• Title/Summary/Keyword: 임상실험

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The Effects of Virtual Simulation Program based Convergence Action Learning on Problem-Solving, Critical Thinking, Communication Skills, and Clinical Competency of the Nursing students (융합 액션러닝 기반 가상 시뮬레이션 프로그램이 간호대학생의 문제해결 능력, 비판적 사고, 의사소통 능력, 임상수행 능력에 미치는 효과)

  • Kim, Kyeng-Jin;Ha, Young-Sun;Park, Yong-Kyung
    • Journal of the Korea Convergence Society
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    • v.13 no.5
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    • pp.489-499
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    • 2022
  • This study examined the effect of convergence action learning based virtual simulation program for nursing college students. The study was carried out according a nonequivalent control group design. The study subjects were 54 nursing college students. The data collection period was from April 12, 2021 to June 18, 2021. Collected data were analyzed using SPSS PC+ 23.0. The experimental group had significantly different to communication skills, and clinical competency in comparison to the control group. This suggests that the convergence action learning based virtual simulation program can be applied as a way to increase nursing students' communication skills, and clinical competency.

Evaluation of Therapeutic Effect of the Extract from Rhubarb (Rheum officinalis) in Dogs with Chronic Renal Failure (개의 만성 신부전에서 대황 추출물의 치료학적 효과의 평가)

  • Kim, Ye-Won;Hyun, Changbaig
    • Journal of Veterinary Clinics
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    • v.29 no.6
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    • pp.435-440
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    • 2012
  • This study was designed to evaluate the clinical efficacy and safety of Rhubarb extracts ($Rubenal^{(R)}$) in dogs with chronic renal failure (CRF). Client-owned 40 dogs with CRF graded International renal interest Society (IRIS) II-III were enrolled in this study. The dogs were equally allocated and blindly administered with $Rubenal^{(R)}$ or placebo. The following items were evaluated at day 0, 30, 90 and 180: body condition score (BCS), clinical score (appetite, polydipsia/polyuria, quality of life score), hemogram (WBC, RBC, PCV), serum biochemistry (ALT/AST, ALP, Creatinine/BUN, total protein, albumin), serum electrolyte (Na, K, Cl, Ca, P), systolic blood pressure, urinalysis (UPC, USG) and IRIS stage. In this study, we found that the $Rubenal^{(R)}$ preparation was well tolerated by dogs and induced no adverse effects. Statistically significant improvements were observed in clinical score (quality of life score by vet and clients), serum BUN and creatinine levels, serum phosphorus concentration, level of proteinuria, and the IRIS score of CRF in dogs after 6 month of treatment of $Rubenal^{(R)}$. Those findings suggested that the Rhubarb extracts can improve the clinical signs of CRF (i.e. azotemia, hypertension, proteinuria, hyperphosphoremia) and the quality of life (i.e. BCS, clinical score) and can retard the progression of CRF in dogs. Therefore the Rhubarb extracts can be a good supplementary drug for treating dogs with subclinical and clinical renal diseases. However, care should be taken for interpreting our result, because this study is not double-blinded controlled study but pilot study.

Imaging Studies in Mouse Brain Using Clinical 3T MRI Scanner (임상용 3T MRI를 이용한 마우스 뇌의 영상)

  • Lim, Soo-Mee;Park, Eun-Mi
    • Progress in Medical Physics
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    • v.21 no.4
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    • pp.348-353
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    • 2010
  • The purpose of this study was to explore the potentials of a clinical 3T MRI in mouse brains and technical adaptation and optimization. T1-weighted images (T1WI), T2-weighted images (T2WI), FLAIR (Fluid Attenuated Inversion Recovery) images, Gadolinium enhanced T1-weighted images (Gd-T1WI), Diffusion weighted images (DWI) were acquired in brain of 2 mice (weight 20~25 g) with cerebral infarction by occlusion of right middle cerebral artery, 1 hour, 24 hours, 72 hours after infarction and 1 normal mouse brain using clinical 3T MRI scanner. We analyzed differentiation of striatum, ventricle, cerebral cortex, and possibility of detection of acute cerebral infarction. We could differentiate the striatum, ventricle, cerebral cortex on T2WI and on DWI, FLAIR, T1WI, the differentiation of each anatomy of brain was not definite, but acute cerebral infarction was detected on DWI of 1 hour, 24 hours, 72 hours after infarction and on T2WI, FLAIR of 24 hours, 72 hours after infarction. Clinical 3T MRI can be used in differentiation of anatomy of mouse brains and DWI can be helpul in detection of acute cerebral infarction in acute phase. With technical adaptation and optimization clinical 3T MRI can be useful tool for provide preclinical and clinical small animal studies.

