• The Korean Journal of Pesticide Science
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• v.14 no.4
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• pp.490-498
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• 2010

Isotianil is a fungicide which has prevention effects against rice blast disease. In order to register this new pesticide, the series of toxicity data on animal testing were reviewed to evaluate its hazards to consumers and to determine its acceptable daily intake. Isotianil was almost excreted by urine and feces. It has low acute oral toxicity while has no skin toxicity and ocular irritation. Its skin sensitization was evaluated as slight. Genotoxicity of parent compound and metabolite was negligible. Chronic toxicity tests on rats and dogs showed changes of hematology, clinical biochemistry and liver weight. It had no reproductive and teratogenic effects. The estimation of Acceptable Daily Intake(ADI) is based on the lowest no-observed adverse effect level (NOAEL). The lowest NOAEL of 2.83 mg/kg bw/day was found in the twelve-months rats study. The NOAEL was based on increased liver weight and treatment-related effect on clinica chemistry finding at the nest higher dose level of 2.83 mg/kg bw/day. Therefore, it is considered appropriated to apply an uncertainty factor of 100 to the NOAEL 2.83 mg/kg bw/day from the rat study, resulting in an ADI of 0.028 mg/kg bw/day.

• The Korean Journal of Pesticide Science
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• v.15 no.2
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• pp.208-217
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• 2011

Pyrimisulfan is a herbicide. In order to register this new pesticide, the series of toxicity data on animal testing were reviewed to evaluate its hazards to consumers and also to determine its acceptable daily intake. Pyrimisulfan was excreted mostly by feces. It has low acute oral toxicity while it has no dermal, ocular irritation and skin sensitization (As the result of subchronic and chronic toxicity and carcinogenicity showed changes of hematology and liver.). Two-generation reproduction toxicity, genotoxicity, carcinogenicity and prenatal development toxicity were not proven. Therefore, the ADI for Pyrimisulfan is 0.1 mg/kg/ bw/day, based on the NOAEL of 10 mg/kg/ bw/day of 90-days repeated dose oral toxicity study in dogs while applying an uncertainty factor of 100.

• Journal of Food Hygiene and Safety
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• v.16 no.3
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• pp.178-187
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• 2001

A study has been performed to estimate the average and high (90th percentile of consumers-only) daily intakes of sorbates by age-sex groups (> 3 years old) in Korea. The estimation of daily intakes was based on individual-based dietary intake data in ‘National Health and Nutrition Survey in 1998’and the contents of sorbates from samples. The estimated daily intakes (EDI) of sorbates for average consumers ranged from 0.09 mg/kg/bw/day to 0.51 mg/kg bw/day corresponding to 0.4-2.1% of acceptable daily intake (ADI). For high consumers, the range of EDI of sorbates was 3.42-14.65 mg/kg bw/day corresponding to 13.7-58.6% of ADI. Foods that contributed most to the daily intakes of sorbates for all age-sex groups were processed fish products, processed meat products, and salted floods. There was an inverse relationship between age and the consumption of sorbates for average and high consumers, whereas no marked pattern was emerged by sex categories. The intake levels of sorbates even among high consumers were below the ADI in Korea.

• The Korean Journal of Pesticide Science
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• v.15 no.2
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• pp.218-229
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• 2011

Lepimectin is a insecticide agent. In order to register this new pesticide, the series of toxicity data on animal testing were reviwed to evaluate its hazards to consumers and to determine its acceptable daily intake. Lepimectin was mostly excreted by feces. It has low acute oral toxicity while it has no dermal, ocular irritation and skin sensitization (As the result of subchronic, chronic toxicity and carcinogenicity showed changes of hematology and clinical biochemistry parameter of serum and blood.). Two-generation reproduction toxicity, genotoxicity, carcinogenicity and prenatal development toxicity were not proven. Therefore, the ADI for Lepimectin is 0.02 mg/kg/ bw/day, based on the NOAEL of 2.02 mg/kg/ bw/day of two-years carcinogenic toxicity study in rats and applying an uncertainty factor of 100.

• Journal of Food Hygiene and Safety
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• v.16 no.1
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• pp.53-60
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• 2001

A study has been carried out to estimate the average daily intakes of sorbates, benzoates, and and esters of $\rho$-hydroxybenzoic acid commonly used in Korea. The estimation of daily intakes was based on individual dietary intakes in “National Health and Nutrition Survey in 1998”and the the contents of preservatives from 264 samples. Estimated daily intakes(EDI) of sorbates, benzoates, esters of $\rho$-hydroxybenzoic acid were 0.22, 0.015, and 0.004 mg/kg bw/day, respectively. When assuming the standard body weight of 55 kg for Korean, ratios to acceptable daily intake (ADI) of sorbates, benzoates, and esters of $\rho$-hydroxybenzoic acid were 0.88, 0.30, and 0.04%, respectively.

