• Clinical and Experimental Pediatrics
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• v.51 no.11
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• pp.1211-1216
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• 2008

Purpose : Diamond-Blackfan anemia (DBA) is a rare heterogeneous genetic disorder of infancy and early childhood. It is characterized by red cell aplasia, congenital anomalies, and a predisposition to cancer. Corticosteroids and red cell transfusions are the mainstays of therapy. We describe our experience of 6 cases of DBA that were encountered over a period of 16 years. Methods : Medical records of 6 patients diagnosed to have DBA and admitted to the Chonnam National University Hospital between 1992 and 2008 were retrospectively reviewed. Results : Three patients were males. The age at diagnosis ranged from 3 to 18 months (median, 5.5 months). Heart defects were observed in 4, polydactyly in 2, and strabismus in 1 patient. The median number of transfusions was 3 (range, 2-8). All patients responded to initial treatment with steroids and had a hemoglobin level ${\geq}9g/dL$ with a median of 12.5 days (range, 7-22 days). Three patients are currently not receiving steroid therapy. A minimum dose of oral prednisolone (<5 mg per day) was required to maintain hemoglobin ${\geq}9mg/dL$ in 3 cases. Red cell transfusion was infrequently required in 1 patient. In the median follow-up of 14 years, there was no development of malignancy. No significant side effects of steroids were found, except for short stature in 2. Conclusion : The majority of DBA patients achieved complete response and under maintenance therapy with low dose of steroids. Close observation is needed to monitor steroid side effects, cardiac function, and development of malignancy. A nation-wide survey is necessary to further characterize this rare disease in Korean children.

• Radiation Oncology Journal
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• v.11 no.2
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• pp.403-409
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• 1993

Between 1988 and 1992, seven patients with overt meningeal leukemia who had received adequate central nervous system (CNS) prophylaxis were treated with intermittent craniospinal irradiation and intrathecal methotrexate (IIIC). Follow-up time ranged from 8 months to 41 months with median of 20 months. Three of 7 patients developed subsequent CNS relapse. CNS remission durations were 8, 9, 13, 20, 28, 34, 36 months from diagnosis of CNS leukemia for which IIIC was given. Disease free survival after CNS relapse ranged from 2 to 36 months with median of 11 months. Overall survival after CNS relapse ranged from 8 to 41 months with median of 28 months. Five patients died of sepsis and bleeding secondary to bone marrow relapse. Two patients are alive at present. But they developed recurrent CNS disease 10 to 11 months after completion of IIIC. To improve the outcome, modification of IIIC by reduction of rest period and prolonged administration of intrathecal chemotherapy after completion of IIIC are required.

• Economic and Environmental Geology
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• v.50 no.5
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• pp.353-361
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• 2017

Uranium concentration in groundwater of the Goesan area was anticipated high because the area contains Ogcheon metamorphic rock zone which partly includes coal bed bearing high uranium content and nearly half of the area is covered by granitic rocks. Groundwater samples collected from 250 wells in five 5 lithology (Ogcheon meta-sandy rock zone (Og1), Ogcheon lower phyllite zone (Og2), Ogcheon pebble bearing phyllite zone (Og3), Jurassic granite (Jgr), Cretaceous granite (Kgr)), of the area were analyzed and equivalent uranium concentrations (e(U)) from 200 rocks near sampled wells were measured using portable gamma spectrometry. Higher median value of e(U) (8.2 mg/kg) was found on Kgr outcrops. The median e(U) value of Og2 was not as high as that of Kgr and similar to those of Jgr, Og1, and Og3 (3.05~3.90 mg/kg). The uranium level in groundwater of the area ranged from 0.01 to $293.0{\mu}g/L$ with a median value of $0.87{\mu}g/L$ which is similar to the national median uranium level of $0.74{\mu}g/L$. The uranium concentration was high in the samples from the Kgr (median $4.74{\mu}g/L$) and low samples from the Og1, Og2, and Og3 (median $0.35{\sim}0.74{\mu}g/L$). The percentage of total samples having uranium level above $30{\mu}g/L$ was 2.8%, on the other hand, that of Kgr is 20.7%, reflecting additional survey on the Kgr area is needed.

