• Proceedings of the Korea Contents Association Conference
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• 2009.05a
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• pp.306-311
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• 2009

We initially obtained human diseases-related proteins dataset from the OMIM and the SWISS PROT and then constructed disease-related protein-protein interaction network. The protein network contains 40 hub proteins such as CALM1, ACTB and ABL2. The protein network can be derived the map of the relationship between different disease proteins, denoted disease interaction network. We demonstrate that the associations between diseases are directly correlated to their underlying protein-protein interaction networks. From constructed the disease-protein bipartite network, we derived 38 diseasomal proteins, including APP, ABL1 and STAT1. We previously demonstrated that hub proteins in the network tend to be diseasomal proteins in the disease-related protein sub-networks. However, we found that 18% hubs are only diseasomal proteins in the whole disease network. At this point, we could not elucidate difference in the hub-diseasomal proteins tendency between sub0network and whole network. In spite of we still have unsolved problems, our results elucidate that the discovery of protein interaction networks assigned by diseases will provide insight into the underlying molecular mechanisms and biological processes in complex human disease system.

• Korean Chemical Engineering Research
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• v.54 no.3
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• pp.310-314
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• 2016

The search for natural antioxidants as alternatives to synthetic products is growing. Microalgae have emerged as a source of natural antioxidants with significant and diverse health-promoting properties. In this study, the effects of hot-water extraction conditions on total polyphenol compounds (TPC) production were investigated for lipid extracted microalgae (LEA). In order to enhance the polyphenol productivity, the extraction variables including solvents, temperature, time and ethanol concentration were optimized. The results showed hot-water extraction provided a higher extraction efficiency than the organic solvents and extraction at high temperatures showed a better extraction efficiency. While hot-water extract showed a higher extraction efficiency compared to 98% ethanol extraction, the mixture of water and ethanol (40:60 v/v) showed the highest production of polyphenols. The maximum polyphenols of 3.35 mg GAE (gallic acid equivalent)/g DM were obtained at the optimized extraction time of 10 min, $100^{\circ}C$ and 40% ethanol, respectively. Although Tetraselmis KCTC 12236BP was preprocessed by hexane to remove lipid for bio-diesel production, the results showed LEA contains relatively high level of polyphenols compared to untreated microalgae which can be used in the production of value-added materials. The predictions obtained from the developed Peleg's model were compared with the experimental data under the same operating conditions. The predicted and experimental data were consistent, indicating the reliability of the model.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.3
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• pp.609-614
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• 2017

In this study, a new type of eccentric cam was used for the development of a small size reducer with a two-shift reduction ratio while maintaining the same volume as the existing one-shift speed reducer. Therefore, a two-shift speed reducer was designed using the concept of a continuously variable transmission applied to automobiles. The cam was designed to have an eccentric shape with a $180^{\circ}$ phase difference to act as a tensioner to minimize slip by squeezing the V-belt connected to the deceleration pulley and the acceleration pulley, respectively. The cam was designed to have a diameter of 35mm and an outer diameter of 18mm so that the outer portion of the v-belt could contact the cam perfectly. A pulley with a diameter of 50.8mm was installed on the low speed pulley input shaft for deceleration and a pulley with a diameter of 76.2mm was provided on the output shaft. In the high-speed pulley for acceleration, a pulley with a diameter of 76.2mm is provided on the input shaft, and a pulley with a diameter of 50.8mm is provided on the output shaft. Based on the design details, the power transmission efficiency test and the heating characteristics of the transmission were tested to verify the feasibility. In addition, through validation, the suitability of the reducer was demonstrated.

• Korean Journal of Optics and Photonics
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• v.31 no.5
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• pp.205-212
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• 2020

In the performance of a wind turbine system, the blades play a vital role. However, they are susceptible to damage arising from complex and irregular loading (which may even cause catastrophic collapse), and they are expensive to maintain. Therefore, it is very important both to find defects after blade manufacturing is completed and to find damage after the blade is used for a certain period of time. This study provides a new perspective for the detection of internal defects in glass-fiber- and carbon-fiber-reinforced panels, which are used as the main materials in wind turbine blades. A gap or fracture between fiber-reinforced materials, which may occur during blade manufacturing or operation, is simulated by drilling a hole 5 mm in diameter in the middle layer of the laminated material. Then, a digital-image-correlation (DIC) method is used to detect internal defects in the blade. Tensile load is applied to the fabricated specimen using a tensile tester, and the generated changes are recorded and analyzed with the DIC system. In the glass-fiber-reinforced laminated specimen, internal defects were detected from a strain value of 5% until the end of the experiment, while in the case of the carbon-fiber-reinforced laminated specimen, internal defects were detected from 1% onward. It was proved using the DIC system that the defect was detected as a certain level of strain difference developed around the internal defects, according to the material properties.

