• Journal of the Korea Institute of Information and Communication Engineering
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• v.19 no.3
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• pp.537-542
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• 2015

SNOMED CT, which is a standard clinical terminology, imposes an ambiguity problem of terminology selections caused by its huge expressive power and structural complexity. It is very difficult to distinguish similar terms and to select an appropriate term among them within short consultation hours. This paper analyzes the ambiguity problem and proposes a novel scheme for comparative search of similar terms. The proposed scheme provides a differential view of similar terms by defining a "is-not-a" relationship based on the hierarchical structure of the concepts. The result of this work improves the utilization of SNOMED CT such that medical officers can efficiently select an appropriate term among similar terms which represents patient's status adequately.

• Journal of KIISE:Databases
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• v.30 no.2
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• pp.145-156
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• 2003

Most of the content-based image retrieval systems focuses on similarity-based retrieval of natural picture images by utilizing color. shape, and texture features. For the neuroscience image databases, we found that retrieving similar images based on global average features is meaningless to pathological researchers. To realize the practical content-based retrieval on images in neuroscience databases, it is essential to represent internal contents or semantics of images in detail. In this paper, we present how to represent image contents and their related concepts to support more useful retrieval on such images. We also describe the operational semantics to support these advanced retrievals by using object-oriented message path expressions. Our schemes are flexible and extensible, enabling users to incrementally add more semantics on image contents for more enhanced content searching.

• The Korean Journal of Applied Statistics
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• v.26 no.1
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• pp.15-22
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• 2013

In clinical study or epidemic research, the $2{\times}2$ frequency table is useful to present a summary statistic The values of four cells in $2{\times}2$ table use to calculate the effect measures such as risk ratio, relative ris ratio or odds ratio. In this paper, we suggest that the improved visualization method using a radar diagram supported by MS-office Excel from the $2{\times}2$ frequency table is able to understand and draw easily betweendiagnosti measures such as sensitivity, specificity, predictivity, and likelihood ratio. We use some numerical example in order to show the usage of the proposed method.

• Proceedings of the Korean Information Science Society Conference
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• 2010.06c
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• pp.226-229
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• 2010

본 연구에서는 다양한 density profile 특징추출에 기반한 염색체 자동분류방법들의 성능을 비교분석하였다. density profile은 염색체의 밴드패턴을 가장 잘 표현한 특징으로 염색체의 중심축을 구성하는 화소들의 밝기 값을 추출하는 방법이다. 염색체의 밴드패턴은 염색체의 끝단까지를 잘 표현해주어야만 정확한 염색체번호를 확인할 수 있다. 따라서 염색체의 중심축을 추출하여 염색체 끝단까지 확장 처리한 방법에 대한 성능을 확인하였다. 염색체 중심축에 위치한 화소만을 이용한 프로파일은 잡음에 민감할 수 있으므로 이를 해결하기 위하여 염색체의 중심축에 대한 화소 값 대신 주변 밝기 값들에 대한 평균을 이용한 국소평균방법과 중심축의 수직라인 상에 존재하는 화소 값들에 대한 평균을 구한 수직평균방법을 비교하였다. 분류알고리즘은 k-NN을 사용하였고, 실험데이터는 (주)Gendix 로부터 제공받은 임상적으로 정상인 100명(남자 50명, 여자 50명)으로부터 추출한 4600개의 염색체 영상을 훈련데이터와 테스트데이터로 각각 50%씩 랜덤하게 분리하여 실험하였다. 실험결과 중심축을 확장하고 수직평균에 대한 프로파일을 특징으로 추출하여 분류한 경우가 가장 좋은 성능을 보였다.

• Journal of Music and Human Behavior
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• v.9 no.1
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• pp.37-53
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• 2012

This study is conducted to analyse the process and the pattern of motivation for musical expression in clinical music therapy for the adults in the mental health center. The participant were 8 adults purposive sampling who had more than one year music therapy experience in the mental health center and their age ranged from 27 to 53. A major category derived and analysed from the grounded theory method by Strauss and Corbin. The qualitative analysis indicated that motivation for musical expression in music therapy, which was the central phenomenon in this study, was determined by the music therapist and songs used in the sessions. The central phenomenon was caused by the therapist's friendly attitude, high musical capacity, the familarity of the selected songs and the significancy of the lyrics of selected songs. The levels of reliability about the therapist's personality and musical ability as a professional music therapist and the positive arousal of the songs used in sessions affected as the contextual condition. Spontaneous musical expression in music therapy brought the escape from reality, release of stress and sharing by the intervening condition 'empathy' and this resulted in mood regulation, the instillation of hope and group cohesion. It has been found that there were three types of motivation in music therapy: intrinsic motivation, relationship dependent extrinsic motivation and evasive motivation.

