• Korean Journal of Food Science and Technology
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• v.52 no.1
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• pp.81-88
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• 2020

The biological activities of Platycodon grandiflorum (PG) root extracts have been studied intensively, whereas there are limited number of studies on PG seed extract (PGSE). PGSE was prepared by ethanol extraction, and its antidiabetic effect was evaluated in mice with type 2 diabetes (C57BLKS/J-db/db). Results indicated that the administration of high-dose PGSE (600 mg/kg, wb) significantly stabilized the blood glucose levels, as evidenced by the results of the oral glucose tolerance test. Mice treated with high-dose PGSE exhibited significantly lower serum hemoglobin A1c, insulin, and leptin levels after eight weeks of feeding trial (p<0.05). High-dose PGSE administration significantly improved glucose uptake in the femoral muscle of db/db mice by activating both IRS-1/PI3K/AKT/AS160 and AMPK phosphorylation pathways. GLUT4 translocation from the cytosol to the plasma membrane increased 1.7-fold in the PGSE high-dose group. These results suggest that PGSE has potential for development as an antidiabetic agent.

• Journal of Korean Academy of Nursing
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• v.46 no.6
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• pp.813-823
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• 2016

Purpose: This study was done to develop and validate a measure to evaluate the Korean version of psychological insulin resistance (K-PIR) in patients with diabetes in Korea. Methods: Items were initially generated from literature reviews and interviews with 19 patients with diabetes. The content validity of the items was evaluated by experts. Participants were 424 patients with diabetes recruited through convenience sampling. A cross-sectional survey was designed for item-analysis, exploratory factor analysis with principal axis factoring, and confirmatory factor analysis. Cronbach's alpha was calculated to measure the internal consistency. Results: For the 24 items of the Korean version of psychological insulin resistance, six items were eliminated because of low correlation with the other items. Exploratory factor analysis with 18-item showed that two factors (psycho-cognitive factor and supportive factor) explained 41.8% of the variance, and the factor structure of K-PIR model had a good fit. Internal consistency of K-PIR with 18 items revealed good reliability. Conclusion: The findings show that the K-PIR is reliable for measuring the psychological resistance to insulin therapy for Korean patients with diabetes. However, further study is needed to evaluate the validation because the proportion of variation of K-PIR was low in this study.

• Journal of Korean Clinical Nursing Research
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• v.28 no.3
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• pp.277-288
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• 2022

Purpose: This study was conducted to evaluate the effects of the insulin therapy adherence program (INSTA GRAM) for patients with type 2 diabetes mellitus. Methods: This study examined a total of 63 patients with type 2 diabetes for whom the initiation of insulin therapy is being considered or within 6 months of undergoing insulin therapy. INSTAGRAM is a stage-specific intervention consisting of strategies for motivating patients to initiate and maintain insulin therapy using the transtheoretical model on the stages of change, the process of change, and self-efficacy. The participants were randomly assigned to either the INSTAGRAM group (experimental group, n=32) or the standard diabetes education group (control group, n=31). The INSTAGRAM group received 6 sessions over 8 weeks(face-to-face education was conducted in the first and last sessions, and telephone coaching was conducted from the second to fifth sessions). The outcomes were measured by psychological insulin resistance, self-efficacy, and glycosylated hemoglobin (HbA1c). Results: Psychological insulin resistance (p<.001), self-efficacy (p<.001), and HbA1c (p=.024) of the participants in the INSTAGRAM group significantly improved compared to those in the control group. Conclusion: INSTAGRAM is effective in overcoming psychological insulin resistance and improving self-efficacy and HbA1c. Therefore, the INSTAGRAM can be recommended as a nursing intervention for type 2 diabetic patients who delay the initiation of insulin therapy.

