• Parasites, Hosts and Diseases
• /
• v.31 no.3
• /
• pp.277-284
• /
• 1993

Leishmaniasis is one of the important tropical diseases in the world. Although it is not prevalent In Korea, imported cases have been recorded. The karyotype of Leishmcnic sp. has been observed to be variable by localities or by strains, but the karyotype of a strain is known to be stable. This study was performed to observe if the karyotype of a Leishmonio sp. would be changed under some stressful conditions. The karyotype, analyzed by pulsed Held gradient gel electrophoresis, was not grossly changed by heat shock, chemotherapeutics, UV illumination, and gamma irradiation. Radiation destroyed the chromosomes mechanically but subcultured organisms after irradiation showed unaffected karyotype. The present findings suggest that the karyotype of a Leishmnnia strain is so stable that it is not altered by temporary stimulation with heat, drugs, and radiation.

• Journal of agricultural medicine and community health
• /
• v.13 no.1
• /
• pp.82-87
• /
• 1988

사람의 흡충류감염(吸蟲類感染)은 대부분(大部分) 열대(熟帶) 및 동부아세아지역(東部亞細亞地域) 여러 국가(國家)에서 발생(發生)한다. 주혈흡충증(住血吸蟲症), 간흡충증(肝吸蟲症), 태국간흡충증(泰國肝吸蟲症), 간흡충증(肝吸蟲症), 요꼬가와흡충증(吸蟲症), 이형이형흡충증(異型異型吸蟲症) 및 폐대흡충증(肺大吸蟲症)등은 어떤 일부(一部) 아세아국가(亞細亞國家)에 있어서 공중보건상(公衆保健上) 중요(重要)한 문제(間題)가 되어 있다. 이와 같은 패류매개성기생충감염(貝類媒介性寄生蟲感染)은 풍토병(風土病)을 일으키고 있다. 사람들의 생활습관은 풍토병을 일으키게될 원인이 될 뿐만 아니라 때로는 그 질병(疾病)을 유행(流行) 전파(傳播)시키는 기본적 요소가 되기도 한다. 주혈흡충을 제외한 흡충류감염은 우리가 중간숙주(中間宿主)을 먹었을때 그곳에 있었던 피낭유충(被囊幼蟲)에 의하여 감염이 이루어 진다. 식물(植物)의 생식(生殖)(간질(肝蛭), 폐대흡충(肺大吸蟲)), 게 및 가재 생식(폐흡충), 민물고기 생식(간흡충, 요꼬가와흡충, 이형이형흡충), 또는 우렁이 생식(극구흡충(棘口吸蟲)), 기타(몇가지 우연적감염(偶然的感染))등은 사람의 흡충류감염의 주 원인이 되는 것이다. 한편 주혈흡충 감염은 요염수원(汚染水源)에 접촉한 피부을 뚫고 들어온 쎌카리아 유충(幼蟲)에 노출되기 때문에 일어난다. 흡충류감염에 대하여 예방과 방어에 관한 공중보건학적 조치는 많다. 이들의 조치중에는 화학요법에 의한 감염원을 감소시키는 것, 패류숙주의 박멸, 만족할만한 위생시설의 비치, 급수시설, 보건교육, 진단기술의 보급, 환경관리 및 개선 등이 포함된다. 그러나 감염자들에 대한 화학요법은 가장 빠르고 효과적인 억제방법인 것으로 나타나고 있다. 흡충류감염을 예방하는데 있어서 가장 중요한 변화는 프라지콴텔과 같은 신약의 개발이었다. 프라지콴텔은 모든 종류의 주혈흡충, 간흡충, 폐흡충 및 여러가지 장내기생 흡충류등 사람의 병원성흡충류에 대한 치료제로서 가장 좋은 특효약이다. 흡충류감염이 중요한 보건문제가 되어 있는 곳에서는 그 예방과 억제책에 있어서 장단기계획(長短期計劃)을 수립하는 것이 좋을 것 같다. 단기는 집단화학요법을 조기에 실시하여야 하고 자기는 "비특이성 기구"로써, 예를들면 위생시설 및 급수시설의 설치, 보건교육등으로 감염을 감소시켜 감염유지 수준이하로 보지(保持)시키는 것이다. 이와같은 억제조치를 착실히 수행하기 위하여 많은일이 있다. 예를 들면 집단참여, 역학적 조사, 약물의 공급, 환경관리, 보건교육, 지역사회관련, 일차보건 진료와의 협조 및 재정후원등에 대하여 검토하고 연구하여야 할 것이다.

• Parasites, Hosts and Diseases
• /
• v.27 no.3
• /
• pp.213-216
• /
• 1989

Seven cases of Diphyllcbothrium latum infection were proved by collection of worms after prasiquantel treatment between October, 1986 and July, 1987. The patients were all males aged 20~44 years residing in Seoul or Ulungdo, Kyungpook Province. All of them had the history of eating several kinds of raw marine fishes, and they had never been to abroad. One of them exporienced abdominal pain and 6 experienced natural discharge of a chain of worm segments, but none revealed any sign of anemia, Total 12 worms (1~3/patient) were collected after praiiquantel treatment. The worms were 85~423 cm in length, and revealed the characteristic rosette-shape uterus in their gravid proglottides. The average egg size varied $61.0~65.3{\times}41.7~46.1{\;}{\mu\textrm{m}}$. The eggs were yellowish. brown, and ovoid to elliptical. Including the present 7 cases, the total number of human D. latum infections proven by worms in Korea becomes 28 cases.

• Parasites, Hosts and Diseases
• /
• v.33 no.4
• /
• pp.313-322
• /
• 1995

Metosonimus yokosawai was found deeply invaded into the submucosa of the small intestine of mice (ICR) when they were immunosuppressed by prednisolone injection. Experimental groups consisted of control, fluke infection (1,800 metacercariae per mouse) and fluke infection plus immunosuppression. In fluke infection group, many worms were found sectioned in the intervillous space of the jejunum and ileum at 6 hrs, 12 hrs, and 1 day after infection, and pathological changes characterized by villous atrophy and crypt hyperplasia were observed. After 3 days, only a few worms were found in intestinal sections, and after 7 days, the pathological changes became minimal. No worm was found penetrated beyond the mucosal layer. On the other hand, in immunosuppressed mice, numerous worms were found sectioned in the duodenum and jejunum, irrespective of the infection period up to 14 days. Pathological changes of the mucosa were minimal until 3 days after infection, but at 5 days marked destruction of the mucosal layer was observed. At this time many flukes were found invaded deeply into the submucosa facing the muscular layer. Despite continuous immunosuppression, the mucosal damage was gradually recovered at 7-21 days post-infection. The results showed that immunosuppression of ICR mice can induce, for a short perid of time, severe mucosal damage, and allow deep invasion of M. yokogcuwai into the submucosa of the small intestine.