• Korean Journal of Psychosomatic Medicine
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• v.25 no.1
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• pp.3-11
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• 2017

Objectives : The aim of this study was to draw attention toward so called 'behavioral variant frontotemporal dementia(bvFTD) phenocopy syndrome', which is difficult to discriminate with the primary psychiatric disorders, showing poor response to conventional therapeutic drugs, leading to higher risk to misdiagnoses and legal problems. Furthermore, the author insisted that our interest and study on them must be continued. Methods : English articles published during 2000 thru 2016 had been searched by internet with the combination of words such as 'frontotemporal', 'phenocopy' and 'behavioral', and reviewed. Besides, two clinical vignettes were described. Results : Precise diagnosis is important because patients' behavioral symptoms can influence on their families and community. However, disease-modifying treatment for bvFTD are not developed until now, and recent therapeutic drugs are only good for specific symptoms, while deterioration progresses in spite of proper psychiatric management. The possible bvFTD patients are not progressed into probable bvFTD clinically, showing no decline of cogntive and social function, no decrease of activity function, longer survival time, and normal neuroimaging for several years. Conclusions : Rather than expected, there are much more patients having clinical symptoms, course and diagnostic findings including neuroimaging, which are atypical to classical frontotemporal dementia and primary psychiatric disorders. If our knowledge and discriminating ability is improved, discovery rate of that cases will be increased. However, the identity of these atypical features are not clarified until now, it must be further actively investigated.

• Journal of Genetic Medicine
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• v.6 no.1
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• pp.67-73
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• 2009

Purpose : In spite of the karyotype and phenotype diversity in Turner syndrome patients, there are few reports about such differences in Korea. We reviewed the data of chromosome abnormalities, clinical manifestations, and comorbidities of Turner syndrome patients in Kyungpook National University Hospital to compare them to the recent hypotheses about sex chromosome gene loci related to Turner symptoms. Materials and Methods : We identified the cytologic findings of 92 patients with Turner syndrome and the clinical findings of 62 patients among them. Results : 54.3 percent of patients had 45,X while 45.7 percent showed other karyotype combinations (45,X/46,XX, 45,X/46,XX/47,XXX, 46,X,del(Xp), 46,X,del(Xq), 45,X/46,X,del(Xq), 46,X,i(Xq), 45,X/46,X,i (Xq)). The Turner symptoms found included short neck, high arched palate, broad chest, Madelung deformity, short metacarpals, scoliosis, cubitus valgus, low hair line, webbed neck, edematous extremities, pigmented nevus, and sexual infantilism. The specific diseases associated Turner syndrome included renal abnormalities, congenital heart disease, hearing defects, diabetes mellitus, hyperlipidemia, and decreased bone density. The phenotype of the mosaicism group was milder than that of the monosomy group. In the case of 46,X,del(Xp) and 45,X/46,X,del(Xq) groups, all had skeletal abnormalities, but the 46,X,del(Xq) group had none. In the case of 46,X,del(Xp) group, all showed short statures and skeletal abnormalities, but no sexual infantilism was observed. In the case of 46,X,i(Xq) and 45,X/46,X,i(Xq) groups, they all showed delayed puberty and had primary amenorrhea. Conclusion : It is important to study karyotype-phenotype correlations in patients with Turner syndrome to obtain interesting information about the genotype-phenotype correlations related to the X chromosome.