• The Monthly Diabetes
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• s.208
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• pp.25-28
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• 2007

운동요법은 인슐린이 발견되기 수세기 이전부터 당뇨병의 치료로 이용되어 왔으며, 운동이 당뇨병환자의 신체 대사에 미치는 단기 및 장기 효과에 대해서도 이미 많은 연구결과들이 보고되어 그 유용성이 증명되었다. 그러나 많은 당뇨병환자들이 막상 운동을 시작하려해도 어떻게 시작하는 것이 효과적이고 어떤 점을 유의해야하는 지에 대해서는 잘 알지 못하고 있는 것이 사실이다. 그래서 여기서는 당뇨병환자에게 있어서 실제적인 운동 시 주의해야 할 점에 대해서 알아보고자 한다. 사실 운동프로그램을 시작하기 전에 당뇨병환자는 적절한 진단 검사와 자세한 의학적 평가가 이루어져야만 한다. 여기에는 운동에 의해서 악화될 수 있는 혈관성 합병증의 유무도 자세히 살펴보아야만 한다. 심장, 혈관, 눈, 신장, 신경계에 영향을 미치는 질병의 증상과 증후에 초점을 맞추어 세심한 병력과 신체진찰을 받고 환자 개개인에 대한 위험을 최소화 할 수 있는 개별화된 운동처방에 따라 운동을 시작하는 것이 바람직하다.

• Journal of Veterinary Clinics
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• v.18 no.1
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• pp.74-77
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• 2001

A ten-year-old, male cat presented with recent loss of body weight, depression, vomiting, anorexia, polydipsia, and polyuria. General physical findings included depression, weakness, severe dehydration and a strong acetone odor on the breath. A complete blood count and serum biochemical profiles were leukocytosis, hyperglycemia (286 mg/dl), hypokalemia (2.6 mEq/L), hyponatremia, and high serum fructosamine (600 $\mu$mol/L). In blood gas analysis the cat had acidosis (pH 7.127, p$CO_2$26.7 mmHg). In urinalysis glycosuria and ketouria were appeared. On the basis of clinical signs, serum chemistry, blood gas analysis and urinalysis, diabetic ketoacidosis was diagnosed. Treatment included subcutaneous administration of protamine zinc insulin (0.75 U/head) and intravenous administration of 0.9% saline. Potassium phosphate and sodium bicarbonate was added to the fluids. Serum fructosamine for assessment of glycemic control was measured on occasion calls. On day 296, the patient improved clinically and did not experience any problems resulting from diabetic ketoacidosis.

• The Journal of Korean Physical Therapy
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• v.6 no.1
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• pp.185-200
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• 1994

The purpose of this study was to investigate the glucose and lipid metabolic changes physical exercise of patients with NIDDM. The physical exercise consisted of 15 minutes per day on a bicycle ergometer at $70\%$ maximum heart rate. The results of this study which were calculated from the level of glucose and lipid metabolism of the preexercise and after 2weeks exercise were as follows. 1. Blood glucose was siginificiantly decreased after physical exercise of two weeks(P<0.005). 2. Total cholesterol showed a tendency to decrease after physical exercise of two weeks, but the difference was statistically insignificiant. 3. Triglyceride showed a tendency to decrease on female, but triglyceride on man was inclose after exercise. 4. HDL showed a tendency to increase after physical exercise of two weeks, but the results were statistically insigificiant. 5. LDL showed a tendency to decrease after physical exercise of two weeks, but the results were statistically insignificiant. 6. HDL/cholesterol showed a tendency to increase aftre physical exercise of two weeks, but the results were statistically insignificiant.

