• Title/Summary/Keyword: 일반독성

Search Result 395, Processing Time 0.033 seconds

DEVELOPMENTAL DISTURBANCE OF PERMANENT TEETH AFTER RADIOTHERAPY FOR TREATMENT OF MALIGNANT TUMOR : REPORT OF CASES (소아암 환자에서 방사선 치료 후 영구치 치근발육장애 : 증례보고)

  • Heo, Su-Kyung;Choi, Nam-Ki;Kim, Seon-Mi;Yang, Kyu-Ho
    • Journal of the korean academy of Pediatric Dentistry
    • /
    • v.35 no.1
    • /
    • pp.144-150
    • /
    • 2008
  • Multimodal cancer therapy including surgery, chemotherapy, and radiotherapy could not only improve the prognosis of malignancy but also reduce the dosage and toxicity of cancer drug for treatment of malignant tumor. The effects of radiotherapy are generally localized, additive, and accumulative, and depend on dosage, site and cell sensitivity. However, in growing individuals, the dental and skeletal sequelae to radiotherapy result in dental or facial abnormalities that are irreversible : arrested root development, disturbances in enamel formation, microdontia, anodontia, altered tooth eruption and mandibular or maxillary hypoplasia. Especially, the teeth which are developing is affected according to the stage. We report three cases of developmental disturbance of permanent teeth after radiotherapy. These children had received radiotherapy for malignant tumor at the age of 3 to 4 years, in which root hypoplasia, short tapered root and early apex closure were observed. For the management of radiation caries and radiotherapy-related teeth, periodic recall check and oral hygiene instruction are required.

  • PDF

Pathogenesis of Inflammation in H. pylori Infection

  • 정현채
    • 대한위암학회:학술대회논문집
    • /
    • 2002.04a
    • /
    • pp.9-17
    • /
    • 2002
  • 위의 parietal cell 혹은 대식세포와 유사한 세포 내부에서 H. pylori가 발견된다는 보고가 있기는 하나 일반적으로 H. pylori는 Shigella와 같은 침습성 세균은 아닌 것으로 알려져 있다. 그럼에도 불구하고 H. pylori에 감염된 위점막에는 많은 수의 호중구를 위시한 염증세포의 침윤이 관찰되는데 H. pylori가 위상피세포에 부착 할 경우 위상피세포를 자극하여 interleukin-8을 위시한 cytokine 을 발현케하고 이에 의하여 호중구 등의 염증세포가 몰려들게 된다. 한편 고유층에 몰려든 호중구에서는 다시 interleukin-8을 위시한 일련의 호중구 활성화 chemokine을 분비하여 염증반응을 증폭해 나갈 것이다. 호중구에서 발현되는 myeloperoxidase나 활성 산소 등도 위점막의 조직 손상에 기여할 것이다. 위상피세포를 덮고 있는 점액층은 위상피세포를 보호한다고 알려져 있으나 H. pylori 감염의 경우 점액층에 의하여 H. pylori의 운동성이 증가하고 이것이 위상피세포로부터의 cytokine 발현을 자극하여 염증반응을 증폭하는데 관여할 가능성도 있다. H. pylori는 위상피세포에 대하여 apoptosis를 유도함과 동시에 고유층에 몰려든 호중구에 대하여는 apoptosis를 억제케하여 궁극적으로 염증반응을 증폭 및 지속시켜 나가는 쪽으로 작용한다. 한편 H. pylori는 위상피세포로부터 COX-2의 발현을 증가시키는데 이는 위상피세포의 apoptosis를 억제하는 방향으로 작용한다. 이외에 H. pylori의 urease에 의하여 발생한 암모니아나 H. pylori 자신이 분비하는 세포독소가 세포 손상을 유발할 가능성도 있다. 상술한 여러 독성 인자들 중 어느 하나가 단독으로 작용하기보다는 여러 인자가 같이 동시에 또는 시차를 두고 작용할 가능성이 많다고 생각된다.(\gamma-FeOOH)$, 침철광$(\alpha-FeOOH)$, 적금광$(\beta-FeOOH)$, 그리고 자철광$(Fe_3O_4)$이다. 인위적 부식에서는 전부 인철광의 부식물이 생성되었고 자연적 부식에서는 모두 침철광의 부식물이 생성되었다. 특히 철제 표면에 자연적으로 생성된 공식 녹을 XRD 분석한 결과 적금광으로 동정되었다. 이런 모든 시편들을 각 탈염방법에 따라 탈염처리한 후 XRD와 SEM-EDS으로 분석한 결과 인철광과 침철광은 어떠한 변화도 보이지 않았고, 다만 적금광으로 동정된 시편만이 잔존하지 않았다. 철기 제작별 $Cl^-$ 이온 추출량과 탈염효과에 대한 비교 실험은 이온 크로마토그래피 분석 결과와 마찬가지로 단조 철제유물이 주조 철제보다 $Cl^-$ 이온을 많이 가지고 있었으며, 탈염 처리 후에는 $Cl^-$ 이온은 전혀 발견되지 않았다. 이상의 결과 $K_2CO_3$와 Sodium 용액은 탈염처리에서 가장 적합한 탈염처리 용액으로 알수가 있었으며 특히 어떠한 탈염 용액으로 유물을 처리한다 해도 철제유물에 생성된 부식물은 제거되지 않는다는 것을 알게 되었다. 따라서 보존처리자는 유물 표면의 부식 상태만을 보고 처리하기 보다는 철기제작물로 고려하여 처리하는 것이 필요하다. 또한 금속에 부식을 야기시키는 $Cl^-$ 이온과 부식물을 완전하게 제거하여 탈염처리를 하는 것이 유물 부식을 최대한 지연시킬 수 있는 것이라 생각된다.TEX>$88\%$)였다.(P=0.063). 결론: 본 연구에서는 MTHFR C/T & T/T 유전자 다형성이 위암의 발생과 그 위치에 대해 관련이 있는 것으로 여겨지고, 흡연력, 음주력과는 관련이 없는 것으로 여겨진다.험이

