (iNOS), interleukin-1β (IL-1β), cyclooxygenase-2 (COX-2), tumor necrosis factor-α (TNF-α) and activated phagocytosis in RAW264.7 cells. Inhibition of toll-like receptor 2/4 (TLR2/4) partly blocked LIF, LIL and LIS mediated production of immunostimulatory factors. In addition, inhibition of mitogen-activated protein kinases (MAPK) signaling attenuated the production of immunostimulatory factors induced by LIF, LIL and LIS. Based on these results of this study, LIF, LIL and LIS is thought to activate macrophages the production of immunostimulatory factors and phagocytosis through toll-like receptor 2/4 (TLR2/4) and MAPKs signaling pathway. In anti-obesity study, LIF reduced the lipid accumulation in 3T3-L1 cells. LIF increased the protein phosphorylation expressions such as AMP-activated protein kinase (AMPK), hormone sensitive lipase (HSL), adipose triglyceride lipase (ATGL) related to the lipolysis of the adipocytes. In addition, LIF increased the expression of proteins involved in energy metabolism and brown adipose tissues differentiation such as peroxisome proliferator-activated receptor gamma coativator 1α (PGC-1α) and PR domain-containing16 (PRDM16). These results suggest that LIF is involved in lipid accumulation inhibition through expressing the proteins such as lipolysis and differentiation of white adipocytes to brown adipocytes.

• The Journal of Engineering Geology
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• v.19 no.3
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• pp.295-306
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• 2009

The risk assessment of groundwater and soil in Sasang industrial complex in Busan Metropolitan City was carried out in order to estimate risks to human health and the environment. The carcinogenic risk (CR) of receptors to soil and air was not identified. However, the CRs for TCE and PCE were 6.7E-6 and 1.0E-5, respectively. Hazard quotient (HQ) and hazard index (HI) did not appear through air exposure pathways. Yet the HQ and HI of soil were 3.4E-5 and 5E-5, respectively, and lower than the critical value (1.0). On the contrary, HQ and HI with respect to groundwater were calculated as 0.7 (not hazardous) and 1.4 (hazardous). The constituent reduction factor (CRF) for TCE in the study area was determined as 2.5, and thus remediation work is demanded. As a result of sensitivity analysis for 18 exposure factors, eight exposure factors (life time of carcinogens, age, body weight, exposure duration, exposure frequency, dermal exposure frequency, water ingestion rate, and soil ingestion rate) varied with the variation of risk.

• Journal of Korean Society of Environmental Engineers
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• v.31 no.4
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• pp.300-307
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• 2009

The transport of landfill leachate in the subsurface formations of unlined landfill sites is considered. The impacts of hydrogeological and chemical heterogeneities on the leachate transport are assessed by examining the results from a series of Monte-Carlo simulations. The landfill system simulated in this study is hypothetically represented with three levels of spatial variability for the hydrogeological and chemical parameter; (1) homogeneous hydraulic conductivity (K) and distribution coefficient ($K_d$), (2) K heterogeneity only, and (3) combined heterogeneities of K and $K_d$. To calculate the transport of leachate through negatively-correlated random hypothetical K-$K_d$ fields generated using geostatistical input parameters, a saturated flow model is linked with a contaminant transport model. Point statistic values such as mean, standard deviation, and coefficient of variation of the concentration were obtained from 100 Monte-Carlo trials. Results of point statistics show that the heterogeneities of K and $K_d$ in the landfill site prove to be an important parameter in controlling leachate concentrations. Consideration of combined K and $K_d$ heterogeneities results in enhancing the variability of contaminant transport. The variability in the leachate concentration for different realizations also increases as the distance between source and monitoring well increase.

• Journal of Plant Biotechnology
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• v.38 no.4
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• pp.241-250
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• 2011

The most part of vegetable oils is accumulated as storage lipid, triacylglycerol (TAG) in seed and used as energy source when seed is germinated. It is also used as essential fatty acids and energy source for human and animal. Recently, vegetable oils have been more and more an important resource because of the increasing demand of vegetable oils for cooking and industrial uses for bio-diesel and industrial feedstock. In order to increase vegetable oils using biotechnology, over-expressing or repressing the regulatory genes involved in the flow of carbon into lipid biosynthesis is critical during seed development. In this review, we described candidate genes may influence oil amount and investigate their potential for oil increase. Genes involved in the regulation from biosynthesis of fatty acids to the accumulation oils in seed can be classified as follows: First, genes play a role for synthesis precursor molecules for TAG. Second, genes participate in fatty acid biosynthesis and TAG assembly. Lastly, genes encodes transcription factors involved in seed maturation and accumulation of seed oil. Because factors/genes determining oil quantity in seed is complex as mentioned, recently regulation of transcription factors is being considered more favorable approach than manipulate multiple genes for increasing oil in transgenic plants. However, it should be figured out the problem that bad agricultural traits induced by the overexpression of transcription factor gene.