• The Korean Journal of Pesticide Science
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• v.11 no.4
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• pp.289-298
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• 2007

In order to set ADIs for pesticides registered for use in Korea, an analysis of guidelines on setting ADIs and ADIs established by international bodies and advanced countries was conducted General guidelines on the derivation ADIs are very similar among regulatory authorities. However, there were large differences in the ADIs' setting status and ADI values set for some individual pesticides. ADIs were established for 213 pesticides in UN, 332 in USA, 230 in Japan, 219 in UK and 435 in EU and Australia. Of the established ADIs in other countries, 87 to 252 pesticides were the pesticides registered in Korea depending countries. The number of lowest ADIs depending countries was 32 in USA, 23 in Japan, 6 in EU and Australia. The key target organs and endpoints used for setting ADIs were in the order of enzyme inhibition, body weight change and adverse effect on liver. The number of ADIs used for setting MRLs in Korea was high in the order of JMPR, Japan and USA. ADIs of EU and JMPR had highest similarity among bodies investigated. By referring to the guidances investigated at this study, guideline for setting ADI and ADIs for 64 pesticides registered in Korea were proposed.

• The Korean Journal of Pesticide Science
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• v.15 no.4
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• pp.453-462
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• 2011

This study was carried out to survey the residual characteristics of pesticides and assess their safety. Nineteen agricultural commodities, collected from wholesale and traditional markets in Cheongju. Nineteen agricultural commodities including perilla leaves were collected from the markets on October 29th, 2010. Total 240 pesticides which can be analyzed by multiresidue analysis method by GLC and HPLC were monitored and the pesticides detected were confirmed by GC-MSD and LC-MS. Five pesticides, alachlor, bifenthrin, endosulfan, procymidone and triflumizole, were detected from five samples, such as welsh onion, leek and celery in case of wholesale market and perilla leaves and welsh onion in case of traditional market. Detection rate of 13.2% was obtained as a result of pesticide analysis but 2.6% of the pesticides detected exceeded their maximum residue limits. The estimated daily intakes (EDIs) and maximum permissible intakes (MPIs) of the pesticides detected were less than 26% and 0.05% of their acceptable daily intakes (ADIs) respectively, representing that residue levels of the pesticides detected would be safe.

• Journal of the Korean Society of Food Science and Nutrition
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• v.34 no.1
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• pp.75-80
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• 2005

This study was carried out to measure the amount of daily intake on three synthetic food red colors (Amaranth: R2, Erythrosine: R3, Allura Red: R40) in foods by Korean. Analysis of three synthetic food red colors was conducted by HPLC with the foods including bread, confection, candy, alcoholic beverage, soft drink, ice cream, chocolate, and chewing gum. Recovery rates from the known concentrations of three standard food red colors which were spiked into foods were ranged from 85.1 to 100.4 (%) for each foods. Total Estimated Daily Intake (∑EDI) was from 0 to 1.632 mg/kg bw/day for each food item and from 0.512 to 7.281 mg/person/day for ages (1∼over 65 years old). The data of average food intake for each food item per person per day were obtained from the report of Korean National Nutrition Survey conducted by the Korea Ministry of Health and Welfare in 2001. Total EDI of each red colors per person per day were showed as follows; 0.742 mg/kg bw/day for R2, 0.391 mg/kg bw/day for R3 and 2.018 mg/kg bw/day for R40 as total amount respectively, and the ranges of these values were 0.5∼7.1% of FAO/WHO's Acceptable Daily Intake (ADI) values. Therefore, the amount of daily intake of three synthetic food red colors in Korea was regarded as safe.

• Journal of Food Hygiene and Safety
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• v.17 no.3
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• pp.166-172
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• 2002

This study has been carried out to estimate the average daily intakes of preservatives commonly used in Korea. The survey method, which is specific approach that can be applicable for Koreans has been proposed to estimate the daily intakes. The ADIS of sorbates, benzoates, and esters of p-hydroxybenzoic acid were less than 1% and judged to be safe. The EDIs of sorbates, benzoates, and esters of p-hydroxybenzoic acid were 0.39, 0.29, and 0.04 mg/kg bw/day respectively. And these data were compared with existing data. In case with sorbates, the EDI of survey data was higher than that of analytical data but much lower than that of maximum permitted level data. Also, the EDIs of benzoates and esters of p-hydroxybenzoic acid showed to be the same results. In conclusion, the EDIs of survey data lie between maximum Permitted level data and analytical data of Preservatives. The survey method could be considered as the possible alternative of refined method.

• The Korean Journal of Pesticide Science
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• v.14 no.1
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• pp.1-9
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• 2010

In order to survey residual characteristics of pesticides in the agricultural products selling at markets and to assess their safety, a total of 120 agricultural products were collected from the wholesale and traditional markets in Cheongju and analyzed the pesticide residues in them by multiresidue analysis method using GLC, HPLC and GC-MSD. Three pesticides, procymidone, penconazole, and tetraconazole, were detected from 4 samples such as onion, leek, tomato, and green pepper. Fungicide penconazole was detected from the onion collected from wholesale market. Fungicide procymidone was detected from leek and tomato and fungicide tetraconazole was detected from green pepper. Pesticide residues were detected from 3.3% of the total samples. The estimated daily intakes (EDIs) of the pesticides detected were less than 0.1% of their acceptable daily intakes (ADIs), representing that residue levels of the pesticides detected were evaluated as safe.