  • PDF

The Anti-cancer Effects of Bigihwan, Daechilgithang, and Mokwhyangbinranghwan Ethanol Extracts in Human Hepatocellular Carcinoma Cells (인체 간암세포에서 비기환(肥氣丸), 대칠기탕(大七氣湯) 및 목향빈랑환(木香檳榔丸)의 항암 활성 비교)

  • Kim, So Young;Hong, Su Hyun;Choi, Sung Hyun;Cheong, JaeHun;Choi, Yung Hyun
    • Journal of Life Science
    • /
    • v.30 no.5
    • /
    • pp.460-467
    • /
    • 2020
  • Hepatocellular carcinoma (HCC) is one of the most commonly diagnosed cancers in the word. Although radiation and chemotherapy are generally effective, there are various side effects that greatly limit the effectiveness of these treatments. Therefore, traditional herbs may have potential as important resources for the discovery of liver cancer therapeutics. In this study, we selected three Korean herbal medicine formulas from the Donguibogam, namely Bigihwan (BGH), Daechilgithang (DCGT), and Mokwhyangbinranghwan (MHBRH), and evaluated their anti-cancer effects on HCC cells. According to our results of three ethanol extracts, BGH was more effective at suppressing HCC growth than DCGT or MHBRH. Furthermore, flow cytometry analysis showed that inhibition of HCC proliferation by the three extracts was associated with the induction of apoptosis and autophagy. In particular, BGH significantly increased mitochondrial impairment and showed the possibility of inducing mitophagy in comparison with the other two extracts. BGH prominently upregulated the levels of microtubule-associated protein light chain-3 which was accompanied by a decrease in the expression of anti-apoptotic Bcl-2 without altering the expression of pro-apoptotic Bax. In addition, the levels of PTEN-induced kinase 1 were also markedly increased in BGH-treated HCC cells. Moreover, autophagy blocking improved cell viability and reduced apoptosis after the three treatments, indicating that autophagy by these extracts enhances HCC cells against cytotoxicity. In conclusion, our findings show that BGH demonstrates the highest anti-cancer activity among the three formulas and inhibits the proliferation of HCC cells through autophagy induction.

