• Korean Journal of Cognitive Science
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• v.33 no.1
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• pp.51-75
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• 2022

Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation that is able to alter neuronal activity in particular brain regions. Many studies have researched how tDCS modulates neuronal activity and reorganizes neural networks. However it is difficult to conclude the effect of brain stimulation because the studies are heterogeneous with respect to the stimulation parameter as well as individual difference. It is not fully in agreement with the effects of brain stimulation. In particular few studies have researched the reason of variability of brain stimulation in response to time so far. The study investigated individual variability of brain stimulation based on circadian rhythm and chronotype. Participants were divided into two groups which are morning type and evening type. The experiment was conducted by Zoom meeting which is video meeting programs. Participants were sent experiment tool which are Muse(EEG device), tdcs device, cell phone and cell phone holder after manuals for experimental equipment were explained. Participants were required to make a phone in frount of a camera so that experimenter can monitor online EEG data. Two participants who was difficult to use experimental devices experimented in a laboratory setting where experimenter set up devices. For all participants the accuracy of 98% was achieved by SVM using leave one out cross validation in classification in the the effects of morning stimulation and the evening stimulation. For morning type, the accuracy of 92% and 96% was achieved in classification in the morning stimulation and the evening stimulation. For evening type, it was 94% accuracy in classification for the effect of brain stimulation in the morning and the evening. Feature importance was different both in classification in the morning stimulation and the evening stimulation for morning type and evening type. Results indicated that the effect of brain stimulation can be explained with brain state and trait. Our study results noted that the tDCS protocol for target state is manipulated by individual differences as well as target state.

• Science of Emotion and Sensibility
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• v.14 no.3
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• pp.371-384
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• 2011

Three experiments were carried out to examine how LED lighting hues influence to the rating and recognition of affective stimuli. In Experiment 1 and 2, IAPS affective pictures were used and an affective rating(valence and arousal) task and a recognition memory task were conducted under red, green, blue, and white hue LED lightings in Experiment 1 and cyan, magenta, yellow, and white ones in Experiment 2, respectively. In Experiment 3, affective words were used and the same two tasks were conducted under red, green, blue, and white hue LED lightings. According to the results of affective rating tasks, when primary hues(RGB) were used, red LED lighting elicited an excitement at the arousal dimension and green LED lighting evoked pleasantness at the valence one. When secondary hues(CMY) were used, magenta and cyan showed the similar but weaker patterns of responses comparing to red and green. The results of recognition memory task showed that the responses to the picture stimuli presented at green and cyan hue lightings tended to be a bit faster comparing to the stimuli presented at the other conditions but the difference was insignificant. In Experiment 3, however, recognition memory responses to the affective words presented at green hue lighting were faster significantly. These results indicate that warm colors like red and magenta elicit unpleasantness or excitement while cool colors like green and cyan evoke pleasantness or relaxation, and the primary hues provoke more positive or negative affectivity than secondary ones do. Particularly, the result of recognition memory task in Experiment 3 suggests that green hue LED lighting might be advantageous at the memory performance of language stimuli rather than visual ones.

• Clinical and Experimental Pediatrics
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• v.48 no.8
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• pp.881-885
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• 2005

Purpose : Airway dehydration and subsequent hyperosmolarity of periciliary fluid are considered critical events in exercise-induced bronchoconstriction. The aim of this study was to establish if a hyperosmolar challenge could induce activation of eosinophils. Methods : Human eosinophilic leukaemic cell lines, EoL-1 cells were incubated with hyperosmolar solutions for 15 minutes. Activation of EoL-1 cells was monitored by degranulation and superoxide anion production. In addition, we examined surface expression of CD69 and ICAM-1. Results : Hyperosmolar stimuli didn't induce superoxide anion production and degranulation. In addition, EoL-1 cells cultured with hyperosmolar medium at 930 mOsm/kg $H_2O$ resulted in no significant increment in fluorescent intensity of CD69 and ICAM-1 expression compared with results for cells incubated with isomolar medium. Conclusion : We found that hyperosmolar stimuli don't cause activation of EoL-1 cells, but further studies are required to determine the role of eosinophil in the mechanism of exercise-induced asthma.

• Korean Journal of Food Science and Technology
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• v.44 no.2
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• pp.251-256
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• 2012

Stilbenes are known as antioxidants and some of them demonstrate anti-pigmentation activity. The purpose of the present study was to investigate whether two stilbene compounds produced by biotransformation of the extract of $Morus$ $alba$ root show skin irritation and sensitization. In skin irritation test, 1% oxyresveratrol (OXY), and 5% OXY, and 1% oxyresveratrol-3-$O$-glucoside (OXY-3) showed a P.I.I score of 0, 0.04, and 0, respectively. Accordingly, the two stilbenes were evaluated to be virtually 'non-irritant' materials. In a skin sensitization study by GPMT, 1% OXY, 5% OXY, and 1% OXY-3 did not cause edema and erythema at 24 h and 48 h after topical application and exhibited a sensitization score of 0 and a rate of 0%. Consequently, it was confirmed that OXY and OXY-3 had no contact allergic sensitization in GPMT. Therefore, OXY and OXY-3 might be potential candidates as skin-whitening agents without posing any serious side effects.