Status of Employment-Related Qualifications Similar to a Medical Laboratory Technology Major (임상병리기술학 전공 유사 취업연계 자격 현황)

  • Sung, Hyun Ho;Kim, Dae Sik;Cho, Young Kuk;Yoon, Ki Nam
    • Korean Journal of Clinical Laboratory Science
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    • v.50 no.4
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    • pp.525-534
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    • 2018
  • This study evaluated the various qualifications that can be linked to employment similar to the medical laboratory technology major. The qualifications for employment outside the medical laboratory technology major are industrial health instructor, doping control officer, audiologist, sign language interpreter, health education specialist, claim adjuster, Korea life underwriter, administrative manager, hospital administrator, insurance review manager, and hospital coordinator. The qualifications for employment similar to the medical laboratory technology major include the clinical research coordinator, clinical research associate, anatomist, analytical chemistry analysts, hazardous materials industry engineers, biotechnologist, biosafety managers, biotechnology technicians, medical device quality officers, animal care nurse, industrial engineer hazardous material, bioprocess engineer, biosafety officer, certified technology consultant, director of medical device quality control, laboratory animal technician, animal nursing technician, and cruise medical manager. Therefore, it is necessary to conduct a social analysis survey of the various qualifications currently held by medical technologists. In addition, it will be necessary to investigate the current status of medical technologists working in other fields. In the future, medical technologists should expand the scope of their work through efforts to strengthen their individual work capacity, share cases, and strengthen their expertise.

The Effects of Clinical Convergence Self-directedness Practice Learning Program on Self-directedness and Competency in Fundamental Nursing Skills in Undergraduate Nursing Students (임상융합 자기주도적 실습교육 프로그램이 간호대학생의 자기주도성 및 기본간호술기 수행능력에 미치는 영향)

  • Park, Jihyun
    • Journal of the Korea Convergence Society
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    • v.7 no.4
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    • pp.51-58
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    • 2016
  • The purpose of this study was to examine the effects of clinical convergence self-directedness practice learning program on self-directedness and competency in fundamental nursing skills in undergraduate nursing students. The study design was a non-equivalent pre-post quasi-experimental design. The participants were 80 nursing students in D city. The experimental and control groups were randomly assigned with 40 participants in each group. Interventions for the experimental group were visiting clinical practice, video recording and students' self-debriefing of what they did over the 5 days. Self-directedness and competency in fundamental nursing skills were measured 2 times (pre-, and post-intervention) over the 5 days. Independent t-test, Mann-Whitney U test and chi-square test were used for data analyses. There was statistically significant difference for self-directedness(t=12.93, p=.001) and competency in fundamental nursing skills(t=8.34, p=.021). Results indicate that self-debriefing method using video recording is an effective learning way to improve Self-directedness and competency in fundamental nursing skills in nursing students.

Clinical Evaluation of Passive Eruption Using Occlusal Reduction on Periodontium (교합면 삭제(occlusal reduction)를 이용한 수동적 정출 (passive eruption)이 치주조직에 미치는 영향)

  • Kim, Yoo-Jin;Kim, Sung-Jo;Choi, Jeom-Il;Lee, Ju-Youn
    • Journal of Dental Rehabilitation and Applied Science
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    • v.28 no.1
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    • pp.15-25
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    • 2012
  • The relationship between occlusion and periodontal health has been extensively studied. However, reports on the effects of passive eruption using occlusal reduction has not been sufficient. The purpose of the present randomized clinical trial was to assess the influence of passive eruption using occlusal reduction on the clinical periodontal parameters consisting of attachment level, pocket depth, tooth mobility, width of keratinized gingiva and osseous defect. The study was performed on 40 teeth of 16 subjects who have been treated for the moderate periodontitis at the Department of Periodontology, Pusan National University Hospital. At the baseline examination, after hygienic-phase and after 6 month from passive eruption using occlusal reduction, clinical parameters were monitored and radiographs were taken. The 20 teeth in the test group received passive eruption using occlusal reduction while the 20 control teeth did not receive any occlusal reduction. The results were as follows; 1) Degree of inflammation of periodontium was improved by initial therapy 2) Teeth received passive eruption using occlusal reduction demonstrated significantly greater reduction in pocket depth, tooth mobility and amount of bone loss, and increase in the width of keratinized gingiva, but no significant changes in the attachment level compared to the control teeth 3) There was significantly greater reduction in pocket depth, mobility, amount of bone loss and attachment level in the test teeth after initial hygienic phase when compared with baseline data. Taken together, these results suggest that the passive eruption using occlusal reduction would be helpful to improve periodontal health.