Simultaneous Analysis of Antimicrobial Three Straight Chain 1,2-alkanediols in Cosmetics by Gas Chromatography (가스크로마토그래피를 이용한 화장품 중 항균작용의 3종의 직쇄상 1,2-알칸디올류의 동시분석)

  • Lee, Hoo Seob;Lee, Sang Hun;Kim, Eun Juk;Chung, Cheol Hee;Pyo, Hyeong Bae
    • Journal of the Society of Cosmetic Scientists of Korea
    • /
    • v.40 no.1
    • /
    • pp.37-44
    • /
    • 2014
  • Preservatives such as paraben, phenoxyethanol, and chlorphene are commonly used in cosmetics thanks to cheap price and good antiseptic effect. Recently, consumers' concerns about their possible toxicity and skin irritation forced them to be replaced with straight 1,2-alkanediols. However, as the alkanediols may also irritate skin, limited amount of them should be used in cosmetics. Three 1,2-alkanediols including 1,2-pentanediol, 1,2-hexanediol, and 1,2-octanediol in cosmetics were analyzed simultaneously by gas chromatogrphy with flame ionization detector. As a result of method validation, the specificity was confirmed by the calibration curves of 1,2-pentanediol, 1,2-hexanediol, and 1,2-octanediol showing good linearity correlation coefficient of above 0.999 over the concentration range of $100{\sim}1,200{\mu}g/g$. The limit of detection (LOD) and quantification (LOQ) of 1,2-pentanediol, 1,2-hexanediol, and 1,2-octanediol were 31, 40, and $19{\mu}g/g$ and 98, 108, and $57{\mu}g/g$, respectively. The precision (Repeatability) of the amount in cosmetics showed less than 2.0%. Relative Standard Deviation (% RSD) and the Accuracy (% recovery) of the amount in cosmetics showed 99.3 ~ 103.3, 99.4 ~ 106.7, 97.5 ~ 107.3% respectively. As a result, simultaneous analysis of antimicrobial three 1,2-alkanediols in cosmetics were possible. This method can be utilized in accurate quantitative analysis of 1,2-alkanediols in cosmetics.

The Removal of Dioxins and the Formation of 2, 3, 7, 8-TeCDF in Drinking Water Treatment in Japan (정수처리에서의 다이옥신 제거 및 2, 3, 7, 8-TeCDF 생성)

  • Kim, Hyun-koo
    • Journal of Korean Society on Water Environment
    • /
    • v.24 no.6
    • /
    • pp.758-766
    • /
    • 2008
  • To evaluate homologue patterns and removal efficiency before and after water treatment, the concentrations of dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs) and coplanar polychlorinated biphenyls (Co-PCBs) were determined in 122 samples from 42 drinking water treatment plants throughout Japan over a two year period. The mean concentrations and toxic equivalent (TEQ) values of dioxins in raw and treated waters were 60.24 pg/L (0.14 pg-WHO-TEQ/L) and 4.15 pg/L (0.016 pg-WHO-TEQ/L), respectively. The dioxins contribution ratio of drinking water in relation to dioxins tolerable daily intake (TDI, 4 pg-TEQ/kg/day) was 0.016%. The mean TEQ removal rate of dioxins by drinking water treatment was over 88%. However, the mean removal rate of 2, 3, 7, 8-TeCDF (tetrachlorodibenzofuran) by water treatment in the 122 samples was minus 17%. Therefore, to identify which process affected the level of 2, 3, 7, 8-TeCDF, the removal efficiencies at both the advanced and conventional water treatment plants were investigated. For the TEQ removal rate across the processes, the dioxin congeners, TeCDF and non-ortho-PCBs remarkably indicated minus values after chlorination in both the advanced and conventional water treatments plant. From this study, the level of 2, 3, 7, 8-TeCDF was found to be increased as a result of chlorination.

