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Application of Matrix-assisted Laser Desorption/Ionization Time-of-flight Mass Spectrometry (Matrix-assisted Laser Desorption/Ionization Time-of-flight Mass Spectrometry의 활용)

  • Pil Seung KWON
    • Korean Journal of Clinical Laboratory Science
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    • v.55 no.4
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    • pp.244-252
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    • 2023
  • The timeliness and accuracy of test results are crucial factors for clinicians to decide and promptly administer effective and targeted antimicrobial therapy, especially in life-threatening infections or when vital organs and functions, such as sight, are at risk. Further research is needed to refine and optimize matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS)-based assays to obtain accurate and reliable results in the shortest time possible. MALDI-TOF MS-based bacterial identification focuses primarily on techniques for isolating and purifying pathogens from clinical samples, the expansion of spectral libraries, and the upgrading of software. As technology advances, many MALDI-based microbial identification databases and systems have been licensed and put into clinical use. Nevertheless, it is still necessary to develop MALDI-TOF MS-based antimicrobial-resistance analysis for comprehensive clinical microbiology characterization. The important applications of MALDI-TOF MS in clinical research include specific application categories, common analytes, main methods, limitations, and solutions. In order to utilize clinical microbiology laboratories, it is essential to secure expertise through education and training of clinical laboratory scientists, and database construction and experience must be maximized. In the future, MALDI-TOF mass spectrometry is expected to be applied in various fields through the use of more powerful databases.

Analysis of Autonomous Vehicles Risk Cases for Developing Level 4+ Autonomous Driving Test Scenarios: Focusing on Perceptual Blind (Lv 4+ 자율주행 테스트 시나리오 개발을 위한 자율주행차량 위험 사례 분석: 인지 음영을 중심으로)

  • Seung min Oh;Jae hee Choi;Ki tae Jang;Jin won Yoon
    • The Journal of The Korea Institute of Intelligent Transport Systems
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    • v.23 no.2
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    • pp.173-188
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    • 2024
  • With the advancement of autonomous vehicle (AV) technology, autonomous driving on real roads has become feasible. However, there are challenges in achieving complete autonomy due to perceptual blind areas, which occur when the AV's sensory range or capabilities are limited or impaired by surrounding objects or environmental factors. This study aims to analyze AV accident patterns and safety issues of perceptual blind area that may occur in urban areas, with the goal of developing test scenarios for Level 4+ autonomous driving. It utilized AV accident data from the California Department of Motor Vehicles (DMV) to compare accident patterns and characteristics between AVs and conventional vehicles based on activation status of autonomous mode. It also categorized AV disengagement data to identify types and real-world cases of disengagements caused by perceptual blind areas. The analysis revealed that AVs exhibit different accident types due to their safe driving maneuvers, and three types of perceptual blind area scenarios were identified. The findings of this study serve as crucial foundational data for developing Level 4+ autonomous driving test scenarios, enabling the design of efficient strategies to mitigate perceptual blind areas in various scenarios. This, in turn, is expected to contribute to the effective evaluation and enhancement of AV driving safety on real roads.

Development of hydro-mechanical-damage coupled model for low to intermediate radioactive waste disposal concrete silos (방사성폐기물 처분 사일로의 손상연동 수리-역학 복합거동 해석모델 개발)

  • Ji-Won Kim;Chang-Ho Hong;Jin-Seop Kim;Sinhang Kang
    • Journal of Korean Tunnelling and Underground Space Association
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    • v.26 no.3
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    • pp.191-208
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    • 2024
  • In this study, a hydro-mechanical-damage coupled analysis model was developed to evaluate the structural safety of radioactive waste disposal structures. The Mazars damage model, widely used to model the fracture behavior of brittle materials such as rocks or concrete, was coupled with conventional hydro-mechanical analysis and the developed model was verified via theoretical solutions from literature. To derive the numerical input values for damage-coupled analysis, uniaxial compressive strength and Brazilian tensile strength tests were performed on concrete samples made using the mix ratio of the disposal concrete silo cured under dry and saturated conditions. The input factors derived from the laboratory-scale experiments were applied to a two-dimensional finite element model of the concrete silos at the Wolseong Nuclear Environmental Management Center in Gyeongju and numerical analysis was conducted to analyze the effects of damage consideration, analysis technique, and waste loading conditions. The hydro-mechanical-damage coupled model developed in this study will be applied to the long-term behavior and stability analysis of deep geological repositories for high-level radioactive waste disposal.

