• Title/Summary/Keyword: 조직학

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Extract of Ranunculus sceleratus Reduced Adipogenesis by Inhibiting AMPK Pathway in 3T3-L1 Preadipocytes (3T3-L1 전구지방세포에서 개구리자리(Ranunculus sceleratus) 추출물의 AMPK 신호전달을 통한 지방생성 억제 효과)

  • Kim, Yae-Ji;Cho, Sung-Pil;Lee, Hui-Ju;Hong, Geum-Lan;Kim, Kyung-Hyun;Ryu, Si-Yun;Jung, Ju-Young
    • Journal of Korean Medicine for Obesity Research
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    • v.22 no.1
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    • pp.30-37
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    • 2022
  • Objectives: Adipogenesis is the process by which pre-adipocytes are differentiated into adipocytes. It also plays an important role in adipocyte formation and lipid accumulation. Ranunculus sceleratus (R. sceleratus) extracts are used for the treatment of various diseases such as hepatitis, jaundice, and tuberous lymphadenitis in oriental medicine. However, its effect on adipogenesis has not yet been studied. In this study, we investigated the effects of R. sceleratus on adipogenesis in 3T3-L1 cells. Methods: Cells were treated with 50, 100, and 200 ㎍/ml of R. sceleratus and cell viability was evaluated. To differentiate the 3T3-L1 preadipocytes, a 3-isobutyl-1-methylxanthine, dexamethasone, and insulin (MDI) solution were used. The accumulation of lipid droplets was determined by Oil Red O staining. The expression levels of adipogenesis-related proteins were also determined. Results: MDI solution differentiated the preadipocytes into adipocytes and accumulation of lipids was observed in the differentiated 3T3-L1 cells. Interestingly, the amount of lipid droplets was reduced after R. sceleratus treatment. In addition, the expression levels of key adipogenic transcription factors, such as CCAAT/enhancer-binding proteins-𝛼 (C/EBP-𝛼) and peroxisome proliferator-activated receptors-𝛾 (PPAR-𝛾) were also reduced after R. sceleratus treatment. Furthermore, R. sceleratus increased AMP-activated kinase (AMPK) phosphorylation and decreased sterol regulatory element-binding protein-1 expression. Conclusions: Our results showed that R. sceleratus reduced preadipocyte differentiation by inhibiting C/EBP-𝛼 and PPAR-𝛾 levels via the AMPK pathway. Therefore, we suggest that R. sceleratus may be potentially used as an anti-adipogenic agent.

A Study on the Health and Organizational Effectiveness of Korea Coast Guard Substation organization: Focused on Recognition of Workers (해양경찰 파출소 조직의 건강성과 조직효과성에 관한 연구 - 근무자의 인식을 중심으로 -)

  • Kim, Sang-Goo;Park, Jae-Hong
    • Journal of Navigation and Port Research
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    • v.34 no.1
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    • pp.83-89
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    • 2010
  • By analyzing the data collected through surveys conducted on coast guard officers, this paper measures the level of organizational health and explores indicators of organizational health that influence organizational effectiveness. The findings of the analysis can be summarized as follows: First, the scores of all the organizational health indicators except job stress exceed average, which leads a conclusion that coast guard organizations' organizational health is in considerably good condition. Second, the indicators of organizational health included in the analyses are found to have both positive and negative effects on organizational effectiveness. While such variables as pay, co-worker relationship, job autonomy, job itself, organizational trust, job orientation influence positively, other variables including development-oriented culture, promotion system and supervision influence negatively on organizational effectiveness.

The Impact of Communication and Conflict on Group Cohesiveness and Organization Effectiveness in Ship Organization (선박조직의 의사소통과 갈등이 집단응집성 및 조직유효성에 미치는 영향)

  • Lee, Jong-Seok;Kim, Tae-Hyung;Shin, Yong-John
    • Journal of Navigation and Port Research
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    • v.36 no.6
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    • pp.489-499
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    • 2012
  • The purpose of this study is to examine the relation between communication and conflict in the ship organization and to analyze the affect of the conflict on the group cohesiveness and organizational effectiveness in the view of dysfunctional conflict that would play on the negative role to decrease the group cohesiveness and organizational effectiveness. The empirical survey showed that the intragroup and intergroup communications in the ship organization affect on the conflict of within and between groups, these conflicts decrease the group cohesiveness and organizational effectiveness, and that cohesiveness affect the organizational commitment and the job satisfaction of ship organization member significantly.