• Proceedings of the Korean Information Science Society Conference
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• 2006.10a
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• pp.43-47
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• 2006

개인의 삶의 질과 관련되어 건강과 가장 밀접한 관계가 있는 헬스케어 서비스 분야에서 유비쿼터스 비즈니스 모델의 개발이 활발히 이루어지고 있다. 최근 서구화된 식생활과 고령화로 암, 당뇨, 고혈압 등 만성 질환과 노인성 질환이 우리나라에서도 증가하고 있다. 단순히 혈액 중의 당이 높은 것만으로는 즉각적인 증상을 보이지 않는다. 하지만 당뇨병으로 인한 심각한 합병증이 발생할 수 있으므로 당뇨병의 치료 및 예방이 중요하다. 따라서 본 논문에서는 유비쿼터스의 핵심 기술 중 하나인 RFID를 이용하여 당뇨병 환자들의 혈당 및 혈압을 모니터링 하고 식사, 운동, 인슐린 등을 조절하는 헬스케어 서비스 시스템을 구현한다

• The Korean Journal of Medicine
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• v.99 no.2
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• pp.78-83
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• 2024

Incretin-based obesity treatments are making remarkable progress, marking a new era in the field of obesity pharmacotherapy. These treatments not only meet the long-standing demands for safety and sustainability in obesity medications but also go beyond, significantly improving complications associated with obesity, such as cardiovascular diseases. This review explores the advancement in obesity treatments through the latest research findings on semaglutide and tirzepatide, two incretin-based obesity treatments currently receiving considerable attention.

• Journal of Life Science
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• v.27 no.3
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• pp.289-294
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• 2017

Diabetes mellitus is associated with insulin resistance, which leads to down-regulation of insulin signaling and the decreased glucose uptake. Adipocytes are sensitive to insulin, and closely implicated in insulin resistance and diabetes. Insulin stimulates differentiation of preadipocytes to adipocytes, and increases glucose transport. Allium species have been used as traditional medicine and health-promoting foods. Allium hookeri (A. hookeri) is reported to improve the pancreatic ${\beta}-cell$ damage and exhibit pancreatic anti-inflammatory activity in streptozotocin-induced diabetic rats. We investigated whether A. hookeri extract (AHE) may stimulate glucose uptake in adipocytes through increasing insulin sensitivity. AHE enhanced fat accumulation, a differentiation biomarker, under the partial induction of differentiation by insulin. $PPAR{\gamma}$, a transcription factor highly expressed in adipocytes, promotes adipocyte differentiation and insulin sensitivity. AHE increased the differentiation of preadipocytes through up-regulation of $PPAR{\gamma}$. The activation of $PPAR{\gamma}$ increases the GLUT4 expression during adipocyte differentiation. GLUT4 is responsible for glucose uptake into the adipocytes. AHE increased the expression of GLUT4 in adipocytes, and subsequently enhanced the insulin-stimulated glucose uptake. These results suggest that AHE promotes adipocyte differentiation through activation of $PPAR{\gamma}$, and leads to enhance glucose uptake in adipocytes along with GLUT4 up-regulation. Thus, AHE may be effective for the insulin-sensitizing and anti-diabetic activities.

• Journal of Food Hygiene and Safety
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• v.28 no.2
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• pp.152-157
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• 2013

We evaluated the anti-diabetic effects of Isaria tenuipes in diabetes mellitus type 2. For the experiments, the diabetic animal model OLETF rats were divided to 4 groups: Isaria tenuipes was administered mixed with the high fat diet 45% at dose levels of 0.0%, 0.1%, 1.0%, and 5.0% for 4 weeks. All animals have free access to water and high fat diet 45%. The diabetic clinical markers, including clinical signs, body weight and food intake, organ weights, blood glucose level, insulin level and HOMA-IR index, oral glucose tolerance test, GLUT4 mRNA and protein were measured at a time. After administration for 4 weeks, the blood glucose levels, insulin levels and HOMA-IR index of test groups were decreased compared with control group in dose-dependent manner. The body weight and diet consumptions were reduced in control group at 4 weeks. The treatments of Isaria tenuipes also showed high expression of GLUT4 mRNA and protein in the muscle of OLETF rats. The results suggest that Isaria tenuipes has anti-hyperglycemic effect attenuating blood glucose in the animal model of type 2 diabetes and might be useful as a functional diet for human diabetic diseases.