• Proceedings of the Korean Society for Cognitive Science Conference
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• 2002.05a
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• pp.119-124
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• 2002

공간적 관계정보(spatial relation)가 언어적 표상시스템과 비언어적 표상시스템에서 어떻게달라지는가를 범주화 모델의 원형이론 모델을 적용하여 알아보고자 하였다. 이전의 연구들에 따르면 공간적 관계정보에 대한 프로토타입이 언어적 범주와 비언어적 범주에서 다르다는 연구 결과(Crawford 등 2000, Huttenlocher 등 1991)와 동일하다. (Hayward & Tarr 1995)는 상반된 연구 결과가 제기되고 있다. 하지만 이전 연구들에서의 문제점은 언어/비언어 표상체계 간의 편향을 통제하지 못했기 때문에 과제에 따라 서로 다른 결과가 나온 것이라고 볼 수 있다 본 연구에서는 두 대상간의 관계정보를 문장으로 제시한 조건, 그림으로 제시한 조건, 그리고 두 조건을 혼합한 조건을 사용하여 편향에 의한 효과를 제거하고자 하였다. 실험은 각 조건에 따라 짝으로 구성된 자극을 학습한 후 검사자극을 공간적 관계정보를 다양하게 하여 학습자극과 동일한지 아닌지를 판단하게 하였다. 실험결과 관계정보를 언어적으로 제시한 조건과 비언어적으로 제시한 조건간에 대상의 위치에 따른 반응시간의 경향성에서 차이가 없었으며, 대상이 단어인지 그림인지에 따라서 반응시간에서 통계적으로 차이가 나타났다. 그리고 두 표상체계에서 공간적 관계에 대한 프로토타입을 분석한 결과 수직축을 중심으로 전형성 효과가 나타나는 것을 알 수 있었다.

• Annual Conference of KIPS
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• 2017.11a
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• pp.1097-1099
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• 2017

본 논문은 대뇌 활성화 상태 변화와 혈액형간의 상관성 분석을 목적으로 한다. 혈액은 인체의 혈관을 통하여 몸 전체로 순환하는 액체 성 물질이다. 이 혈액을 구성하는 물질의 이질적 차이를 나타내는 차별적 유형을 혈액형이라 하며, 혈액형은 멘델의 법칙에 따라 부모에서 자식으로 유전된다. [1] 최근 들어 혈액형이 가지는 유전적 특징을 통한 질병 진단 및 치료, 예방을 위한 연구가 진행되고 있으나, 대부분의 연구는 육체적인 질병과 관련되어 있는 실정이다. 그러나, 혈액형의 경우 유전적 특성을 가지고 있으며, 신경 전달 망에 영향을 끼칠 것으로 추정 되는바 육체적 질병뿐만 아닌 정신적인 질환에도 혈액형에 따른 치료 및 예방방법을 차별화 하여, 보다 효율적인 치료 및 예방을 수행 할 수 있을 것으로 판단된다. 본 논문에서는 이를 위하여, 외부자극에 따른 대뇌 활성화 상태 변화를 분석하며, 특히 혈액형에 따른 상태변화의 상관성을 분석하고자 한다. 본 논문에서 활용하는 외부 자극은 청각 자극을 활용하며, 먼저 혈액형에 따른 피험자 군의 분류를 수행하여 동일 군 내 공통반응 및 상이한 군 간의 특이반응을 분석하여, 혈액형이 대뇌 활성화 상태 변화 및 정신질환에 따른 증상발현 등과 유관함을 검증하고자 한다.

• Prospectives of Industrial Chemistry
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• v.24 no.6
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• pp.19-31
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• 2021

자극응답성 액정 엘라스토머(liquid crystal elastomer)는 하이드로겔(hydrogel), 형상 기억 고분자(shape memory polymer)와 더불어 생체 특성을 모방한 인공 근육, 소프트 액추에이터 및 소프트 로봇을 위한 스마트 소재로 최근 높은 관심을 받고 있다. 특히, 액정 엘라스토머는 고무 탄성과 액정 이방성이 결합된 비등방성 탄성 고분자로, 열, 빛, 전기 및 수분과 같은 외부자극에 반응하여 가역적이며, 액정 분자들의 배향조절을 통한 프로그램된 변형이 가능하다. 액정 엘라스토머가 개념 증명을 하는 수준을 넘어 실제로 유용한 소프트 액추에이터 및 로봇 시스템에 적용되기 위해서는 우수한 구동력 및 작업 용량, 높은 구동 변형률, 빠른 응답 시간, 낮은 구동 온도, 다양한 외부 자극반응성 및 높은 에너지 전환 효율 등을 확보하는 것이 중요하다. 본 기고문에서는 액정 엘라스토머의 개념에 대해 소개하고, 이러한 소재가 소프트 액추에이터로써 광범위하게 활용될 수 있도록 다양한 성능들을 향상시킬 수 있는 방법에 대해 소개하고자 한다.