• Culinary science and hospitality research
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• v.15 no.3
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• pp.1-14
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• 2009

One of the tasks given to the hotel business is to improve ES(Employee Satisfaction) through educational training for enhancing job efficiency and service quality, not product competition. In the current domestic field, however, ES(Employee Satisfaction) based on appropriate educational training hasn't been established yet. The purpose of this study is to verify the effect of educational training including recognizing the necessity of frequency, the level of lecture conscience, motivation, and internalization along with job commitment. The cohort of women(n=128, 44.4%) and men(n=160, 55.6%) was monitored by the questionnaire data from October 13th to 31st, 2007. It was assessed by (1) the recognition of educational training, (2) educational training practices, (3) organizational identification, (4) brand identification, and (5) job commitment. Statistical analysis was conducted using SPSS (Statistical Package for Social Science), data coding, and the data cleaning system. As a result, it was proved that frequency, the level of lecture conscience, motivation, the recognition of necessity are in proportion to brand identification and organization identification. In addition, identification through educational training can raise the efficiency of job commitment.

• Journal of Navigation and Port Research
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• v.42 no.3
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• pp.151-158
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• 2018

Students from the Maritime universities enrolled themselves into one year navigational training, according to The International Convention on Standards of Training, Certification and Watchkeeping for Seafarer(STCW). The purpose of this paper is to analyze if the students demonstrate improvements and accomplishments while they participate in their practical training. The subjects are third year students of the Korea Maritime and Ocean University who were onboard the Training Ship of the University. The purpose of this paper is to cover the degree of improvement by training, based on the core competency of officers. We also present the basic data for the efficiency in the curriculum of the practical training course for the school. As a result of the research, most of the students showed high improvements in their core competency subjects at the end of their one-year training. However, subjects such as cargo management and protection of the maritime environment resulted in below average results. These were some of the areas that needed improvement.

• Journal of The Korean Association For Science Education
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• v.19 no.4
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• pp.528-541
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• 1999

In order to obtain data for developing an ideal science curriculum. four kinds of General Science textbooks based on the 6th curriculum were analyzed. Particularly inquiry activities were analyzed by Scientific Inquiry Evaluation Inventory(SIEI). The results are as follows: 1) The average number of inquiry activities in four kinds of textbooks is 115.5. And the number in each textbook is very diverse: textbook A contains 94 inquiry activities, textbook B 147. textbook C 100 and textbook D 121. 2) As for the number of inquiry activity scopes in four kinds of textbook. observation comes to 22, experiment 117, interpreting data 196, investigation 64, discussion 51, classification 4 and prediction 8. And then the conceptional inquiry activity is about 2.3 times as many as the inquiry experiment. 3) According to the analysis of each inquiry task by SIEI. textbook A has 268, textbook B 328, textbook C 207 and textbook D 304. 4) In the analysis of the structure of inquiry activity, the evaluation of the competition and cooperation scale shows more emphasis on common tasks. no pooled results(87.1 %). The discussion scale mostly consists of activities without discussion required among students(83.5%). The evaluation of openness scale shows more emphasis on activities with problems, procedures and answers presented(58.3%). In the evaluation of inquiry scope scale, the inquiry scope scale mostly has the activities to demonstrate or verify the contents of the text(66.9%). 5) As for the analysis of inquiry activities as a whole. The inquiry pyramid in four kinds of General Science textbooks shows the type I that emphasizes the inquiry activities in low level such as gathering and organizing data. The inquiry index in four kinds of textbooks is average 47.8, shows very high level (above 35).

• Proceedings of the Acoustical Society of Korea Conference
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• autumn
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• pp.233-236
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• 2001