Usage and Dosage of Ginseng Radix (panax ginseng C. A. Meyer) Based upon Traditional and Recent Scientific Clinical Applications (인삼의 한의학적 및 현대임상적 측면에서의 복용량 검토)

  • 남기열;박종대
    • Journal of Ginseng Research
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    • v.24 no.2
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    • pp.99-105
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    • 2000
  • Ginsenf Radix (Panax ginseng C. A. Meyer) has been traditionally used as a herbal medicine for many therapeutic or prophylactic purposes in the oriental countries such as Korea, Japan and China for at least two thousand years and also extensively studied in the modern scientific field of chemistry, biochemistry and pharmacology. The herb is now also indicated for use as tonic or a prophylactic and restorative agent for enhancement of mental and physical capacities, in case of weahess exhaustion tiredness loss of concentration, impotence, cold limbs, during illiness anuor convalescence. Ginseng is commonly used in the form of detections, extract and powderl and ginseng products, in the form of capsules tablets and drinks. And also ginseng radix has been widely traditionally prescribed as an important comuonents of manny Chinese prescriptions or alone in various diseases and for health with its different dosages. Nowadays since rinsenf can be generally classified into food or medicine in many nations, it is very difficult to give any exact desnition on the dosage, which may be of particular importance in clinical applications. In addition, the establishment of the reasonable dosage is currently of great significance to meet the demand for such wide applications. Accordingly in this review paper we summarized the dosage of ginseng on the basis of oriental medical books oriental and western pharmacopeias and modern scientific clinical data. The recent survey demonstrated that the averare dosare of finsenf is considered to be three to four grams per day unless prescribed apart, while one to two grams per day in western countries from the western viewpoint of classification of ginseng as a medicine, surrorted by the dosage of not more than one gram per day in most clinical studies. For that reason, it seems likely that the dosage in western countries is ascribed to the safety of ginseng considering side or unwanted effects. Consequently whether the differences of dosage between oriental and western countries depend on dietary habits and races should be closely investigated. Besides, further studies on the pharmacokinetics and bioavailability of ginseng components in clinical trials need to be done to decide optimum dosage of ginseng.

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Development of an EEG Software for Two-Channel Cerebral Function Monitoring System (2채널 뇌기능 감시 시스템을 위한 뇌파 소프트웨어의 개발)

  • Kim, Dong-Jun;Yu, Seon-Guk;Kim, Seon-Ho
    • Journal of Biomedical Engineering Research
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    • v.20 no.1
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    • pp.81-90
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    • 1999
  • This paper describes an EEG(electroencephalogram) software for two-channel cerebral function monitoring system to detect the cerebral ischemia. In the software, two-channel bipolar analog EEG signals are digitized and from the signals various EEG parameters are extracted and displayed on a monitor in real-time. Digitized EEG signal is transformed by FFT(Fast Fourier transform) and represented as CSA(compressed spectral array) and DSA(density spectral array). Additional 5 parameters, such as alpha ratio, percent delta, spectral edge frequency, total power, and difference in total power, are estimated using the FFT spectra. All of these are effectively merged in a monitor and displayed in real-time. Through animal experiments and clinical trials on men, the software is modified and enhanced. Since the software provides raw EEG, CSA, DSA, simultaneously with additional 5 parameters in a monitor, it is possible to observe patients multilaterally. For easy comparison of patient's status, reference patterns of CSA, DSA can be captured and displayed on top of the monitor. And user can mark events of surgical operation and patient's conditions on the software, this allow him jump to the points of events directly, when reviewing the recorded EEG file afterwards. Other functions, such as forward/backward jump, gain control, file management are equipped and these are operated by simple mouse click. Clinical tests in a university hospital show that the software responds accurately according to the conditions of patients and medical doctors can use the software easily.