• Journal of Nutrition and Health
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• v.50 no.5
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• pp.447-459
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• 2017

Purpose: Metabolic Syndrome (MetS) is defined as a cluster of inter-connected metabolic disorders involving the glucose metabolism, dyslipidaemia, high blood pressure, and abdominal obesity. The worldwide prevalence has been rapidly increasing to approximately 20~25%, and the prevalence in Korea as of 2012 was reported to be 31.3%. The association of MetS with various diseases needs to be analyzed by conducting an investigation of frequently consumed foods, such as dairy products, fish, and shellfish in prediabetic subjects. Methods: The dietary intake of subjects who met the criteria of the study from January to December 2015 was assessed using the 24-hour recall method. After adjusting the age, sex, BMI, and total energy intake, which are confounding factors that may affect the dietary intake of the subjects, the associations of dairy products, fish, and shellfish intake with the MetS risk factors was analyzed. Results: In prediabetes, the intake of subjects who consumed more than the dairy products median (187.0 g) and the elevation risk of TC [OR, 2.369; 95% CI, 1.057 to 5.312] showed a significant positive association. In prediabetes, the intake of subjects who consumed more than the fish and shellfish median (44.0 g) and the elevation risk of BP showed a significantly weak negative association [OR, 0.073; 95% CI, 0.010 to 0.520]. The probability that the blood LDL cholesterol was ${\geq}100mg/dL$ decreased 0.397 times [95% CI, 0.189 to 0.832]. Conclusion: To control the metabolic risk factors of pre-diabetic and vascular disease subjects, proper dairy, fish and shellfish intake will be important.

• Journal of Family Resource Management and Policy Review
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• v.25 no.4
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• pp.43-54
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• 2021

The purpose of this study was to explore the effects of perceived care-related burden and social support on life satisfaction and the moderating effect of social support from elderly spouses caring for their elderly partners with dementia. The subjects were 165 spouses aged over 60 years, caring for their elderly partners afflicted with dementia, and living in Seoul and Gyeonggi Province. The analysis results are as follows: First, the quantified total care-related burden shouldered by the participant spouses was 3.76 points (SD = .57), which was slightly higher than the median value. In the case of social support, informal support was scored 2.65 (SD = .78), and formal support was scored 2.60 (SD = .77), which was lower than the median value. Life satisfaction earned a score of 3.11 points (SD = .78), which somewhat exceeded the median. Second, subjective health status, income level, burden from social activity, and informal support influenced life satisfaction. Put differently, the higher the subjective health status of a caring spouse, the higher the income level, the lower the social activity burden, the stronger the informal support, and the greater the life satisfaction. Third, the interaction terms of social activity burden and informal support were significant. Therefore, informal support had a moderating effect on the relationship between social activity burden and life satisfaction among the elderly with dementia. In other words, even though the caring spouses experienced a burden from social activities, the higher the frequency with which they accessed informal support, the lower the decrease in life satisfaction.

• Journal of Conservation Science
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• v.35 no.6
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• pp.641-651
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• 2019

This study investigates three buildings arranged alongside at the same level, namely, the Josadang, the Buljojeon, and the Palsangjeon. Their backside is blocked by an embankment with an environmental condition unsuitable for wooden buildings. The pillar behind the Josadang had termite damage for which termite damage and environmental investigations had been conducted for the past four years. The termite damage was monitored four times using the termite detection dogs, and the environmental factors were surveyed 27 times, except during the winter season. As a result, the locations of the columns with a high frequency of responses from the termite detection dogs were found and damage was confirmed. According to the surface moisture content investigations, the surface moisture content was highest in the Josadang and lowest in the Buljojeon. After a statistical analysis, the mean, the median, and the mode values were compared. The difference between the mean and the median was found to be less, however, the mode varied significantly. The mode values of the Josadang and the Palsangjeon were 14.5% and 10.8%, respectively, higher than the 6.1% mode value of the Buljojeon. It was concluded that the temperature and the water content affected the termite damage, which increases if the temperature and the water content remain constant owing to the environmental factors.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.27 no.2
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• pp.103-111
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• 2014