Research Trends in Hormetic Stimulation Effects of Herbicides in Plants (식물에서 제초제의 양면성 촉진반응 연구동향)

  • Pyon, Jong-Yeong;Uddin, Md. Romij;Kim, Sang-Woo;Park, Kee-Woong
    • Korean Journal of Weed Science
    • /
    • v.32 no.3
    • /
    • pp.159-169
    • /
    • 2012
  • Hormesis is a dose-response phenomenon that is characterized by low-dose stimulation and high-dose inhibition. This biphasic dose-responses have had a long and extensive history in the fields of chemical toxicology, radiation biology and pharmacology. Hormesis has been found from bacteria, fungi, plants and animals, but hormesis in plants has received relatively little attention. Thus principles, occurrence, factors affecting the expression of hormetic responses, and their mechanisms in plants induced by herbicides are reviewed to provide the potentials for crop enhancement. Bromacil, bromoxynil, chloramben, propachlor, terbacil, EPTC, MSMA, and glyphosate at low doses showed stimulatory response in growth. Subtoxic dose of glyphosate increased sucrose content in sugarcane that is used worldwide in sugarcane production. Low dose of protoporphyrinogen-inhibiting herbicides induced increased pathogen defence, and low dose of triazine herbicides improved nitrogen metabolism and increased protein content in some crops. Further researches on potential benefits and risks of hormesis and its mechanism are needed for application of crop enhancement in agriculture.

Neuroprotective Effects of Bread Containing Cirsium setidens or Aster scaber (곤드레 또는 참취를 함유한 빵의 뇌신경 보호효과)

  • Kwon, Ki Han;Lim, Heekyung;Chung, Mi Ja
    • Journal of the Korean Society of Food Science and Nutrition
    • /
    • v.43 no.6
    • /
    • pp.829-835
    • /
    • 2014
  • This study investigated the neuroprotective effects of bread containing extract from Cirsium setidens (CS) or Aster scaber (AS) against $H_2O_2$-induced death of human brain neuroblastoma SK-N-SH cells. Treatment with bread containing extract from CS (CSB) or AS (ASB) reduced $H_2O_2$ cytotoxicity in SK-N-SH cells, the intracellular ROS level, and the phospho-p38 mitogen-activated protein kinase (MAPK) level. In the sensory evaluation, wild vegetable flavor scores of CSB were higher than those of ASB and bread containing 0% CS or AS (NB). In terms of appearance, color, flavor, softness, and overall acceptability, CSB and ASB showed higher scores than NB, but no differences were observed between CSB and ASB. These results indicate that CSB and ASB have potent health benefits in terms of neuroprotection against oxidative stress mediated through antioxidant activity and inhibition of p38 phosphorylation in brain neural cells. Thus, CS and AS could be considered as a health functional material.

Simultaneous Reduction of CH4 and NOx of NGOC/LNT Catalysts for CNG buses (CNG 버스용 NGOC/LNT 촉매의 CH4와 NOx의 동시 저감)

  • Seo, Choong-Kil
    • Journal of the Korea Academia-Industrial cooperation Society
    • /
    • v.19 no.6
    • /
    • pp.167-175
    • /
    • 2018
  • Natural gas is a clean fuel that discharges almost no air-contaminating substances. This study examined the simultaneous reduction of $CH_4$ and NOx of NGOC/LNT catalysts for CNG buses related to the improvement of the $de-CH_4/NOx$ performance, focusing mainly on identifying the additive catalysts, loading of the washcoat, stirring time, and types of substrates. The 3wt. % Ni-loaded NGOC generally exhibited superior $CH_4$ reduction performance through $CH_4$ conversion, because Ni is an alkaline, toxic oxide, and exerts a reducing effect on $CH_4$. A excessively small loading resulted in insufficient adsorption capacity of harmful gases, whereasa too high loading of washcoat caused clogging of the substrate cells. In addition, with the economic feasibility of catalysts considered, the appropriate amount of catalyst washcoat loading was estimated to be 124g/L. The NOx conversion rate of the NGOC/LNT catalysts stirred from $200^{\circ}C$ to $550^{\circ}C$ for 5 hours showed 10-15% better performance than the NGOC/LNT catalysts mixed for 2 hours over the entire temperature range. The NGOC/LNT catalysts exhibitedapproximately 20% higher $de-CH_4$ performance on the ceramic substrates than on the metal substrates.