A Study on the Effect of Swift Trust on the Cohesiveness and Organizational Effectiveness of Ship Organization (선박조직 구성원의 속성신뢰가 집단응집성 및 조직유효성에 미치는 영향에 관한 연구)

  • Kim, Jong-Tea;Cho, Ho-Heang;Shin, Yong-John
    • Journal of Navigation and Port Research
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    • v.37 no.4
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    • pp.429-438
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    • 2013
  • This study set up research models and hypothesis in order to analyze those factors assuming that swift trust affects group cohesiveness, group cohesiveness affects organizational civil activities and organizational effectiveness (job satisfaction and organizational commitment) and at the same time plays as a medium for the swift trust, organizational civil activities and organizational effectiveness. Based upon these finding, variables in the ship unit are analyzed through surveys. This shows that the swift trust has statistically a meaningful and beneficial impact on group cohesiveness which has statistically a meaningful and beneficial impact on organizational civil activities and organization effectiveness. In terms of effects of crew members' the swift trust on organizational civil activities, organizational commitment, and job satisfaction, group cohesiveness has a partial medicated effect.. This paper has its significance in practically proving that the established swift trust of crew members increase group cohesiveness, the heightened group cohesiveness results in the changes of behaviors and attitudes of crew members in the seagoing vessel.

프로스포츠 산업의 조직 구성원의 역량에 따른 관리자의 역할: 미국프로농구(NBA)와 한국프로농구(KBL) 감독의 실증연구 분석

  • Jeong, Tae-Seong;Lee, Sang-Beom;Lee, Sang-Hyeon;Kim, Pil-Su
    • 한국벤처창업학회:학술대회논문집
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    • 2022.11a
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    • pp.227-236
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    • 2022
  • 벤처기업 CEO의 본질적 역량과 역할은 조직의 자원을 얼마나 효율적으로 운영하는가에 따라 관리자로서 조직성과에 큰 영향을 미친다. 이러한 중요성에도 불구하고 CEO 역량 수준이 조직이 내재하는 자원에 미치는 영향에 대한 이론적 고찰과 CEO의 역량 수준과 조직성과 간의 관계가 조직 구성원의 역량에 따라서 어떻게 달라지는가에 관한 실증연구는 매우 부족한 실정이다. 기존 선행연구의 한계점을 보완하기 위해 본 연구에서는 자원기반이론(resource-based view of the firm)을 바탕으로 프로스포츠 산업에서의 조직 구성원의 역량에 따른 관리자의 감독역할에 대해 실증적으로 분석하였다. 구체적으로, 본 연구에서는 기존의 스포츠 기업가정신(sport entrepreneurship) 연구 분야의 이론을 경영전략의 자원기반관점과 융합하여 벤처기업 CEO와 프로스포츠 감독의 역할이 조직구조와 성과 메커니즘의 측면에서 매우 흡사하며 조직의 자원을 효율적으로 운영하고 성과를 도출하는 측면에서 모두 기업가(entrepreneur)적 특성을 반드시 내재해야 한다고 본다. 이러한 맥락에서 프로스포츠팀에서의 관리자로서의 감독 역량과 조직성과 간의 관계에서 조직의 자원 효율성의 매개효과와 조직 구성원 역량에 대한 조절효과를 설명하고자 한다. 미국프로농구(NBA) 30개 구단과 한국프로농구(KBL) 10개 구단의 9개 시즌(2013~2014시즌 - 2021~2022시즌)의 감독과 팀 데이터를 실증분석에 있어 프로세스 매크로 58 모형을 적용하여 본 연구의 가설을 검증하였다. 실증분석 결과, 미국프로농구과 한국프로농구 데이터 모두에서 (1) 프로농구팀의 자원 효율성은 감독의 역량과 승률 간의 정(+)의 관계를 매개하고, (2) 조직 구성원의 역량은 농구팀의 자원 효율성을 통한 감독 역량이 승률에 미치는 간접효과를 조절(p<.05) 하는 것으로 나타났다. 본 연구는 비교적 객관적으로 조직의 성과측정이 가능한 프로스포츠 데이터를 활용하여 프로스포츠 산업에서 벤처기업의 CEO와 유사한 기업가적 역할을 수반해야 하는 감독 및 조직 구성원의 역량이 조직의 성과에 미치는 영향을 실증분석하는 한편 스포츠 애널리틱스(sport analytics) 분야와 경영학 연구를 융합하였다는 의의가 있다.

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The Relationship among Dropout, Organizational Trust, and Intention to Transfer in the Department affiliated with Physical Education (체육계열 학과 학생의 전과의도에 영향을 미치는 요인과 조직신뢰의 매개효과 분석)

  • Kim, Mi-Suk;Kim, Bok-Yeon;Choi, Jin-Ho
    • Journal of Digital Convergence
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    • v.14 no.1
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    • pp.453-463
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    • 2016
  • This study examined the relationship among dropout, organizational trust, and intention to transfer in the department affiliated with Physical Education. Data were collected from 480 students in the department affiliated with Physical Education from 6 institutions of a 4-year university located in Seoul, Gyeonggi-do, Incheon, and ChungChong-do. For the research model analysis, a structural equation model and bootstrapping were conducted. Results indicated that the academic domain, the social domain, and the environmental domain of dropout had a positive effect on organizational trust. But the only the academic domain in the relationship between dropout and intention to transfer affected intention to transfer positively. The social domain and the environmental domain were not statistically significant on intention to transfer. Moreover, organizational trust had a positive effect on intention to transfer. Finally, organizational trust partially mediated the path between the academic domain and intention to transfer. It fully mediated the paths between the social domain and the environmental domain and intention to transfer.