일반적으로 스피커를 동작시키게 되면, 스피커 보이스 코일에 열이 발생하게 되고, 열에 의한 보이스코일의 저항의 증가가 나타나게 되는데, 기존의 연구는 저음용 스피커(Woofer) 만을 대상으로 스피커의 음향특성 변화들에 관해 수행되었다. 그러나, 현대의 스피커는 A/V시스템분야의 발전에 따라 고음재생의 충실도가 강조되고 있는 경향이므로, 고음용 스피커(Tweeter)에 대한 열 발생의 영향을 조사하였다. 본 연구에서는 고음용 스피커의 입력전력에 따른 특성 변화를 조사하고, 입력전력의 증가로 인한 보이스코일(voice coil)의 저항 증가에 따른 고음용 스피커의 특성변화에 관해 실험하였다. 그리고, 스피커의 진동에 의한 펌프(pump) 역할을 이용하는 냉각용 구멍을 뚫어 스피커의 특성변화를 검토하였다. 실험대상으로는 직경 25mm의 돔(Dome)형 진동판을 가진 고음용 스피커와 이 스피커의 후면 중심부에 구멍을 뚫어 열 방출구가 형성된 3종의 시료를 대상으로 특성변화를 비교$\cdot$측정하였다. 여기에서, 사용된 시료는 국내 Y사의 판매용 고음용 스피커로 제품의 원 상태인, 구멍이 없는 것을 기준시료로 하고, 이와 동일한 제품들의 후면에 각각 직경 5mm, 10mm, 15mm의 구멍을 가공하여 비교시료로 하였다. 기준 및 비교시료의 스피커 특성을, 한국산업규격 KS C 6027의 측정법에 따라, 입력 1W 상태에서 기준시료의 사양을 측정하였고[1], 입력을 0.5W, 1W, 2W, 4W, 8W, 16W로 가하여, 시료별 입력증가에 따른 스피커의 주파수 응답특성, 임피던스(Impedance), 조화 왜(Harmonic Distortion)의 변화율 측정을 통해 스피커의 특성변화 정도를 검토하였다. 향후, 본 연구의 결과는 고음용 스피커의 특성 열화에 대한 예측 및 개선 방안을 제시하는 기본 자료로 활용이 가능할 것으로 사료된다.용하여 현금흐름예측을 할 수 있는 Model을 제시하였다. 특히 건설공사의 현금흐름 예측의 중요한 요소인 Cash-Out에 대하여, 공사비 구성요소인 자재, 노무, 중기, 외주, 경비등 각 Resource의 보할(Weights)을 실 공사원가에 따른 보할의 변화와 Resource들의 Time Lag를 적용 기존 연구자의 Model과 다른 Model을 제시하였다. 또한 기존 연구자들의 Model과 비교하여 편리성, 정확도 및 신뢰성이 높은 Model임도 증명하였다.세대까지도 발현수준이 유지될 것으로 판단된다. 이러한 연구결과는 계통으로 확립된 형질전환 동물에 부여된 새로운 유전형질은 지속적으로 후대로 유전될 수 있음을 제시한다.잖⨀瘀Ā퀇Āゑ잖⨀Ā퀇Ԁ￿™잖⨀䌀Ā퀇ĀꄏĀꀏꄏĀꀏ₱?⨀Ā Ԁ￿䂱?⨀ऀĀ耀Ā삱?⨀؀Ā Ā?⨀ጀĀ耀Ā?돀ꢘ?⨀硩?⨀ႎ?⨀?⨀넆돐쁖잖⨀쁖잖⨀／ࠐ?⨀焆덐瀆倆Āⶇ퍟ⶇ퍟ĀĀĀĀ磀鲕좗?⨀肤?⨀⁅Ⴅ?⨀쀃잖⨀䣙熸ጁ↏?⨀

• KIPS Transactions on Software and Data Engineering
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• v.6 no.3
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• pp.161-166
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• 2017

In recent times, many people have problems of nutritional imbalance; lack or surplus intake of a specific nutrient despite the variety of available foods. Accordingly, the interest in health and diet issues has increased leading to the emergence of various mobile applications. However, most mobile applications only record the user's diet history and show simple statistics and usually provide only general information for healthy diet. It is necessary for users interested in healthy eating to be provided recommendation services reflecting their food interest and providing customized information. Hence, we propose a menu recommendation method which includes calculating the recommended calorie amount based on the user's physical and activity profile to assign to each food group a substitution unit. In addition, our method also analyzes the user's food preferences using food intake history. Thus it satisfies recommended intake unit for each food group by exchanging the user's preferred foods. Also, the excellence of our proposed algorithm is demonstrated through the calculation of precision, recall, health index and the harmonic average of the 3 aforementioned measures. We compare it to another method which considers user's interest and recommended substitution unit. The proposed method provides menu recommendation reflecting interest and personalized health status by which user can improve and maintain a healthy dietary habit.

• Journal of Life Science
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• v.24 no.12
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• pp.1284-1290
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• 2014

Fatty acid transporter protein 1 (FATP1) is highly expressed in skeletal muscle and modulates fatty acid uptake and metabolism. However, the influence of insulin-like growth factor-I (IGF-I), a master regulator of skeletal muscle cells, on FATP1 in skeletal muscle cells has not been demonstrated. To investigate the effect of IGF-I on FATP1 and the expression of the IGFBP5 protein, differentiated C2C12 murine skeletal muscle cells were treated with 20 ng/ml of IGF-I at different time points. The results showed that IGF-I increased FATP1 and IGFBP5 protein expression in a time-dependent manner. To determine whether this induction of FATP1 by the IGF-I treatment was regulated pretranslationally, the mRNA level of FATP1 was measured by real-time quantitative PCR. The IGF-I treatment resulted in very rapid induction of the FATP1 mRNA transcript in C2C12 myotubes. FATP1 mRNA increased 169% and 132% after 24 and 48 h of the IGF-I treatment, respectively, and it returned to control levels after 72 h of the treatment, suggesting that the FATP1 gene is regulated pretranslationally by IGF-I in skeletal muscle cells. This is the first evidence that IGF-I can regulate the expression of FATP1. In conclusion, IGF-I induced rapid transcriptional modification of the FATP1 gene in C2C12 skeletal muscle cells and had modulating effects on fatty acid uptake proteins and oxidative proteins.