• Economic and Environmental Geology
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• v.40 no.1 s.182
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• pp.115-128
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• 2007

This study proposed a modified logistic regression model for a probabilistic prediction of debris flow on natural terrain at the granitic rock area. The modified model dose not contain any categorical factors that were used in the previous model and secured higher reliability of prediction than that of the previous one. The modified model is composed of lithology, two factors of geomorphology, and three factors of soil property. Verification result shows that the prediction reliability is more than 86%. Using the modified regression model, the landslide prediction maps were established. In case of Sacheon area, the prediction map showed that the landslide occurrence was not well corresponded with the model since, even though the forest-fred area was distributed on the center of the model, no factors were considered for the landslide predictions. On the other hand, the prediction model was well corresponded with landslide occurrence at Jumunjin-Yeongok area. The prediction model developed in this study has very high availability to employ in other granitic areas.

• Journal of the Korean Society of Food Science and Nutrition
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• v.44 no.12
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• pp.1763-1770
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• 2015

The effects of root of Taraxacum coreanum Nakai (TC), on the suppression of inflammation and oxidative stress induced by lipopolysaccharide (LPS) in ICR mice were studied. LPS (10 mg/kg body weight) was injected into ICR mice in between two consecutive oral administrations. Hot water extract of fresh TC (HWETC) was administered to mice immediately before and 24 h after LPS injection. The animal groups used in this study were as follows: NOR group (PBS injection, DW administration), CON group (LPS injection, DW administration), and TC group (LPS injection, 1.4 g/kg bw of HWETC administration). Mice in the CON group lost weight due to inflammation induced by LPS, while the body weight of the TC group mice increased significantly, indicating that inflammation was inhibited by HWETC administration. Compare with the CON group, plasma and hepatic triglyceride, reactive oxygen species, peroxynitrite, and hepatic thiobarbituric acid reactive substances concentrations of the TC group decreased significantly (P<0.05). The protein expression of a pro-inflammatory transcription factor, nuclear $factor-{\kappa}B$ ($NF-{\kappa}B$) and its target enzyme, cyclooxygenase 2, increased in response to LPS injection, but was suppressed by HWETC administration (P<0.05). In conclusion, HWETC appears to ameliorate the oxidative stress and inflammatory responses induced by LPS via inhibition of $NF-{\kappa}B$ activation.

• Economic and Environmental Geology
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• v.40 no.5
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• pp.563-574
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• 2007

Laser induced breakdown spectroscopy (LIBS) is a recently developed analytical technique that is based upon the measurement of emission lines generated by atomic species close to the surface of the sample, thus allowing their chemical detection, identification and quantification. With powerful advantages of LIBS compared to the conventional analytical methodology, this technique can be applied in the detection of heavy metals in the field. LIBS allows the rapid analysis by avoiding laborious chemical steps. LES have already been applied for the determination of element concentration in a wide range of materials in the solid, liquid and gaseous phase with simplicity of the instrument and diversity of the analytical application. These feasibility of rapid multi elemental analysis are appealing proprieties for the in-situ analytical technique in geochemical investigation, exploration and environmental analysis. There remain still some limitations to be solved for LIBS to be applied in soil environment as an in-situ analytical technology. We would like to provide the basic principle related to the plasma formation and laser-induced breakdown of sample materials. In addition, the matrix effect, laser properties and the various factors affecting on the analytical signal of LIBS was dealt with to enhance understanding of LIBS through literature review. Ultimately, it was investigated the feasibility of LIBS application in soil environment monitoring by considering the basic idea to enhance the data quality of LIBS including the calibration method for the various effects on the analytical signal of LIBS.

• The Journal of Engineering Geology
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• v.26 no.2
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• pp.235-250
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• 2016

In Korea, 70% of the annual rainfall falls in summer, and the number of days of extreme rainfall (over 200 mm) is increasing over time. Because rainfall is the most important trigger of landslides, it is necessary to decide a rainfall threshold for landslide warning and to develop a landslide warning model. This study selected 12 study areas that contained landslides with exactly known triggering times and locations, and also rainfall data. The feasibility of applying a Rainfall Triggering Index (RTI) to Korea is analyzed, and three RTI models that consider different time units for rainfall intensity are compared. The analyses show that the 60-minute RTI model failed to predict landslides in three of the study areas, while both the 30- and 10-minute RTI models gave successful predictions for all of the study areas. Each RTI model showed different mean response times to landslide warning: 4.04 hours in the 60-minute RTI model, 6.08 hours in the 30-minute RTI model, and 9.15 hours in the 10-minute RTI model. Longer response times to landslides were possible using models that considered rainfall intensity for shorter periods of time. Considering the large variations in rainfall intensity that may occur within short periods in Korea, it is possible to increase the accuracy of prediction, and thereby improve the early warning of landslides, using a RTI model that considers rainfall intensity for periods of less than 1 hour.