In this study, the probabilistic internal pressure fragility analysis was performed by using the non-linear finite element analysis method. The target structure is one of the containment buildings of typical domestic pressurized water reactors(PWRs). The 3-dimensional finite element model of the containment building was developed with considering the large equipment hatches. To consider uncertainties in the material properties and structural capacities, we performed the sensitivity analysis of the ultimate pressure capacity with respect to the variation of four important uncertain parameters. The results of the sensitivity analysis were used to the selection of the probabilistic variables and the determination of their probabilistic parameters. To reflect the present condition of the tendon pre-stressing force, the data of the pre-stressing force acquired from the in-service inspections of tendon forces were used for the determination of the median value. Two failure modes(leak, rupture) were considered and their limit states were defined to assess the internal pressure fragility of target containment building. The internal pressure fragilities for each failure mode were evaluated in terms of median internal pressure capacity, high confidence low probability of failure(HCLPF) capacity, and fragility curves with respect to the confidence levels. The HCLPF capacity was 115.9 psig for leak failure mode, and 125.0 psig for rupture failure mode.

• Radiation Oncology Journal
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• v.16 no.4
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• pp.433-440
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• 1998

Purpose : Although small ceil lung cancer (SCLC) has high response rate to chemotherapy and radiotherapy (RT), the prognosis is dismal. The authors evaluated survival and failure patterns according to the prognostic factors in SCLC patients who had thoracic radiation therapy with chemotherapy. Materials and Methods : One hundred and twenty nine patients with SCLC had received thoracic radiation therapy from August 1985 to December 1990. Seventy-seven accessible patients were evaluated retrospectively among 87 patients who completed RT. Median follow-up period was 14 months (2-87months). Results : The two years survival rate was 13$\%$ with a median survival time of 14 months. The two year survival rates of limited disease and extensive disease were 20$\%$ and 8$\%$, respectively, with median survival time of 14 months and 9 months, respectively. Twenty two patients (88$\%$) of limited disease showed complete response (CR) and 3 patients (12$\%$) did partial response (PR). The two year survival rates on CR and PR groups were 24$\%$ and 0$\%$, with median survival times of 14 months and 5 months. respectively (p=0.005). No patients with serum sodium were lower than 135 mmol/L survived 2years and their median survival time was 7 months (p=0.002). Patients whose alkaline phophatase lower than 130 IU/L showed 26$\%$ of 2 year survival rate and showed median survival time of 14 months and those with alkaline phosphatase higher than 130 IU/L showed no 2 year survival and median survival time of 5 the months, respectively (p=0.019). No statistical differences were found according to the age, sex, and performance status. Among the patients with extensive disease, two rear survivals according to the metastatic sites were 14$\%$, 0$\%$, and 7$\%$ in brain, liver, and other metastatic sites, respectively, with median survival time of 9 months, 9 months, and 8 months, respectively (p>0.05). Two year survivals on CR group and PR group were 15$\%$ and 4$\%$, respectively, with a median survival time of 11 months and 7 months, respectively (p=0.01). Conclusion : For SCLC, complete response after chemoradiotherapy was the most significant prognostic tactor. To achieve this goal. there should be further investigation about hyperfractionation, dose escalation, and compatible chemo-radiation schedule such as concurrent chemo-radiation and early radiation therapy with chemotherapy.

• Proceedings of the Korean Society of Computer Information Conference
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• 2016.07a
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• pp.289-291
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• 2016

본 논문에서는 VR의 발전과 함께 주목받고 있는 컴퓨터 비전 관련 기술들에 대하여 살펴보고, 가장 먼저 선행되어야 하는 이미지 필터링 알고리즘에 대하여 살펴 본다. 다양한 case에서의 여러 Image Filter를 구현, 성능을 비교 분석해 보고, 정확도를 향상 시킬 수 있는 방안에 대하여 연구한다.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 2001.10a
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• pp.45-49
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• 2001

Success in Knowledge Management depends critically on the evaluation system that managers of an organization evaluate objectively performance of members of the organization. In particular, the differences in the standard of Performance evaluation used by managers in Governmental Institution or Agency of make an issue of the standardization of Performance evaluation. Therefore, in this paper we propose the alternative evaluation method, which minimizes the bias resulted from the different standards by measuring ranking of knowledge workers, instead of quantitative analysis, using Median Rank method in Reliability and verify our proposition using the analysis of examples.