Age related changes of ICAM-1 expression in the heart of mice

마우스 심장에서 노화에 따른 ICAM-1 표현양상의 변화

  • 류시윤 (충남대학교 수의과대학) ;
  • 정규식 (한국과학기술연구원 생명공학연구소 유전자원센터) ;
  • 조성환 (충남대학교 수의과대학) ;
  • 윤원기 (충남대학교 수의과대학) ;
  • 박배근 (충남대학교 수의과대학) ;
  • 김무강 (충남대학교 수의과대학) ;
  • 권오덕 (전북대학교 수의과대학) ;
  • 김성호 (전남대학교 수의과대학)
  • Published : 1997.03.01


It is well estabilished that IL-4, IL-6, $IFN{\gamma}$ and immunoglobulin production are increased as a consequence of advancing age, and endothelial cells increase their expression of pro-inflammatory surface protein, such as ICAM-1, as a consequence of contact with inflammatory cytokines, including IL-1, $TNF{\alpha} or INF{\gamma}.$ This study was designed to define the relationship between age-associated changes of cytokines and immunoglobulin production and ICAM-1 expression in aged mice. Serum from aged mice had elevated IL-6 and immunoglobulin levels compared to mature adult controls and activation-induced production of $IFN{\gamma}$ of splenocytes from aged mice were increased above normal adult level. By immunoperoxidase staining, ICAM-1 in hearts of normal adult mice was expressed occasionally at low levels, but in aged mice, the number of positive blood vessels for ICAM-1 were increased and also the immunoreactivity were stronger. Therefore, these finding indicate that the altered expression of ICAM-1 eith normal aging may actually be correlative to these age-related changes in cytokiness and immunoglobulin production.



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