Effect of p-Phenylenediamine to Rat Skin (p-Phenylenediamine이 흰쥐의 피부 조직에 미치는 영향)

  • Lee, SangHee;Cho, HyunGug;Lee, Sang-Il
    • Journal of the Korean Society of Food Science and Nutrition
    • /
    • v.34 no.9
    • /
    • pp.1330-1335
    • /
    • 2005
  • Red brownish p-pheylenediamine (PPD) has been widely used hair dye for women. The dye was known to cause systemic anaphylaxis, dermatitis and bladder cancer. But the effect of PPD toxicity with oxygen free radical has not been studied. This study investigated the degree of skin injury by PPD. PPD ($2.5\%$ PPD in $2\%\;NH_{4}OH$) was applied to the rat skin ($25 mg/16.5\;cm^2$) 3 or 5 times every other day. Histopathological findings demonstrated the proliferation of epithelial cells and the increased keratinization by PPD. The activities of glucose 6-phosphatase (G6Pase) was decreased and acid phosphatase (ACP) was increased in PPD-applied rat skin. Groups in which PPD was applied 5 times were more damaged than groups applied 3 times. To examine the relationship between tissue damage and oxygen free radicals, effect of PPD on xanthine oxidase (XO) activity was measured and XO activity was more significantly increased in the group treated with PPD 5 times than 3 times. However, reduced glutathione (GSH) content, and the activities of catalase (CAT), super-oxide dismutase (SOD) and glutathione S -transferase (GST) were more decreased in PPD-applied groups than in controls. Even though the activities of XOD was not changed in the group treated with PPD 3 times, the decreased activities of oxygen free radical system and the damaged skin tissue were observed. This result might be caused by the production of toxic PPD metabolites in rat skin. In conclusion, topical PPD application led to skin injury in a dose-dependent manner, probably due to the generation rate of oxygen free radical.

Analysis of Trace Levels of Lodinated Trihalomethanes in Water Using Headspace - GC/ECD (Headspace - GC/ECD를 이용한 수중의 미량 요오드계 트리할로메탄류 분석)

  • Son, Hee-Jong;Song, Mi-Jung;Kim, Kyung-A;Yoom, Hoon-Sik;Choi, Jin-Taek
    • Journal of Korean Society of Environmental Engineers
    • /
    • v.36 no.1
    • /
    • pp.35-41
    • /
    • 2014
  • Trihalomethanes (THMs) are formed as a results of the reaction of residual chlorine, used as a disinfectant in drinking water, with the organic matter in raw water. Although chlorinated and brominated THMs are the most common disinfection byproducts (DBPs) reported, iodinated THMs (I-THMs) can be formed when iodide is present in raw water. I-THMs have been usually associated with several medicinal or pharmaceutical taste and odor problems and is a potential health concern since they have been reported to be more toxic than their brominated and chlorinated analogs. Currently, there is no published standard analytical method for I-THMs in water. An automated headspace-gas chromatography/electron capture detector (GC/ECD) technique was developed for routine analysis of 10 THMs including 6 I-THMs in water samples. The optimization of the method is discussed. The limits of detection (LOD) and limits of quantification (LOQ) range from 12 ng/L to 56 ng/L and from 38 ng/L to 178 ng/L for 10 THMs, respectively. Matrix effects in river water, sea water and wastewater treatment plant (WWTP) final effluent water were investigated and it was shown that the method is suitable for the analysis of trace levels of I-THMs, in a wide range of waters. The method developed in the present study has the advantage of being rapid, simple and sensitive.