• Title/Summary/Keyword: 저선량

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Expression profile of defense-related genes in response to gamma radiation stress (방사선 스트레스 반응 방어 유전자의 탐색 및 발현 분석)

  • Park, Nuri;Ha, Hye-Jeong;Subburaj, Saminathan;Choi, Seo-Hee;Jeon, Yongsam;Jin, Yong-Tae;Tu, Luhua;Kumari, Shipra;Lee, Geung-Joo
    • Journal of Plant Biotechnology
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    • v.43 no.3
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    • pp.359-366
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    • 2016

  • Tradescantia is a perennial plant in the family of Commelinaceae. It is known to be sensitive to radiation. In this study, Tradescantia BNL 4430 was irradiated with gamma radiation at doses of 50 to 1,000 mGy in a phytotron equipped with a $^{60}Co$ radiation source at Korea Atomic Energy Research Institute, Korea. At 13 days after irradiation, we extracted RNA from irradiated floral tissues for RNA-seq. Transcriptome assembly produced a total of 77, 326 unique transcripts. In plantlets exposed to 50, 250, 500, and 1000 mGy, the numbers of up-regulated genes with more than 2-fold of expression compared that in the control were 116, 222, 246, and 308, respectively. Most of the up-regulated genes induced by 50 mGy were heat shock proteins (HSPs) such as HSP 70, indicating that protein misfolding, aggregation, and translocation might have occurred during radiation stress. Similarly, highly up-regulated transcripts of the IQ-domain 6 were induced by 250 mGy, KAR-UP oxidoreductase 1 was induced by 500 mGy, and zinc transporter 1 precursor was induced by 1000 mGy. Reverse transcriptase (RT) PCR and quantitative real time PCR (qRT-PCR) further validated the increased mRNA expression levels of selected genes, consistent with DEG analysis results. However, 2.3 to 97- fold higher expression activities were induced by different doses of radiation based on qRT-PCR results. Results on the transcriptome of Tradescantia in response to radiation might provide unique identifiers to develop in situ monitoring kit for measuring radiation exposure around radiation facilities.

  • https://doi.org/10.5010/JPB.2016.43.3.359 인용 PDF KSCI

Lung Cancer Screening (폐암 조기 진단)

  • Kim, Ju Ock
    • Tuberculosis and Respiratory Diseases
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    • v.61 no.3
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    • pp.207-213
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    • 2006

  • 기존의 폐암 발생의 고위험군(나이. 흡연력, $FEV_1$, 가족력, 직업적 발암물질의 노출력, 기존의 폐암 및 두경부 종양)에 대한 저선량 나선식 CT와 기관지 내시경 검사로 선별 검사 시 폐암의 유병률은 높아야 2%내외이고 대부분 그보다 낮은 것으로 알려져 있다. 특이도는 49-90%, 양성예측률은 10%이하로 선별검사 시 불필요한 검사를 초래하고 그에 따른 이환률과 사망률을 증가시키며 비용적인 문제를 야기하는 것으로 알려져 있다. 이에 기존의 고위험군에 대해 대상 환자를 더욱 더 좁힐 필요가 있으며, 이는 실제 임상적으로 이용 가능한 생물학적 표지자의 개발의 필요성이 있다고 하겠다. 그러나 현재까지 알려진 폐암조기검진에 대한 각종 진단 수기 중애서 상기의 3가지 방법(저선량 MDCT, 자가형광기관지경 및 객담내 MAGE)을 한꺼번에 시행하는 program은 비용적인 문제는 있지만 시도해 볼 만한 방법이라고 생각된다.

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Algorithm of low dose CT based automatic lung nodule detection (저선량 CT 기반 폐 결절 자동 검출 알고리즘)

  • Ko, Hoon;Lee, Woo Chan;Moon, Chanki;Nam, Yunyoung;Lee, Jinseok
    • Proceedings of the Korea Information Processing Society Conference
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    • 2015.04a
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    • pp.1041-1043
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    • 2015

  • 본 논문은 저선량 흉부 CT 영상을 활용하여 패결절을 자동으로 검출하는 알고리즘에 관한 연구내용을 담고 있다. 폐 결절 자동 검출을 위해 폐 CT 영상 내에 폐결절의 가지고 있는 특징들 중, 이동성 및 기하학적 특징을 가지고 폐혈관과 폐결절을 구분하였다. 실험한 영상은 폐결절이 없는 정상환자군을 가지고 실시 하였으며, 그 결과 4.4False Positive / Scan이 발생하였다.

  • https://doi.org/10.3745/PKIPS.y2015m04a.1041 인용 PDF

Determination of Personnel Exposures in the Lower Energy Ranges of X-Ray by Photographic Dosimeter (저(低)에너지 X-선장(線場)에서 필름배지에 의한 개인피폭선량(個人被曝線量)의 결정(決定))

  • Ha, C.W.;Kim, J.R.;Suh, K.W.
    • Journal of Radiation Protection and Research
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    • v.11 no.1
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    • pp.57-64
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    • 1986

  • This paper described an improved technical method required for proper evaluation of personnel exposures by means of the photographic dosimeter developed by KAERI in lower gamma or X-ray energy regions, with which response of the dosimeter varies significantly. With calibration of the dosimeter in the energy range from 30 to 300 keV, the beam spectrum was carefully selected and specified it adequately. The absorber combinations and absorber thickness used to obtain the specified X-ray spectra from a constant potential X-ray machine were determined theoretically and also experimentally. A correlation between the density and exposure for the four separate energies, such as $49\;keV_{eff},\;154\;keV_{eff}\;250\;keV_{eff}\;and\;662\;keV$, is experimentally determined. As a result, it can be directly evaluated the exposure from the measured response of dosimeter.

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