Development of Autonomous Cable Monitoring System of Bridge based on IoT and Domain Knowledge (IoT 및 도메인 지식 기반 교량 케이블 모니터링 자동화 시스템 구축 연구)

  • Jiyoung Min;Young-Soo Park;Tae Rim Park;Yoonseob Kil;Seung-Seop Jin
    • Journal of the Korea institute for structural maintenance and inspection
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    • v.28 no.3
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    • pp.66-73
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    • 2024
  • Stay-cable is one of the most important load carrying members in cable-stayed bridges. Monitoring structural integrity of stay-cables is crucial for evaluating the structural condition of the cable-stayed bridge. For stay-cables, tension and damping ratio are estimated based on modal properties as a measure of structural integrity. Since the monitoring system continuously measures the vibration for the long-term period, data acquisition systems should be stable and power-efficiency as the hardware system. In addition, massive signals from the data acquisition systems are continuously generated, so that automated analysis system should be indispensable. In order to fulfill these purpose simultaneously, this study presents an autonomous cable monitoring system based on domain-knowledge using IoT for continuous cable monitoring systems of cable-stayed bridges. An IoT system was developed to provide effective and power-efficient data acquisition and on-board processing capability for Edge-computing. Automated peak-picking algorithm using domain knowledge was embedded to the IoT system in order to analyze massive data from continuous monitoring automatically and reliably. To evaluate its operational performance in real fields, the developed autonomous monitoring system has been installed on a cable-stayed bridge in Korea. The operational performance are confirmed and validated by comparing with the existing system in terms of data transmission rates, accuracy and efficiency of tension estimation.

A Research on the Regulations and Perception of Interactive Game in Data Broadcasting: Special Emphasis on the TV-Betting Game (데이터방송 인터랙티브 게임 규제 및 이용자 인식에 관한 연구: 승부게임을 중심으로)

  • Byun, Dong-Hyun;Jung, Moon-Ryul;Bae, Hong-Seob
    • Korean journal of communication and information
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    • v.35
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    • pp.250-291
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    • 2006
  • This study examines the regulatory issues and introduction problems of TV-betting data broadcasts in Korea by in-depth interview with a panel group. TV-betting data broadcast services of card games and horse racing games are widely in use in Europe and other parts of the world. In order to carry out the study, a demo program of TV-betting data broadcast in the OCAP(OpenCableTM Application Platform Specification) system environment, which is the data broadcasting standard for digital cable broadcasts in Korea was exposed to the panel group and then they were interviewed after watching and using the program. The results could be summarized as below. First of all, while TV-betting data broadcasts have many elements of entertainment, the respondents thought that it would be difficult to introduce TV-betting in data broadcasts as in overseas countries largely due to social factors. In addition, in order to introduce TV-betting data broadcasts, they suggested that excessive speculativeness must be suppressed through a series of regulatory system devices, such as by guaranteeing credibility of the media based on safe security systems for transactions, scheduling programs with effective time constraints to prevent the games from running too frequently, limiting the betting values, and by prohibiting access to games through set-top boxes of other data broadcast subscribers. The general consensus was that TV-betting could be considered for gradual introduction within the governmental laws and regulations that would minimize its ill effects. Therefore, the government should formulate long-term regulations and policies for data broadcasts. Once the groundwork is laid for safe introduction of TV-betting on data broadcasts within the boundary of laws and regulations, interactive TV games are expected to be introduced in Korea not only for added functionality of entertainment but also for far-ranging development of data broadcast and new media industries.