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Studies on Restoration of Forest-Floor Vegetation Devastated by Recreational Trampling (I) -Seeding, Fertilizing and Soil Surface Treatment Effect on Restoration of Forest-Floor Vegetation- (답압(踏壓)으로 훼손(毁損)된 임간나지(林間裸地)의 임상식생복원(林床植生復元)에 관한 연구(硏究)(I) -임상식생복원(林床植生復元)에 미치는 파종(播種), 시비(施肥) 및 표토처리효과 (表土處理效果)-)

  • Oh, Koo Kyoon;Woo, Bo Myeong
    • Journal of Korean Society of Forest Science
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    • v.81 no.1
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    • pp.53-65
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    • 1992
  • For elucidating effective methods of restoration of forest recreational sites where management goals are maintaining naturalness and conserving natural ecosystem, seeding, fertilization and soil surface treatment were used for four years at the devastated forest-floor. For restoration of forest-floor vegetation, factorial experiment was used with a split plot design(main plot : fertilization, subplot : soil surface${\times}$seeding) and a randomized complete block design (fertilization${\times}$seeding) at the Kwanaksan Aboretum, Anyang, Kyonggido. Results were summarized as follows : Soil surface softening with tipping and ripping and straw-mat mulching (70% coverage) treatment was effective on germination, survival and growth of seeded vegetation at devastated forest-floor. Especially, straw-mat mulching treatment was effective on soil surface stabilization and seedling's survival at eroded soil surface, while complete soil surface softening treatment was effective on germination, survival and early growth of tree species of late-successional series. Introducing seeds of native species of pioneer or early-successional series, with good growth capability in barren soil was effective on rapid restoration in devastated forest-floor with its soil surface previously compacted and its surviving seeds washed away. When the seeding and straw-mat mulching after partial soil surface softening with tipping and ripping treatment were employed, it took about three years to restore the devastated forest-floor where surface erosion had been undertaken for an extended period of time and where naturally surviving seeds of native species had been washed away. Softening treatment of soil surface was effective for about two years, and seeding and soil surface treatment increased number of seedlings and improved soil surface environment through fixing of movement of the fallen leaves. Fertilizing effect was not oberserved, mainly due to seeding exposure and poor physical condition including soil surface erosion, low soil water potential and drought, etc, at the field experimental site. However, application of nitrogen and phosphate fertilizers was effective on seedling survival of the species in late-successional series, while lime application adversely affected the seedling survival.

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Clinical Usefulness of 99mTc-DMSA Renal SPECT Using High Sensitivity-All Purpose Collimator for Pediatric Patients (고감도 범용성 콜리메이터를 이용한 소아 환자 99mTc-DMSA 신장 SPECT의 유용성)

  • Kim, Jin-Eui;Kim, Jung-Soo;Han, Jae-Bok;Choi, Nam-Gil
    • The Journal of the Korea Contents Association
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    • v.16 no.3
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    • pp.219-231
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    • 2016
  • $^{99m}Tc$-DMSA planar scan that can analyze the functions of kidney quantitatively provides less information on a lesion than tomography scanning. Therefore, this study applied a high sensitivity all-purpose collimator that is sensitive to photonic signals to $^{99m}Tc$-DMSA and carried out a clinical scan with single photon emission computed tomography (SPECT). And diagnostic accuracy and time requirement of were analyzed to know the clinical usefulness of the applied scanning method. 10 subjects were intravenously injected with radiopharmaceutical product (1.0-1.2 MBq/kg) and scanned by a gamma camera with planar scanner (high resolution (HR)-mode, $256{\times}256$, 50 kcts/view, 4 image) and SPECT (HR / high sensitive (HS)-mode, $128{\times}128$, step and shoot, $180^{\circ}$, variable sec/angle, total 64 frame, OSEM reconstruction), respectively. The collected data was compared with an analysis program. The results showed that HS-mode SPECT detected total counts 1.8-5.6 times more than planar scan. Relative renal function evaluated based on the counts was not significantly different by two scanning methods (p=0.96) and it turned out that test time was shortened by 39% when HS-mode SPECT was used. Therefore, SPECT using HR, HS-mode collimator could analyze renal function more quantitatively than using planar scan and the former could diagnose the location information of a lesion more accurately than the latter as well as shortened test time requirement, which demonstrated the clinical usefulness of $^{99m}Tc$-DMSA renal SPECT using high sensitivity all purpose collimator.