• Tuberculosis and Respiratory Diseases
• /
• v.49 no.2
• /
• pp.198-206
• /
• 2000

Background : Pulmonary complications following bonemarrow transplantation (BMT) are common and associated with a high mortality rate. We investigated the yield, safety, and impact of fiberoptic bronchoscopy (FOB) for diagnosis of postBMT pneumoniae. Methods : From May 1997 to April 2000, 56 FOBs were performed in 52 post BMT patients for clinical pneumoniae. BMT patients with respiratory symptoms and/or pulmonary infiltrates had a thoracic HRCT(high resolution computed tomography) and bronchoscopic examination including BAL (bronchoalveolar lavage), TBLB (transbronchial lung biopsy), PSB (protected specimen brush). Results : The characteristics of the subjects were as follows : 37 males, 15 females, mean age of 31.3 years(l7-45), 35 sibling donor allogenic BMTs, 15 nonrelated donor allogenic BMTs, and 2 autologous BMTs. Fiftynine percent of FOBs (33 FOBs, 31 patients) were diagnostic. Isolated pathogens included the following : 12 cytomegalovirus (CMV) (21.4 %), 7 pneumocystis carinii (PC) (12.5 %), 11 CMV with PC (19.6 %), 2 Mycobacaterium tuberculosis (3.6%), and 1 streptococcus (1.8%). Most of the radiographic findings were diffuse interstitial lesions. CMV pneumoniae had mainly diffuse interstitial nodular lesion, and PC pneumoniae had diffuse, interstitial ground glass opacity(GGO). When CMV was accompanied by PC, a combined pattern of nodular and GGO was present. Of the 56 cases (23.2%), 13 died of CMV pneumoniae (n=2), PCP (n=2),mixed infection with CMV and PC (n=3), underlying GVHD (n=1), underlying leukemia progression (n=1), or respiratory failure of unknown origin (n=4). There was no major complication by bronchoscopy. Only 3 cases developed minor bleeding and 1 episode temporary hypoxemia. Conclusion : Based on our findings, CMV and PC are the major causes of postBMT pneumoniae. In addition, BAL can be considered a safe and accurate procedure for the evaluation of pulmonary complications after BMT.

• Journal of the Korean Data and Information Science Society
• /
• v.28 no.2
• /
• pp.251-260
• /
• 2017

The option pricing of Black와 Scholes (1973) and Merton (1973) has been widely reported to fail to reflect the time varying volatility of financial time series in many real applications. For example, Duan (1995) proposed GARCH option pricing method through Monte Carlo simulation. However, financial time series is known to follow a fat-tailed and leptokurtic probability distribution, which is not explained by Duan (1995). In this paper, in order to overcome such defects, we proposed the option pricing method based on GARCH models with normal mixture errors. According to the analysis of KOSPI200 option price data, the option pricing based on GARCH models with normal mixture errors outperformed the option pricing based on GARCH models with normal errors in the unstable period with high volatility.

• The Korean Journal of Applied Statistics
• /
• v.28 no.2
• /
• pp.289-294
• /
• 2015

Linear mixed models are commonly used in the clinical pharmaceutical studies to analyze repeated measures such as the crossover study data of bioequivalence studies. In these models, random effects describe the correlation between repeated outcomes and variance-covariance matrix explain within-subject variabilities. Bioequivalence analysis verifies whether a 90% confidence interval for geometric mean ratio of Cmax and AUC between reference drug and test drug is included in the bioequivalence margin [0.8, 1.25] performed using linear mixed models with period, sequence and treatment effects as fixed and sequence nested subject effects as random. A Levofloxacin study is referred to for an example of real data analysis.

• Transactions of the Korean Society of Mechanical Engineers B
• /
• v.33 no.9
• /
• pp.658-665
• /
• 2009

Lean premixed combustors are used for significant NOx reduction which one of issues in current gas turbine combustor. This study was investigated to estimate the effects of the unmixedness of fuel-air, equivalence ratio on the instability mechanism, NOx emission and combustion oscillation in a lean premixed combustor. The experiments were conducted in a dump combustor at atmospheric pressure conditions using methane as fuel. The swirler angle was $45^{\circ}$, the degrees of fuel-air mixing were 0, 50 and 100 and inlet temperature was 650K. The equivalence ratio was ranging from 0.5 to 0.8. This paper shows that NOx emission was increased when the degree of fuel-air mixing is increased in same equivalence ratio and when equivalence ratio is increased. And the range of the combustion instability was enlarged as a function of increasing of the degree of fuel-air mixing.

• Journal of the Korean Society for Aeronautical & Space Sciences
• /
• v.34 no.12
• /
• pp.35-40
• /
• 2006

The combustion instability in a model dump combustor with an exhaust nozzle and the possibility of combustion control using a loudspeaker to these instabilities were studied. By changing inlet velocity, combustor length and equivalence ratio, dynamic pressure signals and flame structures were simultaneously taken. Because inlet velocity and combustor length affect the life time of vortex in the dump combustor, the results showed that as the combustor length increased and the inlet velocity decreased, the instability frequency decreased and the maximum power spectral density of the dynamic pressure generally decreased. Also, instability frequency and maximum power spectral density of the dynamic pressure increased with the increment of equivalence ratio. From the data of close-loop control, the optimum time-delay control using a loudspeaker was confirmed to be able to reduce the vortex shedding induced from the mixed acoustic-convective mode combustion instability.