Evaluation of the preservation state of human skeletal remains using real-time PCR (출토 인골 DNA의 real-time PCR 정량에 의한 보존상태 평가 연구 - 부여 오수리 출토 인골을 중심으로 -)

  • Kwon, Eun-Sil;Cho, Eun-Min;Kim, Sue-Hoon;Kang, Soyeong
    • 보존과학연구
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    • s.32
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    • pp.171-183
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    • 2011
  • In this study molecular genetic analysis was carried out on 4 human skeletal remains from Osuri, Buyeo. We showed that real-time PCR is the method of the choice to assess the initial number of genuine ancient DNA molecules. Human mitochondrial DNA quantification was accomplished by the real-time PCR for the cytochrome b gene of the mitochondria. Histological results proved to be a good potentiality for biochemical analysis using biomolecule. The level of specimen's preservation state was proved that level of quantitative result was BO-04, BO-01, BO-03, BO-02. Continually, we showed that biochemical and biomolecule results for the level of preservation state were similar. This study will be useful to important material for predicting biochemistry and biology analysis of the ancient bone.

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A Study on Development of the Major Areas and Content Elements in the Information Organization Field (정보조직분야의 주요영역 및 내용요소 개발에 관한 연구)

  • Choi, Ye Jin;Chung, Yeon-Kyoung
    • Journal of the Korean Society for information Management
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    • v.37 no.1
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    • pp.23-49
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    • 2020
  • This study derives the main areas of information organization that should be covered in the formal curriculum of Library and Information Science, and suggests content elements for each area. Literature research, content analysis, survey and expert evaluation were conducted. Based upon these, information organization field was composed of four areas: information organization in general, classification, inventory, and practice, and a total of 31 content elements were presented. The content elements derived from each area through this study can be used as basic and helpful data when designing syllabus or teaching subjects in the field. In addition, it is possible to expand the content elements of each area of the information organization field through the research method used in this study. Finally, the results of this study will be used as basic materials when conducting the educational contents of information organization field.

The Impact of Manager's Leadership on Organizational Innovation Behavior in China's Star-Rated Hotel Industry: Focused on the mediating effect of Empowerment (중국 호텔 관리자의 리더십이 조직 혁신 행동에 미치는 영향: 심리적 임파워먼트의 매개효과를 중심으로)

  • Li, Meng;Lee, Yoon-koo
    • Journal of Digital Convergence
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    • v.19 no.1
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    • pp.151-165
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    • 2021
  • The purpose of this research is to explore the impact of managers' leadership on organizational innovation behavior in Star-Rated hotels. 244 valid Chongqing hotels' questionnaires were obtained. Through SPSS 23.0, the model structure was verified between the four variables. The results as below. First, transformational, transactional leadership has a positive impact on organizational innovation behavior. Second, transformational, transactional leadership has a significant effect on empowerment. Third, empowerment has a positive impact on organizational innovation behavior. Lastly, empowerment plays a mediation effect between transformational, transactional leadership, and organizational innovation behavior. In conclusion, managers can contribute to organizational innovation behavior by improving the abilities of leadership.

A Study on the Source and History Management of Records According to Administrative Organizational Changes-Focused on D Regional Local Government (행정조직의 변동에 따른 기록물 출처 및 이력 관리-D광역지방자치단체를 중심으로)

  • Sujin Choi;Seongsin Lee
    • Journal of Korean Society of Archives and Records Management
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    • v.23 no.1
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    • pp.27-45
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    • 2023
  • A source of records is critical and highly valuable for records management. The compositions and functions of an administrative organization, which is the source of public records, are changing according to its frequent reorganizations. In particular, changes in local governments are frequent, and the possibility of change increases over time. The processing department is responsible for various records management tasks as the source and producer of records; however, its scope of qualifications is unclear. As such, this study aims to clarify these sources of records and suggest ways to improve their management. For the objective, this study selected D regional local government and analyzed the forms and frequency of its administrative organizational changes. In particular, the processing department's modified organizational functions and compositions due to reorganizations were also examined. Through the analysis, problems concerning records sources that could arise from changes in the administrative organization and processing department were identified, and improvement plans for records management were suggested.