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Nutritional Effects of Paper Board Sludge on the Garlic(Allium sativum L.) (마늘에 대(對)한 판지(板紙) SLUDGE의 영양학적(營養學的) 연구(硏究))

  • Kim, Moon-Kyu;Chang, Ki-Woon;Choi, Woo-Young;Lee, Chang-Jun
    • Korean Journal of Soil Science and Fertilizer
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    • v.23 no.3
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    • pp.208-213
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    • 1990
  • The parer board sludge (PBS) itself and compost sludge manure (CSM) made of sawdust, fowl droppings, and urea to the PBS were treated to garlic to determine the effects of growing characters, yield components, and nutritional compounds in the plants. 1. The differences of the rate of missing plants were not found between control and treatments. 2. Plant height of the garlic increased in the treatments of PBS and CSM rather than control. Numbers of leaf, and width of the largest leaf and stem did not have any distinct tendency to change. 3. Total weight and weight of the above ground part were highest in the treatment of 1,600kg/10a PBS, and CS-2 treatment mixed with high portion of additives. The weight of underground part and yield increased with the increase of paper board sludge, and highest in CS-2 treatment. 4. The contents of nitrogen in the plant were higher in the treatments of PBS and CSM than control. And CSM treatments had generally higher concentrations than PBS treatments. 5. In conclusion, PBS itself had nutritional effects. The PBS could be used to some crops after fermentation with adequate additives.

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Development and Application of the Slope Management Program in Urban Area (대도시 사면관리프로그램 개발 및 적용)

  • Kim, Kyeong-Su;Chae, Byung-Gon;Cho, Yong-Chan;Lee, Choon-Oh;Song, Young-Suk
    • The Journal of Engineering Geology
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    • v.17 no.1 s.50
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    • pp.15-25
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    • 2007
  • In general, the life and asset casualties that occur due to landslide or slope failure in urban areas are larger than that in rural areas. In order to reduce the casualties, a slope management program is necessary to categorize slopes based on properties and to manage them systematically. The slope management system is the establishment of the data base for the geological and geotechnical factor according to slope stability, and the utilization of the data base to manage slopes. The suitable system must develop to slopes in urban area through the survey, analysis and evaluation process. Based on the above necessity, the slope management program which is applicable to slope management in an urban area has been developed at Hwangryung Mt. in Busan as a target area. The developed slope management program has various functions such as slope ID number of each slope or sub-region of a mountain, making a slope data sheet, analysis and grouping of slope stability, and establishment of a data base. The slope management program is constructed by use of GIS, and the survey, test and analysis data according to all slopes can be input and edited into the program. The program can also be utilized practically by end users due to the convenient input, edition printing, management and operation of slope data. Therefore, the slope management system has been established on the application of the developed program in Busan which is located in slope area. As the system is widely applied to other cities, the slope in urban area can be managed systematically and the slope hazards can be minimized.

Preliminary Diagnosis of Fishing Ground Environment for Establishing the Management System in Fisheries Resources Protection Area (수산자원보호구역 관리체제 구축을 위한 어장환경 예비진단)

  • Lee, Dae-In;Park, Dal-Soo;Jeon, Kyeong-Am;Eom, Ki-Hyuk;Park, Jong-Soo;Kim, Gui-Young
    • Journal of the Korean Society of Marine Environment & Safety
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    • v.15 no.2
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    • pp.79-89
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    • 2009
  • For preliminary diagnosis on current fishing ground environment and basic information for establishment of effective and rational management policy in fisheries resources protection area, water and sediment quality and changes of total area in the 10 marine protection areas designated for fisheries resources management in Korea were assessed. Results showed that environmental quality in these areas has been degraded by pollution sources, coastal utilization and development stress, etc. The pattern and degree of contamination differed by protection areas, suggesting that it is necessary for optimum environmental management plan considering the regional characteristics. The total designated area of protection areas in 2003 changed by $-22.9{\sim}2.4%$, on average -6.4%, compared with the first year of designation; Wando-Doam Bay showd the highest increase rate (2.4%), and Hansan Bay has the highest decrease rate (-22.9%) Decrease rate of land and sea in total area showd 6.1% and 6.6%. An integrated management of environmental data in protection areas is required for systematic assessment. Therefore, the suitable environmental and information management is needed specifically considering the environment characteristics such as development and utilization conditions of land and sea area Furthermore, bemuse urbanization and industrialization threats the junctions of the protection areas, authorized ministry (MIFAFF) should develope and establish monitoring and management procedures based on the related laws.