• Journal of Veterinary Clinics
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• v.14 no.1
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• pp.30-36
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• 1997

It is well estabilished that IL-4, IL-6, $IFN{\gamma}$ and immunoglobulin production are increased as a consequence of advancing age, and endothelial cells increase their expression of pro-inflammatory surface protein, such as ICAM-1, as a consequence of contact with inflammatory cytokines, including IL-1, $TNF{\alpha} or INF{\gamma}.$ This study was designed to define the relationship between age-associated changes of cytokines and immunoglobulin production and ICAM-1 expression in aged mice. Serum from aged mice had elevated IL-6 and immunoglobulin levels compared to mature adult controls and activation-induced production of $IFN{\gamma}$ of splenocytes from aged mice were increased above normal adult level. By immunoperoxidase staining, ICAM-1 in hearts of normal adult mice was expressed occasionally at low levels, but in aged mice, the number of positive blood vessels for ICAM-1 were increased and also the immunoreactivity were stronger. Therefore, these finding indicate that the altered expression of ICAM-1 eith normal aging may actually be correlative to these age-related changes in cytokiness and immunoglobulin production.

• Journal of The Korean Society of Inherited Metabolic disease
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• v.16 no.3
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• pp.117-122
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• 2016

제1형 고셔병(Gaucher disease type 1)은 리소좀 효소인 산성 ${\beta}$-글루코시다아제(acid ${\beta}-glucosidase$)의 결핍으로 인한 리소솜 축적 질환이다. 효소 활성도가 감소되어 기질이 축적되어, 간비종대, 빈혈, 혈소판감소증 및 골질환을 포함한 전신 증상이 발생한다. 재조합 효소 단백을 정맥 주입하는 효소 대체요법(Enzyme replacement therapy)는 지난 20년 넘게 고셔병의 표준 치료법이었다. 그러나 성공적인 효소 대체요법에도 불구하고, 심각한 폐증상과 골격 증상 등 고셔병 치료에 여전히 해결되지 않는 문제들이 남아 있다. 기질 감소 치료(Substrate reduction therapy)는 기질의 생합성을 억제하여 축적을 감소시킨다. 최근 새로운 경구용 기질감소 치료제인 엘리글루스타트(eliglustat)가 적합한 CYP2D6 대사 표현형을 가진 고셔병 성인 환자를 위한 1차 치료제로 미국과 유럽에서 승인되었다. 엘리글루스타트가 아직 한국에서는 쓰이지 않고 있지만, 본 종설에서는 문헌 검토를 통해 고셔병의 새로운 치료로서의 효소 대체요법을 소개하고자 한다. 아직 확고한 결론을 도출하기에는 연구 결과가 제한적이기는 하지만, 현재까지의 데이터에 따르면 엘리글루스타트는 임상 효능에 있어서 효소 보충 요법에 비열등성을 보인다. 장기 결과에 대한 추가 연구가 필요하지만, 엘리글루스타트의 승인은 해당 1형 고셔병 성인 환자들에게 경구 치료제라는 새로운 선택을 가능하게 하였다. 향후 국내에서 엘리글루스타트가 처방 가능해 지면, 각 환자 마다 철저한 평가를 통해 치료법을 선택할 수 있도록 해야 할 것이다. 나아가, 국내 1형 고셔병 환자들을 위해 엘리글루스타트의 사용에 관한 임상적 지침 또한 조만간 개발될 필요가 있다.

• Journal of Korean Clinical Nursing Research
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• v.17 no.1
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• pp.101-112
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• 2011

Purpose: The purpose of this study is to develop a detailed clinical model for recording initial nursing assessment items, and to test the applicability of the model to facilitate semantic interoperability for sharing and exchanging nursing information. Methods: First, the researchers extracted items by analyzing initial nursing assessment records. Second, defining characteristics were identified by analyzing nursing records and reviewing the literature. Third, value sets for defining characteristics were identified and types and cardinalities of defining characteristics were defined based on the value sets. Finally, the detailed clinical model was tested through evaluation by experts and comparison with the initial nursing assessment in a clinical setting. Results: Sixty-one detailed clinical models were developed with 178 defining characteristics and value sets. The experts evaluation and comparison with the initial nursing assessment in a clinical setting showed that the detailed clinical model developed in this study was valid. Conclusion: Use of this detailed clinical model can ensure that the Electronic Health Record contains meaningful and valid information and supports semantic interoperability of nursing information. This use will promote quality in the nursing records and eventually quality of nursing care.