• Clinical and Experimental Pediatrics
• /
• v.50 no.11
• /
• pp.1072-1077
• /
• 2007

Purpose : It has been described that the incidence of breastfeeding jaundice is 13% and that of breast milk jaundice is 2%. The incidence in Korea was believed to be higher, but there were no studies to prove this assumption. The purpose of this study was to investigate the incidence of jaundice of healthy breastfed full-term infants in Korea. Methods : 839 infants were enrolled who were admitted to the Postpartum Care Center of the Cheil General Hospital between January 1 and December 31, 2005, and were followed up for more than 7 days. Those infants were divided into 3 groups; Exclusive breastfeeding group; Partial breastfeeding group; Formula feeding group. If they became icteric, transcutaneous bilirubin (TcB) was measured by research nurses with JM-103 Jaundice meter (Konica Minolta sensing, Inc., Osaka, Japan). Using this method we investigated the incidence of breast milk jaundice of healthy breastfed full-term infants. Results : There were no significant differences in sex, birth weight, Apgar score, or obstetric risk factors among 3 groups but there were higher rates of vaginal delivery in the exclusive breastfeeding group. The incidence of breast milk jaundice was 10.8% in the exclusive breastfeeding group and 4.4% in the partial breastfeeding group. The incidence of breast milk jaundice in the breastfed infants was 6.3%. The incidence was significantly higher in the exclusive breastfeeding group than in the partial breastfeeding group. Conclusion : The incidence of breast milk jaundice of healthy breastfed full-term infants was 6.3%. It was found that the incidence of breast milk jaundice was higher in this study than in other countries. But it was not a population-based study, so further study with the large sample sizes is needed.

• Journal of the Korean Geotechnical Society
• /
• v.23 no.4
• /
• pp.91-100
• /
• 2007

In most design codes, soils are classified as either sand or clay, and appropriate design equations are used to represent their behavior. For example, the behavior of sandy soils is expressed in terms of the relative density, whereas consistency limits are often used for clays. However, sand-clay mixtures, which are typically referred to as intermediate soils, cannot be easily categorized as either sand or clay and therefore a unified interpretation of how the soil will behave at the transition point, i.e., from sandy behavior when fines are low to clay behavior for high fines content, is necessary. In this study, active natural clays are mixed with sand, and the fines content varied in order to produce different structures, ranging from one state where only sand particles form the soil structure to another where the matrix of fines make-up the structure. While paying attention to the granular void ratio in order to clarify the shear properties of sand-clay mixtures with increasing fines content monotonic, shear tests were performed on isotropically, and anisotropically consolidated specimens. From the test results, it was observed that the monotonic shear strength of sand-clay mixtures is dependent on the granular void ratio.

• Journal of the KSME
• /
• v.33 no.9
• /
• pp.803-810
• /
• 1993

벽면에서의 전단응력 분포와 유동장 내에서의 3차원 유동 요소를 추적하는 유동가시화 기법중 에서 몇 가지를 그 응용 예와 함께 살펴보았다. 3차원 유동의 주요 특징들과 한계유선(limiting streamlines)을 관찰하기 위해서는 oil and lampblack 기법이 충분하나 유속이 작거나 유동의 방향이 분명하지 않은 곳에서는 ink dot 기법을 적용하는 것이 좋다. Oil and lampblack 기법은 실험하고자 하는 유동의 조건에 따라 기름과 분말의 혼합비, 기름의 점도 등을 잘 선택하여야 한다. 안장점(Saddle point) 이나 재부착선(reattachment line)과 같이 성격상 중요한지점을 찾기 위해서는 털실 프로브(single tuft probe)가 유용하게 쓰이며, 이는 또 유동내에서 와동의 존재와 위치를 찾는데 쓰이기도 한다. 수치해석 결과 얻을 수 잇는 속도벡터와 같이 비교적 넓은 유동 장을 한눈에 관찰하기 위해서는 털실 격자망 (tuft grid)을 사용할 수 있으며 각 털실은 그 지 점세서의 유동의 방향과 그 안정성(steadiness)를 나타내준다. 이러한 유동가시화 방법들은 각 유동의 특성에 맞는 적절한 조건을 맞추기 위해서 많은 시행착오를 거쳐야 하며, 하나의 만족 스러운 결과를 얻기 위해서는 많은 기술과 시간과 연습을 요구하고 있어서 다른 정량적인 측정 기술과 더불어 커다란 노력과 관심을 기울여서 발전시켜야만 할 것이다.

• Journal of the Korean Society of Combustion
• /
• v.8 no.2
• /
• pp.1-6
• /
• 2003

Numerical simulations are conducted at atmospheric pressure in order to understand the effect of the oxygen enrichment level on structure of $CH_4/O_2/N_2$ premixed flames. Under several equivalence ratios the flame speeds are calculated and compared with those obtained from the experiments, the results of which are in good agreement. The effects of the oxygen enrichment are investigated on flames under fuel-rich conditions. As the oxygen enrichment level is increased from 0.21 to 1, the flame speed and the temperature are increased. The emission index of $CO_2$ is decreased in cases of flames for fuel rich mixtures, so the efficiency of combustion may be decreased. The maximum emission index of NO is obtained for 0.6 of the oxygen enrichment level.

• 한국연소학회:학술대회논문집
• /
• 2002.06a
• /
• pp.113-122
• /
• 2002

The purpose of this study is to verify that the modified Lagrangian model can predict temperature, flow and scalar fields in the high temperature recirculation region of swirling confined diffusion flame. In the meantime numerical results from EBU and Equilibrium PDF models as well as experimental results are compared with those from the modified Lagrangian model. Adaption of three different turbulent models were accompanied with this procedure. Look-up table of the ignition characteristic time scale which is one of important factors of the Lagrangian model was referred to the 11-step reduced mechanism. Eventually, results with the Lagrangian model show a good accordance with experimental results, which shows the validity of this model. Results from Chen's model differ from those of the others. Numerical results of ${\widetilde{k}$ show significant deviation from experimental results for three models.