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The Development and Application of Informal Gifted and Talented Education program utilizing Local Resources in Yeongheung Island (영흥도 지역자원을 활용한 학교 밖 영재 프로그램 개발 및 적용 효과)

  • Ock, Seong-Hyun;Choi, SunYoung
    • Journal of Science Education
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    • v.38 no.2
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    • pp.356-375
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    • 2014
  • The purpose of this study was to develop the informal education based elementary gifted education program utilizing local resources in Yeongheung island for enhancing the creative problem solving, science process skills, scientific attitudes. This program was totally consisted 36 lessons and 3 part. For this purpose, 7 weeks' informal gifted education program utilizing local resources was treated to a class students who were 5th graders of elementary school in Yeongheung island. The results of this study were as follows : First, the change of science creative problem solving ability in the gifted class was found statistically meaningful difference. Second, science process skills were showed statistically meaningful difference. Third, scientific attitudes were not showed statistically meaningful difference. Fourth, the student responses about effectiveness of this programs were generally positive. Therefore, the gifted education programs showed meaningful results. Based on the results of this study, a number of studies to overcome the limitations will be needed.

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Surgical Treatment of Primary Lung Cancer (원발성 폐암의 외과적 치료)

  • 김성완;구본원;이응배;전상훈;장봉현;이종태;김규태;강덕식
    • Journal of Chest Surgery
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    • v.31 no.2
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    • pp.134-141
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    • 1998
  • Primary lung cancer has recently increased progressively in its incidence in Korea. It is clearly evident that surgical resection offers the best offortunity for cure of non-small cell carcinoma. This study was designed to analyse the clinical data of 100 primary non-small cell carcinoma patients who underwent lung resection surgery from January 1992 to July 1995 at the department of Thoracic and Cardiovascular Sugery, Kyungpook National University Hospital. There were 86 males and 14 females(6:1). In the age distribution, the peak incidence was recorded in the seventh decade(43%). The methods of tissue diagnosis were bronchoscopic biopsy in 53 patients(50.5%), percutaneous needle aspiration in 17 patients(16.2%), transbronchial lung biopsy in 11 patients(10.5%), mediastinoscopic biopsy in 2 patients (1.9%), sputum cytology in 2 patients(1.9%), and thoracotomy in 20 patients(19.0%). Fifty-five lobectomies, 22 pneumonectomies, 15 bilobectomies, 2 segmentectomies, 4 sleeve lobectomies, a sleeve pneumonectomy, and a wedge pneumonectomy were performed. Operative mortality occured in 4 cases(sepsis in 2 cases, respiratory failure in 1 case, and acute myocardiac infarction in 1 case). The histologic types of tumor were 67 squamous cell carcinomas, 26 adenocarcinomas, 6 large cell carcinomas, and an adenosquamous cell carcinoma. Eighteen patients with N2 mediastinal lymph node metastases had 8 squamous cell carcinomas(11.9%), 9 adenocarcinomas(34.6%), and a large cell carcinoma(16.7%). The primary tumors in these patients were in the right upper lobe in 4 patients, the right middle and lower lobe in 9 patients, the left upper lobe in 3 patients, and the left lower lobe in 2 patients. With regard to pathologic stages, 45 patients had stage I disease; 13 patients, stage II; 36 patients, stage IIIa; 5 patients, stage IIIb; and 1 patient, stage IV. The overall actuarial survival rate was 77.5% at 12 months, 56.1% at 24 months and 43.7% at 43 months. The actuarial survival rates at 43 months were 81.3% in Stage I, 20.8% in Stage II, 27.9% in Stage IIIa, 25.0% in Stage IIIb and 33.3% in Stage IV. These facts suggest that early detection and surgical resection are recommended for favorable postoperative survival in non-small cell lung cancer.

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