• Clinical and Experimental Pediatrics
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• v.51 no.10
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• pp.1096-1101
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• 2008

Purpose : Patients with chronic granulomatous disease (CGD) have genetic mutations in a component of the NADPH oxidase enzyme that is necessary for the generation of the superoxide anion. The profound defect in innate immunity is reflected by the patients susceptibility to catalase-positive bacteria and fungi. In addition, CGD patients display signs of persistent inflammation, which is not associated only with deficient superoxide anion production. The aim of this study was to elucidate the cytokine responses in CGD patients after $TNF-{\alpha}$ stimulation. Methods : Heparinized blood samples were collected from 8 CGD patients and 10 healthy volunteers. Monocytes ($1{\times}10^6cell/well$) isolated by the magnet cell isolation system were incubated with a constant amount of $TNF-{\alpha}$ (10 ng/mL) at $37^{\circ}C$ for 6 h. Incubated cells were harvested at 60-min intervals for IL-8 and IL-10 mRNA analysis, and the supernatant was collected at the same intervals to determine IL-8 and IL-10 expression. Monocytes from healthy volunteers were also incubated with antioxidants followed by $TNF-{\alpha}$ stimulation for IL-8 and IL-10 expression. Results : In CGD patients, a high expression of IL-8 together with a significantly higher IL-10 expression than in the healthy controls was seen after $TNF-{\alpha}$ stimulation. Moreover, normal monocytes treated with antioxidants exhibited increased IL-8 responses. Conclusion : The absence of phagocyte-derived reactive oxidants in CGD might be associated with a dysregulated production of pro- and antiinflammatory cytokines. Additional research related to reactive oxidants is needed to clarify the role of cytokines in CGD patients.

• Korean Journal of Cognitive Science
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• v.25 no.3
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• pp.211-232
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• 2014

People search a certain object or a person so many time in a day. Besides the information about what the target is, perceptual information of the target can influence on the search process. In the current study, using an eye-tracker we aimed to examine whether the perceptual information of previewing target stimuli on the visual search process of the target and the task performance. Participants had to identify the previewing target stimulus presented in the middle of the screen, and then had to search the target among 8 items presented in a circle array, and had to decide whether the size of the target in the search display was same as that of the previewing stimulus. The experimental conditions were divided into 8 within-subject conditions by whether the search display was consisted of all the same size items or different size items (homogeneous search display vs. inhomogeneous search display), by the size of the preview target stimulus, and by the size of the target stimulus in the search display. Research hypothesis is that the size information of the previewing influence on the visual search process of the target and task performance when the items in the search display are in different sizes. In the results of behavioral data analysis, the reaction time showed the main effect of the search display, and the size of the target stimulus in the search display. and the interaction between the size consistency effect of target stimulus and the search display condition. In the results of analysis of eye-movement information, the Initial Saccade to Target Ratio measurement showed the interaction between the size consistency effect of target stimulus and the search display condition as the reaction time measurement did. That is, the size consistency effect of target stimulus only in the inhomogeneous search display condition indicated that participants searched the items in the same size as that of preview target stimulus. Post-hoc analyses revealed that the search and task performance in the inhomogeneous display condition were faster when the target size was consistent, but rather slower when the target size was inconsistent.

• Korean Journal of Food Science and Technology
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• v.23 no.1
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• pp.37-43
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• 1991

The nerve impulse pattern of Chorda tympani(CT) of cat was tested with Monosodium glutamate(MSG) solutions as well as some basic taste substances applied on the tongue of cat. The effect of MSG applied in the tongue prior to the stimulation of other taste substances was also investigated. The response impulse frequency of CT of cat was changed by the kind and concentration of taste substances. The response to citric acid was the highest among the tested substances, NaCl, KCl and MSG showed similar responses. When different concentrations of MSG were applied on the tongue prior to other substances, the response to NaCl increased with the maximum response at the MSG concentration of 0.02 M. The response to sucrose tended to be reduced, but the response to citric acid was distinctly supressed by the previous MSG stimulation. These results were well consistent with the sensory evaluation on the effect of MSG to some basic taste substances. previously reported by the authors.