• Proceedings of the KSCN Conference
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• 2003.11a
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• pp.1091-1092
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• 2003

당뇨병은 발병한 후에는 혈당조절을 위한 식사요법 실천이 평생에 걸쳐 지속적으로 이루어져야하는 질환이므로 식사요법에 대한 영양교육이 매우 중요하다. 본 연구에서는 지속적인 실습을 포함하는 소그룹 단위의 영양교육프로그램을 실시함으로써 식사요법 실천에 미치는 영향에 대해 알아보고자 하였다. 2003년 4월부터 7월까지 보건소에서 여성 당뇨병 환자 13명을 대상으로 혈당에 가장 영향을 미치는 당질식품의 적정섭취와 균형있고 규칙적인 식사를 강조한 쉬운 식사요법 교실의 형태로 연속 4주간, 2시간의 교육형태로 그룹인원을 5명 이하로 하여 실시하였다. 설문조사를 통하여 식사요법 장애 인자를 파악하였으며 교육 전후에 식사 섭취량, 혈당 허리둘레를 측정하여 비교하였다. 대상자의 평균 연령은 57.85 $\pm$ 9.55세, 유병 기간 6.38 $\pm$ 2.9년이었다 식사요법 교육을 받은 경험이 있는 환자는 15.4%이며 당뇨병 가족력을 가지고 있는 환자는 53.8%이었다. 당뇨병 발견 동기는 증상 .있었던 경우가 23.1%, 종합 진단시 발견된 경우 15.4%, 타 질환 치료시 알게된 경우 61.5%이었다. 저혈당 증세 및 대처방법을 알고 있는 환자는 53.8%이었다. 식사요법시 장애인자를 항목별로 질문하였을 때 가장 큰 장애는 주위에서 더 먹으라고 권유하는 것, 식사요법은 나에게 큰짐이 된다는 생각, 식사요법보다 일상생활에서 더 중요한 것이 많음이 53.8%로 답하였다. 교육 전후의 식사 섭취 량을 비교하였을 때 교육 전 에너지 섭취량은 1579.6 $\pm$ 355.8㎉ 교육 후 1505 $\pm$ 425.3㎉로서 70㎉정도 감소하였다. 교육 시 처방한 열량의 98.3%를 섭취하고 있었다. 당질섭취는 교육 전 257$\pm$60.6g 교육 후 214.8$\pm$56.1g로 감소하였고 단백질, 지질의 섭취는 교육전후에 큰 차이가 없었다. 총열량에 대한 3대 영양소의 섭취비율은 교육 전 57:23:20에서 교육 후 51:28:21로 당질비율은 감소하고 지질이나 단백질 섭취비율이 증가하였다. 교육전 후 식품군 별 섭취 량을 식품교환단위 수로 비교하였을 때 곡류군 섭취는 교육 전 5.87 $\pm$ 2.51에서 교육 후 5.38 $\pm$ 1.71로 교육후 당질 식품 섭취량이 감소하였으나 통계적으로 유의성은 나타나지 않았다. 교육 후 식품선택에서의 큰 변화는 과일류 중 토마토 섭취 비율 증가로 교육 전에는 총 과일 섭취량의 19.87%에서 교육 후에는 56.32%로 증가했다. 혈당은 교육후 42.8mg/㎗ 감소한 것으로 나타났으며 허리둘레는 교육 전 평균 83.8 $\pm$ 5.75에서 교육 후 82.33 $\pm$ 5.89cm로 약 1.5cm가량 감소하였다. 따라서 당질 식품 적정 섭취에 대한 실습 위주의 단기간 영양교육은 당뇨병 관리에 유익한 것으로 평가되었다.

• The Journal of Engineering Geology
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• v.24 no.1
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• pp.53-67
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• 2014

Numerical modeling is commonly used to reproduce the physical phenomena of dam-break and to compile resulting flood hazard maps. The accuracy of a dam-break model depends on the physical structure that describes the volume of storage, breach formation and progress, input variables, and model parameters. Model input and parameters are subjective in that they are prescribed; hence, caution is needed when interpreting the results. This study focuses on three parameters (breach degree ${\theta}$, shape factor P, and collapse rate k) used when the dam-break model is coupled with FLO-2D (a two-dimensional flood simulation model) to estimate flood coverage and depth etc. The results show that the simulation is sensitive to the shape factor P and the collapse rate k but not to the breach degree ${\theta}$. This study will contribute to reducing flood damage from dam-break disasters in the future.